Canis lupus familiaris (dog): 486223
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Entry
486223 CDS
T01007
Symbol
POLE
Name
(RefSeq) DNA polymerase epsilon catalytic subunit A isoform X2
KO
K02324
DNA polymerase epsilon subunit 1 [EC:
2.7.7.7
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa03030
DNA replication
cfa03410
Base excision repair
cfa03420
Nucleotide excision repair
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03030 DNA replication
486223 (POLE)
03410 Base excision repair
486223 (POLE)
03420 Nucleotide excision repair
486223 (POLE)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
cfa03032
]
486223 (POLE)
03400 DNA repair and recombination proteins [BR:
cfa03400
]
486223 (POLE)
Enzymes [BR:
cfa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.7 Nucleotidyltransferases
2.7.7.7 DNA-directed DNA polymerase
486223 (POLE)
DNA replication proteins [BR:
cfa03032
]
Eukaryotic type
DNA Replication Elongation Factors
DNA polymerase epsilon complex
486223 (POLE)
DNA repair and recombination proteins [BR:
cfa03400
]
Eukaryotic type
SSBR (single strand breaks repair)
BER (base exicision repair)
Long Patch-BER factors
DNA polymerase epsilon complex
486223 (POLE)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DUF1744
POL2_thumb
DNA_pol_B_exo1
zf_DPOE_2
DNA_pol_B
zf-DPOE
DNA_pol_B_exo2
RNase_H_2
APP_N
Motif
Other DBs
NCBI-GeneID:
486223
NCBI-ProteinID:
XP_038315346
Ensembl:
ENSCAFG00000006215
VGNC:
44779
LinkDB
All DBs
Position
26:470023..522861
Genome browser
AA seq
2300 aa
AA seq
DB search
MVWRNSGRRRAEPGPDGEASRDDGLSSSVSALKRLERSQWTDKMDLRFGFERLKESGEKT
GWLINMHPTEILDEDKRLVSAVDYYFIQDDGSRFKVALPYEPYFYIAARKGCEREVSSFL
SKKFQGRIAKIETVPKEDLDLPNHLVGLKRNYIKLSFHTVEDLVRVRKDVSPAVKKNREQ
GHAGDAYTAMLSSVLQGGSVVIDEEEASKKVTDQLDNIVDMREYDVPYHIRLSIDLKIHV
AHWYNIRYRGSAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMI
DGQGYLITNREIVSEDVEDFEFTPKPEYEGPFCVFNEPDEVHLIQRWFEHVQEMKPTIMV
TYNGDFFDWPFVEARAAVHGLSMYQEIGFQKDSQGEYKASQCIHMDCLRWVKRDSYLPVG
SHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFA
LCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTGDGHVLDAETYV
GGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTMRHAIEEEEKVPMEHVTNFQEVC
DQIKTKLTSLKDVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAVVDEATCAACDFNKPG
ANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLTAEGPARAFHELSREEQAKYEK
RRLSDYCRKAYKKIHVTRVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLS
AAMEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRRGARWYSMEMAGIVCFTGA
NIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVIKTTSVKKPKVTISYPGAMLNIM
VKEGFTNDQYQELTEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFN
EDGSLAELKGFEIKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSK
AANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYII
SRKPEGSPVTERAIPLAIFQAEPMVRKHFLRKWLKSSSLQDFDIRTILDWEYYIERLGSA
IQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVCKQKKISELFVLEGRRQVGMAQV
PEGTQSLGAPDMEDFGLMKPLHLAVPIATKRKRVLWESQEESHDLELTVPWQEILGQPPA
LGTTQEEWLVWLRFHKKKWQLQARQRLACKKRRCVEVAEGEPLPGAIRERPATGLGGFLR
RTARSILDLPWQIVQISETSQAGLFRLWAVISSDLYCIRLNIPRVFYVNQQVAKAEEGPS
YRKVSRVLPRSNMVYNLYEYSVPEDMYQEHINEINTELSAPDIEGVYETQVPLLFRALVQ
LGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHLYLYHHAQGHKALF
GLFVPSQRRASVFVLDTVRSNQMPSLSALYSAEHSLLMEKVGPELLPPPKHTFEVRAETD
MKTICRAIQRFLLAYKEERRGPTLIAVQSNWELKRLAGEVPVLEEFPLVPVHVADKISYG
VLDWQRLGARRMIRHYLNLDTSLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRH
SHLLWLSPTSRPDLGGKEADDNRLVMEFDDQASVEINCPGCYSTVCVELDIQNLAVNTIL
QSHHINDMEGADSMGISFDVIQQASLEDMITGNQAASTPASYDETALCSSTFRILKSMVV
GWVKEITQYRNIYADNQVMHFYRWLRSPSSLLHDPVLHRTLHNMMKKLFLQLIAEFKRLG
SSVVYANFNRIILCTKKRRIEDAIAYMEYITSSIHSKEIFHSLTISFSRCWEFLLWMDPS
NYGGIKGNAPSSIHYGQQDSQKGGRVEEEEEEEEEEEEEEGKQEPDVEDMLENNWNIVQF
LPQAASCQSYFLMIVSAYIVAVYHSMKEELRRSAPGGTPLRWRGPSQLSQDAAASSALPA
MVPALLGMITFSQDYVANELTQNFFTITQKIQKKVTGSRSSTELSSMFPALPGSHLLLKN
PALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICR
SCNFCRDLDLCKEFAFSQDGAVLPQWLCSNCQVAYDTSVIEMALVEALQKKLMAFTLQDL
AGETPDQDCSSLQICLKCRGVKETNMPVYCSCAGGFTLTIHTKVFMEQIGIFQNIAQHYG
MSYLTETLEWLLQKNPQLGH
NT seq
6903 nt
NT seq
+upstream
nt +downstream
nt
atggtttggaggaacagcggccggcgtcgcgcggagccgggcccggacggcgaggccagc
cgggatgatggcctctcctcttctgtctcagcacttaagcgcctggagcgcagtcagtgg
acagataagatggatttgcggtttggttttgagagactcaaggagtctggggagaagacg
ggctggcttatcaacatgcaccctactgagattttagatgaagacaaacgcttagtcagc
gcagtagattactactttattcaagatgatgggagcagatttaaggtggccttgccctac
gagccgtatttctacattgcagccagaaagggttgtgaacgagaagtttcatcttttctc
tccaagaagtttcagggtagaattgctaaaatagagactgtccccaaagaggatctagac
ttgccaaatcacttggtgggtttgaagcgaaattacattaagctgtccttccacactgtg
gaggatcttgttagagtgaggaaggatgtctcccctgctgtgaagaagaaccgggagcag
ggtcatgctggtgatgcctacacagctatgctgtccagcgttctgcaagggggcagtgtg
gttattgatgaagaggaagcctctaagaaggtcactgaccagttggacaatattgtggac
atgcgagagtatgatgtgccctaccacatccgcctctccattgacctgaagatccatgtg
gctcattggtacaacatcagataccgaggaagtgcctttcctgtggaaatcacccgccga
gatgaccttgttgaacgacctgaccctgtggttttggcatttgacattgagacaaccaaa
ctgcctctcaagtttcctgatgctgagactgaccagattatgatgatttcctacatgatt
gatggtcagggctacctcatcaccaacagggagatcgtttcagaagatgtcgaagatttc
gagttcacccccaagccagagtatgaaggacctttttgtgtctttaatgaacctgacgag
gttcatctaatccagagatggtttgaacatgtccaggagatgaaacccaccatcatggtc
acctacaatggggacttttttgactggccgtttgtggaggccagagcagcagtccacgga
ctaagcatgtaccaggagatcgggttccagaaggacagtcagggagagtacaaggcatcc
cagtgcatccacatggactgtctcaggtgggtgaagagggacagttaccttcctgtgggc
agccacaacctcaaggcagctgccaaagccaagctaggctatgacccagtggagctggac
cctgaggacatgtgccgaatggccaccgagcagccccagactctggccacgtactccgtg
tcagatgcagtggccacgtactacctgtacatgaaatacgtccacccctttatattcgcc
ctttgcaccattatccccatggagcctgatgaggtgctgcggaagggctctgggactctc
tgtgaggccttgctgatggtgcaggccttccacgccaacatcatcttccccaataagcag
gagcaggagttcaacaagctgacaggtgatggccacgtgctggatgccgagacctatgtg
ggtggccacgtggaggcccttgagtcaggcgtctttcgcagtgacatcccctgccggttc
aggatgaatcctgctgcctttgacttcctgctgcagagggtggagaagaccatgcgccat
gccatcgaggaagaggagaaggtgcccatggagcatgtcaccaacttccaagaggtgtgt
gatcagattaagaccaagctcacctccctgaaagatgttccaaacagaatagagtgtccc
cttatctaccacctggatgtgggggccatgtaccctaacatcatcctgacgaaccgcctg
cagccctctgccgtggtggatgaggctacctgtgctgcctgtgacttcaataagcctggg
gccaactgccagagaaagatggcctggcagtggaggggcgagttcatgccagccagtcgc
agtgagtaccatcggatccagcaccagctggagtcagagaagttccctcccttgactgca
gagggtccagcccgggcctttcacgagctctctcgagaggagcaggctaaatatgagaag
cggaggctgtcagattactgccggaaggcatacaagaagatacacgtcaccagggtggag
gagcgcctcaccactatctgccagcgggagaactctttctatgtggacacagtgcgcgcc
ttccgagacaggcgttatgaattcaaaggtctccacaaggtgtggaagaagaaactctct
gcagccatggaggtgggtgatgcggccgaagtgaagcgctgcaagaacatggaggtcctg
tatgactccctgcagctggcgcacaagtgcatcctcaactccttctatggctacgtcatg
cgcagaggggctcgctggtactccatggagatggcaggcattgtctgcttcacaggggct
aacatcatcacccaggcacgggagctgattgagcagatcgggagacccttggagctggac
acagacggaatatggtgcgtcctgcccaacagctttcctgaaaactttgtcatcaagaca
accagtgtgaaaaagcccaaggtgaccatttcctaccctggggccatgttgaacatcatg
gtgaaggaaggcttcaccaatgatcagtaccaggagctgactgaaccatcctcactcacc
tatgtcacccgttcagagaacagcatctttttcgaggttgacggaccctaccttgccatg
atccttccagcctccaaggaagaaggcaagaaactgaagaagagatatgctgtcttcaac
gaggacggttccctggctgagctgaagggcttcgagatcaaacgccgaggggagctgcag
ctgattaagatcttccagtcctcagtgttcgaggctttcctcaagggcagcaccttagaa
gaagtgtatggctctgttgccaaggtggctgactactggctggacgtgctgtacagtaag
gcagctaacatgcccgattctgagctgtttgagctgatctctgagaatcgctccatgtct
cggaagctggaagattatggggagcagaagtccacgtctatcagcacagccaagcgcctg
gctgagttcctgggagatcagatggtgaaggatgcagggctgagctgccgttacatcatc
tctcggaagcccgagggctctccggtcacagagagggccatcccgcttgccattttccag
gcagagcccatggtgaggaagcactttctccggaaatggcttaagagttcttccctccaa
gactttgatattcgcacgattttggattgggagtactacattgagcggctagggagtgcc
atacagaagatcatcacgatccctgcagctttgcagcaggtaaagaacccagtaccacgc
gtcaagcaccctgactggctgcacaagaaacttttggagaagaatgatgtctgcaagcag
aagaagatcagcgagctctttgtcctcgagggcaggagacaggtgggcatggcccaggtt
ccagaaggcacccaaagcctgggtgctcctgatatggaagattttggcctcatgaagcca
ttgcacttggccgttcctattgccactaagaggaagcgtgtcctctgggagagccaggag
gagtcacacgacctggagctgacggtgccctggcaggaaatcttggggcagcctccagcc
cttggaaccacccaggaagagtggctggtttggctccggttccataagaagaagtggcag
ctgcaggcccggcagcgcctggcttgcaagaagaggcggtgtgtggaggtggcagagggc
gaacctctgcctggggccatccgagaaaggcctgccactgggttggggggcttcctgcga
aggaccgcccgcagcatcttggaccttccatggcagattgtgcagatcagtgaaaccagc
caggctggtttattcaggctgtgggctgtcatcagcagtgacttgtactgcatcaggctg
aacatcccccgagtattctatgtcaaccagcaggtggctaaagctgaggaggggccttcc
tatcgcaaggtcagccgagtccttcctcgctccaacatggtctacaatctctatgagtac
tccgtgcctgaggacatgtaccaggaacatatcaatgaaatcaatactgagttatcagcc
ccagacattgagggcgtgtatgagactcaggttccattactattccgcgccctagtgcag
ctgggctgtgtctgtgtggtcaataaacagctggtgaggcacctttcaggctgggaagca
gaaacctttgctctcgagcacctggagatgcgttctctggctcagttcagctacctggaa
ccagggagcatccgccacctctacctgtaccatcatgcacagggccacaaagcactcttc
ggcttgttcgtgccctcccagcgcagagcatctgtgtttgtgttggacactgtgcgaagc
aaccagatgcccagcctcagcgctctttactcagccgagcacagccttctgatggagaaa
gtgggcccggagctcctgcctcctcccaaacacacttttgaagttcgggcggaaactgac
atgaaaaccatctgcagagccatccagcgcttcctgctggcctacaaagaggagcgccgt
gggcccacactcatcgctgttcagtccaactgggagctaaagaggctggctggtgaggtt
cctgtcctagaggaattcccactagtgcctgtccacgtggcagataagatcagctatgga
gtcctggactggcagcgcctcggagcccggcgcatgatccgccactacctcaacctggac
acctctctgtcacaggccttcgagatgagcaggtacttccacatccccattggtaatctg
cctgaggacatctccacctttggctccgacctcttctttgcccgccatctccagcgccac
agccacctgctctggctgtcgcctacgtcacgccctgacctgggtggcaaggaggctgat
gacaatcgccttgtcatggaattcgatgaccaggccagcgtggagatcaattgtccaggc
tgctactctacagtgtgtgtggagctggacatccaaaacctggctgtcaacaccatcctg
cagtcccaccatatcaatgacatggagggggctgacagcatgggcatcagctttgatgtg
atccagcaagcctctctggaggacatgatcactggcaaccaggccgccagcactccagcc
agctacgatgagacagccctctgctccagcaccttcaggatcctgaagagcatggtggtg
ggctgggtgaaggagatcacacagtaccgcaacatctatgctgacaaccaggtgatgcac
ttttaccgctggctccggtccccatcatcactgctccatgaccctgtgctgcatcgcaca
ctccacaacatgatgaagaagctctttctgcagctcatcgctgagttcaagcgcttgggg
tcatctgtcgtctatgccaacttcaaccgcatcatcctctgcacgaaaaagcggcggatc
gaggatgccattgcttacatggagtacatcaccagcagcatccattctaaagagatcttc
cattctttgacaatatctttctctcggtgctgggaatttcttctctggatggatccctct
aactatggtggaatcaaaggaaatgctccatctagtatccactatggacagcaagactcc
caaaaagggggcagagtagaggaggaggaggaggaggaggaggaggaagaggaggaggaa
ggcaaacaggaaccagatgtggaggacatgctggaaaacaactggaacattgtgcagttc
ctgccacaggcagcctcctgccagagctacttcctcatgattgtttcagcatacatcgtg
gccgtgtaccacagcatgaaggaggagctgcggcgcagtgccccagggggcacacccctg
agatggcgggggcccagccagctctcccaggatgctgcggcctccagtgcccttcctgct
atggtccctgccctcctaggaatgatcaccttctcccaagactacgtggccaacgagctg
actcagaacttcttcaccatcactcagaagattcagaagaaagtcacaggctcccggagc
tccactgagctctccagcatgtttcctgcccttccaggttctcacttgctgctcaaaaac
cccgcattggagttcatcaagtacgtgtgcaaggttctgtctctggacacgaacatcaca
aaccaggtgaacaaattgaaccgggatctgcttcgtctggtggatgttggcgagttctcg
gaggaggcacagttccgagacccttgccgttcctacgtgctccctgaggtcatctgccgc
agctgtaacttctgccgggacctggacctgtgtaaagagttcgccttctcgcaggatggg
gccgtgctgcctcagtggctctgctcaaactgtcaggttgcctatgacacctcagtcatc
gagatggccctggtggaagccctgcagaagaaactgatggccttcactctgcaggacctg
gctggggagactcctgaccaggactgctcctcattgcagatctgcctgaagtgccgaggt
gtgaaggagaccaacatgcctgtgtactgcagctgcgccgggggctttaccctcaccatc
cacaccaaggtcttcatggagcagattggaatcttccagaacattgcccagcactatggc
atgtcctacctcacagagaccctggagtggctgctgcagaagaaccctcagctgggccac
tag
DBGET
integrated database retrieval system
