KEGG   Camelus ferus (Wild Bactrian camel): 102513431
Entry
102513431         CDS       T02979                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cfr  Camelus ferus (Wild Bactrian camel)
Pathway
cfr00562  Inositol phosphate metabolism
cfr01100  Metabolic pathways
cfr04015  Rap1 signaling pathway
cfr04020  Calcium signaling pathway
cfr04022  cGMP-PKG signaling pathway
cfr04062  Chemokine signaling pathway
cfr04070  Phosphatidylinositol signaling system
cfr04071  Sphingolipid signaling pathway
cfr04072  Phospholipase D signaling pathway
cfr04081  Hormone signaling
cfr04082  Neuroactive ligand signaling
cfr04261  Adrenergic signaling in cardiomyocytes
cfr04270  Vascular smooth muscle contraction
cfr04310  Wnt signaling pathway
cfr04371  Apelin signaling pathway
cfr04540  Gap junction
cfr04611  Platelet activation
cfr04613  Neutrophil extracellular trap formation
cfr04621  NOD-like receptor signaling pathway
cfr04713  Circadian entrainment
cfr04720  Long-term potentiation
cfr04723  Retrograde endocannabinoid signaling
cfr04724  Glutamatergic synapse
cfr04725  Cholinergic synapse
cfr04726  Serotonergic synapse
cfr04728  Dopaminergic synapse
cfr04730  Long-term depression
cfr04742  Taste transduction
cfr04750  Inflammatory mediator regulation of TRP channels
cfr04911  Insulin secretion
cfr04912  GnRH signaling pathway
cfr04915  Estrogen signaling pathway
cfr04916  Melanogenesis
cfr04918  Thyroid hormone synthesis
cfr04919  Thyroid hormone signaling pathway
cfr04921  Oxytocin signaling pathway
cfr04922  Glucagon signaling pathway
cfr04924  Renin secretion
cfr04925  Aldosterone synthesis and secretion
cfr04926  Relaxin signaling pathway
cfr04927  Cortisol synthesis and secretion
cfr04928  Parathyroid hormone synthesis, secretion and action
cfr04929  GnRH secretion
cfr04933  AGE-RAGE signaling pathway in diabetic complications
cfr04934  Cushing syndrome
cfr04935  Growth hormone synthesis, secretion and action
cfr04961  Endocrine and other factor-regulated calcium reabsorption
cfr04970  Salivary secretion
cfr04971  Gastric acid secretion
cfr04972  Pancreatic secretion
cfr04973  Carbohydrate digestion and absorption
cfr05010  Alzheimer disease
cfr05016  Huntington disease
cfr05017  Spinocerebellar ataxia
cfr05022  Pathways of neurodegeneration - multiple diseases
cfr05142  Chagas disease
cfr05143  African trypanosomiasis
cfr05146  Amoebiasis
cfr05163  Human cytomegalovirus infection
cfr05200  Pathways in cancer
cfr05415  Diabetic cardiomyopathy
cfr05417  Lipid and atherosclerosis
Module
cfr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102513431 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    102513431 (PLCB4)
   04310 Wnt signaling pathway
    102513431 (PLCB4)
   04070 Phosphatidylinositol signaling system
    102513431 (PLCB4)
   04072 Phospholipase D signaling pathway
    102513431 (PLCB4)
   04071 Sphingolipid signaling pathway
    102513431 (PLCB4)
   04022 cGMP-PKG signaling pathway
    102513431 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    102513431 (PLCB4)
   04081 Hormone signaling
    102513431 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102513431 (PLCB4)
   04613 Neutrophil extracellular trap formation
    102513431 (PLCB4)
   04062 Chemokine signaling pathway
    102513431 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    102513431 (PLCB4)
   04922 Glucagon signaling pathway
    102513431 (PLCB4)
   04929 GnRH secretion
    102513431 (PLCB4)
   04915 Estrogen signaling pathway
    102513431 (PLCB4)
   04921 Oxytocin signaling pathway
    102513431 (PLCB4)
   04926 Relaxin signaling pathway
    102513431 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    102513431 (PLCB4)
   04918 Thyroid hormone synthesis
    102513431 (PLCB4)
   04919 Thyroid hormone signaling pathway
    102513431 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    102513431 (PLCB4)
   04924 Renin secretion
    102513431 (PLCB4)
   04925 Aldosterone synthesis and secretion
    102513431 (PLCB4)
   04927 Cortisol synthesis and secretion
    102513431 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    102513431 (PLCB4)
   04971 Gastric acid secretion
    102513431 (PLCB4)
   04972 Pancreatic secretion
    102513431 (PLCB4)
   04973 Carbohydrate digestion and absorption
    102513431 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    102513431 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    102513431 (PLCB4)
   04725 Cholinergic synapse
    102513431 (PLCB4)
   04728 Dopaminergic synapse
    102513431 (PLCB4)
   04726 Serotonergic synapse
    102513431 (PLCB4)
   04720 Long-term potentiation
    102513431 (PLCB4)
   04730 Long-term depression
    102513431 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    102513431 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    102513431 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    102513431 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    102513431 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102513431 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    102513431 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102513431 (PLCB4)
   05142 Chagas disease
    102513431 (PLCB4)
   05143 African trypanosomiasis
    102513431 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102513431 (PLCB4)
   05016 Huntington disease
    102513431 (PLCB4)
   05017 Spinocerebellar ataxia
    102513431 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    102513431 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102513431 (PLCB4)
   05415 Diabetic cardiomyopathy
    102513431 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102513431 (PLCB4)
   04934 Cushing syndrome
    102513431 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfr04131]
    102513431 (PLCB4)
Enzymes [BR:cfr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102513431 (PLCB4)
Membrane trafficking [BR:cfr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102513431 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102513431 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 102513431
NCBI-ProteinID: XP_032317725
UniProt: A0A8B8RIF2
LinkDB
Position
19:complement(28843415..29227827)
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESYVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGIDLVNISFTYMVAESPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDDIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSDYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLITVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFLVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEETFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKTLEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSDMINTHSAEEQEIRDLHLTQQCELLRKLLINAHEQQTQQLKMS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQMQGEGDAADGEIGSRDGPQTSNSCV
KLQDTN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatatgaagaggaatcttatgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggagaagtgaaggcaaggaagggcaagtgcta
gaatgttccctcatcaacagtgttcggctgggagccaccccaaaggatcccaaaattttg
gctgctcttgaagctgttggaaaatcagaaaatgatctggaagggcggatagtctgtgtc
tgcagtggtatcgacctggtgaacatcagtttcacgtacatggtggctgaaagtccagaa
gtaactaagcaatgggtagaaggcctgagatccataatacacaacttcagggccaacaac
gtcagtccgatgacttgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaatcccagttaggagtattaccagaacttttgcatcgggaaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttccaagtggaaagaatgatgacattgag
cctgcagcgtttacttacgaaaagttctatgaactgacgcaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcggttgaatgaaattttattc
ccattttatgatgctaaaagggccatgcagatcattgagatgtatgagcctgatgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttctgcagatacctgatgtccgatgag
aatgccccagtcttcctggatcgtctagaactttaccaagaaatggaccaccccctggct
cactacttcatcagttcctcccacaacacgtatctcactggccgacagtttggtgggaag
tcttcagtggaaatgtacagacaggtcctcctggctggctgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaggaccaagaaccgataataactcacggaaaagcgatgtgt
acagatattctttttaaggatgttattcaagccatcaaggagactgcctttgtcacatcc
gactatcctgtcattctctcctttgaaaatcactgcagcaaataccagcagtacaagatg
tccaaatactgtgaagatctgtttggggatctcctgttgaaacaagcacttgaatcccat
ccactggaaccaggcaggcccttgccatcccccaatgacctcaaaagaaaaatcctcatc
aaaaataaacggctgaaacctgaagtggaaaaaaagcagcttgaagctttgaaaagtatg
atggaagcaggggaatccgctgccccagtgaacatcttagaggatgataacgaagaggaa
atagaaagtgctgagcaagaggaggaagctcaccccgagtacaagtacggaaatgaactt
tccgcggacgacctgggtcacaaggaagccgtcgccaacagtgtcaagaaggcttcagat
gaccttgaacatgaaaacaacaaaaagggcctgattactgtagaagatgagcaggcgtgg
atggcatcttataaatatgtaggtgctaccactaacatccatccgtatttgtccacaatg
atcaactatgcacagcctgtaaagtttcaaggtttccttgtggctgaagaacgcaacatt
cattataacatgtcttcttttaacgagtcagtcggtctgggctacctgaagacacatgcg
attgagttcgtgaattacaataaacggcaaatgagtcgcatttaccccaaggggggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtgtca
ctcaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaagccagatttcatgaggcggcccgaccgcacatttgat
cctttctctgaaacacctgttgatggcgttatcgcagccacttgctccgtgcaggtcatc
tcgggtcagttcttatccgataagaagatcggcacgtatgtggaggtggatatgtacggg
ctgcccactgacaccatccggaaagaattccgaacccgcatggtgatgaacaacggactc
aaccccgtttacaatgaagagacattcgtgtttcggaaggtgatcctccctgacctggct
gtcttgagaatcgccgtgtatgatgacaacaacaaactgattggccaaaggattcttccc
ctcgatggtctccaagcgggctatcgacacatttcccttcgaaatgaggggaataaacct
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatatcgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaacgagtgacatcgccgatgtgcccagtgac
acgtcaaagaacgacaagaaaggcaaagccaacacagccaaggccaacgtgaccccccag
agcagctccgagctcaggccgaccaccacggccgccctgggggccggcctggaagccaag
aaaggtattgagctgatcccgcaggtgaggatagaagatttaaagcagatgaaggcttac
ttgaaacatttaaagaaacaacagaaggagctaaattctttaaagaagaaacatgcaaag
gagcacagtacgatgcagaagttacactgcactcaagtggacaagatcgtggcgcagtac
gacaaagagaagtcgactcacgagaaaaccctggagaaggcaatgaagaagaaggggggg
agtaattgtctcgaaatgaaaaaagaaacggaaattaaaattcagacattgacatcagat
cacaaatctaaggtcaaagagattgtggcacagcacacgaaggagtggtcagacatgatc
aacacgcacagtgcggaggagcaggagatccgggacctgcacctcacccagcagtgcgag
ctgctccggaagctcctgatcaacgcgcacgagcagcagactcagcagctgaaaatgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaacagc
aaagccatcagccaggataaatctatcaagaataaagcagaacgggaaaggcgagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaagcgtctcgcaatgaag
cagtccaaagaaatggatcagttgaaaaaagtccaacttgagcacctagaattcttagaa
aaacagaacgaacagcttttgaaatcctgtcatgcagtgtcccaaatgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagttgtgtg
aaactccaggacacaaactga

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