Canis lupus familiaris (dog): 489390
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Entry
489390 CDS
T01007
Symbol
BACE1
Name
(RefSeq) beta-secretase 1 precursor
KO
K04521
beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:
3.4.23.46
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa05010
Alzheimer disease
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
489390 (BACE1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
cfa01002
]
489390 (BACE1)
Enzymes [BR:
cfa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.23 Aspartic endopeptidases
3.4.23.46 memapsin 2
489390 (BACE1)
Peptidases and inhibitors [BR:
cfa01002
]
Aspartic peptidases
Family A1: pepsin family
489390 (BACE1)
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Motif
Pfam:
Asp
TAXi_C
TAXi_N
Motif
Other DBs
NCBI-GeneID:
489390
NCBI-ProteinID:
NP_001271401
Ensembl:
ENSCAFG00000013069
VGNC:
38358
UniProt:
M1VPK8
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All DBs
Position
5:16347976..16371490
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AA seq
417 aa
AA seq
DB search
MAQALPWLLLWMGSGVLPARCTPPGIRLPRETVEEPDEPGRRGSFVEMVDNLRGKSGQGY
YVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQG
KWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVII
VRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWL
GEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFA
ISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFITLDMEDCG
YNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK
NT seq
1254 nt
NT seq
+upstream
nt +downstream
nt
atggcccaagccctgccctggctcctgctgtggatgggctccggagtgctgcccgcccgc
tgcaccccgcccggcatccggctgccccgggagaccgtcgaggagcccgacgagccgggc
cggaggggcagctttgtggagatggtggacaacctgagaggcaagtccggtcagggctac
tacgtggagatgaccgtgggcagccccccgcagacgctcaacatcctggtggacacaggc
agcagtaactttgcagtgggggctgccccccaccctttcctgcatcgctactaccagagg
cagctgtccagtacataccgggacctccgaaagggcgtgtatgtgccctacacccagggc
aagtgggagggggagctgggcaccgacctgctctgtggcgctggcttccccctcaaccag
tcagaagtgctggcctcggttggagggagcatgatcatcgggggtatcgaccactcactg
tacacgggcagcctctggtacacacccatccggcgggagtggtactacgaggtgatcatt
gtaagggtggagatcaacgggcaggacctgaaaatggactgcaaggagtacaactatgac
aagagcattgtggacagtggcaccaccaaccttcgtttgcccaagaaagtgtttgaagct
gctgtcaaatccatcaaggcagcctcttcgacggagaagttcccggatgggttctggctg
ggggagcagctggtgtgctggcaggcaggcaccaccccttggaacattttcccggtcatc
tccctctacctgatgggcgaggtcaccaatcagtccttccgcattaccatccttcctcag
caatacctgcggccagtggaagacgtggccacatcccaagacgactgctacaaattcgcc
atttcacagtcatccacgggcaccgtaatgggagctgttatcatggagggcttctacgtt
gtctttgaccgggcccgaaaacgaattggctttgccgtcagtgcttgtcatgtgcacgat
gagttcaggacggcagcagtggaaggcccgtttatcaccctggacatggaagactgtggc
tacaacattccacagacagatgagtcaaccctcatgaccatagcctacgtcatggctgcc
atttgcgccctcttcatgctgccgctctgcctcatggtgtgccagtggcgctgcctccgc
tgcctgcgccatcaacatgatgactttgccgatgacatctccctgctgaagtga
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