Carassius gibelio (silver crucian carp): 127933154 Help Entry 127933154         CDS       T08819                                  Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism cgib  Carassius gibelio (silver crucian carp) Pathway cgib04020   Calcium signaling pathway cgib04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cgib00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     127933154    04020 Calcium signaling pathway     127933154  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cgib04040]     127933154 Ion channels [BR:cgib04040]  Voltage-gated cation channels   Ryanodine receptor    127933154 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  127933154 NCBI-ProteinID:  XP_052385870 LinkDB All DBs Position A17:26929856..27042612 Genome browser AA seq 4880 aa AA seqDB search MAEGGDAEDEIQFLRTDDEVVLQCVACIQKENRKFCLSAEGLGNRLCYLEPTSEAKYVPP DLCICSFVLEQSLSVRALQEMLAKTGQNNDQFIRKAAQSGGHRTLLYGHAVLLRHSFSRM YLTCLKTSRSVTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSS ERYLHLSISNGSIQVDVSFMQTLWNVHPTCSGSNVEEGYLLGGHVMRLFHGHDEVLTIPG SDQSEEEQRLVNYETGKAGAKARSLWRLEPLRISWCGSHIRWGQPFRLRHLTTGHYLALT DDRGVVLQDRERSDTTSTAFCFRASKEKLECGLKRDIEGMGVAEIKYGDSLCFLMHVATG LWLSFQAPDVKSARLGPLKRRVCLHSEGHMDDGLTLQRCQHEESRAARIIRNTTRLFSCF IRELDGLSAKNRSSVVLPIEEVLQTLNDLIAYFRLPDAELEHEKKQIKLRSLKNRQNLFK QEGMLSLVSSCIDRLSVYNSAAHFGECAGEEAGVAWKDILNLLYELLAALIRGNRNNCTQ FSHNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKTIISLLYKHGRNHKI LDVLCSLCVCNGVAVRANQNLICDHLLPRRDLLLQTRLVNDVQSMRPNIFVGVSEGSAQY RKWYFELMIDHVDHFLTGEPSHLRVGWASTKGYAPYPGGGEGWGGNGVGDDLYSYGFDGL HLWSGRIPRTVASVKQHLLASDDVVSCCMDLNAPSISFRINGQPVQGMFENFNIDGLFFP VVSFSAGVKVRFLLGGRHGDFKFLPPSGYAPCYEALLPKEKMRVEPVKEYKRDADGVRDL LGNTHFISQTSFIPKPVDTSQIGMPPHLEKVRDRLAENIHELWGMNKIELGWSYGKIRED NKRQHPCLVDFSKLPETERNYNLQMSTETLKTLLALGCHVVQVKVNAEEELKKLKLPKNY MMSNGYKPSPLDLSDVKLSAGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDVKNKRNP RLVPYALLDERTKKSNRDSLREAIRTLIGYGYNVEPPDQDAGHVLERLSIDKIRFFRVER TYAVKTGRWYFEFEAVTGGDMRVGWARPGCRPDVELGTDEQAYVFDGHRGHRLHSGSRLF GRCWHAGDVVGCMINLEDKSMIFTLNGEILITNKGSELCFADFDIDDGFIPVCSLGLSQV GRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFCNVPKDHHHIAVTR IDGTVDGPPCLKVTHKTFGTQNSNADMVFCRLSMPVESHSSFRSSSCTHINGLCEDEPLK LRHRHPVKSTKHSEEVRRTDYSTITTYYHSVRIFAGQDPSCVWVGWVTPDYHYYSNHFSL SKNRSVTVTLGDERGRVHESVKRSNCYMVWGGDITSTAHASGRSNVDLEIGCLIDLATGL LSFTINGKELPTTYQVEPSTKLFPAVFVRPTSSSLFQFELAKIKNAMPISSAIFKSEHKN PVPQCPPRLDVQTINSVLWSRMPNTFLKVETARVSERHGWMVQCVEALQMLAVHIPEENR CVDIMELSEQEELRRFHYHTLKLYCALCAHGNTRVAHALCSHLDQSQLLYTIDNQYLSGL LREGFYDVLISVHLETARAARRMMSSEFIIPITAETRSIRLFPDASKQHRPPGVGLSTCL KPRLSFGPPCFISSKREQHLFSPEIPLDVLKERAICMLTEAVQGGGDHIRDPVGGSVEFQ FVPILRLIGALLTMGVLNSHDVHKILLLIEPGVFGERRDDGAKEGLTGAEEKAVEAGEEE EARDGKVLVKSLLEKKLPESVKRQMCELLHYFCDCELRHRVEAIVSFSDSFVSKLQVNQK FRYNELMLALNMSAAVTAKKTREFRSPPQEQINMLLNFTVGEDCPCPADIQEELYDFHSE LRLHCGIPVEEDEEDQDSSIKARLLALIYKIKGQPQRSERESTEEEQAAPSNLKELISQT MVSWAQETHIQDPELVRLMFSLLRRQYDSIGELLRAMRKTYTISAASVHDTIHLLASLGQ IRSLLSVRMGKEEEQLMIHGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGGKSQ EIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAS SVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLAKGYPDISWNPIEGERYLSFLRFA VFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISENPSLDLPSAG PAHASDASTEGEEEEEVVHMGNAILSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILR SLVPTEDLVGIISIPLKMPVVNKDGGVSEPDMSATFCPDHKAPMVLFLERVYGIEDQSFL LHLLEVGFLPDLRAAASLDTEALRTTETALAMNRYIGSAVLPLLTRCAPHFSGTEHHAAL IDSTLYTVYRLSKGCSLTKAQRDAIEECLLAICRYLRPSMLQHLLRRLVFDVPLLSEYCK MPLKLLTNHYEQNWKYYCLPSGWGSYGQASEEELLLTKKIFWGIFDSLSQKKYEQDLFKM AMPCLSAIAGALPPDYIDSTLSTTLEKQVSVDTQGNFNPRPVNTANICLPEKLEYIANKY AEHSHEKWAAEKVLLGWKHGENIDEKAKTHPMLRSYKSLTEKEKEMYCWTVRESLKSMLA MGWSIDRTREEDSVFQQREMEKMRRISQASQGNGFNPNPLDMSSVLLSRELQSMVEVVAE NYHNIWAKKKKSDLCSRAAGGAHPLLVPYDTLTAKEKTRDRERAQDLFRFLQINGYAVSR RLKHMEQDSSSMEKRFAYRFLKKLLKYVDSAQEFIAHLEAMATSGKNDRSPHEQEIKFFA KVLLPLIDQYFKNHSLYFLSSPTKNLSSSGYASNKEKEMVTSLFCKLATLVRHRISLFGS DSTTIVSCLHILAHTLDTRTVMKSGSELVKAGLRTFFESAAEDLEKTLENLKLGKFTHSR SQMKGVSQNINYTTVALLPILTALFEHITEHQFGSDLLLDDVQVSCYRILTSLYSLGTGK NIYVERQLPALGECLATLAGAMPVAFLEPQLNTHNPCSIFNTKTSRERALVGLPESVEDV CPEMPRLDGLIKDITDVSESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENRPRPAGVC SSTVTSEHLSLVLGNILKILNSNLGIDEASWMKRIAVYAQPIISKARADLLKTHFLPTLE KLKKKTVKVVSEEELLKADGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRW LKEPDTDSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDSKTKLAKSFL PKAGGQDQERKHKKRRGDFYSVQTSLIVAALKKMLPIGLNMCTPGDQELILLAKTRYGLK DTDEEVKEHIRQNLHLQEKSADPAVQWQLNLYKDVKVKTDDTLDPERSIGRIQSISAAVF HLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLTGYQRLWIEA EMYSFEEKLVQDLAKTKTDEEEEEITDTQPDPLHQLILHFSHNALTERSSLEEDQLYIAY ADMMAKSCAENEEEDEEGKEKTFEEKEMEKQKTLYQQARLHDRGAAEMVLQMISASKGHL GPMVTFTLKLGISILNGGNITVQQKMLDYLKEKRDVGFFKSLSGLMQSCSVLDLNAFERQ NKAEGLGMVTEEGSINVRERGSKVLQNDEFTRDLFRFLQLLCEGHNNDFQNFLRTQTGNT TTVNIIISTVDYLLRLQESISDFYWYYSGKDVMDEAGQRNFSKALAVAKQIFNSLTEYIQ GPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMIVMMLSL LEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSENFKEHDPDRKGVISK KEFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEEFVNRFHEPAKDIGFNVAVLLTNL SEHMPHDSRLSTFLNLAESVVNYFEPYLGRIEIMGGGKRIERVYFEISESSRTQWEKPQV KESKRQFIFDVVNKGGESEKMELFVNFCEDTIFEMQLASLISEPDAAERQEEVDDEDDAR SVDLDEDDEDAAQESSSAFALACVSMRKSLSNLRQLLTFRSMRRQYRKLRKMSVREMIRG FFFFFWMIFTGMFRFLYSLVWGFFHILWSTLFGGGLVEGAKNMKVTDILGNMPDPTQFGI HGDVLELEKLEYCDVSSVAELGRMTAGDQAEMELMTELMYMQPRREGGKHGMEPGLGDVS EVIGVDTPSLASAVHQKKAQEAASKQTDESETKSESEKADVEDREKKDQDKGREESVSDS LTDEEKKPQKKRRGQRKEQAEAFMAAFLASLDVHQTKTLNYLARNFYNLRFLALFVAFAI NFILLFYKVTGEDSDDLDPWTRREEDDEAALEYFVLQESTGYMAPTLRFLAVMHTVISFL CVLGYYYLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVINTPSFPNNYW DKFVKRKVINKYGNLYGAERIAELLGLDKSALDFNPTEETVIKDASLLSWLSSIDTKYHV WKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQL VLTVGLLAVVVYLYTVVAFNFFRKFYNKSADEDEPDMKCDDMMTCYLFHMYVGVRAGGGI GDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETK CFICGIGNEYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQER CWDFFPAGDCFRKQYEDQLG NT seq 14643 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggcggagacgcggaggatgagatccagttcctgcgcacggatgatgaggtg gttctgcagtgtgtggcctgcattcagaaggagaaccgcaagttctgtctgagcgccgag ggtttggggaaccgcctgtgttacctggagcccacatcagaggctaagtatgttcctcca gatctgtgcatctgtagttttgtgctggagcagtcgctgtccgtccgagcgctgcaggag atgctcgccaaaaccggacagaacaacgaccagttcatcagaaaggcggctcagagcgga ggacaccggacgttactgtacggccacgctgtgctcctcagacactccttcagcaggatg tatctgacctgtttgaagacgtcgcgctcagtgacggataaactgtcgtttgatgtggga cttcaggaagactcgacaggtgaggcctgctggtggaccattcatcctgcatctaaacag agatcagaaggggagaaggtgcggatcggagatgatctcatactcgtcagcgtctcatca gagcgatatctgcatctgtccatatccaacggcagcatccaggtggatgtgtccttcatg cagacgctgtggaacgtccatcccacctgctcagggagcaacgtggaggaaggatacctt cttggaggtcatgtgatgcgtctttttcatggacacgatgaggttctgaccatcccggga tctgatcagagtgaagaagagcagagattggtgaactatgagacaggtaaagccggagca aaagcccgatctctctggcggctggagccactacgcatcagttggtgtggcagtcacatc cgctggggtcagccgttccgtctgcgtcacctgaccaccggtcactatctggcgcttaca gatgaccgaggcgtcgttctgcaggacagagagagatcagacaccacgtccacagccttc tgcttcagagcctccaaggaaaagctggagtgtggtctgaagcgggacatcgaggggatg ggagtggccgagatcaaatacggagattctctgtgtttcttgatgcacgtggcgacgggt ctctggctgtcctttcaggcaccagatgtcaaatccgctcgactcgggccgctcaaacgc cgggtgtgtcttcattcagaaggacacatggacgatggtttgacgttacagcgatgtcaa cacgaggagtcgagagccgctcgaatcatccgcaacaccacgcgactcttcagctgcttc atcagagagctggacggtttgagtgccaagaaccgctcgtctgtggttctgcccatcgaa gaggttctccagactctaaacgacctgatcgcgtacttcagacttcctgacgccgagctg gagcacgagaagaagcagatcaagctgcgctcgctgaagaaccgacagaacctcttcaag caggaggggatgctgtccctggtgtccagctgcatcgaccgcttgagtgtttataacagc gcagctcatttcggagagtgtgcgggtgaagaggccggagtcgcgtggaaggacatcctc aaccttctctacgagcttctggccgctctgatccgcgggaaccggaacaactgcacacag ttctcacacaacctggactggctcgtcagcaaactggagcgactggagtcgagttcaggg atcttggaggttcttcactgtattctgattgaaagtcccgaggctctgaacatcatccag agaggacacatcaaaaccatcatctctctgctctacaaacacggacgaaaccacaagatc ctggacgtcctctgctctctgtgtgtgtgtaacggagtcgctgtcagagccaatcagaac ctgatctgtgatcacctgctgcccagacgagatctgctgctgcagacgcgattggtcaac gacgtccagagcatgaggcccaatatcttcgtgggagtcagcgaaggctccgcccagtac aggaagtggtattttgagctgatgatcgatcacgtggatcacttcctgacgggcgagccg tcgcacctgcgggtgggctgggcgtccactaaaggctatgctccctacccgggcggcgga gagggctgggggggcaatggtgtaggggacgatctctactcctacggcttcgatggactg cacctgtggtcaggacgcatcccgaggacagtggcgtctgtgaagcagcatcttctggcg tctgatgatgtggtgagctgctgcatggatctgaacgctcccagcatctccttcaggatc aacgggcagccggtgcaggggatgttcgagaacttcaacatcgacggcctcttcttcccc gtcgtcagcttctccgccggcgtcaaggtgcgcttcctgttgggcggtcgccacggagac ttcaagttcctgccaccgtcgggttatgcgccgtgttacgaggctctgctgcccaaagag aagatgagggtcgagccggtcaaagaatacaagagagacgcggacggagtgagagaccta ctgggaaacacacacttcatatcacagacctccttcatacctaaacctgtggacacgtct cagatcgggatgcctcctcatctggagaaggttcgggatcgtctggcggagaacatccat gagctctggggaatgaacaagatcgagctgggctggtcctacgggaagatcagagaggat aacaagcggcagcacccgtgtctggtggatttctccaaactaccagaaaccgagaggaac tacaacctgcagatgtccaccgaaacactcaagactctgctggcgttgggctgtcatgtg gtccaggtgaaggtcaacgctgaagaggagctgaagaagctcaagctccctaagaattat atgatgtctaacggctataagccatcgccgctggatctgtcagacgtcaaactgagcgcc ggtcaggaactgctcgtggacaaactggcagaaaacgctcacaatgtctgggccaaagac cgcatcaaacagggctggacctacggcatccagcaggatgtgaagaacaagcgaaaccct cgtctggtgccgtacgctttacttgatgagcgcaccaagaagtctaaccgtgacagtctt cgggaggccattcgcacgctgatcggatacggatacaacgtggagccgcccgaccaggac gcaggtcatgtgttagagcggctgagcatcgataagatccgtttcttccgtgtggagcgc acgtatgcggtgaagacgggccggtggtatttcgagttcgaggcggtgacggggggagac atgcgtgttggctgggctcggcccggctgtagaccagatgtggagctgggaacggacgag caggcctatgtcttcgacggtcaccggggtcatcggctgcactcgggcagccgtctgttc ggacgctgctggcacgctggggatgttgtgggttgtatgatcaacttggaggacaaatcc atgatcttcaccctgaacggagaaatcctgatcaccaacaagggctctgagctgtgcttt gccgactttgacattgacgacggtttcatcccggtctgtagtttgggtctgtctcaggtg ggccgtatgaatctggggaaggacgccagcacctttaagtactacaccatgtgtggcctg caggagggcttcgagcccttcgctgtcaacatgaaccgtgaagtgaccatgtggttcagc aaacgcctgcccaccttctgcaatgtgcccaaagaccaccatcacatcgcggtcacccgg atcgacgggacagtggacggtccgccgtgtctcaaagtcacccataagacgttcgggacg cagaacagtaacgctgacatggtgttctgcagactcagcatgcctgtggagtctcactcc agcttcaggagcagctcttgcacacacatcaacggcctgtgtgaggacgagccgctcaag ctcagacacaggcatccagtgaagtccaccaaacactcggaagaagtcaggagaacagat tacagcaccatcaccacatactatcattcggtcaggatattcgcaggtcaggacccatcc tgcgtgtgggtcggatgggtcacccctgactaccattactatagcaaccacttcagcctc agcaagaaccgctcagtgaccgttaccctgggagatgagcggggccgcgtgcatgagagc gtgaagaggagtaactgttacatggtgtggggtggagacatcaccagcaccgctcatgcg tccggccgcagcaacgtggatttagaaatcggatgcctcatcgatttggccacgggtctg ttatcatttaccatcaatgggaaagagcttcccacaacctaccaggtggagcccagcaca aaactctttcctgctgtgtttgtgaggcccacaagctcaagtctcttccagtttgaactg gccaaaatcaagaacgccatgcccatatcgtcggccatctttaagagcgaacacaagaat cccgttcctcagtgtcctccacgactggacgtccagaccattaactcggtgctgtggagc cgaatgcccaacaccttcctgaaggtggagacggcccgtgtcagcgagagacacggatgg atggtgcagtgtgtagaagcgctgcagatgctggccgtacacatccccgaggagaaccgg tgtgtggacatcatggagctgtcggagcaggaggagctacgtaggttccactatcacacg ctaaagctgtactgcgctctgtgtgctcacgggaacacgcgtgtggctcacgcgctctgc agtcacctcgaccaatcacagctgctctacaccatcgataaccagtacctgtcagggctg ctgcgcgagggcttttacgacgtcctcatcagcgtgcacctggagacggccagagctgcc cgccgcatgatgagcagcgagttcatcatccccatcaccgccgagacgcgcagcatccgc ctcttccccgacgcctccaaacagcaccggcctccaggcgtcgggctcagcacctgcctc aaacccagactcagcttcggcccgccctgcttcatcagcagcaagcgcgagcagcacctc ttcagcccggagatcccgctggatgtgctgaaggagagggccatctgcatgctgacggag gccgtgcagggcggaggagaccacatccgtgaccccgtgggaggaagcgtggagttccag ttcgtgccgatcctgcggctcatcggcgcgctgctcaccatgggagtcctgaacagccat gacgtgcacaagatcctgctgctcatcgagcccggcgtgttcggggagcgcagggacgac ggagccaaagaagggctgacgggagccgaggagaaggcggtggaggccggagaggaggag gaggcccgagacgggaaagtgctggtgaagagcctgctggagaagaaactccccgagtct gtcaaacgacagatgtgcgagctgctgcactatttctgtgactgtgagctgaggcaccgc gtcgaggccatcgtgtcgttctccgacagcttcgtctctaagctgcaggtcaatcagaag ttccgctataacgagctgatgctggcgctcaacatgtcagccgccgtcacagccaaaaag acccgagagttccgctcgccgccgcaggaacagattaacatgctgctgaacttcaccgtg ggcgaggactgtccgtgtcccgcagatatacaggaggagctgtacgacttccacagcgag ctgcggctgcactgcgggattccagtggaggaggatgaggaggatcaggactcgtctatt aaagctcgtctgctcgctctcatctataagatcaaaggtcaaccgcagcgatctgagcgc gagtccacagaggaagagcaggccgctccctcgaatctgaaggagctgatctctcagacg atggtgagctgggctcaggagacacacatccaggacccggagcttgtgcggctgatgttc agtctgctgagacgacagtacgacagcatcggagagcttctccgagccatgaggaagacc tacaccatcagcgctgcctccgtccacgacaccatccacctgctggcgtctctgggccag atccgctcgctgctgagcgtccgcatggggaaggaggaggagcagctgatgatccatggc ctcggggacatcatgaataataaggtgttctaccagcatcctaacctgatgcgtgttctg gggatgcacgagaccgtgatggaggtgatggtgaacgtcctgggtggaggaaagtctcag gaaatcgcctttcctaagatggtggcgagctgctgtcgcttcctgtgctacttctgtcgc atcagtcgtcagaaccagaaggccatgtttgatcacctgagctacctgctggagaacagc agcgtgggattggcgtctccgtccatgagagggtccactcctctagacgtggcggcttca tcagtgatggacaacaacggtctggcgctggcgctggaggagcccgacctggacaaggtc gtgacgtatctggccggctgcggtctgcagagctgtccgatgctcctggccaaaggatat ccagacatcagctggaaccctattgagggagaacgttacctgtccttcctgcgattcgcc gtgtttgtcaacggtgagagcgtggaggagaactccagtgtggtggtgaagctcctgatt cgtcggcccgagtgtttcggtcctgctctgagaggagaaggaggaaacgggctgctggcc gcaatgaaggaggccatcaagatctcagagaaccccagcctggatctgcccagcgccggg ccggctcacgcttcagacgcctccactgagggcgaggaggaagaggaagtggttcacatg ggaaacgccatcctgtccttctactcggctctgatcgatcttctgggccgctgcgctcct gagatgcacctgatcaataagggtaaaggtgaagctctgaggattcgtgccatccttcgt tctctggttcccacggaggatctggtgggcatcatcagcatccctctcaagatgcccgtc gtcaataaagacggcggcgtgtctgagcctgacatgtcggccacgttctgcccggaccac aaggccccgatggtgctgttcctggagcgtgtgtatggcatcgaggaccagagcttcctg ctgcatctgttagaggtgggcttcctgccggacctgagagccgctgcctcgctggacacg gaggctttgcgcaccacagaaaccgctctggcgatgaacaggtacatcggttcggccgtg ttgcccctgctgacccgctgcgctcctcacttctccggcacagagcatcacgccgcgctc atcgactccacgctttacaccgtctaccgtctgtccaagggctgctcgctcaccaaagcc caacgcgacgccatcgaggagtgtctgctggccatctgcaggtacctcagaccctccatg ctccagcatctgctgcgccgactggtgtttgacgtcccgttgttgtctgaatactgtaag atgcctctaaagctgttgacgaatcattacgagcagaactggaagtattactgtctgccg tccggatgggggagttacggtcaagcgtccgaggaggagctgctgcttaccaagaagatc ttttggggaatctttgactctctgtctcagaagaagtatgagcaggatctgtttaagatg gccatgccgtgtctgagtgccatcgctggagctctgccgccggactacatcgactccacg ctcagcaccacgctggagaaacaggtgtctgtcgacacgcagggaaacttcaaccccaga cccgtaaacacagccaacatctgcctgccggagaagctggagtacatcgcaaacaaatac gctgaacattcccatgagaaatgggctgctgagaaggtgcttctgggctggaaacatgga gaaaacatcgacgagaaagcaaaaactcatccgatgctgagatcctacaagtccctgaca gagaaggagaaggagatgtattgctggacggtgcgcgagtccttgaagagcatgttagcg atgggctggagcatcgaccgcaccagagaagaagacagcgtgttccagcagagagagatg gagaagatgcgccgcatctcacaggcctctcagggtaacggcttcaatccaaacccgctg gacatgagcagcgtccttctgtccagagaactgcagtcgatggttgaggtcgtagctgaa aactatcacaacatctgggccaagaagaagaagagtgatctgtgcagcagagccgcagga ggagctcatccgctgctggtgccctacgacacgctcacggccaaagagaagaccagagac cgcgagcgagcgcaggatctcttccgcttcctgcagatcaacggatacgccgtcagcagg cgtctgaagcacatggagcaggactcgtcttcgatggagaaacgcttcgcctaccgcttc ctgaagaagctgctgaagtacgtggactcggcgcaggagttcatcgctcacctcgaggcg atggctaccagcggaaagaatgacagatcgccacatgaacaggaaatcaagttctttgct aaggtgctcctccccctcatagaccagtactttaaaaaccactcgctctacttcctgtcg tcacccaccaagaatctgagcagcagcggatacgcgtcgaacaaagagaaggagatggtc accagtctgttctgtaagctggccactctggttagacacaggatctctctgtttggaagt gactccaccacgatagtcagctgtctgcacatcctcgcacacacgctggacaccaggact gtgatgaagtctggatcggagctggtcaaggccggtttgaggacgttctttgagagcgcg gctgaagatctggagaagactctggagaacctgaagctggggaagttcacgcactcacgc agtcagatgaagggcgtctcgcagaacatcaactacaccacagtggctctgctgcccatc ctgaccgctctgttcgagcacatcactgaacaccagttcggctccgaccttctgctggat gatgtgcaggtgtcgtgttatcggatcctgaccagtttatactcgctggggaccgggaag aacatctacgtggagaggcagctgccggcgctgggggagtgtttggcgactctagccggt gcgatgcccgtggcgtttctggagccgcagctaaacacacacaacccctgctccatcttc aacaccaagacgtctcgagaacgagctctggtcgggctgccggagtcggtggaggacgtg tgtcctgagatgcctcgtctggacggtctgatcaaggacatcactgacgtgtcagagtcc ggcgcgcgctacacagagatgccgcacgtcatcgaggtggtgctgcccatgctgtgtaat tatctgtcgtactggtgggagcgaggcccggagaaccgtccccgtcccgcaggcgtctgc agcagcaccgtcacctccgaacacctcagcctcgtcctcgggaacatcctcaagatcctc aacagcaacctgggcatcgacgaggcctcctggatgaagcgcatcgcagtgtacgctcag cccatcatcagtaaggcgcgcgctgatctgctgaagacgcacttcttgccgacgctggag aagctgaagaagaagacggtgaaggtggtgtcggaggaggagcttctgaaagctgatggg aagggcgacacccaggaggcggagcttctgatcctggatgagtttgcagtgctgtgcaga gatctgtatgccttctaccccatgctcatccgctacgtggacaacaacaggtctcggtgg ctgaaggagccggacacagattccaacgagctcttcaggatggtcgcagagatcttcatc ctgtggtgtaaatcacacaacttcaagagggaagagcagaactttgtggttcagaacgag atcaacaacctctcgttcctcaccggcgacagtaaaaccaagttggcaaagtcattcctc cccaaggctggtggtcaggatcaggagcggaagcataagaagcgccgtggagacttttac tccgtccagacgtctctgatcgtggcggcgctgaagaagatgcttcccatcggtctgaac atgtgcacgccgggagaccaggagctcatcctgctggctaagacacgatacggcctgaag gacacagatgaagaggtgaaggagcacatcagacagaacctgcacctgcaggagaagtca gcggatccggctgttcagtggcagctcaacctctataaggatgtgaaggtgaagacagat gacactctggatccggagcggagcattgggagaatccagagcatctcagccgctgtattc caccttgagcaggttgagcagccgttgcgctctaagaagtgtgtttggcagaagttgttg tctaagcagcggaagcgagccgttgtggcgtgtttcagaatggctccgctctacaacctg cccaggcatcgctctattaacctgttcctcacgggctaccagcggctctggatcgaggca gagatgtactcgtttgaggagaagctagtgcaggatctggcaaagacgaagactgatgaa gaggaggaggagatcacagacactcagccagaccctcttcatcaactcatcctgcacttc agtcacaacgcactgacagaacgcagctcactagaagaggatcagctgtacatcgcatac gcagacatgatggctaagagctgtgctgaaaatgaggaagaggatgaggaaggaaaagaa aaaacatttgaggagaaggagatggagaagcagaagactctgtaccaacaggcccgactc catgacagaggagcagcagagatggtcttacagatgatcagcgctagtaaaggtcatttg ggtccaatggtcacgttcacgctgaagctcggcatctccattctcaacggtggaaacatc acagtccagcagaaaatgctggactatttgaaggagaagcgagatgtgggtttcttcaag agtctgtcaggactgatgcagtcgtgcagtgttctggatctgaacgcgttcgagcgtcag aataaggccgagggtttggggatggtgactgaggaaggctccatcaacgtgagggagcgc ggctctaaagttcttcagaatgacgagttcaccagagatctgttcaggttcctgcagctc ctgtgtgagggacacaataacgacttccagaactttctcaggacgcagacaggaaacacg accacagtcaatataatcatcagcacagtggactatctgctcagactgcaggagtcaatc agtgatttttactggtattactctggtaaagacgtgatggacgaggcaggtcagcggaat ttctccaaagctctcgctgtagccaaacagatcttcaactcactcactgaatacatacag ggtccgtgtatcgggaaccagcagagtttggctcacagcagactttgggacgccgtcgtc ggatttctgcacgtcttcgccaacatgcagatgaagctgtcacaggactccagtcagatc gagctgctgaaggagctgatggatctgcagaaggacatgatagtcatgatgctgtcactg ctggaaggaaatgtggtgaatgggaccatcggcaagcagatggtggacactcttgtggag tcctccagcaacgtggagatgattctcaagttcttcgacatgttcctcaagctgaaagat ctaacaacctcggagaacttcaaggagcatgaccctgaccgtaaaggcgtcatctccaag aaggagttccagaagtccatggagaaccagaagcagtactctcagtccgagatcgagttc ctgctgtcctgcgccgaggccgacgagaacgacatgttcaactacgaagagttcgtcaat cgcttccacgaacccgccaaagacatcggcttcaacgtggcggttcttctcaccaatctg tcggagcacatgcctcatgattcccgactgtccaccttcctgaacctggccgagagcgta gtgaactacttcgagccctacctgggccgcatcgagatcatgggcggcggcaagagaatc gagagggtttacttcgagattagcgagtccagccgaacgcagtgggagaaaccgcaggtc aaagagtccaagcggcagtttatcttcgatgtcgtcaacaagggcggagaatctgagaag atggagctgttcgtgaacttctgcgaggacaccatcttcgagatgcagctagcgtctctg atctccgagccggacgctgctgagagacaagaggaggtcgatgatgaagatgatgctcgg agcgtggatctagacgaggacgatgaagatgccgcacaggagtcttcctcagcgttcgct ctggcctgcgtctccatgaggaagagtctgtccaacctgcggcagctgctgaccttcagg agcatgaggagacagtatcgcaagctgaggaagatgagcgtccgcgagatgatccgagga ttcttcttcttcttctggatgatcttcactggcatgttccgcttcctctacagcctggtc tggggcttcttccacatcctgtggtccacgctgttcggcggcggtctcgtggaaggagcc aagaacatgaaggtgacggacattctggggaacatgccggatcccacgcagttcgggatc cacggagacgttctggagctggagaagctggagtactgtgacgtgtcgtcggtggcggag ctggggcgcatgacggcgggagatcaggcggagatggagctcatgacggagctgatgtac atgcagcccaggagggaaggaggcaagcatggcatggagccggggctgggagacgtgtcc gaggtgatcggagtggacactccgtctttagccagcgccgtccatcagaagaaagctcag gaagctgccagtaaacagactgatgaatcagagaccaaatcagagtcggagaaggcagat gttgaggacagagagaagaaagaccaggacaagggtagagaggagagtgtgtcagactcg ctgacagacgaagagaagaagccgcagaagaagagacgcggccagaggaaggagcaggcc gaggccttcatggcggcgttcttagccagtctagacgtccatcagaccaaaaccctgaat tatctggccagaaacttctacaacctgcgattcctggctctgtttgtggcgtttgccatc aacttcatcctgcttttctacaaggtgaccggtgaggactctgatgatctggacccgtgg acgcggcgagaggaggatgatgaagctgcgctggagtattttgttcttcaggagagcaca ggttacatggctccgaccctgcgcttcctggccgtcatgcacaccgtcatctccttcctc tgtgtgctgggatattactatctgaaggtgccgctggtggtgttcaagcgtgagaaggag atcgcacgcaagctggagttcgatgggctctacatcaccgagcagccgtctgatgatgat atcaaaggccagtgggacagactcgtcatcaacacgccgtcgttccccaacaactactgg gacaagtttgtcaaacggaaggttattaataagtacggcaatctgtacggagccgagcgg atcgcggagctgctgggtttggacaaaagtgctttagacttcaatcccaccgaagagacg gtcattaaagacgcctcgctgctgtcctggttgagctccattgacaccaagtatcacgtg tggaagatgggcgtcgtgttcactgataactcgttcctgtatctggtctggtacaccacc atgtccatcctgggacattataataatttcttcttcgccgctcatctgctggacatcgcc atgggcttcaaaacactgaggaccatcctgtcctccgtcacacacaacggcaaacagctg gtgcttacagtcgggctgctcgctgtggtcgtgtatctctacaccgtcgtagcgttcaac ttcttccgcaagttttataacaagagcgctgacgaggacgagcccgatatgaagtgtgat gacatgatgacgtgttatctgttccacatgtacgtgggcgtccgtgctggcggcgggatc ggtgacgagattgaggaccccgcgggcgacccgtacgaactctaccggatcctgttcgac atcaccttcttcttcttcgtcattgtgatcctgctggccatcatacaaggtttgatcatc gatgcgtttggagagctgagagaccagcaggagcaggtcaaagaggacatggagaccaaa tgcttcatctgtggaatcgggaacgagtatttcgacacgacgccgcacggcttcgagact cacacgttacaagagcacaacctcgccaactacctatttttcttgatgtacctgatcaac aaggatgaaaccgagcacactggtcaggagtcgtacgtgtggaagatgtaccaggagcga tgctgggatttcttcccggccggagactgtttccgtaagcagtatgaagaccagctgggc tga

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