KEGG   Canis lupus familiaris (dog): 489692
Entry
489692            CDS       T01007                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00562  Inositol phosphate metabolism
cfa01100  Metabolic pathways
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04020  Calcium signaling pathway
cfa04062  Chemokine signaling pathway
cfa04064  NF-kappa B signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04072  Phospholipase D signaling pathway
cfa04360  Axon guidance
cfa04370  VEGF signaling pathway
cfa04380  Osteoclast differentiation
cfa04517  IgSF CAM signaling
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04625  C-type lectin receptor signaling pathway
cfa04650  Natural killer cell mediated cytotoxicity
cfa04662  B cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04666  Fc gamma R-mediated phagocytosis
cfa04670  Leukocyte transendothelial migration
cfa04722  Neurotrophin signaling pathway
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04919  Thyroid hormone signaling pathway
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04935  Growth hormone synthesis, secretion and action
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05169  Epstein-Barr virus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05171  Coronavirus disease - COVID-19
cfa05200  Pathways in cancer
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05214  Glioma
cfa05223  Non-small cell lung cancer
cfa05225  Hepatocellular carcinoma
Module
cfa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    489692 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    489692 (PLCG2)
   04014 Ras signaling pathway
    489692 (PLCG2)
   04370 VEGF signaling pathway
    489692 (PLCG2)
   04064 NF-kappa B signaling pathway
    489692 (PLCG2)
   04066 HIF-1 signaling pathway
    489692 (PLCG2)
   04020 Calcium signaling pathway
    489692 (PLCG2)
   04070 Phosphatidylinositol signaling system
    489692 (PLCG2)
   04072 Phospholipase D signaling pathway
    489692 (PLCG2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    489692 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    489692 (PLCG2)
   04613 Neutrophil extracellular trap formation
    489692 (PLCG2)
   04625 C-type lectin receptor signaling pathway
    489692 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    489692 (PLCG2)
   04662 B cell receptor signaling pathway
    489692 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    489692 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    489692 (PLCG2)
   04670 Leukocyte transendothelial migration
    489692 (PLCG2)
   04062 Chemokine signaling pathway
    489692 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    489692 (PLCG2)
   04919 Thyroid hormone signaling pathway
    489692 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    489692 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    489692 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    489692 (PLCG2)
   04380 Osteoclast differentiation
    489692 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    489692 (PLCG2)
   05206 MicroRNAs in cancer
    489692 (PLCG2)
   05205 Proteoglycans in cancer
    489692 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    489692 (PLCG2)
   05214 Glioma
    489692 (PLCG2)
   05223 Non-small cell lung cancer
    489692 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    489692 (PLCG2)
   05171 Coronavirus disease - COVID-19
    489692 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    489692 (PLCG2)
   05169 Epstein-Barr virus infection
    489692 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    489692 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    489692 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    489692 (PLCG2)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     489692 (PLCG2)
Membrane trafficking [BR:cfa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    489692 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    489692 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF_HAND_2_PLCG C2 SH3_1 PH SH3_9 PH_12 EF_HAND_1_PLCG SH2_1 PH_14 SH3_2 GDPD EF-hand_like
Other DBs
NCBI-GeneID: 489692
NCBI-ProteinID: XP_022274836
Ensembl: ENSCAFG00000019989
VGNC: 44652
LinkDB
Position
5:complement(70073218..70247127)
AA seq 1265 aa
MTALAHVDSLPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEECCFTILYGTQFVLSTLSLAADSKEDAN
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVNSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLLHEQQELWAQDLNKVRARMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDQLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDTPPTELHFGEEWFHKKVEKR
TSAEKLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIRSTVEGGTMKYF
LTDNVMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGQHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDISTVDVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDKVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLSVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMQPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SRFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgactgccctggcccacgtggacagccttccggaatacgagaagagtcagatcaagaga
gccctggagctgggcacggtgatgacggtgttcagcttccgcaagtccaccccagagcgg
aggactgtccaggtgatcatggagacacgccaggtggcctggagcaagacagccgacaag
atcgagggcttcttggatatcatggaaatcaaggaaatccgcccagggaagaactccaag
gattttgagcgtgcaaaagcagtccgccagaaggaagagtgctgttttaccatcttgtac
ggcacccagtttgttctgagcacactcagtctggcagctgactctaaagaagatgcgaat
aagtggctctctggcttgaaaatcttacaccaggaagcgatgagtgcatctacacccacc
attattgagagttggctgagaaagcagatttattcagtggaccaaaccagaagaaacagc
atcagcctccgagagttgaagaccatcttacccctggtcaactttaaggtgaacagtgcc
aagttcctcaaagataagtttgtggaaattggtgcacacaaagatgagctcagctttgag
cagttccacctgttctataaaaaacttatgtttgagcagcaaaagtcgattcttgatgaa
ttcaaaaaagattcttccgtgttcatcttgggcaacactgaccggccggacgcctctgct
gttcacctgcacgacttccagcgctttctcttacatgagcaacaggagctttgggctcag
gatctgaacaaagtccgtgcgcggatgacaaagtttatcgatgacaccatgagggaaaca
gccgagcccttcttgtttgtcgatgagttcctcacatatctgttttcgcgggagaacagc
atctgggatgagaagtatgacgtggtggacatgcaggacatgaacaaccccttgtcccat
tactggatctcctcttcgcataacacgtacctcaccggtgaccagctacggagtgagtca
tccacagaagcgtacattcgctgcctgcggatgggctgtcgctgcattgagttggactgc
tgggacgggcccgatgggaagcccatcatctaccacggctggacacggaccaccaagata
aagtttgacgacgtcgtgcaggccatcaaagaccatgcctttgtcacttcaagcttcccc
gtgatcctgtccatcgaggagcactgttgcgtggagcagcagcgccacatggccagggtg
ttcaaggaggtgtttggcgaccagctgctgacgaagcccacggaggccagtgctgaccag
ctgccctcgcccagccagttgcgggagaagatcatcatcaagcataagaagctgggtccc
cgaggggacgtggatgtcaacatggaggacaagaaagatgagcacaagcaacagggtgaa
ctgtatatgtgggattccatcgaccagaaatggactcggcactactgtgccatcgccgat
gccaaactgtctttcagcgatgacattgagcagactgcagaagaggagctgccccaggac
acaccccccacggagctgcattttggggaggagtggttccacaagaaagtagagaagagg
acgagtgccgagaagctgctgcaggaatactgtgcagagaccgggggcaaggatgggact
ttccttgtgcgggagagcaagaccttccccaatgactacaccctgtccttctggcggtcc
ggccgcgtccagcactgccggatccgttccaccgtggaggggggcaccatgaagtacttc
ctgactgacaacgtcatgttcaccagcatctacgccctcatccagcactaccgcgagacc
cacctgcgctgcgccgagttcgagctgcggctcaccgaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactacgacgggctgagccgtggggaggcagaggacatgcta
atgagggtgccccgggacggcgccttcctgatccggaggcgagaaggtaccgattcctac
gccatcaccttcagggccaggggcaaggtgaagcactgccgcattcaccgggatggccag
cactttgtgctggggacctctgcctacttcgagagcctcgtggagctagtcagctactac
gaaaagcacgcgctctaccgaaaaatgcgactgcgctaccccgtgacgcctgagctcctg
gagcgctacaatatggaaagagatataaactccctctatgacgtcagcagaatgtatgtg
gatcccagtgagatcaatccttctatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagtttctgccgtggggccctcattcacaacgtctcg
aaggagccctggggctggtggaagggggactatggaaccagaatccagcagtacttccca
tccaattacgtcgaggacatttcaacggtcgacgtggaggagctggagaagcagattatt
gaagacaatcccttagggtctctttgtaggggaatactggatctcaatacctataacgtt
gtgaaagccccccaggggaaaaaccagaagccattcgtgtttatcctggagcccaagaag
caaggtgaccccccggtggagtttgccacggacaaggtggaggagctctttgagtggttt
cagagcatccgggagatcacctggaagatagacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtcgtctactgcaagccaacc
agcaagaccaaggacaatttagaaaaccctgacttccgagaaatccggtcctttgtggag
acaaaggcagacagtgtcgtcagacagaaacccgttgacctcctgaagtacaatcagaag
ggcctgacccgtgtttacccgaagggacagagggtggactcctccaactacgaccccttt
cgcctctggctgtgcggctcccagatggtggcactcaatttccagactccagacaagtat
atgcagatgaatcacgccttgttctcactcaatgggcgaacgggctacgtcctacagcct
gagagcatgaggacggagaagtatgaccccatgccacctgagtcccagaggaagatcctg
atgactctgtcagtcaaggttcttggggctcgccatctccccaaacttggacgaagtatc
gcgtgtccctttgtggaggtggaaatttgtggagctgaatatgacaacaacaagtttaag
acaacagtcgtgaatgacaatggcctaagccctgtttgggctccaacacaggagaaagtg
acctttgaaatttacgaccccaacctggcgtttctgcgctttgtggtctatgaggaagat
atgttcagtgaccccaatttccttgctcacgccacttaccccatcaaaggaatcaaatca
ggattcagatctgttcctctgaagaacgggtacagtgaagacattgagctggcttccctc
ctggttttctgtgagatgcagccagtcctggagagcgaagaggaactttattcctcctgt
cgccagctgcgaaggcggcaggaagagctcaacaatcagctctttctgtacgacacacac
cagaacttgcgcaacgccaaccgggatgccctcgttaaagagttcaatgtcaacgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttgagagagaagcgagtcagcaac
agcaggttttactcctag

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