KEGG   Cricetulus griseus (Chinese hamster): 100689251
Entry
100689251         CDS       T02813                                 
Symbol
Pik3ca
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
cge  Cricetulus griseus (Chinese hamster)
Pathway
cge00562  Inositol phosphate metabolism
cge01100  Metabolic pathways
cge01521  EGFR tyrosine kinase inhibitor resistance
cge01522  Endocrine resistance
cge01524  Platinum drug resistance
cge04012  ErbB signaling pathway
cge04014  Ras signaling pathway
cge04015  Rap1 signaling pathway
cge04024  cAMP signaling pathway
cge04062  Chemokine signaling pathway
cge04066  HIF-1 signaling pathway
cge04068  FoxO signaling pathway
cge04070  Phosphatidylinositol signaling system
cge04071  Sphingolipid signaling pathway
cge04072  Phospholipase D signaling pathway
cge04081  Hormone signaling
cge04140  Autophagy - animal
cge04150  mTOR signaling pathway
cge04151  PI3K-Akt signaling pathway
cge04152  AMPK signaling pathway
cge04210  Apoptosis
cge04211  Longevity regulating pathway
cge04213  Longevity regulating pathway - multiple species
cge04218  Cellular senescence
cge04360  Axon guidance
cge04370  VEGF signaling pathway
cge04380  Osteoclast differentiation
cge04510  Focal adhesion
cge04550  Signaling pathways regulating pluripotency of stem cells
cge04611  Platelet activation
cge04613  Neutrophil extracellular trap formation
cge04620  Toll-like receptor signaling pathway
cge04625  C-type lectin receptor signaling pathway
cge04630  JAK-STAT signaling pathway
cge04650  Natural killer cell mediated cytotoxicity
cge04660  T cell receptor signaling pathway
cge04662  B cell receptor signaling pathway
cge04664  Fc epsilon RI signaling pathway
cge04666  Fc gamma R-mediated phagocytosis
cge04668  TNF signaling pathway
cge04670  Leukocyte transendothelial migration
cge04722  Neurotrophin signaling pathway
cge04725  Cholinergic synapse
cge04750  Inflammatory mediator regulation of TRP channels
cge04810  Regulation of actin cytoskeleton
cge04910  Insulin signaling pathway
cge04914  Progesterone-mediated oocyte maturation
cge04915  Estrogen signaling pathway
cge04917  Prolactin signaling pathway
cge04919  Thyroid hormone signaling pathway
cge04923  Regulation of lipolysis in adipocytes
cge04926  Relaxin signaling pathway
cge04929  GnRH secretion
cge04930  Type II diabetes mellitus
cge04931  Insulin resistance
cge04932  Non-alcoholic fatty liver disease
cge04933  AGE-RAGE signaling pathway in diabetic complications
cge04935  Growth hormone synthesis, secretion and action
cge04960  Aldosterone-regulated sodium reabsorption
cge04973  Carbohydrate digestion and absorption
cge05010  Alzheimer disease
cge05017  Spinocerebellar ataxia
cge05020  Prion disease
cge05100  Bacterial invasion of epithelial cells
cge05132  Salmonella infection
cge05135  Yersinia infection
cge05142  Chagas disease
cge05146  Amoebiasis
cge05160  Hepatitis C
cge05161  Hepatitis B
cge05162  Measles
cge05163  Human cytomegalovirus infection
cge05164  Influenza A
cge05165  Human papillomavirus infection
cge05166  Human T-cell leukemia virus 1 infection
cge05167  Kaposi sarcoma-associated herpesvirus infection
cge05168  Herpes simplex virus 1 infection
cge05169  Epstein-Barr virus infection
cge05170  Human immunodeficiency virus 1 infection
cge05171  Coronavirus disease - COVID-19
cge05200  Pathways in cancer
cge05203  Viral carcinogenesis
cge05205  Proteoglycans in cancer
cge05206  MicroRNAs in cancer
cge05207  Chemical carcinogenesis - receptor activation
cge05208  Chemical carcinogenesis - reactive oxygen species
cge05210  Colorectal cancer
cge05211  Renal cell carcinoma
cge05212  Pancreatic cancer
cge05213  Endometrial cancer
cge05214  Glioma
cge05215  Prostate cancer
cge05218  Melanoma
cge05220  Chronic myeloid leukemia
cge05221  Acute myeloid leukemia
cge05222  Small cell lung cancer
cge05223  Non-small cell lung cancer
cge05224  Breast cancer
cge05225  Hepatocellular carcinoma
cge05226  Gastric cancer
cge05230  Central carbon metabolism in cancer
cge05231  Choline metabolism in cancer
cge05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cge05415  Diabetic cardiomyopathy
cge05417  Lipid and atherosclerosis
cge05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cge00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100689251 (Pik3ca)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100689251 (Pik3ca)
   04014 Ras signaling pathway
    100689251 (Pik3ca)
   04015 Rap1 signaling pathway
    100689251 (Pik3ca)
   04370 VEGF signaling pathway
    100689251 (Pik3ca)
   04630 JAK-STAT signaling pathway
    100689251 (Pik3ca)
   04668 TNF signaling pathway
    100689251 (Pik3ca)
   04066 HIF-1 signaling pathway
    100689251 (Pik3ca)
   04068 FoxO signaling pathway
    100689251 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    100689251 (Pik3ca)
   04072 Phospholipase D signaling pathway
    100689251 (Pik3ca)
   04071 Sphingolipid signaling pathway
    100689251 (Pik3ca)
   04024 cAMP signaling pathway
    100689251 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    100689251 (Pik3ca)
   04152 AMPK signaling pathway
    100689251 (Pik3ca)
   04150 mTOR signaling pathway
    100689251 (Pik3ca)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100689251 (Pik3ca)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100689251 (Pik3ca)
  09143 Cell growth and death
   04210 Apoptosis
    100689251 (Pik3ca)
   04218 Cellular senescence
    100689251 (Pik3ca)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100689251 (Pik3ca)
   04550 Signaling pathways regulating pluripotency of stem cells
    100689251 (Pik3ca)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100689251 (Pik3ca)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100689251 (Pik3ca)
   04613 Neutrophil extracellular trap formation
    100689251 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    100689251 (Pik3ca)
   04625 C-type lectin receptor signaling pathway
    100689251 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    100689251 (Pik3ca)
   04660 T cell receptor signaling pathway
    100689251 (Pik3ca)
   04662 B cell receptor signaling pathway
    100689251 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    100689251 (Pik3ca)
   04666 Fc gamma R-mediated phagocytosis
    100689251 (Pik3ca)
   04670 Leukocyte transendothelial migration
    100689251 (Pik3ca)
   04062 Chemokine signaling pathway
    100689251 (Pik3ca)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100689251 (Pik3ca)
   04923 Regulation of lipolysis in adipocytes
    100689251 (Pik3ca)
   04929 GnRH secretion
    100689251 (Pik3ca)
   04915 Estrogen signaling pathway
    100689251 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    100689251 (Pik3ca)
   04917 Prolactin signaling pathway
    100689251 (Pik3ca)
   04926 Relaxin signaling pathway
    100689251 (Pik3ca)
   04935 Growth hormone synthesis, secretion and action
    100689251 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    100689251 (Pik3ca)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100689251 (Pik3ca)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100689251 (Pik3ca)
  09156 Nervous system
   04725 Cholinergic synapse
    100689251 (Pik3ca)
   04722 Neurotrophin signaling pathway
    100689251 (Pik3ca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100689251 (Pik3ca)
  09158 Development and regeneration
   04360 Axon guidance
    100689251 (Pik3ca)
   04380 Osteoclast differentiation
    100689251 (Pik3ca)
  09149 Aging
   04211 Longevity regulating pathway
    100689251 (Pik3ca)
   04213 Longevity regulating pathway - multiple species
    100689251 (Pik3ca)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100689251 (Pik3ca)
   05206 MicroRNAs in cancer
    100689251 (Pik3ca)
   05205 Proteoglycans in cancer
    100689251 (Pik3ca)
   05207 Chemical carcinogenesis - receptor activation
    100689251 (Pik3ca)
   05208 Chemical carcinogenesis - reactive oxygen species
    100689251 (Pik3ca)
   05203 Viral carcinogenesis
    100689251 (Pik3ca)
   05230 Central carbon metabolism in cancer
    100689251 (Pik3ca)
   05231 Choline metabolism in cancer
    100689251 (Pik3ca)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100689251 (Pik3ca)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100689251 (Pik3ca)
   05212 Pancreatic cancer
    100689251 (Pik3ca)
   05225 Hepatocellular carcinoma
    100689251 (Pik3ca)
   05226 Gastric cancer
    100689251 (Pik3ca)
   05214 Glioma
    100689251 (Pik3ca)
   05221 Acute myeloid leukemia
    100689251 (Pik3ca)
   05220 Chronic myeloid leukemia
    100689251 (Pik3ca)
   05218 Melanoma
    100689251 (Pik3ca)
   05211 Renal cell carcinoma
    100689251 (Pik3ca)
   05215 Prostate cancer
    100689251 (Pik3ca)
   05213 Endometrial cancer
    100689251 (Pik3ca)
   05224 Breast cancer
    100689251 (Pik3ca)
   05222 Small cell lung cancer
    100689251 (Pik3ca)
   05223 Non-small cell lung cancer
    100689251 (Pik3ca)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100689251 (Pik3ca)
   05170 Human immunodeficiency virus 1 infection
    100689251 (Pik3ca)
   05161 Hepatitis B
    100689251 (Pik3ca)
   05160 Hepatitis C
    100689251 (Pik3ca)
   05171 Coronavirus disease - COVID-19
    100689251 (Pik3ca)
   05164 Influenza A
    100689251 (Pik3ca)
   05162 Measles
    100689251 (Pik3ca)
   05168 Herpes simplex virus 1 infection
    100689251 (Pik3ca)
   05163 Human cytomegalovirus infection
    100689251 (Pik3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100689251 (Pik3ca)
   05169 Epstein-Barr virus infection
    100689251 (Pik3ca)
   05165 Human papillomavirus infection
    100689251 (Pik3ca)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100689251 (Pik3ca)
   05135 Yersinia infection
    100689251 (Pik3ca)
   05100 Bacterial invasion of epithelial cells
    100689251 (Pik3ca)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100689251 (Pik3ca)
   05142 Chagas disease
    100689251 (Pik3ca)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100689251 (Pik3ca)
   05017 Spinocerebellar ataxia
    100689251 (Pik3ca)
   05020 Prion disease
    100689251 (Pik3ca)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100689251 (Pik3ca)
   05418 Fluid shear stress and atherosclerosis
    100689251 (Pik3ca)
   05415 Diabetic cardiomyopathy
    100689251 (Pik3ca)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100689251 (Pik3ca)
   04932 Non-alcoholic fatty liver disease
    100689251 (Pik3ca)
   04931 Insulin resistance
    100689251 (Pik3ca)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100689251 (Pik3ca)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100689251 (Pik3ca)
   01524 Platinum drug resistance
    100689251 (Pik3ca)
   01522 Endocrine resistance
    100689251 (Pik3ca)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cge04131]
    100689251 (Pik3ca)
Enzymes [BR:cge01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100689251 (Pik3ca)
Membrane trafficking [BR:cge04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100689251 (Pik3ca)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 100689251
NCBI-ProteinID: XP_027247822
UniProt: A0A8C2MP62
LinkDB
Position
1
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
SFTMPSYSRRISTATPYMNGETTTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcgtcgggtgaactgtggggcatccacttgatgcccccacgaatc
ctagtggaatgtttactcccaaatggaatgatagtgactttagaatgcctccgtgaggct
acactaatcaccataaaacacgaactgtttaaagaagccagaaaataccctctgcatcag
cttctgcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgtt
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtccaggacttccga
aggaacattctgaatgtttgcaaagaagctgtggatctgcgggatctcaactcccctcat
agcagagcaatgtatgtctaccctcccaacgtagagtcttccccagaattgccaaagcac
atctacaacaagttagataaaggacaaatcatagtggtgatttgggtaattgtctctcca
aacaatgacaagcagaagtataccctgaagatcaaccacgactgtgtgccagagcaagtc
attgctgaagccatcaggaagaagactcggagcatgctgctctcgtctgagcagctgaaa
ctctgtgttttagaataccagggcaagtatattctgaaagtgtgtggctgtgatgaatac
ttcctagaaaaataccctctgagtcagtacaagtacataagaagctgtataatgctgggg
aggatgcccaacttgatgttgatggccaaagaaagcctttactctcagctgccaatggat
agcttcacaatgccgtcatactccaggcgcatctccacagccacgccctatatgaatgga
gagacaactacgaaatccctctgggttataaatagtgcgcttagaatcaaaattctttgt
gcaacttatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccacggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgacatatacattcctgatcttcctcgcgctgct
cgcctttgcctttccatttgctctgttaaaggccgaaagggtgctaaggaggagcactgt
ccattggcctggggaaatataaacttgtttgattacacagacaccctagtatctgggaaa
atggctttgaatctctggcctgtaccacatgggttagaagatctgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgattggttc
agcagtgtggtgaagtttccagacatgtctgtgatcgaagagcatgctaattggtctgtg
tcccgagaagctggattcagttactctcatacaggactgagtaacagactcgccagagac
aatgaactaagagaaaatgacaaagaacagctccgagcactttgcacccgggacccactg
tctgaaatcactgaacaagagaaagatttcctatggagccacagacactactgtgtaact
attcctgaaatcctacccaaattgcttttgtctgtcaagtggaattccagagatgaagta
gcccagatgtactgcttagtcaaagattggcctccaatcaagcctgagcaggccatggag
cttctggactgtaattatccagatcctatggttcggagttttgccgttcggtgcttggaa
aaatacttaacagatgacaaactttctcagtacctcattcagcttgtccaggtcttaaaa
tatgaacaatatttggataacctgcttgtgagatttttactcaagaaagcgttgacaaat
caaaggattggccattttttcttttggcatttaaaatctgagatgcacaataagaccgtc
agtcaaaggtttggcctcctgttggagtcctactgccgtgcctgtgggatgtatctgaaa
cacctgaacagacaggtagaggccatggagaagctcatcaacctaactgacatcctcaaa
caggagaagaaggatgaaacacaaaaggtacagatgaagtttttggttgagcagatgaga
cagccagatttcatggatgctctgcagggttttctgtctcctctaaaccctgctcatcag
ctagggaacctcagacttgaagagtgtcgaattatgtcctctgcaaaaagaccactgtgg
ttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatcatc
tttaaaaatggcgatgatttacggcaagatatgttaacacttcagatcatccggattatg
gagaacatctggcaaaaccaaggccttgaccttcgaatgctaccttatggctgtctgtcc
attggggactgtgtggggctcatcgaagtggtgagaaactctcacactatcatgcagatc
cagtgcaaaggaggcctaaagggggcactgcagttcaacagtcacacactgcaccagtgg
ctcaaggacaagaataagggagaaatatatgatgcagccattgacctattcacaaggtca
tgtgctggctactgtgtggcaaccttcatcttggggattggagaccggcacaatagcaac
atcatggtgaaagatgatggacagctgtttcatatagattttgggcactttttggatcac
aagaagaagaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatatacaaagaccagagagtttgagagattt
caggagatgtgttacaaggcttacctagcaattcggcagcatgccaatctcttcatcaac
ctgttttcaatgatgcttggctctggaatgccggaactgcagtcttttgatgacattgca
tatattcgaaagactctggccttagacaaaactgagcaagaggctttggaatatttcaca
aaacaaatgaatgatgcacatcatggcggctggacgacaaaaatggattggatcttccac
accatcaagcagcatgcattgaactga

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