Camelus ferus (Wild Bactrian camel): 102522121 Help Entry 102522121         CDS       T02979                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism cfr  Camelus ferus (Wild Bactrian camel) Pathway cfr04020   Calcium signaling pathway cfr04371   Apelin signaling pathway cfr04713   Circadian entrainment cfr04921   Oxytocin signaling pathway cfr04970   Salivary secretion cfr05010   Alzheimer disease cfr05012   Parkinson disease cfr05020   Prion disease cfr05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:cfr00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102522121 (RYR3)    04020 Calcium signaling pathway     102522121 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     102522121 (RYR3)   09154 Digestive system    04970 Salivary secretion     102522121 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     102522121 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     102522121 (RYR3)    05012 Parkinson disease     102522121 (RYR3)    05020 Prion disease     102522121 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     102522121 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cfr04040]     102522121 (RYR3) Ion channels [BR:cfr04040]  Voltage-gated cation channels   Ryanodine receptor    102522121 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  102522121 NCBI-ProteinID:  XP_032337457 UniProt:  A0A8B8T606 LinkDB All DBs Position 6:28313388..28812568 Genome browser AA seq 4874 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKFVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGFQRKAAQGGGHRTLLYGHAILLRHSFS GMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSV SSERYLHLSISNGNIQVDASFMQTLWNVHPTCSGSSVEEGYLLGGHVVRLFHGHDECLTI PSTDQNDSQHRRVFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLA LTEDQGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQ HVASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQQEESQAARIIRNTTA LFSQFVSGNNRTTAPVTLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLF KEEGMLALVLNCIDRLNIYNSIAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCA QFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHK VLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQ YKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDG LHLWSGRIPRAVASVNQHLLRSDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFF PVVSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRD LLGTTQFLSQASFIPCPIDTSQVVLPPHLEKVRDKLAENIHELWGMNKIELGWTFGKIRD DNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKN YMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRLKQGWTYGIQQDLKNKRN PRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRV ERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSG YFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIHNGFVPICSLGLS QIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPQIEV VRIDGTMDSPPCLKVTHKTFGTQNSNATMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQ MQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLSKNCTVTVTLGDERG RVHESVKRSNCYMVWGGDVVATSQRASRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQ VEPNTKVFPAVFLQPTSTSLFQFELGNLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQ PVLWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQ FHYHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLA SAKERKLMMKNEYIIPITGTTRKIRLYPDASKRHGLPGVGPRTCLKPGFRFSTPCFVVTS EEHQKQSPEIPLELLKTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMG VFDDEDVRQILLLIDPSVFGEHSAEMEEGAEKEEVTQVEEKAVEAGEKASKEAGKEAPVK GLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQAL NMSAALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLE EEEEEEEDASWTGRFRALVYKIKGLPKPEKEQPTEEEERSPTTLKELVSQTMIRWAQEDQ IQDAELVRMMFTLLRRQYDSIGELLQALRKTYTISQASVSDTIGLLAALGQIRCLLSVRM GKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVAS CCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELAL GLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEE NASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQVYKREVSTEGD GDEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGI ISIPLKLPSLNKDGSIYEPDMAANFCPDHKAPMVLFLDRVYGIKDQAFLLHLLEVGFLPD LRASASLDTVALSTTEAALALNRYLCAAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRL SKGRSLTKAQRDTIEQCLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYE QCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKRYDSDLFRMALPCLSAIAGA LPPDYLDTRMSATLEKQVSVDADGNFDPKPINTVNFSLPEKLEYIVTKYAEHSHDKWACD KSQNGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEG EALVQQRENEKLRSVSQASQGNSYSPTPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKK LELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGVVVSRGMKDMELDASSM EKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKPPHDQEIKFFAKVLLPLVDQYFT NHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSATMVSCLHIL AQTLDTRTVVKSGSELAKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINY TTVALLPILTSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALG ECLASLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERAILGMPDTVEEMCPDIPQLEGLMK EINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVV LGNILKIINNNLGIDEASWMKRIAVFAQPIISKARPDLLRSHFIPTLEKLKKKALKTVQE EEQLKADSKGDTQEAELLILDEFAILCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLF RMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRG DLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYKDTDEEVKEHLRNNLHLQ EKSDDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHK LLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPK LEEEEEEETEKQPDPLHQIILHFSRNALTERSKLENDPLYTSYSSMMAKSCQSGEDEEEE EDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILN GGNASVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLI VRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRL QESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLW DAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVD TLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQS EIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLEP AESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGG EQEKMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEEDAPYTLEMEGEEEDDKSF ECASAFAVACASVRRNVANFLRRATLKNLRKQYRKVKKMSLKELVKVFFSFFWMLIMGFF QLVFAILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDALEAERAEGP ELGITTELIHFVKGEKGNADVMSDLFGFHPKKEGGVKHGPEVGLGDLSEIIGKDEPPTLE STIRRKRKAQAAERKTAHEAEGRVESEKAGIEDGEKEDAAKEEEQPEALWADVTKRKKRR CGQKAEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEE PLEEETEDIANLWNSFNDEDEEEAMVFFVLQESTGYMAPALRALAVIHTIISLVCVVGYY CLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKR KVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVV FTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL LAVVVYLYTVVAFNFFRKFYNKSEDDEEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIED PAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGI GNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP AGDCFRKQYEDQLG NT seq 14625 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagtttctgcggactgaggatgaa gtggtcctccagtgcatcgcgaacgttcacaaggagcagaggaagttctgcctggcagcc gagggactagggaatcgcctgtgcttcttggaacccacatcagaagccaagtttgttcct ccagatctctgcgtctgcaattttgtgctggagcagtccctctctgtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaagggtttcaaaggaaggcagcacaa ggcggtggccacaggaccctgctgtacggccacgcgattctcctgcggcactctttcagc ggaatgtatctaacatgcttgactacatcgagatcccagacagataaacttgcctttgat gtaggtctacgcgaacatgccacaggtgaagcctgttggtggaccatacatcctgcttcc aagcagaggtctgagggagaaaaggttcgaattggcgatgacctcatccttgtcagcgtg tcctctgaaagataccttcatctctcaatatccaatggtaacatacaagtggatgcctcc ttcatgcaaaccctctggaacgtacatccgacgtgctcaggaagtagcgtagaagaagga tacctgcttggtgggcacgtagtacgtcttttccatggtcatgatgagtgtttgacgata ccatctacagaccagaatgattcccagcacaggagggtattctatgaagccgggggagct ggcacgagagctagatctctgtggagagtggaaccccttcggataagctggagtggcagt aacatcagatggggccaggctttccgacttcggcacctcaccacaggccactacctggcc ttgacagaggaccaaggccttatactgcaagaccggggaaaatcagacaccaagtccaca gccttctctttccgggcatcaaaggaaatcaaggagaaattggattccagccacaagcga gatatagaaggcatgggagtcccggaaatcaagtatggagattccgtctgctttgtccag cacgtagccagtggtctgtgggtgacctacaaagcacaggatgccaagacatcccgcctt ggacctctgaaaagaaaggtcatactccatcaggaaggccacatggatgacggcttaacc ctgcagagatgccagcaggaggagtcccaggctgctcggatcatacggaatacgacagcc ttgttcagccagttcgtcagtggaaacaatcgcacaactgcccctgtcaccctgccgata gaagaggtcctacagaccttgcaggacttgattgcctacttccagcccccagaggaggag atgcagcatgaagacaagcagaacaagctccgctcactcaaaaacagacagaatcttttc aaggaagagggaatgttggcccttgtgttaaactgcattgatcgcttaaatatctacaat agcatcgctcacttcgcagggattgccagggaggagagtggcatggcctggaaagaaatt ctgaacctcctgtacaaactgctggctgctctcatccgtggaaacagaaacaattgcgct caattctccaataaccttgattggctaatcagcaaactggacagactagaatcttcctca ggtatcttggaagttctgcactgcatcctgatcgaaagcccagaagccttaaatctgata gcagagggtcacatcaagtctatcatctccctgttggataagcacgggcggaatcacaag gtgctggatgtgctgtgctccctctgtctctgcaatggggtcgcagtgagagccaaccag aatctgatctgcgacaacttgctgccccggagaaatctgctcctgcagacgcggctgatt aacgatgtgacaagtattcggccaaacatcttcctgggagtcgctgagggctcagcgcag tacaagaagtggtacttcgagctgatcatcgaccaggtggaccccttcctcacagcagag cccacacacctgcgggtgggctgggcctcttcctcaggctatgctccgtaccccggaggt ggggaaggatggggaggcaacggtgttggcgacgacctgtactcctatggctttgatggg ctgcacctttggtcaggccgcataccccgagccgtggcctccgtcaaccagcacctcctc cggtcggacgacgtggtgagctgctgcctggacctcggagcgcccagcatctctttccgc atcaacgggcagcctgtccaggggatgtttgagaacttcaacacagatgggctcttcttc cctgtggtgagcttttcagcaggtgtcaaagtacgtttcctgatgggtggacgtcatgga gaatttaagtttctgcctccctccggctatgccccttgctatgaagccttacttccaaaa gaaaagatgagattggagcctgtcaaagagtataaacgagatgccgaaggcgtcagagat ctgttgggtaccacccagtttctgtcccaagcctctttcatcccgtgccccatagacacc agccaggtggttttgccacctcacctagagaaggtccgggacaagctggcagaaaacatc cacgagctttggggaatgaataagatagagctgggctggacttttggcaagatacgggat gacaataaaagacaacacccctgccttgtcgagttttcaaagctgcccgaaactgagaag aattataacctacaaatgtcaaccgaaactctaaagaccctcctggccctggggtgtcac atcgctcacgttaacccggctgccgaagaggatctaaagaaggtcaaattgcccaaaaac tacatgatgtccaacggctataagcctgcccctttggatttgtctgatgtgaagctgcta cctcctcaagaaattctagtggataagcttgcagaaaatgcacacaacgtttgggcaaaa gacaggctaaaacagggatggacctatggcattcaacaggatttaaagaacaaaagaaac ccccggctggtaccatacgcgctactggatgagcgtaccaagaagtccaacagagatagc cttcgtgaagctgttcggacgtttgtcggttatggctataacattgagccatcagaccaa gaactggcagacccagctgtggagaaagtcagcatagacaagatccggtttttccgagta gagcggtcatatgccgtgagatctggaaagtggtattttgagtttgaggtggtgaccgga ggagacatgcgcgtcggctgggccaggccaggctgtcggccggacgttgagctgggggcc gatgaccaagcctttgtgtttgaaggcagcaggggccagcgctggcatcaagggagtggg tattttggacggacctggcagccaggagacgtggttggatgtatgattaacctggatgat gcttcaatgatcttcacactgaacggggagctgctgatcaccaacaaaggctctgaactt gccttcgctgactatgagattcacaacggctttgtgcccatctgctccctgggactctct cagatcgggcgcatgaatctcgggacagatgccagcaccttcaagttttataccatgtgt ggcctccaagagggctttgagccttttgctgtcaacatgaaccgagacgtggccatgtgg ttcagcaagcggctcccaacatttgtcaacgtgccaaaggaccatccacagatagaggtc gtgaggatcgacggcaccatggacagccctccgtgtctcaaggtgacccacaagacgttc ggcacccaaaacagcaatgccaccatgatctactgccgcctgagcatgcccgtcgagtgc cactcttccttcagtcacagcccctgtctggacagtgaggctttccagaaaaggaaacag atgcaagaaatactctctcacacaacaacacagtgctactatgcaatccgcatctttgct gggcaggacccttcctgcgtctgggtcggatgggtgactccggactatcacttgtatagt gagaagttcgacctgagtaaaaactgtaccgtgactgttactctgggggatgaaagaggc cgagtccatgaaagtgtgaagcgcagcaactgctacatggtctggggtggggacgttgtg gccacatcccaaagggcgagtcgcagcaacgtggacctggagatcggctgcctcgtggac ctggccatgggcatgttgtccttctcggccaatgggagggaactcggcacctgctaccag gtggagcccaataccaaagtgtttccagcggtcttcctgcaacctacaagcacctctttg tttcagtttgaacttgggaacctgaagaacgcgatgcccctgtctgcggccatatttaag agtgaagagaagaacccagtcccacagtgccctccccggctggacgtccaaaccatccag cccgtgctctggagccgcatgcccaacagcttcctgaaggtggagacggagcgggtgagc gagcgccacggctgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatc ccggaggagaacaggtgtgtggacatcctggagctgtgtgagcaggaggacctgatgcag ttccactaccacacgctgagactctacagcgccgtgtgtgccctgggaaacagccgggtg gcctacgccctgtgcagccacgtggacctctcccagctcttctacgccattgacaacaag tacctccccggcctcctgcgctctggcttctatgacctgctcatcagcatccacctggcc agcgcgaaggagaggaagctgatgatgaagaatgagtacatcatccccatcaccggcacc acccggaaaatccgcctgtaccccgacgcgtccaagaggcatgggctccctggggtgggc ccaagaacgtgcctcaagccagggttcaggttctccaccccttgtttcgtcgtgaccagc gaggagcaccagaagcagagccctgagatccccttggagctcctcaagacgaaggcgctg agcatgctgacggaggccgtgcagtgcagcggggctcacatccgggaccccgtcggcggg tctgtggagttccagtttgtgcccgtgctgaaactcattggaactctgttggtcatgggg gtatttgacgatgaagacgttcggcagatcctcctcctcatcgacccctctgtgtttggg gaacacagtgcagagatggaggagggggcagagaaggaggaggtgacccaggtggaggag aaggctgtggaggctggggaaaaggccagcaaggaggccggcaaggaggctcccgtcaaa ggcttgctgcagacccggttaccggagtctgtcaagctgcagatgtgtgagctcctcagc tatctctgtgactgtgagctgcagcaccgagtggaggccattgtggcatttggcgacatt tatgtctccaagctccaggcaaatcagaagttccgctacaatgagctcatgcaagccctg aacatgtctgcagccctgaccgcccggaagaccagggagttccgctcacccccgcaggag cagatcaacatgcttcttaactttcaactcggggagaactgcccgtgcccagaggagatc cgggaggagctctatgacttccacgaggaccttctcattcactgtggggttcccctggag gaagaggaagaagaggaggaagacgcctcctggacaggaagattccgtgccctggtgtat aaaatcaaaggccttcccaagccggagaaggagcagccaacggaggaagaggagagaagc cctacgacgctgaaggagcttgtctcccagaccatgatccgctgggcgcaggaggaccag atccaggacgcggagctggtccggatgatgttcacactcctgcggaggcagtacgacagc atcggggagctactgcaggctctgaggaagacctacaccatcagccaggcctccgtgagc gacaccattggcctgctggctgccctgggccagattcgctgcctgctcagcgtccggatg ggcaaggaggaggagctgctcatgatcaacggtctgggagacataatgaacaacaaggtg ttttaccagcaccccaacctcatgcgcgtcctcggcatgcacgaaacggtgatggaggtg atggtgaacgtgctgggtacagagaagtctcagatcgcctttccaaagatggttgctagc tgttgccgcttcctgtgctatttctgccgaattagccgacaaaaccagaaggccatgttt gagcatctaagttacctgctggagaatagcagtgttggcctagcctccccatcgatgaga gggtccaccccgctggatgtggcagcttcctccgtgatggacaacaacgagctggcgctg ggcttagaggagccagacctcgagaaggtggtgacctacttggcaggctgcggcctgcag agctgccccatgcttctggccaaaggatacccggacgtcggctggaaccccattgaaggg gagcgctacctgtccttcctgaggtttgccgtcttcgtgaacagtgaaagtgtggaggaa aatgctagtgtcgtggtcaaactgctcatcagacgccccgagtgcttcggcccagccctg cggggtgaaggaggaaacggtctgctggcagccatgcaaggcgccattaagatctccgag aacccagccctcgacctcccctcgcaggtctacaagagagaagtcagcacagagggcgat ggagatgaagaggagattgtgcacatgggcaatgcaattatgtcattttactcggctcta atagacctgttgggccgctgtgctcctgaaatgcaccttatccagacaggaaaaggggaa gccatccggatcaggtccatcctgcgctccctggtccccactgaggacttggtcgggatc atcagcatccccttgaaactgccctccctgaacaaagacgggtcaatctacgagccggat atggcggccaacttctgccccgaccacaaggcacccatggtgctgttcttggaccgcgtt tacggcatcaaggaccaggctttcctgctccacttgctggaggttggatttttacctgac ttaagagcctctgcctctctagatacggttgccctgagcaccacagaggcggcgctggcg ctgaacaggtacctctgcgcggccgtgctcccgctgctcacacggtgcgccccgctcttt gccggaacagagcactacacctctttgatcgattctacgctgcagaccatctacaggctt tccaagggccgttccctcaccaaagctcagagggacaccatcgagcaatgcttgcttgcc atctgcaatcacttgaggccttccatgttacagcagctcctgcgacgtctagtttttgat gtgccacaactcaacgaatactgcaaaatgcctctgaagcttctgacgaatcactacgag cagtgctggaagtattactgtctgccttcgggctgggggagctacggtctggccgtggag gaagagctgcacctgacagagaagctcttctgggggatttttgactccctgtcccataag aggtatgactcagatcttttccggatggccctgccttgtctcagtgctattgccggggcc ttgccaccagattacttagataccagaatgtcagccacgttggagaagcaggtctcagtg gatgctgatggcaactttgaccccaaacccatcaacaccgtgaatttctccctgcctgaa aaattggaatacatcgtcaccaagtatgcggagcattcacatgataaatgggcctgtgac aagagtcagaatggatggaaatacggcatttccctggacgaaaatgtgaagacacatcca ttgatcaggcctttcaagacattaacagagaaggagaaggaaatttatcgctggcctgcc agggagtccctgaaaacgatgctggctgtgggctggaccgtggagaggaccaaagaggga gaagccctagttcaacagcgggaaaatgagaagctacgaagcgtgtcccaggccagccag ggcaacagctacagccccactcccctggacctctccaacgtcgtgctctccagagagctc caggggatggtggaggtggtagctgagaactatcacaatatctgggccaagaagaagaag ctggaactggagagcaaaggtggcggcagtcaccctcttttggtaccatatgacacgctg actgccaaggaaaagttcagggaccgagagaaggcgcaggacctgtttaaattcctccaa gtgaatggcgtcgtggtttctagaggtatgaaggatatggaactggacgcctcctccatg gaaaagaggtttgcctataagtttttgaagaagatcctgaaatatgttgattctgctcaa gagtttattgcccatttggaagccattgtcagcagtgggaaaactgaaaagcctccccat gaccaggagatcaaattctttgccaaagttctcctcccgctggttgaccagtacttcacc aatcaccgcctctactttctctcgtcccctctgaagccccttagcagcagcgggtatgcc tcccataaggagaaagaaatggtggccagcctgttctgcaaactcgctgctcttgttcgg cacaggatttccctcttcgggagcgattctgctacaatggtgagctgtcttcacatctta gcacagacacttgacacaaggactgtcgtgaagtcaggctcagagctggcaaaggctggg ctacgagcattctttgaaaacgccgcagaagatttggagaagacttcggaaaacctgaag cttgggaagtttacccattccaggacgcagatcaaaggcgtttcccagaacattaactac accacagtggctctgctccccatcctgacatccatctttgagcacgtcgctcagcatcag ttcggggtggacttgctcttgggtgacgtgcagatttcatgctaccacatactgtgcagc ctctactccctcgggacgggcaagaacatctatgttgaaaggcaacgtcctgctcttgga gaatgcctggcctctctggcagccgccataccagtggccttcctggagcccacccttaac cgctacaatccgctctcagtcttcaacaccaaaacccccagggagagggccattctgggg atgccagacacggtggaggagatgtgccccgacatcccccagctggaaggcctgatgaag gaaatcaacgacctggccgagtcgggggcccggtacacggagatgccgcacgtcatcgag gtgatcttgcccatgctctgcaactacctgtcctactggtgggagcggggacctgagcac ctgccccccagcacaggcccctggtgcaccaaggtcacctctgaacacctcagtgtcgtc ctgggcaacattctgaaaatcatcaacaacaacctgggcatcgacgaggcctcgtggatg aagcgcatcgcagtgttcgcccagcccatcatcagcaaagccaggccggacctgctgaga agccacttcatcccgaccctggagaagctgaagaagaaggccctcaagaccgtgcaggag gaggagcagctgaaagccgacagcaaaggggacactcaggaggcggagctcctcatcctg gacgagtttgccatcctctgcagagacctgtacgccttctaccccatgctgatccgctac gtggacaacaacaggtctaactggctcaaaagccctgatgctgactctgaccagctcttc cgcatggtggcagaggtcttcatcctgtggtgcaaatctcacaacttcaagagggaggag caaaattttgtgattcagaatgaaattaataacttggcatttttaactggagacagcaaa agcaagatgtcaaaatctggaggacaggaccaggaacggaagaagacaaagcggagagga gacttgtattccatccagacctccctcattgtggctgcactcaagaagatgctacccatt ggtttgaatatgtgcacccctggcgatcaggagctgatctccctcgcaaaatcacgatac agctataaggatacagatgaagaggtaaaggaacatctgcggaataacttgcacttgcag gaaaagtctgatgacccagctgtaaagtggcagctgaacctgtacaaagatgtcctgaag agtgaagaaccttccaacccagaaaagacagtggagcgtgtgcagagaatttcagcagct gtcttccacctggagcaggtggaacagcctttgagatccaagaaggcagtctggcacaaa ctgctgtcaaagcagcggaaacgggcagtggtggcctgtttcaggatggcccctctctac aacctgcccaggcaccgctctattaacctcttcctccatggctatcagagattttggata gaaacagaggagtattcctttgaagagaaactagtacaggatttggctaaatcccccaag ttggaagaggaggaggaggaggagacggaaaagcagccagacccacttcatcagatcatt ctccacttcagccgcaatgctctcacggagaggagcaaactggaaaatgaccctttgtac acgtcctactccagcatgatggccaagagttgtcagagtggggaggatgaagaagaggag gaagacaaggaaaaaacatttgaagagaaagaaatggaaaagcagaaaaccctctatcag caggctcggctgcacgagcgtggagccgcagagatggtccttcagatgatcagcgccagc aaaggtgagatgagccccatggtggttgagacgctgaagctggggatcgccatcctgaat gggggcaacgccagcgtgcagcagaaaatgctagattacctaaaggagaagaaggatgct gggttctttcaaagcctttctggtcttatgcagtcttgcagtgtcctcgatttgaatgca tttgagaggcagaataaagctgaaggcctggggatggttactgaggaaggaacactcatt gttcgtgagcgtggtgaaaaagtactgcagaatgacgagtttacacgcgatctctttaga ttcctgcagctactttgtgaaggacataacagtgacttccagaacttcctgcggacgcag atgggcaacaccaccaccgtgaacgtcatcatcagcaccgtggactaccttctgcgcctg caggaatcaatcagtgatttctactggtattactcagggaaggacatcattgatgaatcc ggacagcacaatttttctaaagctttggcggtcaccaagcagattttcaattcgcttaca gaatacatccagggcccctgcattgggaaccagcagagcctggcccacagcaggctgtgg gacgcggtggtcggcttcctccacgtgtttgctaacatgcagatgaaactctctcaggat tccagtcagatcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatg cttctgtccctcctggaagggaatgtggtaaatggaactattggcaagcagatggttgac accctggtagagtcctctaccaatgtagaaatgatcttgaaattctttgacatgttcttg aaacttaaagacttaaccagctcagacactttcaaagaatatgaccctgatggtaaaggg atcatctctaaaaaggaattccagaaggccatggaagggcaaaaacagtacacgcagtcg gagattgactttctcctctcgtgcgcagaagctgatgagaatgacatgtttaattacatt gattttgtggaccggttccatgagccagccaaggacatagggtttaacgtggcagtgttg ttgacaaacctctcagagcatatgccgaatgattctcgccttaagtgtctattggaacca gcagaaagtgtactaaactacttcgaaccatacctcggacgcattgagatcatgggtggg gccaagaaaattgaacgtgtttactttgagatcagcgagtccagtcgaactcagtgggag aagccccaggtgaaggagtcgaagcgacagttcatctttgacgtcgtcaatgaaggcgga gagcaggagaagatggaactgttcgtgaacttctgtgaggataccatctttgagatgcag ttagcatctcagatctctgagtcggactcagctgaccggccggaagaggaggaggaggac gaggaagacgctccttatacgttggagatggagggtgaagaggaggacgacaagtctttc gagtgcgcctctgcatttgccgtggcctgtgcctcggtgaggaggaacgtggccaacttt ctgaggagggccaccctgaagaacctcaggaagcagtacaggaaggtgaagaagatgagc ctcaaggagctggtgaaggtgttcttctctttcttctggatgttgatcatggggttcttc cagttggtcttcgccatcttgggaggaatctttcagatcctctggagcacagtgtttgga gggggcctcgtggaaggggccaagaacatccgagtcaccaagatcctgggtgacatgcct gacccgacccagtttggtatccacgatgatgctctggaggctgagcgggcagaggggcct gagctgggcatcaccacggaactcatacacttcgtcaagggggagaagggcaatgcggat gttatgtcggatctctttggattccaccctaagaaagaaggtggcgtaaagcatgggccc gaagtgggtttgggtgacctctctgagattattggcaaggatgagccccctacgttagag agtactatacggaggaaaaggaaagcacaggcagcagagaggaaaacagctcatgaagca gaaggaagagtggagtctgagaaggcaggcatagaagatggggagaaagaggatgcagcc aaggaagaagagcagcccgaggccctctgggcggacgtgacaaagaggaagaagcgacgg tgtggccagaaagctgagaagcccgaagccttcatggccaatttctttaaagggctggaa atctatcagaccaagttgctgcactacctggccaggaatttctacaacctgaggttcctt gctctgtttgtagccttcgctatcaacttcatcctgctcttttacaaggtcaccgaggaa cctttagaagaagagacagaggacattgcaaacctgtggaattcctttaatgatgaggac gaggaagaagcaatggtgttctttgtcctgcaggagagcacggggtatatggcgccagca ctgcgggccctggccgtcatccacaccatcatctctttggtctgcgtggtgggctactac tgcctgaaggtccctctggtggtcttcaaaagagaaaaagaaattgccaggaagctggag tttgatggcctgtatatcaccgaacagccttctgaagatgacatcaaggggcagtgggat cgcctggtgatcaacaccccatcttttcctaataactactgggacaagtttgtcaagaga aaggtgatcaacaaatacggagacctctacggagcggaacgcattgcagaactgctgggt ttggacaaaaatgcccttgactttagcccagtggaagagaccaaagcagaggcggcctcc ctggtgtcatggctgagttccatcgacatgaagtaccatatctggaagctgggagttgtt tttaccgacaactccttcctctacctcgcctggtacacgaccatgtcagtcctaggccac tacaacaacttcttcttcgctgctcatctgctggacatcgccatgggcttcaagactctg aggacgatcctgtcgtccgtcactcacaacggcaaacagctggtcctgactgtcgggctg ctggccgtggtggtctatctctacacggtggtggcattcaacttcttccgcaagttctac aacaaaagcgaggatgacgaggagcccgatatgaagtgtgacgacatgatgacgtgttac ctgttccacatgtacgtgggagtgagagctggaggtggcatcggcgatgaaattgaagac cctgccggggacccctacgaaatgtaccgcatcgtctttgacattaccttcttcttcttc gtcatcgtcatcctgctggccatcatccaaggtcttattatcgatgcttttggagagctg agagaccagcaggaacaagtgcgggaggatatggagacaaaatgtttcatctgcgggatt ggcaatgactacttcgacacgacccctcatggttttgaaacacacaccttacaagagcac aacttagccaactacttgttcttcctgatgtatctgattaataaagacgaaacagagcat acgggtcaggaatcttacgtctggaagatgtaccaggaaaggtgctgggatttcttcccg gctggcgactgcttccggaaacagtacgaagatcagcttggataa

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