KEGG   Canis lupus familiaris (dog): 485864
Entry
485864            CDS       T01007                                 
Symbol
SRC
Name
(RefSeq) proto-oncogene tyrosine-protein kinase Src isoform X1
  KO
K05704  tyrosine-protein kinase Src [EC:2.7.10.2]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa01522  Endocrine resistance
cfa04012  ErbB signaling pathway
cfa04015  Rap1 signaling pathway
cfa04062  Chemokine signaling pathway
cfa04081  Hormone signaling
cfa04137  Mitophagy - animal
cfa04144  Endocytosis
cfa04360  Axon guidance
cfa04370  VEGF signaling pathway
cfa04510  Focal adhesion
cfa04520  Adherens junction
cfa04530  Tight junction
cfa04540  Gap junction
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04625  C-type lectin receptor signaling pathway
cfa04727  GABAergic synapse
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04810  Regulation of actin cytoskeleton
cfa04912  GnRH signaling pathway
cfa04915  Estrogen signaling pathway
cfa04917  Prolactin signaling pathway
cfa04919  Thyroid hormone signaling pathway
cfa04921  Oxytocin signaling pathway
cfa04926  Relaxin signaling pathway
cfa05100  Bacterial invasion of epithelial cells
cfa05135  Yersinia infection
cfa05152  Tuberculosis
cfa05161  Hepatitis B
cfa05163  Human cytomegalovirus infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05168  Herpes simplex virus 1 infection
cfa05203  Viral carcinogenesis
cfa05205  Proteoglycans in cancer
cfa05207  Chemical carcinogenesis - receptor activation
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05219  Bladder cancer
cfa05417  Lipid and atherosclerosis
cfa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    485864 (SRC)
   04015 Rap1 signaling pathway
    485864 (SRC)
   04370 VEGF signaling pathway
    485864 (SRC)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    485864 (SRC)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    485864 (SRC)
   04137 Mitophagy - animal
    485864 (SRC)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    485864 (SRC)
   04520 Adherens junction
    485864 (SRC)
   04530 Tight junction
    485864 (SRC)
   04540 Gap junction
    485864 (SRC)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    485864 (SRC)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    485864 (SRC)
   04613 Neutrophil extracellular trap formation
    485864 (SRC)
   04625 C-type lectin receptor signaling pathway
    485864 (SRC)
   04062 Chemokine signaling pathway
    485864 (SRC)
  09152 Endocrine system
   04912 GnRH signaling pathway
    485864 (SRC)
   04915 Estrogen signaling pathway
    485864 (SRC)
   04917 Prolactin signaling pathway
    485864 (SRC)
   04921 Oxytocin signaling pathway
    485864 (SRC)
   04926 Relaxin signaling pathway
    485864 (SRC)
   04919 Thyroid hormone signaling pathway
    485864 (SRC)
  09156 Nervous system
   04727 GABAergic synapse
    485864 (SRC)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    485864 (SRC)
  09158 Development and regeneration
   04360 Axon guidance
    485864 (SRC)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    485864 (SRC)
   05207 Chemical carcinogenesis - receptor activation
    485864 (SRC)
   05208 Chemical carcinogenesis - reactive oxygen species
    485864 (SRC)
   05203 Viral carcinogenesis
    485864 (SRC)
  09162 Cancer: specific types
   05219 Bladder cancer
    485864 (SRC)
  09172 Infectious disease: viral
   05161 Hepatitis B
    485864 (SRC)
   05168 Herpes simplex virus 1 infection
    485864 (SRC)
   05163 Human cytomegalovirus infection
    485864 (SRC)
   05167 Kaposi sarcoma-associated herpesvirus infection
    485864 (SRC)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    485864 (SRC)
   05152 Tuberculosis
    485864 (SRC)
   05100 Bacterial invasion of epithelial cells
    485864 (SRC)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    485864 (SRC)
   05418 Fluid shear stress and atherosclerosis
    485864 (SRC)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    485864 (SRC)
   01522 Endocrine resistance
    485864 (SRC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    485864 (SRC)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    485864 (SRC)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     485864 (SRC)
Protein kinases [BR:cfa01001]
 Non-receptor tyrosine kinases
  SRC family
   485864 (SRC)
Membrane trafficking [BR:cfa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    485864 (SRC)
 Endocytosis
  Clathrin-mediated endocytosis
   Kinases
    485864 (SRC)
  Lipid raft mediated endocytosis
   Caveolin-mediated endocytosis
    485864 (SRC)
  Macropinocytosis
   Kinases
    485864 (SRC)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_9 SH3_2 SH2_1 ABC1 Haspin_kinase
Other DBs
NCBI-GeneID: 485864
NCBI-ProteinID: XP_005635094
Ensembl: ENSCAFG00000008755
VGNC: 46791
UniProt: A0A8C0SX18 A0A8I3SBF9
LinkDB
Position
24:25618275..25668243
AA seq 553 aa
MGSNKSKPKDASQRRRSLEPAENTHGGGGGAFPTSQTPSKPASADGHRGPSTAFPSAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTRKV
DVSQTWFTFRWLQREGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESER
LLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQF
NSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGE
VWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEY
MSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC
KVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGR
VPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF
TSTEPQYQPGENL
NT seq 1662 nt   +upstreamnt  +downstreamnt
atgggcagcaacaagagcaagcccaaggatgccagccaacggcgccgcagcctagagcca
gctgagaacacccacggtggcggcgggggtgccttccccacctcacagacacccagcaag
ccagcctccgctgatggccaccgaggccccagtacagccttcccttccgcagctgctgag
cccaagctgtttgggggcttcaactcctcggacacggtcacctccccgcagcgggcgggg
ccgctggctggtggagtgaccacctttgtggccctctatgactatgagtctcggacagag
accgatctgtccttcaagaaaggggagcggctccagattgtcaacaacacgaggaaagtg
gatgtcagccagacctggttcacattcagatggctgcaaagagagggtgactggtggctg
gcccactcgctcagcacgggacagacaggctacatccccagcaactacgtggcgccctct
gactctatccaggctgaggagtggtactttggcaagatcaccagacgggagtcagagcgg
ttattgctcaatgcagagaacccgagagggaccttcctggtgcgagaaagcgagaccacg
aaaggcgcctactgcctctctgtgtcggatttcgacaacgccaagggcctcaatgtgaag
cactacaagatccgcaagctcgacagtggtggcttctacatcacctcgcgcacacagttc
aacagcctgcagcagctggtggcctactactccaaacatgccgatggcctgtgccaccgc
ctcaccaccgtgtgccccacatccaagccacagactcaggggctggccaaggatgcctgg
gagatccctcgggagtctctgcggctggaggtcaaactgggccagggctgtttcggagag
gtgtggatgggaacctggaacggaaccaccagggtggccatcaaaaccctgaagccaggc
acgatgtctccagaggccttcctgcaggaggctcaggtcatgaagaaactgaggcacgag
aagctggtgcagctgtacgcggtggtgtctgaggagcccatctacatcgtcacagagtac
atgagcaaggggagtctgctggacttcctcaagggggagacaggcaagtacctgcgacta
cctcagctggtggacatggccgctcagatcgcctcaggcatggcctacgtggaacggatg
aactacgtccaccgtgacctccgtgctgccaacattctggttggagagaatctcgtgtgc
aaagtggccgactttgggctggcccggctcattgaagacaacgagtacaccgcccggcaa
ggtgccaaattccccatcaagtggacagctccggaagcggccctctatggccgattcacc
atcaagtcagatgtgtggtcctttgggatcctgctgacggagctcacgacaaaggggcgg
gtgccctaccccgggatggtcaaccgtgaggtgcttgaccaggtggaacggggctaccgg
atgccctgcccgcctgagtgtcccgagtccctgcacgacctcatgtgccagtgctggcgg
aaggagcctgaggaacgacccacctttgagtacctgcaggccttcctggaggactacttc
acatccaccgagccccagtaccagccgggagagaacctatag

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