Canis lupus familiaris (dog): 486608
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Entry
486608 CDS
T01007
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa05012
Parkinson disease
cfa05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
486608 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
486608 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
cfa01001
]
486608 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
cfa04131
]
486608 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
cfa04147
]
486608 (LRRK2)
Enzymes [BR:
cfa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
486608 (LRRK2)
Protein kinases [BR:
cfa01001
]
Serine/threonine kinases: TKL group
LRRK family
486608 (LRRK2)
Membrane trafficking [BR:
cfa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
486608 (LRRK2)
Exosome [BR:
cfa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
486608 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
COR
LRR_4
Ras
LRR_14
LRR_9
WD40_CDC20-Fz
Arf
Beta-prop_RSE1_2nd
LRR_13
Beta-prop_EML_2
LRR_NXF1-5
AAA_22
T2SSE
Ank_2
nSTAND3
Kdo
PduV-EutP
ABC_tran
MMR_HSR1
GTP_EFTU
WDR55
AAA_7
WD40_WDHD1_1st
G-alpha
AAA_16
SRPRB
TniB
LRR_6
TsaE
cobW
MobB
Septin
AAA_29
NACHT
TrwB_AAD_bind
ARM_LIN_2nd
SRP54
Motif
Other DBs
NCBI-GeneID:
486608
NCBI-ProteinID:
XP_543734
Ensembl:
ENSCAFG00000009926
VGNC:
42823
UniProt:
A0A8C0P161
A0A8I3QYS6
LinkDB
All DBs
Position
27:33032944..33171543
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQGKK
VHVPVLIVLDLYMRVASVQQVGWSLLCKLIEICPNTMKSLMGPQDIGHDWEVLGVHQLIL
KMLTVHNASVNLLTVGLRALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSANDEVQKL
GCKALRVLFERVSEEQLIEFVENKDYMILLNALKNFKDEEEIVLHVLHCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKAFPVHEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
RRYSENATLQIAALSCLALLTETIFLNQDLEEKNENQENDDEEEEKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYFNVLELMQKHIHSPEVAESGCKLLDHLFEGSDATLDIM
AAVAPKIITVMKSHEASSLVQLEALRAILHFIVPGMPEDSREDTEYQHKLNLVKKQCFKN
DIHKLVLAALNRFIGIPGIQKSGLKVISSLAQSPDALEVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCIGTGHLLAKILASSLQRFKDMAEVQIKGFQTILTILELSM
SFGKLLVNHSFDSVIFHQMSSSILESKDQQFLNLCCKCFAKLAMDDELKSVMLERACDQN
NSIMVECLLLLGADANRTKEATSLICQVCEKASSPKLVELLLNGGSREQDVRKALTISIG
KGDSQIISLLLRRLALDLANNSICLGGFCIGKIEPSWLGPLFPDKTSNLRKETNIGSTLA
RMVLRYQMKSTVEGGAASGSNGNFPEEVLDKLDEWTFIPDSYVDSVFGQSDDLDSEGSEG
SFLVKRKSNSISVGEFYHDRALQRCSPNLQRHSNSLGPIFDHEDFLRRKRKILSSDDSLW
SSKLQSHMRHSDSISSLPSEREYITSLDLSANELRDIDALSQKCCISGHLEHLERLELHQ
NALTSFPQQLCEMLKCLTHLDLHSNKFASFPSYLLKMNCIVNLDVSRNDISPSVVLDPTV
KCPTLKQFNLSYNQLSSFPENLGDVVEKLEQLILEGNKIPGICSPLSLKELKILNLSKNH
ITSLAEDFFEACPKVESFSARINYLAAMPFLPSSLTSLKLSQNRFTCVPEAILNLPHLRS
LDMSSNEIEYLPSPAHWKSLNLRELLFSFNQISILDLSEKAYVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTKTKKSDLGVQSATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVKEN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRHISIPKNFSVECMVATNH
NSKNASIWLGCGHPNKGQLSFLDLSTEKHTSEEVTDSRILCLALVHLPVEKESWIVCGTQ
SGMLLVINTEDGAKRHTLEKMTDSVTCLYCNPFPKQSKQRNFLLVGTADGNLAIFEDKTV
KCKGAAPLKILNIGNVSTPLMCLSESMNSTEKNIMWGGCGTKLFSFSDDFTIQKLIETKT
NQLFSYAAFSDSNIIAVVVDTAVYVAKKNSPFVEVRDKKTEKLCELIDCVHFLKEEMVKV
NAESKHKLSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMMT
AQLGSLKNVMLVLGYIRKNTEGTQPQKEIQSCLSVWDINLPHEVQNLEKHIEVRKELAEK
MRRISVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcagggctgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtccaaatcctg
gaggatatgctggtgttcacgtacgccgaccacgcctccaagttatttcaaggcaaaaaa
gtccacgtgcctgtgttgatcgtcttggacttgtatatgagagtcgctagtgtgcagcag
gtgggttggtcgcttctttgcaaattgatagaaatctgtccaaatacaatgaaaagctta
atgggacctcaggatattggacatgattgggaagtccttggggttcaccaactgattctt
aaaatgctaacagttcataatgccagtgtaaacctgttaacagttggactgagggcctta
gatctccttctaacttcaggcaaaatcactttgctgatactggatgaagaaagtgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgatgaagtccagaaactt
ggatgcaaagctttacgtgtgctgtttgaaagagtttcagaggagcagttgattgaattt
gttgagaataaagattatatgatcttgctcaatgcgttaaaaaattttaaagatgaagag
gaaattgtgcttcatgtactacactgtttacattccctagcaattccttgcaataatgtt
gaagtactcatgagtggcaatgtcaggtgttacaatattgtggtagaagccatgaaagcg
ttccctgttcatgaaaaaattcaagaagtgagttgctgcttgctccataggcttacatta
ggtaatttttttaacattctggtattaaacgaggtacatgagtttgtggtgaaagctgtg
aggcggtattcagagaacgccacattacagattgcagccctcagctgtttagcgctcctc
actgagactattttcttaaatcaagacttagaggaaaagaatgagaatcaggagaatgat
gatgaggaagaagaaaaattgttctggttggaagcctgttacaaagcattaacatggcat
agaaaaaacaagcacgtgcaggaagctgcgtgctgggctctaaacaatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccagttcccagctcatagggaa
gtgatgctgtccatgctgatgcattcttcatcaaaagaagtcttccaggcatctgcaaat
gcgttgtcaactctattagaacaaaatgttaatttcagaaaaatcctgttgtcaaaagga
atatacttcaatgtattggagttaatgcagaagcatatacattctcctgaagttgctgaa
agtggctgtaaactgctagatcatctctttgaaggaagtgatgctaccctggatataatg
gcagcagtggcccccaaaatcataacagttatgaaaagtcatgaggcatcctcattggtg
cagctggaggcactccgagctattttacattttatagttccaggcatgccagaagattcc
agggaagatactgaatatcaacataagctaaatctggttaagaagcagtgtttcaagaat
gatattcataaactggtcctagcagctttgaacaggttcattggaattcctgggattcaa
aaaagtggattgaaagtaatttcttctctagcacaatctcctgatgcattagaagtatta
tccttggaaggtgctattgattcagtgcttcacacactgcagatgtacccagatgaccaa
gaaattcagtgtctggggttaagtcttataggatgcttgattacaaagaagaatttatgc
ataggaactgggcatctgctggcaaaaattctggcttccagtttacaacgatttaaagat
atggctgaagtacagattaaaggatttcagacaatcttgacaatactagaattgtcaatg
tcttttggaaagctgctggtgaatcattcctttgattctgtgatattccatcagatgtct
tccagtatccttgaatcaaaggatcaacagtttctaaacctttgttgcaagtgctttgcg
aaattagctatggatgatgagttaaaaagtgtgatgctagagagagcatgcgatcagaat
aacagtatcatggttgaatgcttgcttctgttgggagcggacgccaatcgaacaaaggaa
gcaacatctttaatttgtcaggtatgtgagaaagcgagcagtcccaaattggtggaactg
ttattgaatggtggttcccgtgaacaagatgttcggaaagccttgacaataagcattgga
aaaggtgacagccaaatcatcagcttactcttaaggagacttgccctggatctggccaat
aatagcatttgccttggaggattttgtataggaaaaattgaaccttcgtggcttggtcct
ttatttccggataagacatctaatttaagaaaagaaacaaatataggatccaccctagca
agaatggtgctcagatatcagatgaaaagtactgtggaaggaggggcagcctcaggcagc
aatggaaattttcctgaagaagtacttgataaattggatgaatggaccttcattccagac
tcttacgtggacagtgtgtttggtcaaagtgatgacctggatagtgaaggaagtgaaggt
tcatttcttgtgaaaagaaaatccaattcaattagtgtaggagaattttaccatgatcgt
gccttgcagcgttgctcaccaaatttgcaaaggcattccaattcattgggacccattttc
gatcatgaagatttcttgaggcgaaaaagaaaaatattgtcttcagatgactcactctgg
tcatcaaaacttcaatcccatatgagacattcagacagcatttcttccttgccttctgag
agagaatatattacatcattggacctttcagcaaatgaactaagagatattgatgcccta
agccagaaatgctgtataagtggtcatttggagcatcttgaaaggctggagcttcaccag
aatgcacttacaagctttccacaacaactgtgtgaaatgctgaagtgtttgacacatttg
gacttgcacagtaataaatttgcatcatttccctcttacctgttgaaaatgaattgtatt
gtcaaccttgatgtctctcgaaacgacatcagcccctcagtagttctggatcctacagtg
aagtgcccaaccttgaaacagtttaacttgtcatataatcagctgtcttcttttcctgag
aaccttggcgatgtggtagagaaattggaacagctcattttagaaggaaataagatacca
ggaatatgttcccccttaagcctgaaggaactgaagattttaaaccttagtaaaaaccac
attacatccctagcagaggacttctttgaggcatgtcctaaagtggagagtttcagtgcc
agaattaattatcttgctgctatgccttttttgccttcttctctgacaagcctaaaatta
tctcaaaacagatttacatgtgttccagaagcaattttaaatcttccacacttgcgatcc
ttagatatgagcagcaatgaaattgagtatctaccgagtcctgcacactggaaatctttg
aacttaagggaactcttgttcagttttaatcagatcagcatcttggacttgagtgaaaaa
gcttatgtgtggtcaagagtagagaaactacatctttctcataataaactgaaggagatt
cctccagagattggctgtcttgaaaacctgacctcccttgatgtcagttacaatttggaa
ctgagatcctttcctaatgaaatggggaaattaagcaaaatatgggaccttcctttggat
gaactacggcttaattttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcggttaaaaaaggctgtgccctataaccgaatgaagcttatgattgtg
ggaaatactgggagtggtaaaactaccttattgcagcaattaacaaaaaccaagaaatca
gatcttggggtgcagagtgccacagttggtatagatgtaaaagactggcctatccaaata
agaggcaaagggaagaaagacctcattctaaatgtgtgggattttgcaggtcgtgaggaa
ttctacagcactcatccccacttcatgacccaacgagccctttaccttgctgtttatgat
ctcagcaaagggcaggctgaagtggatgccatgaagccttggctcttcaatataaaggct
cgtgcttcttcttcccctgtgatcctcgttggcacgcatctggatgtttctgatgaaaag
cagcgtaaagcctgcataagtaaaatcaccaaggaactcttgaacaagcgagggtttcct
gcaataagggattaccactttgtgaatgccactgaggaatctgatgctttggcaaaactt
cggaaaaccatcataaatgagagtcttaattttaagatccgagatcagcctgttgttggg
cagctgattccagactgttatgtagaacttgagaaaatcattttatcagagcgtaaaaat
gtgccaattgaatttcctgtaatcgaccggaaacgattattacaacttgtaaaggaaaat
cagctgcagttggatgaaaatgagctccctcatgcagttcacttcctaaatgaatcaggg
gtccttcttcattttcaagatccagctctgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctatccaaaa
catcctaagggaatcatttcacgtagagatgtggaaaaatttctttcaaagaaaaagaga
tttccaaagaactacatgtcacagtattttaaactgctagaaaaattccagattgccttg
ccaataggagaagaatatttgctggttccaagcagtttgtctgatcacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcattcgactatacgaaatgccttatttt
ccaatgggattttggtcgaggttaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcacccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttttgggccaagtt
gtggatcacattgattctctgatggaagaatggtttcctggattgctggagattgatatt
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatcttacttgacgacttgatgaagaaagcagaagaaggagaccttcta
gtaaatccagatcaaccaaggctcaccattccaatatctcaaattgctcctgacttaatt
ttggctgacttacctagaaatattatgttgaataatgatgaattggaatttgaacaagct
ccagagtttctcttaggtgatggcagttttggatctgtttatcgagcagcctatgaagga
gaagaagtggctgtgaagattttcaataaacatacatcacttagactgttaagacaagag
ctggtggtcctttgccacctccaccaccccagcttaatatctttgctggcagctgggatt
cgtcctcgcatgttggtgatggagttggcctccaagggttcgctggaccgcttgcttcag
caggacaaagccagtctcaccagaactctgcagcacagaattgcactacatgtggctgat
ggcttgagatacctccactcagccatgattatataccgtgacttgaagccccacaatgtg
ttgctcttcaccctgtaccccaatgctgccatcatcgcaaagattgctgactatgggatt
gctcagtattgctgtagaatggggataaagacgtcagagggcacaccaggatttcgtgca
cctgaagttgctagaggaaacgttatttataaccaacaggctgatgtttattcatttggt
ttactactctatgacattttgacaactggaggtagaatagcagagggtttgaagtttcca
aatgagtttgatgaactggcaatacaaggaaaattacctgatccagttaaagaatatggc
tgtgccccctggcccatggttgagaagttaattaaaaagtgtttgaaagaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgagttaatctgtctg
atgagacatatatcaatacctaaaaactttagtgttgaatgcatggttgctacaaatcat
aacagcaagaatgcaagcatctggctgggctgtgggcacccgaacaaaggacagctctca
tttcttgacttaagtacagaaaagcacacttctgaggaagttactgatagtagaatactg
tgcctggctttggtgcatcttcctgttgaaaaggaaagttggattgtgtgtggaacacag
tctggcatgctcctggtcatcaataccgaagacggggcaaagagacatacccttgaaaag
atgactgattctgtgacttgcttgtattgcaatccctttcccaagcaaagcaagcaaaga
aattttcttctggtggggactgctgatggcaatttagcaatttttgaagataaaactgtt
aagtgtaaaggagccgctcctttgaagatactaaatataggaaatgtcagtactccactg
atgtgtttgagtgaatccatgaattcaactgaaaaaaacattatgtggggaggatgtggt
acaaaacttttctcattttctgatgatttcaccattcagaaactcattgagacaaagaca
aatcagctgttttcttatgcagcattcagtgattccaacatcatagcagtggtggtagac
acggctgtctacgtcgctaagaaaaatagcccatttgtggaagtacgggataagaaaact
gaaaaactctgtgaactaatagactgtgtgcactttttaaaggaggaaatggtaaaagta
aatgcagagtcaaaacacaagctctcttactctggaagagtgaaaaccctctgcctccag
aagaacactgctctctggataggaactggaggaggccatattttactccttgatctctcg
actcgtcgaattatacgtataattcacaatttttgtgattctgtcagagtcatgatgaca
gcacaattaggaagccttaaaaatgtcatgctggttttggggtatatccggaaaaatact
gaaggtacacaaccccagaaagagatacaatcttgtttgtctgtttgggacatcaatctt
ccacatgaagtgcaaaatttagaaaaacatattgaagtgagaaaagaattagctgaaaaa
atgagaagaatatcggttgaataa
DBGET
integrated database retrieval system
