KEGG   Camelus ferus (Wild Bactrian camel): 102516847
Entry
102516847         CDS       T02979                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
cfr  Camelus ferus (Wild Bactrian camel)
Pathway
cfr01522  Endocrine resistance
cfr04010  MAPK signaling pathway
cfr04015  Rap1 signaling pathway
cfr04068  FoxO signaling pathway
cfr04071  Sphingolipid signaling pathway
cfr04114  Oocyte meiosis
cfr04148  Efferocytosis
cfr04218  Cellular senescence
cfr04261  Adrenergic signaling in cardiomyocytes
cfr04370  VEGF signaling pathway
cfr04380  Osteoclast differentiation
cfr04550  Signaling pathways regulating pluripotency of stem cells
cfr04611  Platelet activation
cfr04613  Neutrophil extracellular trap formation
cfr04620  Toll-like receptor signaling pathway
cfr04621  NOD-like receptor signaling pathway
cfr04622  RIG-I-like receptor signaling pathway
cfr04625  C-type lectin receptor signaling pathway
cfr04657  IL-17 signaling pathway
cfr04658  Th1 and Th2 cell differentiation
cfr04659  Th17 cell differentiation
cfr04660  T cell receptor signaling pathway
cfr04664  Fc epsilon RI signaling pathway
cfr04668  TNF signaling pathway
cfr04670  Leukocyte transendothelial migration
cfr04714  Thermogenesis
cfr04722  Neurotrophin signaling pathway
cfr04723  Retrograde endocannabinoid signaling
cfr04728  Dopaminergic synapse
cfr04750  Inflammatory mediator regulation of TRP channels
cfr04912  GnRH signaling pathway
cfr04914  Progesterone-mediated oocyte maturation
cfr04917  Prolactin signaling pathway
cfr04926  Relaxin signaling pathway
cfr04932  Non-alcoholic fatty liver disease
cfr04933  AGE-RAGE signaling pathway in diabetic complications
cfr04935  Growth hormone synthesis, secretion and action
cfr04936  Alcoholic liver disease
cfr05014  Amyotrophic lateral sclerosis
cfr05020  Prion disease
cfr05022  Pathways of neurodegeneration - multiple diseases
cfr05132  Salmonella infection
cfr05133  Pertussis
cfr05135  Yersinia infection
cfr05140  Leishmaniasis
cfr05142  Chagas disease
cfr05145  Toxoplasmosis
cfr05152  Tuberculosis
cfr05161  Hepatitis B
cfr05163  Human cytomegalovirus infection
cfr05167  Kaposi sarcoma-associated herpesvirus infection
cfr05169  Epstein-Barr virus infection
cfr05170  Human immunodeficiency virus 1 infection
cfr05171  Coronavirus disease - COVID-19
cfr05205  Proteoglycans in cancer
cfr05208  Chemical carcinogenesis - reactive oxygen species
cfr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cfr05415  Diabetic cardiomyopathy
cfr05417  Lipid and atherosclerosis
cfr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102516847 (MAPK12)
   04015 Rap1 signaling pathway
    102516847 (MAPK12)
   04370 VEGF signaling pathway
    102516847 (MAPK12)
   04668 TNF signaling pathway
    102516847 (MAPK12)
   04068 FoxO signaling pathway
    102516847 (MAPK12)
   04071 Sphingolipid signaling pathway
    102516847 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    102516847 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102516847 (MAPK12)
   04218 Cellular senescence
    102516847 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    102516847 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102516847 (MAPK12)
   04613 Neutrophil extracellular trap formation
    102516847 (MAPK12)
   04620 Toll-like receptor signaling pathway
    102516847 (MAPK12)
   04621 NOD-like receptor signaling pathway
    102516847 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    102516847 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    102516847 (MAPK12)
   04660 T cell receptor signaling pathway
    102516847 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    102516847 (MAPK12)
   04659 Th17 cell differentiation
    102516847 (MAPK12)
   04657 IL-17 signaling pathway
    102516847 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    102516847 (MAPK12)
   04670 Leukocyte transendothelial migration
    102516847 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    102516847 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    102516847 (MAPK12)
   04917 Prolactin signaling pathway
    102516847 (MAPK12)
   04926 Relaxin signaling pathway
    102516847 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    102516847 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102516847 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    102516847 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    102516847 (MAPK12)
   04722 Neurotrophin signaling pathway
    102516847 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102516847 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102516847 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    102516847 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    102516847 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    102516847 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102516847 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102516847 (MAPK12)
   05161 Hepatitis B
    102516847 (MAPK12)
   05171 Coronavirus disease - COVID-19
    102516847 (MAPK12)
   05163 Human cytomegalovirus infection
    102516847 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102516847 (MAPK12)
   05169 Epstein-Barr virus infection
    102516847 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102516847 (MAPK12)
   05135 Yersinia infection
    102516847 (MAPK12)
   05133 Pertussis
    102516847 (MAPK12)
   05152 Tuberculosis
    102516847 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102516847 (MAPK12)
   05140 Leishmaniasis
    102516847 (MAPK12)
   05142 Chagas disease
    102516847 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    102516847 (MAPK12)
   05020 Prion disease
    102516847 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    102516847 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102516847 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    102516847 (MAPK12)
   05415 Diabetic cardiomyopathy
    102516847 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    102516847 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    102516847 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102516847 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    102516847 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfr01001]
    102516847 (MAPK12)
Enzymes [BR:cfr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     102516847 (MAPK12)
Protein kinases [BR:cfr01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   102516847 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kinase-like
Other DBs
NCBI-GeneID: 102516847
NCBI-ProteinID: XP_032348470
UniProt: A0A8B8U2W1
LinkDB
Position
12:complement(12395734..12404613)
AA seq 522 aa
MSSQPPPRRGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGVKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDAFTDLEPRPLAWPAILGESP
EHSPQLPYIMELLGWKETVGGGLGVPRGCLPCPCSYLVMPFMGTDLGKLMKHEKLSEDRI
QFLAYQMLKGLKYIHDAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRW
YRAPEVILNWMHYTQTVDIWSVGCIMAEMITGKTLFKGNDHLDQLKEIMKVTGTPPAEFV
QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAERRVTAAEALAHPY
FEALQDTEDEPKAQKYDESFDDVDRTLDEWKRCPPTWTAAHPPSCQRDEVCPGQPIAPHA
FLLLIPNPSSPTGCSDPLPFVLCTSRLRTGHPLRPGPFSSCLRAASICSASGWAQGHLAS
PQASFYWGPDAPCWNGPHPCLLQDSRCLPSVAAGPAWECRDA
NT seq 1569 nt   +upstreamnt  +downstreamnt
atgagctctcagccgcccccccgccgcggcttttaccgccaggaggtgaccaagaccgcc
tgggaggtgcgcgccgtgtaccaggacctgcagcccgtcggttcgggcgcctatggcgcc
gtatgctcggcggtggacagccgcacaggcgtcaaggtggccatcaagaagctctaccgg
cccttccagtccgagctgttcgccaagcgcgcttaccgcgagctgcgtctgctcaagcac
atgcgccacgagaatgtgattgggttgctggatgtcttcacacccgatgagaccctggat
gctttcacagacttggagccccggcccctagcatggcctgccatccttggggaatcccca
gagcacagtccccaactgccctacatcatggagctgctggggtggaaggagaccgtggga
ggtggactcggggtgcctcggggatgcctgccctgtccctgcagttacctggtgatgccg
ttcatgggtaccgacctgggcaagctcatgaagcatgagaagctgagcgaggaccggatc
cagttccttgcctaccagatgctgaaggggctgaagtacatccacgatgctggcatcatc
cacagggacctgaagcctggcaacctggcagtgaatgaggactgtgaactgaagatcctg
gacttcggcttggccaggcaggcagacagcgagatgactggatatgtggtgacccggtgg
tacagggcgcccgaggtcatcttgaattggatgcactacacacagacggtggacatctgg
tcagtgggctgcatcatggcagagatgatcacagggaagacactcttcaaaggcaacgac
cacctggaccagctgaaggagatcatgaaggtgacggggacgccccctgccgagtttgtg
cagaggctgcagagcgatgaggctaagaattatatgaagggcctccctgagctggagaag
aaggattttgcctccatcctgaccaatgcgagccctctggccgtgaacctcctggagaaa
atgctggtgctagatgcagagcggcgggtgacggcagccgaggcgctggcccacccctac
tttgaggccctgcaggacacggaggacgagcccaaggcccagaagtacgatgagtccttt
gatgacgtggaccgcacactggatgagtggaagcgttgccccccgacgtggacagctgca
caccccccatcctgccagcgggatgaggtctgccccgggcagcccatagcacctcacgct
ttcttgctactcatccctaacccctccagccccactgggtgttcagacccccttccattt
gtgctctgcacctcccggcttcgcactggccatccccttagacccggacccttctcctcc
tgtctgagggctgccagcatctgctcagcctctggctgggctcagggacacctggccagt
ccccaggcctccttctactggggtcctgacgcaccatgctggaatgggcctcacccatgt
ctactccaggacagcaggtgtctcccctcagtggctgcaggacccgcctgggagtgcagg
gatgcctaa

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