Canis lupus familiaris (dog): 489490
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Entry
489490 CDS
T01007
Symbol
PFAS
Name
(RefSeq) phosphoribosylformylglycinamidine synthase
KO
K01952
phosphoribosylformylglycinamidine synthase [EC:
6.3.5.3
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa00230
Purine metabolism
cfa01100
Metabolic pathways
Module
cfa_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
489490 (PFAS)
Enzymes [BR:
cfa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.3.5.3 phosphoribosylformylglycinamidine synthase
489490 (PFAS)
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Gene cluster
GFIT
Motif
Pfam:
GATase_5
FGAR-AT_PurM_N-like
AIRS_C
FGAR-AT_N
FGAR-AT_linker
AIRS
Motif
Other DBs
NCBI-GeneID:
489490
NCBI-ProteinID:
XP_038371840
Ensembl:
ENSCAFG00000017021
VGNC:
44439
UniProt:
A0A8C0LUH9
LinkDB
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Position
5:33191282..33212476
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AA seq
1341 aa
AA seq
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MTSVLHFYVHPSGHERAASEHTQRKLQGKLPALQSVKTELCYNVNWTAKSPPNAEEMKKL
MWLFGCPLLLGDVAQESWLHPDSSDLLLEVGPRLNFSTPASTNVVSVCWAAGLGAVDRVE
TTRRYLLSFAHPPSTEMETIALATLHDRMTEQHFPHPIQSFSLGSISTPLNGHINILAEG
RCALEKANQELGLALDSWDLDFYTKRFQELQRNPSTVEAFDLAQSNSEHSRHWFFKGQLH
MDGQELAHSLFESIMSTQASSNPNNVLKFCDNSSAIQGKEVQFLRPEDPTQPSCFQPHRA
LRHVVFTAETHNFPTGVAPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPGY
NLPWEDPSFQYPENFARPLEVAIEASNGASDYGNKFGEPVLAGFTRSFGLQLPDGQRREW
IKPIMFSGGIGSMEAEHVRKEPPEPGMDIVKVGGPVYRIGVGGGAASSVQVQGDNTSDLD
FGAVQRGDPEMEQKMNRVIRACVEAARGNPICSLHDQGAGGNGNVLKELSDPAGAVIYTS
RFQLGDPTLNALEIWGAEYQESNALLLRPLDRDFLSRVSARERCPTCFVGTITGDKRIVL
VDDREYPVGRNGHEDASLSSPPTPVDLELDWVLGKMPRKEFFLKRSHPVLKPLALPPGLR
VRQALERVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLHTPLADVAVVALSHQELIG
AATALGEQPVKSLLDPKVAARLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAA
LADACEAMVAVMAALGVAVDGGKDSLSMAARVGSETVRAPGSLVISAYAVCPDITATVTP
DLKHPGGRGHLLYVSLSPGQHRLGGTALAQCFSQLGEQPPNLDLPENLVRAFSVTQGLLR
DRLLCSGHDVSDGGLITCLLEMAFAGNCGIEVHVPAPGVDALSVLFAEEPGLVLEVQESD
LAQVLKRYRVAGLHCMELGPTGDAGPHALVRVSVNGAVVLEEAVGQLRAVWEETSFQLDR
LQAEPRCVAEEEQGLRERMGPRYCLPAAFPKASVPREPGGPVPRVAILREEGSNGDREMA
DAFHLAGFEVWDVTTQDLCSGAIGLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFHPVAR
AELRRFRKRPDTFSLGVCNGCQLLALLGWVGGSPSEEAKETKETSLDSWPAPPGLVLRHN
LSGRFESRWASVRVGPGPALMLRGMEGAVLPVWSAHGEGYMAFSSPELQAQIEARGLAPL
HWADDNGKPTEQYPMNPNGSPGGVAGVCSLDGRHLAVMPHPERAVRPWQWAWRPPLFDTV
TTSPWLQLFINARDWTRKGGC
NT seq
4026 nt
NT seq
+upstream
nt +downstream
nt
atgacctctgttcttcacttctatgtccatccctctggccatgagagggcagcttcagaa
cacactcaaaggaagctccaagggaagctgccagcactgcagtctgtcaagacagagttg
tgctacaatgtgaactggacagccaagtcccccccaaacgctgaagagatgaagaagctg
atgtggctttttggttgccccttgttactgggtgatgttgctcaggagtcctggctccat
cccgactctagtgacctgctgctggaggttgggcccaggctgaacttctccacgccagca
tccaccaacgtcgtgtcagtgtgctgggctgctgggctgggggctgtggatcgtgtggag
actacccggcgctacttgctctcgtttgcccaccccccgtcaacggagatggagaccatc
gctctggctaccctgcatgatcggatgacagagcagcacttcccccatcccatccagagc
ttctccctcgggagcatttccacacctctcaacggccatatcaacatcctggctgagggc
cggtgtgccctggagaaagccaaccaggagctaggcctggcactagactcctgggaccta
gatttctataccaaacgcttccaggagctacagaggaacccaagcactgtggaggctttt
gacttggctcagtccaatagcgagcacagccgacactggttcttcaagggccagctccac
atggatggtcaggagttggcacactccctgtttgagtccatcatgagtacccaggcatcc
tcgaaccccaacaatgtgctcaagttctgtgacaacagcagcgcaatccaggggaaggaa
gtccaattcctaaggcccgaagaccccactcagccaagctgcttccagccgcaccgggca
ctgagacatgtagtcttcacagcagagacccacaacttccccacaggagtagcccccttc
agtggtgcgaccacaggcacagggggccggatccgagatgtccagtgcacgggccgaggg
gcccacgtggtggctggcactgctggctattgctttggaaacctgcacatcccaggttat
aatctgccttgggaggatccaagcttccagtatcctgagaactttgcccggcccctggag
gttgccattgaggccagtaatggggcttctgattacggcaacaagtttggggagcccgtg
ttggccggcttcacccgctccttcggactccagctcccagacggccagcgtcgtgagtgg
atcaagcccatcatgttcagtgggggcatcgggtccatggaagccgagcatgtgcgcaag
gagcccccagagccaggcatggacattgtaaaggtcgggggtcctgtctatagaattgga
gttggcggtggagctgcgtcatctgtgcaagtgcagggagataacaccagtgacctggac
tttggggctgtgcagcggggagacccggagatggaacaaaagatgaaccgtgtgatccgg
gcatgtgtggaggctgccaggggcaaccctatctgcagcctccacgaccagggtgctggt
ggcaacggcaacgtcctgaaggaactgagtgaccccgccggagctgtcatttacaccagc
cgcttccagctcggggatccaaccctgaacgccctggaaatctggggggctgagtatcag
gagtcaaacgcacttctgctgcggcccctggaccgggattttctcagccgtgtcagcgcc
cgggaacgctgcccgacttgctttgtgggcaccattacaggggacaagagaatagtgctg
gtggatgatcgggagtaccctgttgggagaaatggccatgaggatgcctccctctcatct
cccccaacccccgtggacctggagctggattgggtgttgggcaagatgcctcggaaggag
ttcttcctcaagaggagtcaccccgtgctgaagcctctggccttgcccccaggtctgcga
gtgcgccaggccctggagcgcgtcctgaggctgcctgctgtggccagcaagcgctacctc
actaacaaggtggaccgctctgtgggtggcctggtggcacagcagcagtgcgttggaccc
ctgcacacccctctggcagatgtggcagttgtggcgttaagtcaccaggagctcattgga
gccgccacagctctgggagagcagccagtcaaaagcctgctggacccaaaggttgctgcc
cgactggctgtggctgaagccctcaccaacctggtgtttgctctggtcaccgacctccgg
gacgtgaagtgcagtgggaactggatgtgggcagccaagctcccaggagagggtgcggcc
ctggccgacgcctgtgaggctatggtggcagtgatggcggccttgggtgtggcggtggat
ggtggcaaggactctctcagcatggccgcccgggtcggctctgagacagtgcgggcacct
ggatcactggtcatttcagcttatgccgtctgtccagacattacagccactgtgacccca
gacctcaagcatcctggagggagaggccatttgctgtacgtgtctctgagccccgggcaa
caccggctagggggcacggccctggcccagtgtttctcgcagctaggcgagcagcctccc
aacctggacctccctgagaacttggtgcgtgcctttagcgtcacccaggggctgctgaga
gaccgcctcctctgctcaggccatgatgtcagtgacgggggtctcatcacctgcctgctg
gagatggcctttgctgggaattgtgggatagaggtgcatgtgcctgcccctggggtcgat
gcattgtctgtcctgtttgctgaggagccgggcctggtgctggaggtgcaggagtccgac
ctggcccaggtgctgaagcgctatcgggttgcaggcctccactgcatggagctgggcccc
acgggtgatgccgggccccacgccttggtgcgagtatcggtgaacggggccgtggtcctg
gaggaggctgttgggcagctccgagccgtctgggaggagaccagtttccagctggaccgg
ctgcaggcagagccccgctgcgtggccgaggaagaacaggggctgagggagcggatgggg
ccccgctactgcctgcccgcagccttccccaaagcttccgtgccccgtgagcctggtggg
ccggtgccccgagttgccatcttgcgagaggagggcagcaacggagaccgggagatggcc
gatgccttccacttggctggcttcgaggtgtgggacgtgaccacgcaggacctctgctct
ggggcaatcggtctggacacgttccgtggcgtggccttcgtgggcggctttagctacgca
gatgtcctgggctctgccaaagggtgggcggccgctgtgaccttccacccagtggccagg
gctgaactgaggcgcttccggaagcggcccgacacctttagcctgggcgtgtgtaatggc
tgtcagctgctggctctgctgggctgggtaggaggcagccccagcgaggaggccaaggag
accaaggagaccagcctggactcctggccagccccgcccggccttgtgctgcgccacaac
ctgtctggacgctttgaatctcgctgggccagcgtgcgggtggggcccgggccggccctg
atgctgcgcgggatggagggtgccgtgctgcccgtgtggagcgctcacggggaaggttac
atggcgttttcttctccggagctccaagcccagattgaggccaggggcttggctccgctg
cactgggcagacgacaatgggaagcccacagaacagtaccccatgaaccccaacgggtct
ccaggaggggtggccggcgtctgctcccttgatggccgccacctggctgtcatgcctcac
cctgagcgggctgtgaggccctggcagtgggcatggcgccctcctctgtttgacactgtg
accacctccccctggctccagctcttcatcaatgctcgagactggacccggaaaggaggc
tgctga
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