Canis lupus familiaris (dog): 488012
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Entry
488012 CDS
T01007
Symbol
MYLK
Name
(RefSeq) myosin light chain kinase, smooth muscle isoform X1
KO
K00907
myosin-light-chain kinase [EC:
2.7.11.18
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa04020
Calcium signaling pathway
cfa04022
cGMP-PKG signaling pathway
cfa04270
Vascular smooth muscle contraction
cfa04371
Apelin signaling pathway
cfa04510
Focal adhesion
cfa04611
Platelet activation
cfa04810
Regulation of actin cytoskeleton
cfa04921
Oxytocin signaling pathway
cfa04971
Gastric acid secretion
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04371 Apelin signaling pathway
488012 (MYLK)
04020 Calcium signaling pathway
488012 (MYLK)
04022 cGMP-PKG signaling pathway
488012 (MYLK)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
488012 (MYLK)
09142 Cell motility
04810 Regulation of actin cytoskeleton
488012 (MYLK)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
488012 (MYLK)
09152 Endocrine system
04921 Oxytocin signaling pathway
488012 (MYLK)
09153 Circulatory system
04270 Vascular smooth muscle contraction
488012 (MYLK)
09154 Digestive system
04971 Gastric acid secretion
488012 (MYLK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
cfa01001
]
488012 (MYLK)
Enzymes [BR:
cfa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.18 myosin-light-chain kinase
488012 (MYLK)
Protein kinases [BR:
cfa01001
]
Serine/threonine kinases: CAMK group
MLCK family
488012 (MYLK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
I-set
Ig_3
ig
Ig_2
Pkinase
23ISL
V-set
PK_Tyr_Ser-Thr
C2-set_2
fn3
C2-set_3
Ig_4
Ig_DSCAM-DSCAML_C
Kinase-like
Kdo
AvrM_N
Pur_ac_phosph_N
Motif
Other DBs
NCBI-GeneID:
488012
NCBI-ProteinID:
XP_013965708
Ensembl:
ENSCAFG00000012119
VGNC:
43549
UniProt:
A0A8I3PTT4
A0A8P0PD71
LinkDB
All DBs
Position
33:complement(26685793..26889011)
Genome browser
AA seq
1998 aa
AA seq
DB search
MGDVKLAALTQASKTSVSVDHSRAGSAPPTEAPAFILPPRNLCIREGATAKFEGRVRGYP
EPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVREEDQGKYTCEATNDGGARQVTVE
LTVEGGFMKKHGQPVVSKTLGDRFAAPAVETRPSIWGECPPKFATKLGRAVVKEGQTGRF
SCKITGRPQPQVTWLKGDVALQPSARVSMSEKNGVQVLEIHEVSRDDVGVYTCMVVNGSG
KASMSAELSIQGLDNTSRSLTKVANSDIRKEVTNGTTQGPKLDHLESAAERWPCSSTQIG
GSPTWATSSQPQPLRESKLEPPGDPPRKALRSPVLQKTSSTITLQAAKVQPEPRAPVSSA
LSSPGEERERPAAPPTATFPARQSGLGSQEVVNKVATRKIPMESQRDSTFPKFESKPQSQ
EVSEDETVKFRCEVSGTPKPEVTWFLEGAPVKRREGMVEVYEEGGCHYLCLLRVRAKDSG
SYSCTASNVRGQVSCGWTLLVKRLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVQGTPVP
QITWLLNEQPIQYAHSSCEAGVAELHIQDALPEDDGIYTCLAKNTLGQVSCSARVTVHEK
KSDRKSGYLLRTAPGKPVAPLFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEI
QESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLMVQEPQDGTQPWF
ISKPRSLTASLGQTVLISCAIAGDPFPTVHWLRDGKALSKDSGHFEVLQNEDVFTLVLKN
VQPWHAGQYEIQLKNRVGECSCQVSLMLQSSPTGAPLRGREPASCEGLCSRGAGADGGGG
DCYGTLRPGRPARGQGWPEEEDDGEDVRGVLKRRVETRQHTEEAIRQQQVEQLDFRDLLG
KKVSTKTVSEEDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGT
PKTPVPEKAPLPKPATPDFRSVLGSKKKLPAENGSNNAEALNAKAAESPKAVSNAQPLGS
LKPLGNAKPAETLKPVGNIRPAETLKPIGNAKPAETLKPMGNAKPAETLKPIGNAKLAET
PKPMGNAKPAETLKPLGNAKPAETLKPISNAKPAEPLKPVGNAKPAETPKPIGNAKPAEI
LKPAGKEELKKEVKNDVNCKRAQAGATDNEKRSENQGTAPAFKEKLQDVHVTEGEKLLLQ
CQVSSDPPATITWMLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGFYKCIAKNGAGQ
AECSCQVTVDDAPTKENAKAPEMKARRPKSSLPPMLGTESDATVKKKPAPKTPPKAAMPP
QIIQFPEDQKVRAGESVELFGKVAGTQPITCTWMKFRKQIQESEHIKVETSENGSRLTIV
AARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYD
GGSAVQSYSVEIWDSVDKTWKELATCRSTSFNVQDLLPDREYKFRVRAINVYGTSEPSQE
SELTAVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTVNTEQKVSDFYDIEERLGSGKFGQV
FRLVEKKTGKIWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVL
EIVSGGELFERIIDEDFELTERECIQYMRQISAGVEYIHRQGIVHLDLKPENIMCVNKTG
TRIKLIDFGLARKLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGL
SPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPW
LMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPT
SPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDP
EVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELI
VETMEEGEGEGEEEEEEE
NT seq
5997 nt
NT seq
+upstream
nt +downstream
nt
atgggggatgtgaagctggccgccttgacacaggcttctaaaacctccgtcagtgtggat
cactcgagggccgggtctgcacccccgacagaggcccctgctttcattttgccccctcgg
aacctctgcatcagagaaggagccaccgccaagtttgaagggagggtccggggttaccca
gagccccaggtgacatggcaccgaaatgggcaacccatcaccagtgggggccgcttcctg
ctggattgtggtatccgggggactttcagcctcgtgattcatgctgtccgtgaggaggac
cagggaaagtatacctgcgaagccaccaatgatggtggtgcccgccaggtgacagtggag
ttgactgtagaagggggcttcatgaagaagcatggtcagcccgttgtttccaaaaccttg
ggggacagatttgcagcccccgcagtggagacccgtcctagcatctggggagagtgccca
ccaaagtttgctaccaagttgggccgagccgtagtcaaagaaggacagacgggacggttc
tcctgcaagatcaccggacggccccaaccacaggtcacctggctcaagggggatgttgcc
ctgcagccaagtgcccgtgtgtctatgtctgagaagaacggggtacaagttctggaaatc
catgaggtcagccgcgatgatgtgggagtgtacacatgcatggtggtgaatgggtcgggg
aaggcctccatgtcggctgagctttctatccaaggtttggacaataccagtaggtcatta
acaaaggtggccaattcagatatcaggaaggaggtgaccaatggaaccacgcaggggccg
aaactagaccacctggagtctgcagcggaaaggtggccctgctccagcacccagatcggt
ggctcccccacctgggccacaagtagccagcctcagcccctgagggagtccaagctggag
ccgcctggggacccacccaggaaagccctgaggagccccgtcctacagaagacttccagc
accattaccctgcaggcggcaaaagtccagccagagccaagagcgccggtctcaagtgcc
ctctcgtctcccggagaagagagggagaggccagctgctccccccacagccaccttccct
gcccggcagtctggcctgggaagccaggaggttgtgaacaaggttgctaccagaaaaatc
cccatggaaagccagagagattccacattccccaaatttgagagcaagccccaaagccag
gaggtcagtgaagatgaaacagtcaagttcagatgtgaggtttcagggaccccaaagcct
gaagtgacctggttcctggaaggtgcccccgtgaagagacgagaaggcatggttgaggtt
tatgaagaaggtggatgccactacctctgcttgctgagagtgcgggccaaggacagtggg
agctacagttgcacggcctccaatgtccgaggccaggtgtcctgtggttggaccctcctg
gtgaaacggctggccgtgatggaggtggctccctcgttctccagcgtcctgaaggactgc
gctgtcattgagggccaggactttgtgctgcagtgctcagtgcaggggaccccggtgccc
caaatcacttggctgcttaatgagcagcccatccagtacgctcactcctcctgcgaggct
ggcgtggccgagctccacatccaggatgccctgccggaagatgatggcatttacacctgt
ctggccaagaacaccttgggccaggtgtcctgcagcgcccgggtcaccgtccatgaaaag
aagagcgacaggaagagtgggtatcttctgcgcacagctcccggcaagcccgtcgcaccc
ctcttcctgcagggcctctctgacctcaaagtcatggatggaagccaggtcaccatgaca
gtccaggtgtcagggaatccgccccccgaggtcatctggcttcacaacgggaatgagatc
caggagtcagaggacttccactttgaacagagaggcactcagcacagcctttgtatccag
gaagtgttcccagaggacacaggcacttacacctgcgaagcctggaacagtgctggagag
gtccgcacccaggcagtactgatggtgcaagagccccaggatggcacccagccctggttc
atcagcaagccccgctcactgactgcctccctgggccagactgtcctcatctcctgtgcc
atcgctggggaccccttccccactgtgcactggctgcgagatggcaaagccctctccaaa
gactccggccacttcgaggtgctacagaacgaggacgtgttcaccctggttctaaagaat
gtgcagccctggcacgccggccagtacgagatccagctcaagaaccgggttggcgaatgc
agttgccaggtgtcactgatgctacagagcagccccaccggagcccccctgcgggggagg
gagcctgccagctgcgagggcctctgcagccggggagccggcgctgatggtggtggcggt
gactgctatgggaccctgaggcctggccggccagcgagaggacagggttggccagaggag
gaggacgacggcgaggacgtgcggggggtgctgaagaggcgcgtggagacccggcaacat
actgaggaggccatccgccagcagcaggtggaacagctggacttccgtgacctcctgggg
aagaaggtgagtaccaagaccgtgtcagaagaagacctgaaggagatcccagcggagcag
atggatttccgcgccaacctgcagcggcaagtgaagccaaagactgtgtcagaggaagag
aggaaggtgcatagccctcagcaggtcgacttccgctcggtcctggccaaaaaggggact
cctaagaccccggtgcctgagaaggcacctcttcccaaacccgccaccccagatttccgc
tccgtgttaggtagcaagaaaaaattaccagccgagaatggtagcaacaacgctgaggcc
ttgaatgccaaggcagcagaaagtcccaaggctgtgagcaatgcccagcctttagggtcc
ctgaaacctttgggcaatgccaagcctgctgagactctaaaacctgtgggcaacatcagg
cctgctgagacgctgaaacccataggcaacgccaaacctgctgagaccctgaaacccatg
ggcaacgccaagcctgctgagacgctaaaacccataggcaatgccaagcttgctgagacc
ccgaaacccatgggcaatgccaagcctgctgagaccctgaaacccctgggcaacgccaag
cctgctgagacgctgaaacccataagcaacgccaagcctgctgaacctctgaaacctgtg
ggcaacgccaagcctgctgagaccccaaaacccataggtaatgccaagcctgctgagatc
ctaaaaccagctgggaaggaagaactcaagaaggaggttaagaatgacgtgaactgcaag
agggcacaggcaggagccacagataatgaaaaaagatcagagaaccaagggacagcccca
gccttcaaggagaagctgcaagatgtccatgtgacagagggtgagaagctgctactccag
tgtcaggtgtcgtctgaccctccagccaccatcacctggatgctcaatggaaagacactc
aagaccaccaagttcatcatcctctcccaagaaggctcactgtgctccgtgtccatcgag
aaggccctgcccgaggacagaggcttctacaagtgcatagctaagaatggcgccggccag
gctgagtgctcctgccaagtcaccgtggacgatgctcccaccaaggagaatgccaaggcc
ccggagatgaaagcccggaggcccaagagctctctacctcccatgctaggaacagagagt
gatgcaactgtgaaaaagaaacctgcccccaagacacctccaaaagcagccatgccccct
cagatcatccagtttcctgaggaccaaaaggtgcgcgcaggagagtctgtggagctgttt
ggtaaagtggcaggcacccagcccatcacctgtacgtggatgaagttccgaaagcagatc
caggagagcgagcacatcaaggtggagaccagtgagaatggcagcaggctcaccatcgtg
gccgcacgccaggaacactgcggctgctacactctgctggtggagaacaagctgggcagc
aggcaggcccaggtcaacctcactgtcgtggacaaaccagaccccccagcgggcacacct
tgcgcctccgacatccggagctcgtcgttgaccctgtcctggtatggctcctcgtatgat
gggggcagtgccgtgcaatcctacagcgtcgagatctgggactcggtggacaagacgtgg
aaggaactagccacgtgccgcagcacctcttttaacgtccaggacctgctgcctgaccga
gagtataaattccgcgttcgcgccatcaacgtgtatggaaccagtgagccaagccaggag
tctgaactcacagcagtgggagagaaaccggaggagccgaaggacgaagtggaggtgtcg
gatgatgatgagaaggaacctgaggtcgactaccggacagtgacggtcaacactgaacaa
aaagtgtccgacttctatgacatcgaagagagactaggctctgggaaatttggacaggtc
ttccgacttgtagaaaagaaaactggaaaaatctgggcagggaaattcttcaaggcatat
tcagccaaagagaaggagaatatccggcaggagattagcatcatgaactgcctccaccac
cccaagctggtccagtgtgtggatgccttcgaagaaaaggccaacatcgtcatggtcctg
gagatcgtgtcggggggcgagctgttcgagcgcatcatcgacgaggacttcgagctgacg
gagcgcgagtgcatccagtacatgaggcagatctcggcgggcgtggagtacatccaccgg
cagggcatcgtccacctggacctcaagcccgagaacatcatgtgcgtcaataagaccggc
acgaggatcaagctcatcgacttcggcctggccagaaagctggagaatgcggggtctctg
aaggtcctctttggtaccccggaatttgtggcccccgaagtgatcaactatgagcccatc
ggctatgccacggacatgtggagcatcggagtcatctgctacatcctggttagtggactc
tcccccttcatgggtgacaacgataatgaaaccctagccaacgttacctcagccacctgg
gacttcgatgatgaggcgttcgatgagatctcggatgacgccaaggattttatcagcaat
ttgctgaagaaagatatgaaaaaccgcctggactgtacccagtgccttcagcatccctgg
ctcatgaaagacaccaagaacatggaagccaagaaactctccaaggaccggatgaagaag
tacatggcaagaaggaaatggcagaaaacgggcaatgctgtgagagccatcggaagactg
tcctctatggcaatgatctcagggctcagtggcaggaaatcctcaacaggatcaccgacc
agcccgctcaacgcagaaaaactagaatctgaagaagatgtgtcccaagctttccttgag
gctgttgctgaggaaaagccccatgtaaaaccctatttctctaagaccattcgtgattta
gaagttgtggagggaagcgctgctagatttgactgcaagattgaaggatacccagaccct
gaagttgtctggtttaaagatgaccagtcaatccgggagtcccgccacttccagatagac
tacgacgaggatgggaactgctctttaatcattagcgatgtttgtggggatgacgatgcc
aagtacacctgcaaggctgtcaatagtcttggagaagccacttgcacagcagagctcatt
gtggagaccatggaggaaggggaaggggaaggggaagaggaagaagaggaagagtga
DBGET
integrated database retrieval system
