Cricetulus griseus (Chinese hamster): 100774683 Help Entry 100774683         CDS       T02813                                  Symbol Ryr2 Name (RefSeq) ryanodine receptor 2 isoform X2   KO K04962   ryanodine receptor 2 Organism cge  Cricetulus griseus (Chinese hamster) Pathway cge04020   Calcium signaling pathway cge04024   cAMP signaling pathway cge04260   Cardiac muscle contraction cge04261   Adrenergic signaling in cardiomyocytes cge04371   Apelin signaling pathway cge04713   Circadian entrainment cge04911   Insulin secretion cge04921   Oxytocin signaling pathway cge04972   Pancreatic secretion cge05020   Prion disease cge05022   Pathways of neurodegeneration - multiple diseases cge05410   Hypertrophic cardiomyopathy cge05412   Arrhythmogenic right ventricular cardiomyopathy cge05414   Dilated cardiomyopathy cge05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:cge00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100774683 (Ryr2)    04020 Calcium signaling pathway     100774683 (Ryr2)    04024 cAMP signaling pathway     100774683 (Ryr2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     100774683 (Ryr2)    04921 Oxytocin signaling pathway     100774683 (Ryr2)   09153 Circulatory system    04260 Cardiac muscle contraction     100774683 (Ryr2)    04261 Adrenergic signaling in cardiomyocytes     100774683 (Ryr2)   09154 Digestive system    04972 Pancreatic secretion     100774683 (Ryr2)   09159 Environmental adaptation    04713 Circadian entrainment     100774683 (Ryr2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     100774683 (Ryr2)    05022 Pathways of neurodegeneration - multiple diseases     100774683 (Ryr2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     100774683 (Ryr2)    05412 Arrhythmogenic right ventricular cardiomyopathy     100774683 (Ryr2)    05414 Dilated cardiomyopathy     100774683 (Ryr2)    05415 Diabetic cardiomyopathy     100774683 (Ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cge04040]     100774683 (Ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:cge04990]     100774683 (Ryr2) Ion channels [BR:cge04040]  Voltage-gated cation channels   Ryanodine receptor    100774683 (Ryr2) Domain-containing proteins not elsewhere classified [BR:cge04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    100774683 (Ryr2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  100774683 NCBI-ProteinID:  XP_035297609 UniProt:  A0A9J7GR85 LinkDB All DBs Position 3:complement(235528307..235929563) Genome browser AA seq 4964 aa AA seqDB search MKLGSFDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLE QSLSVRALQEMLANTMEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYL CCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSER YLHLSYGNSSWHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSG EHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLME DKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSICYIQHVDTGL WLTYQSVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFNRFI RGLDALSKKSKAPTIDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQ EEGMINLVLECIDRLHVYSSAAHFTDVAGREAGESWKSILNSLYELLAALIRGNRKNCAQ FSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKV LDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQY KKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGL HLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFP VVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREYKQERTYTRDL LGPTVSLTQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDD NKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNY QLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNP RLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHAARAEVCSGTGERFRIFRA EKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDERAFAFDGFKAQRWHQGNE HYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVA QVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEV TRIDGTVDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGGLPGAGLYGP KNDLEDYDVDSDFEVLMKTAHGHLVPDRIDKDKETPKPEFNNHKDYAQEKPSRLKQRFLL RRTKPDYSTSHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEPANVWVGWITSDF HQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNSNGLEIGC VVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAG LFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMS LHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAI ENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPNENKKHGLP GIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKAKTIQMLTEAVKEGSLHARDP VGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKHILQLIEPSVFKEAATPEEEGGAPEKEIS AEDSKLEGIGEQETKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFS DDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCP EEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVEKVTYLKKKQAEKPVA SDSRKSSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTIN GVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHE TVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGL ASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIG WNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEE AIKIAEDPSRDGPSPTSGSSKTLDIEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLI HAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEPDMSAGFCPDHKAAMV LFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLT RCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLL RRLVFDVPQLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIF DALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTS NITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIFSDSSKVQPLMKPYKLLSEKEKE IYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAHGYSPRAIDMS NVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKA QDIFKFLQISGYAVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRS KGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNKEKEMVTSLFC KLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRAFLDNAAEDLE KTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVS CYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNVYSIYNTRSS RERAALSLPANVEDVCPNIPSLEKLMAEIIELAESGIRYTQMPHMMEVVLPMLCSYMSRW WEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINK VKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAF YPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWSKSHNFKREEQNFVVQNEINNMS FLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELI ALAKNRFSLKDTEEEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDTSDPERTVE RVLDIANVLFHLEQKSKYTEYTGRRYFSLGSTVEHPQRSKKAVWHKLLSKQRKRAVVACF RMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGTEPPEEDEATKRVDP LHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQK LLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKE KKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFL QLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDIIDEQGQ RNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSS QIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKL KDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEF VKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAK RIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLA AQISESDLNERSANKEESEKERPEEQGPRMGFFSLLTIQSALFALRYNVLTLVRMLSLKS LKKQMKRMKKMTVKDMVTAFFSSYWSVFVTLLHFVASVCRGFFRIVSSLLLGGSLVEGAK KIKVAELLANMPDPTQDEVRGDEEEGERKPLESALPSEDLTDLKELAEESDLLSDIFGLD LKREGGQYKLIPHNPNAGLSDLMTNPIPVPEVQEKFQEQKAKEEKEEKEETKSEPEKAEG EDGEKEEKAKDDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRM LALFVAFAINFILLFYKVSTSSVVEGKELPARSSSDTAKVTTSLDSNPHRIIAVHYVLEE SSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSE DDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAR EKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHL LDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPD MKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQ GLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLM YLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14895 nt NT seq  +upstreamnt  +downstreamnt atgaaacttggctcttttgatgatgaggtggttctgcagtgcactgcgactgtccacaaa gagcagcagaaactatgcttggcagccgaaggatttggcaacagactttgttttttggag tctacatcaaattccaagaatgtccctccggacctgtccatctgcacctttgtgctggag cagtccctgtccgtccgtgccctgcaggagatgctagccaacacaatggagaagtcagaa gggcaggttgatgtggaaaaatggaaattcatgatgaagactgctcaaggtggaggccac cggacactcctctatggacatgccatattgctccgccattcctacagtggtatgtatctg tgctgtctctccacctcccggtcttccactgacaaactggcctttgacgttggccttcaa gaggataccacaggggaggcttgctggtggaccatacatcctgcctctaagcagagatca gaaggagaaaaggtgcgggttggagatgacctcatcttggtcagtgtgtcctctgaaagg tacttgcacttgtcatatggcaacagcagctggcatgtggatgctgccttccagcagacc ctctggagcgtggcccctatcagctccggaagtgaagcagcccaagggtatcttattggt ggcgatgttctccggctgctacatggacacatggatgagtgtctcactgtcccttcagga gaacatggtgaagaacagcggagaacagttcattacgaaggtggtgctgtatcagttcat gcacgctccctctggagactagagaccctaagagtcgcgtggagtggaagtcatataaga tggggccagccattccgactccggcatgtcacaacaggaaaatacttaagccttatggaa gacaagaaccttctactcatggacaaagaaaaagccgatgtcaaatcaacagcatttgcc ttccggtcttccaaggaaaaattggatgtaggggtgagaaaagaagttgatggcatggga acctcagaaatcaagtacggagactccatttgctatattcaacatgtggatacaggcctg tggctaacctaccagtctgtggatgtgaagtcagcacggatgggatccatacagcgtaag gccattatgcaccatgaaggccatatggatgacggcttgaacttatccagatctcagcat gaagagtcccgcacagcccgcgttatcaggagtacagtgtttctcttcaatagattcata aggggcctggatgctctcagcaagaaatcaaaggcgcccaccattgacttgccaattgag tctgtgagcctgagtttgcaggacctcatcggctacttccaccccccagatgagcacctg gagcatgaagacaagcagaacaggctgcgagccctgaagaataggcagaatctcttccag gaagagggaatgatcaacttggttctggagtgcatagaccgcctacatgtctacagtagt gcagcccactttacagatgtcgcggggcgagaagcaggggagtcttggaaatccattctg aattctctctatgagttgctggcggctctaattagaggaaatcgtaaaaactgtgctcaa ttttctggctccctcgactggctaatcagcagactggaaagactggaagcatcctctggt attctggaggtcctccactgtgtgttagtagaaagcccagaagctctgaatatcatcaaa gaagggcatatcaaatctatcatctcacttttagacaagcatggaagaaaccacaaggtc ctggatgtgttgtgctctctctgtgtttgccatggggttgctgtccgttctaaccagcat ctcatctgtgacaacctcctgccaggacgagatctcttactgcagacccgtcttgtgaat catgtcagcagcatgaggcctaatattttcctgggtgtcagtgaaggctctgcacagtat aagaagtggtactacgaactcatggtggaccataccgaaccttttgtgacagcagaagct actcatttgcgagtgggctgggcttccaccgaagggtattccccataccctggcggaggt gaagagtggggtggcaatggcgttggtgatgacctcttctcctatgggtttgatggcctt cacctctggtcaggttgtatagctcgaactgtgagctcacccaaccagcacctgttgaga actgacgatgtcatcagttgctgtttagatctaagtgccccgagcatttcatttcgcatt aatggacaacctgttcaaggaatgtttgagaacttcaatatcgatggcttgttctttcca gttgttagtttctctgcaggaataaaggttcgctttttgcttggggggagacatggagaa ttcaagttccttcctccacctggctatgctgcttgctatgaagctgttttgccaaaagag aaattgaaagtagaacacagtcgagaatataagcaagagagaacatacacacgagacttg ctggggcccacagtgtccctgacccaagctgccttcacacccgttcctgtggacaccagc cagattgtgctgcctcctcacctggaaaggataagagaaaaactggcagagaatatccat gagctctgggttatgaataaaattgagcttggctggcagtatggtccggttagagatgac aacaagagacagcacccatgtctggtggagttctgcaaactaccagaacaggaacgcaac tacaatttgcagatgtcgcttgaaactctcaagactttgctggcattaggctgtcatgtg ggtatagcggatgaacatgctgaggagaaggtgaagaaaatgaagctgcctaagaattac cagctgaccagtggatacaagcctgccccaatggatctgagctttataaaactcaccccc tctcaggaagcaatggtggacaagttggctgaaaatgctcacaacgtgtgggccagggac cgaatccggcagggctggacttatggcatccagcaggatgtgaagaacagaagaaatcct cgtcttgttccctatactcttctggatgacagaaccaagaagtcaaacaaagacagcctc cgtgaggcagttcgcacactgctaggctatggctaccacctggaagctcctgatcaggat cacgccgcgagagctgaggtgtgcagtggcactggggagaggtttcgtatcttcagggca gagaagacctatgcggtgaaggccgggcgctggtactttgaattcgaggcagtcactgct ggagacatgcgggtgggctggagcagaccaggctgccaaccagatctcgagctgggttct gatgaacgtgcctttgcttttgatggctttaaggcccagcggtggcaccagggcaatgaa cactatgggcgttcttggcaagcaggtgacgttgtgggctgtatggttgatatgaacgaa cataccatgatgttcactctgaatggtgagatcctgctggatgactcaggctccgaactg gctttcaaggactttgatgttggtgacggattcatccctgtgtgtagccttggggtggca caagtaggcaggatgaactttggaaaggacgtcagcactttgaaatatttcaccatctgt ggcttacaagaaggctatgagccatttgccgttaacacaaatagggacatcactatgtgg ctgagcaagcggcttcctcagttccttcaggttccatcaaaccatgaacatattgaggta acaagaatagatggcaccgtagacagttctccatgtctgaaggtcactcagaagtccttt ggttctcagaacagcaacactgacattatgttttaccgtctgagcatgcccattgagtgt gctgaggtcttctcgaagactgtggcaggagggctccctggtgcgggcctctatgggccc aagaatgatctggaggattatgatgtggactctgattttgaggttttaatgaagacagct cacggtcatctggtgcctgaccgcattgacaaggacaaagaaacaccgaagccagagttc aataaccacaaagattatgctcaagaaaagccttcacgcctaaagcaaagattcttactt agaaggacaaagccagattatagcacaagccattctgcaagactcactgaagatgtcctt gctgatgaccgggatgactacgagtacctgatgcagacatccacgtactattactcagta aggatctttcctggacaagaacctgcgaatgtctgggtgggctggattacatctgacttc caccagtatgacacaggctttgatttggacagagtgcgcacagtgactgtcactctagga gatgaaaaaggaaaagtccacgagagcatcaaacgcagcaactgctatatggtgtgtgcg ggagaaagcatgagccctgggcaaggacgaaacaacagcaatgggctggagattggctgt gtggtggatgctgccagtgggctgctcacgttcattgccaatggcaaggagctaagtact tactaccaggtggagccaagcacaaagttattccccgcggttttcgcacaagctacaagt cccaatgttttccagtttgagttgggcagaataaagaatgtgatgcctctctcagcggga ttgtttaaaagtgagcacaaaaaccccgtgccccagtgtcctcctcgtcttcatgtgcag ttcctgtcacatgtcctgtggagccgaatgcccaaccagtttttgaaggtggatgtctct cgaatcagtgaacgccaaggctggctggtgcagtgtctcgatcctctgcagttcatgtcc ctccatatccctgaggagaacaggtctgttgatatcttagagctgacagagcaggaggag ttgttgcagtttcactatcacaccctccgtctctactctgcagtctgtgcccttgggaat catcgggtggcccatgcactatgcagccatgtggacgaacctcagctgctctatgccatt gagaacaagtatatgcctggcttgctgcgtgctggctactatgacctgctgattgacatc caccttagctcctatgccactgccaggctcatgatgaacaatgagttcattgtccctatg acggaggagacaaagagcatcaccctcttccccaatgagaacaagaaacatggcctcccg ggcatcggcctcagcacttccctccggcctcggatgcagttttcctccccaagtttcgtg agcattagcaatgaatgttatcagtacagtcccgagtttccactggacatcctcaaggcc aagaccatccagatgctcacagaagcagtaaaggagggcagcctccatgcacgggaccct gtgggtgggaccacggagttcctctttgtgcctctcatcaagcttttctacaccctgctt atcatgggtgtctttcacaatgaggatctgaaacacatcctgcagttgatcgagcccagt gtgtttaaggaagctgccactccagaggaggaaggaggagccccagagaaggagatcagt gcagaggactctaagctagaaggaataggtgaacaagaaaccaaagggggcaaaaggccc aaggaaggcctgctccagatgaaactccctgagccagttaaactacagatgtgcctcttg cttcagtacctctgtgactgccaggttcggcaccgaatagaagccattgtagccttttca gatgactttgtagctaagctccaagacaatcaacggttcagatataatgaagttatgcaa gccttaaacatgtctgccgcactcactgccaggaaaacgaaggagttccggtcaccacca caagagcagattaatatgcttctcaattttaaggatgacaaaagtgaatgtccctgtcct gaagaaatcagagaccaacttctggatttccatgaagacctgatgactcactgtggaatt gagctagatgaagatggatccctggatggaagcaatgatttaacaatcagaggacgtttg ctgtccctggtagaaaaggtgacctacctgaagaagaagcaagctgaaaaaccagttgca agtgactccagaaagtcctccagtctccagcaattgatttctgagactatggtgcggtgg gctcaagagtctgtcatcgaggaccctgagctggtgagggccatgtttgtattgctgcat cgacagtatgatggcatcgggggtctagtccgggcactgccaaagacctacactatcaat ggcgtctctgtggaggataccatcaacttacttgcatcactcggtcagattcgatctctg ctgagtgtgagaatgggcaaagaagaagagaagctgatgatccgtggattgggggatatc atgaataacaaagtgttttaccagcaccccaatctcatgagggctcttggaatgcatgaa acagtgatggaagtcatggtgaatgtccttggaggaggggagtccaaggaaatcaccttc cccaagatggtggccaactgttgccgttttctctgttacttctgccgtataagtaggcag aatcagaaagccatgtttgatcatctcagttatttactggaaaacagcagtgttggtctt gcttcaccagccatgagaggttcaactcccctggacgtggctgcagcatcagtcatggat aacaatgaacttgcccttgctctacgggagccggatctggagaaggtagttcgatatctg gctggctgtgggctgcagagctgtcagatgctggtgtctaagggttacccagacattggg tggaatccagttgaaggagagagatacctcgactttctcagatttgctgtcttctgtaat ggggagagtgtagaagagaatgcaaatgttgtggtaaggttgctcatccggaggcctgag tgctttggtcctgccttgagaggagaaggtggcaatggtcttcttgcagccatggaagaa gccataaaaatagctgaggatccttctagagatggcccttccccaaccagtggatccagc aaaacccttgatatagaagaggaggaagatgacaccatccacatggggaatgcgatcatg accttctatgcagctttgattgacttgcttggccgctgtgctcctgaaatgcacttgatt catgctggaaagggagaagccatccgaatcaggtctattttgcgatccctgattccactg ggagacttggtgggtgtaatcagcattgcatttcaaatgccaaccatagccaaagatggg aaggtggtggagcctgacatgtccgcggggttttgcccagatcacaaggcagccatggtt ttgttccttgacagggtctatggaattgaggtgcaagatttcctcctccatctccttgag gttggctttctgccagatctccgagctgctgcctctctagatacggctgcacttagtgct acggacatggccttggccctcaatcggtacctttgcacagctgtcctgcctttgttaaca agatgtgctcccctgtttgctggaacagagcaccatgcttccctcattgactctttgttg catactgtgtacagactgtctaagggatgttccctcaccaaagctcagcgggactccata gaagtctgcctgctctctatatgtggccaactacgaccttctatgatgcaacacctactc agaagactggtatttgatgttccacagttgaatgagcatgcaaagatgcctcttaagctc ctgacaaatcattatgaaagatgctggaaatattactgcctgcctggagggtggggcaat tttggtgctgcctcagaagaagaacttcatttatcaagaaagttattttggggcattttt gatgctttgtctcaaaagaaatacgaacaagaacttttcaaactggccctgccttgcctg agtgcagttgcgggagctttacctccagactacatggagtcaaactatgtcagtatgatg gaaaaacagtcatccatggattctgaagggaactttaacccacaacctgttgatacctca aacattacaattcctgagaagttggaatacttcattaacaaatatgcagagcattcccat gataaatggtccatggacaagttggcaaatggatggatttatggggaaatattttcagac tcttctaaggtccagccactaatgaagccatataaactattgtctgaaaaggaaaaagaa atttatcgctggcccatcaaggaatctttaaaaacgatgctggcttggggttggagaatt gagagaactcgggagggagacagtatggctctttataaccggactcgacgaatttctcag acaagccaggtgtctatagatgctgcgcatgggtatagccctcgtgctattgacatgagc aatgttacactctctcgagacctgcacgctatggcagaaatgatggctgaaaactaccac aacatatgggccaagaaaaagaaaatggagctggaatccaaaggaggaggaaaccacccc ttgctggtgccctatgacacactgacagccaaagagaaagccaaggacagagagaaggcc caggatatcttcaagttcctgcagatcagtggttatgctgtatccagagggttcaaggac ctggatctggacacaccatccatcgagaagcgatttgcctatagtttcctgcagcaactg atccgatatgtggacgaggctcatcagtacatcctggagtttgatggcggcagcagaagc aaaggagaacatttcccgtacgagcaagaaatcaagttctttgccaaagttgttcttcca ttaattgatcagtatttcaaaaaccatcgtctgtacttcctgtctgctgcaagcaggcct ctctgcactggaggacacgcatccaacaaagagaaggagatggtgacgagcctgttctgc aaacttggagttcttgtcaggcataggatttcactgtttgggaatgatgctacctcaatt gtgaactgtcttcatattctgggtcagactttggatgcaaggactgtgatgaagacgggc ctggatagtgtgaaaagtgctctcagggccttcctggacaatgcagcagaggatctggaa aagacaatggagaaccttaagcagggccagtttactcataccaggagccagcccaaaggg gtgactcagatcatcaactacaccaccgtggcactgttgcccatgctctcatccctgttt gaacacatcggccagcatcagtttggagaagatttgatattggaggatgtgcaggtgtct tgttacagaattctgaccagcttgtatgccttgggaaccagtaagagcatctatgtggaa aggcaacgatccgcacttggagaatgcctagctgcctttgctggtgcctttcctatagcc tttttggaaacccacctggacaaacataatgtttactccatctacaacaccagatcttca cgggagagagcagctctcagtttaccagcaaatgtggaggatgtctgtccaaatatacca tccctggagaagctcatggctgagattatagagctggcagagtcaggtatccgctacact cagatgccacacatgatggaggttgtactgcccatgctgtgcagctacatgtcacgatgg tgggaacacggtcctgagaaccacccagagagagctgagatgtgctgcacagctctcaac tctgagcacatgaacacactgctgggcaacattctcaaaatcatctacaacaacctgggg attgacgaaggagcctggatgaaacgcttagcagtgttctcacagcctatcatcaacaaa gtgaaacctcagctcttgaaaactcatttcttgcccttgatggagaaactaaagaaaaag gctgccatggtagtatctgaggaagaccacttgaaagctgaggccagaggggacatgtca gaggctgagctgctcattttagatgagttcaccacactggccagggatctctatgccttc tacccactcttgatccgatttgtggattataacagggcaaagtggctgaaggagcctaac ccagaagcggaggaactgtttcgaatggtggctgaggtcttcatcttctggtccaaatcc cataatttcaaaagagaagaacagaactttgtggtgcagaatgaaatcaacaacatgtcc ttcctcatcactgacacaaagtccaagatgtccaaggcagccgtttctgatcaagagagg aagaaaatgaaacgcaagggggaccggtattctatgcagacatctctgatagttgcagct ctgaagcgactacttcccattgggctgaacatctgtgctcctggggaccaagagctcatt gctctagccaaaaatcgatttagcttgaaagacactgaggaggaagtgcgagatataatc cgcagtaatatacacttacaaggcaagttggaagatccggcaatcaggtggcaaatggct ctctataaagacttgccaaacaggacggaagacacctcagacccagagaggacagtggaa cgtgtcttggatatagcaaatgtactttttcatcttgaacagaaatctaagtatactgag tatactggccggagatatttcagtctgggaagtacagtggaacatcctcagagatcgaag aaggctgtatggcataaactactctccaagcagagaaaaagagccgttgttgcctgcttc cggatggcccccttgtacaatctgccaaggcatcgggctgtcaatctttttcttcaggga tatgaaaagtcttggattgaaacagaggagcattactttgaggataaattgattgaagat ttagcgaaaccaggcactgaacctccagaagaagatgaagccacgaaaagagttgatcct ctccatcagctcattcttctattcagccgcacggccttaacagagaaatgcaaactggag gaagattttctttatatggcgtatgcagatattatggcaaagagttgtcacgatgaggaa gatgatgatggtgaagaagaagtgaagagctttgaagaaaaagaaatggagaagcagaaa cttctctaccagcaagccagactgcatgatcgtggggcagctgagatggtgcttcagacc atcagtgccagcaaaggtgaaactggaccaatggtggctgccactttgaaactgggcatt gctattttaaatggtgggaactccactgtacagcagaagatgctggattacctgaaggag aagaaggatgtaggtttcttccagagcctggcaggcctcatgcagtcctgcagtgtgctt gacctgaatgcctttgagaggcaaaacaaagctgaaggacttgggatggtgactgaggaa ggatcaggagagaaggtactgcaggatgatgagttcacctgtgacctcttccgattcctg cagctgctttgtgagggacacaactcagattttcaaaattacctgagaactcagactggc aacaatacaactgtcaacatcatcatctcgactgtggactacctcctccgagtgcaggag tccattagtgatttctactggtactactctgggaaagacatcatagatgagcagggccag cgcaacttctccaaagccatccaagtggcgaagcaagttttcaacactctcacagaatac attcagggtccttgtactggaaaccagcagagcttggcacacagcaggctatgggatgct gttgtgggcttccttcatgtatttgcccacatgcagatgaagctgtctcaggattctagc caaatcgagctcttgaaagaactaatggatctccagaaggacatggtggtcatgctgctg tccatgctagaaggtaatgttgtgaatggaacaataggcaaacagatggtagacatgctt gtggaatcatccaacaacgtggagatgatcctcaagttttttgacatgtttctgaagcta aaggacttgacatcctctgacacatttaaggagtacgaccctgatggcaaaggggtcatt tccaagagagacttccataaagctatggagagccacaagcactacactcagtcagagacc gagttcctgctgtcctgtgcagagacagatgaaaatgaaacactggactatgaagagttc gtcaaaagatttcatgagcctgcaaaggacattggcttcaatgttgctgtcctattgact aatctctcagagcacatgcccaatgacacgaggctgcagaccttcttggagttggcagag agtgtcctcaactacttccagcctttcctgggtcgcattgagatcatgggcagtgccaag cgcattgagagggtctattttgagatcagcgagtccagcagaacccagtgggagaagcca caggtcaaggagtccaaaaggcagtttatattcgatgtggtcaatgagggtggggagaag gagaagatggagctgtttgtgaacttctgtgaggacaccatctttgagatgcagctggca gctcagatctcagagtctgacctaaatgagagatcagcaaataaagaagagagtgagaag gagaggcctgaagagcagggcccgaggatgggcttcttctccctcctcaccatccagtca gccctgtttgctctcagatacaatgtgctaaccctcgttaggatgctcagcctgaagagc ctaaagaagcagatgaagagaatgaagaagatgacagtgaaggacatggtcacagccttc ttctcgtcctactggagtgtgtttgtgaccctcttacactttgtggccagtgtctgtagg ggcttttttcgcattgtctccagcctgctgcttggggggagcctggtggaaggtgctaag aaaatcaaggtggcagagcttctagccaacatgccagaccccactcaggatgaggtgcga ggagatgaagaagagggagagcggaagcctttagagtcagctctgccctctgaagacctg acagacttaaaggaattggcagaggaaagtgaccttctttcggatatatttggcttggat ctgaagagggaaggagggcagtacaaactaattcctcacaatccaaatgctggcctcagt gacttgatgaccaaccccatccctgtccctgaggtacaagaaaagtttcaggagcagaag gcaaaagaagagaaggaagaaaaagaagaaaccaagtctgaacccgagaaggctgagggg gaagatggagaaaaagaagaaaaagccaaagatgataagggcaaacagaagttgaggcag cttcatacacatcgatatggggaacctgaggttccagagtcagcattctggaagaaaata attgcctatcaacagaagttgctgaactattttgctcgaaacttttacaacatgagaatg ctggccttgtttgtcgccttcgccatcaatttcatcctgctcttctacaaggtctccact tcttctgtggttgaaggaaaggagctgcctgcccgaagctccagtgacactgccaaagtg accaccagcctggacagcaacccacatagaatcatcgcagtgcactacgtcttagaggag agcagtggctacatggaacccaccttgcgcatcttagccatcttgcacactgtcatctct ttcttttgcatcattggatactactgcttgaaagtcccattggttatttttaagcgggag aaggaagtggcacgtaaattggaatttgatgggctttacattacagagcagccttcggaa gatgatattaaaggccagtgggacagactcgtgatcaatacacagtcatttcccaataac tactgggataaatttgttaaaagaaaggtaatggataaatatggagagttttatgggcga gacagaatcagtgagttactgggcatggataaggctgcactggatttcagcgatgcaaga gagaagaagaagcccaagaaagacagttccttgtctgctgtattgaactctattgatgtg aagtaccagatgtggaaactgggagtcgtgttcacagacaactccttcctgtacctagcc tggtatatgaccatgtctgttcttggacactataacaactttttttttgctgctcacctc cttgacatcgcgatgggattcaagaccttgagaaccatactgtcctcagttacccacaat ggaaaacagctcgtgttaacggttggcttattagctgttgttgtgtacctgtacactgtt gtggcattcaatttcttccggaaattctataataaaagtgaagatggtgatactccagat atgaaatgtgatgacatgctgacgtgttacatgttccacatgtatgtgggtgtccgtgct ggagggggcattggtgatgaaattgaagaccccgcaggagatgagtatgagatctatcgc atcatctttgacatcacgttcttcttctttgtgattgtcatccttttggccatcatacaa ggtttgatcattgatgcttttggagaactcagagaccaacaggagcaagtaaaggaagac atggagaccaagtgcttcatctgtggaataggcaatgactactttgacacagtgccacat ggctttgaaacacatactctacaggagcacaacttggccaactacctgttttttctgatg tatctcataaacaaggatgaaacagaacacacaggacaggaatcttatgtctggaagatg tatcaagagaggtgttgggagttttttccagcaggggattgtttccggaaacagtatgaa gaccagttaaattaa

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