Canis lupus familiaris (dog): 609822
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Entry
609822 CDS
T01007
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa00270
Cysteine and methionine metabolism
cfa00480
Glutathione metabolism
cfa01100
Metabolic pathways
cfa01240
Biosynthesis of cofactors
cfa04216
Ferroptosis
Module
cfa_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
609822 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
609822 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
609822 (GCLC)
Enzymes [BR:
cfa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
609822 (GCLC)
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Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
609822
NCBI-ProteinID:
XP_852845
Ensembl:
ENSCAFG00000002288
VGNC:
41147
UniProt:
A0A8P0N5C9
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Position
12:complement(20898243..20947109)
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AA seq
637 aa
AA seq
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MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVRLVLSGEEVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLGENQALCTITSFPRLGCPGFTLPEFKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPEDEEAAKASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARSLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSECGEKYNDIDLTIDKEIYEQLLQ
EGIDRLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
RGMFYFRKDICKGGNTVVDGYGKAQNSTEVAVEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYS
LILKCNQIANELCECPELLGPAFRKVKYSGSKTDSSN
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccaaggctcgccgctgagctgggaggagaccaagcgccacgccgac
cacgtgcggcggcacgggatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgacgaggtggagtacatgttggtgtcttttgatcat
gaaaataaaaaagtccggttggtcctgtctggagaggaagttcttgaaactctacaagaa
aagggggaaaggacaaacccaaaccatcctaccctgtggagaccagagtatggcagttac
atgattgaaggcacacctggacagccatacggtggaaccatgtctgagttcaacacagtc
gaagacaacatgaggaaacgccggaaggaagcaacttctctattaggagaaaatcaggct
ctctgtacaataacttcatttcccagattaggctgtcctgggttcacgctgccagaattc
aaacccaatccagttgaaggaggagcttccaagtccctcttctttcctgatgaagccata
aacaagcacccccgcttcagtaccctaacaagaaatatccgacataggagaggagaaaaa
gttgtcatcaatgtaccaatatttaaggacaagaatacaccgtctccgtttatagaaacg
tttcctgaggatgaggaggcagccaaggcttctaagcctgatcatatttacatggatgcc
atgggatttgggatgggcaattgctgtcttcaggtaacgttccaagcctgcagcatatct
gaggccagatccctttatgatcagttggccactatctgtccaattgttatggctttgagc
gctgcgtctcctttttaccgaggctatgtgtcagacattgattgtcgctggggagtgatt
tctgcatctgtagatgatagaactcgggaggagagaggactggagccactgaagaacaat
aactataggatcagtaaatctcgctatgattcgatagacagttacttatctgagtgtggt
gagaaatacaatgacatcgacttgacaatagataaagaaatctacgaacaactgctgcag
gaaggcattgatcgtctcctggcccagcatgttgctcacctcttcattagagacccactg
actttgtttgaagagaaaatacacttggatgatgccaatgaatctgaccatttcgagaat
atccagtccacaaattggcagacgatgagatttaagccccctcctccaaactctgatatt
ggatggagagtagaattccgacccatggaggttcagttaacagactttgagaattctgca
tatgtggtgtttgtggtgctgcttaccagagtgatcctttcatacaaactggattttctc
attccactatcaaaggttgatgaaaatatgaaagttgcacagaaacgagatgctgtcttg
cggggaatgttttatttcaggaaagatatttgcaaaggtggcaacactgtagtagatggc
tacggcaaggcccagaacagcacagaagtggctgtagaggagtataccctgatgagcata
gacaccatcatcaacgggaaggaaggtgtgtttcctgggctgatcccaattctgaactct
taccttgaaaacatggaagtggacgtggacaccagatgtagtattctgaactacctaaag
ctaattaagaagagagcatctggcgaactaatgacagttgccaggtggatgagagagttt
attgcaaaccatcctgactacaagcaagacagtgtgataactgatgaaatgaactacagc
cttattttgaagtgtaaccaaattgcaaatgaattatgtgaatgtccagagttacttgga
ccagcatttaggaaagtaaaatatagtggaagtaaaactgactcttccaactag
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