Carassius gibelio (silver crucian carp): 128025589 Help Entry 128025589         CDS       T08819                                  Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism cgib  Carassius gibelio (silver crucian carp) Pathway cgib04020   Calcium signaling pathway cgib04260   Cardiac muscle contraction cgib04261   Adrenergic signaling in cardiomyocytes cgib04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cgib00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     128025589    04020 Calcium signaling pathway     128025589  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     128025589    04261 Adrenergic signaling in cardiomyocytes     128025589  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cgib04040]     128025589    04990 Domain-containing proteins not elsewhere classified [BR:cgib04990]     128025589 Ion channels [BR:cgib04040]  Voltage-gated cation channels   Ryanodine receptor    128025589 Domain-containing proteins not elsewhere classified [BR:cgib04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    128025589 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR RIH_assoc Ins145_P3_rec Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 RBSN_mid Motif Other DBs NCBI-GeneID:  128025589 NCBI-ProteinID:  XP_052468028 LinkDB All DBs Position A12:complement(25571938..25649815) Genome browser AA seq 4870 aa AA seqDB search MYLCCLSTARSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYGNCSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECLTV PSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLS MMEDQGLLLMDKEKADVKSTAFCFRSSKEKLDFGLRKEVDGMGVPDIKYGDSVCFIQHVD TGLWLTYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFN RFIRGLDTLSKKGKTSSLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRALKSRQN LFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGESWKSILNSLYEHLAALIRGNRKN CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGT AQYRKWYYELIVDHVEPFVTAEATHLRVGWASTQGYGPYPGGGEGWGGNGVGDDLYSYGF DGLHLWAGCVARSVSSPNQHVLRAEDVVSCCLDLSAPSISFRINGQPVQGMFENFNSDGL FFPVVSFSSGVKVRFLLGGRHGEFKFLPPSGYAPCFEAVLPREKLRVEHSQEYKHDHGRT RDLLGPTVTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAV RDDNKRQHPCLVEFSRLPEQERSYNLQMSQETLKTLLALGCHVGVADERAAEKVKNLKLS AKYELSSGYKPAPMDLSHIKLASTQEAMVDKLAENAHNVWARDRIRQGWTYGVQQVSVCG LYRFQDIKNKRNPRLVPYVLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARADV CNLSAERFRIFRAEKTYSVSGGRWYFELEVVTAGEMRVGWARPGCQPDLELGSDDQAFVF DGFKAQRWHQGNEHFGRSWQSGDVVGCMVDMNERTMIFTLNGEVLLDDSGSELAFKDFEV WEGFIPVCSLGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDLTMWISKRLPQ FIPVPLNHEHIEVTRIDGTVESPPCLKVTQRSFGSQNSSTDIMFYRLSMPIECSEAFLRS ASGSFFSPKRDLEDFETVSDFEVLMKTPHSHMSSNGPDRERDEFNNHKDHNQEKPSKLKQ RFMLKRTKPEMTSSNSSSNARLSEEVLSEERDDCENLKQTSAYYYSVRIFPGQEPSSVWV GWVTSDFHQHDPAFELSTVRTVTVTLGDEKGKVHESIKRSNCYMVWGGECSSPSQGRSNN GLEIGCVVDTANGLLTFTSNGKELGTFYQVEPSTKLFPAVFAQATSPNVFQFELGRIKSV MPLSAGLFKSERKNTVPQCPPRLHVQFLTPVSWSRVPNQFLRAEVSRVSERLGWMVQSSE PLQFMTLHIPEENRSVDILELTEQRELLKFHYHTLRLYSAICALGNNRVAHALCSHVDEA QLLYAIQNKYMPGLLRTGYYDLLIDIHLSSYATARLMMNSEYIVPMTPETKSITLFPNEK KKHGLPGIGLSTSLQPRMRFSSPSFVGAVAGHHGNCFQYSPEFPLETLKSRTMEMLTEAV REGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKTILQLIEPSVFSQDGGESG GGASEPEDGCGRSQLEGGGAEKHDLKGKMPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVR HRIEAVVAFSDDFVANLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNF KDEKQDCPCPEDIREQLLDFHEDLMTHCGIETDDDKSGDGDDFTIRGRLMSLVEKVTYLK KKMTDIPKKKKSKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVR ALPKTYTINAVSVEDTISLLASLGQIRSLLSVRMGREEEKLMIHGLSDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVML MSRGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKISEDPSRDGPSPSTEESRTLNDIMEEEEDDTIHMGNAIMTFYAALIDL LGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLVGVISIPFLMPTLAKDGSVIEPDMSA GFCPDHKAAMVLFLDRVYGIEDQNFLFHLLEVGFLPDLRAAASLDTVSLSATDMALALNR YLCTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCG KLRPSMMQHLLRRLVFDVPVLNEHTKMPLKLLTNHYERCWKYYCLSGGWGSFGVASDEEL HLSRKLFWGIFDALARKKYEVELFKLALPCLSAVGGALPPDYMESNYMAMMEKQSSMDAE GNFNPQPADTSSVVVPEKLDHFINKYAEYSHEKWSMEKFAVGWVHGEQMCESSKVHPVLK PYKCLSEKDKEVYRWPIRESLKTMLSWGWSIERMRESDASTLHNRTRRISLSSQRSIEGA HGFSPRPVDMSNVTLSRDLHTMAELLAENYHNIWAQKKKLELESKGGGSHPLLVPYDTLT AKEKSRDREKAQDILKFFQINGYSVSRAMKEQDLDAPSIEKRFAYTFLQQLITYVDEAHT HMLEYDAGIRPKAEKIPHEQQFKFFGKVVLPLVDQYFKNHRLYFLSTAVRPISSGGHASN KEKEMVTSLFCKLAVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGQDSVKAALR MFFDNAAEDLEKTMENLRQGQFTHTRTQPKGVTQIINYTTIALLPVLSSLFEHIGQNLFG EDLILDDVQVSCYRILNSLYSLGTSKSIYVERQRPALGECLAAFSGAFPVAFLEPSLNRH NTFSIYNCKSSRERTALGLPAQVDEVCALVPSLERALEEIMELAESGMRYTQMPHVMEVL LPMLCSYMSHWWEHGPESVPERSESCCTSLTSEHMNTLLGNILKIIYNNLGIDEGAWMKR LAVFSQPIIGKARSQLLKTHFLPLMEKLKKKAATVLQDEEHMKAEGRGEMSESELLILDE FTVLVRDLYAFYPLLIRFVDYNRAKWLKEPNTEAEELFRMVAEVFIFWAKSHNFKREEQN FVVQNEINNMSFLITDTKSKMSKGAVSDQERKKMKKRGDRYSLQTSLIVAALKRLLPVGL NICAPGDQELIGLAKSRFTQKDTEDEVRETIRNNLHLQGKLEDPAIRWQMALYKDMPNRS ENTSDPEKTVHRVLNIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYN LPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGGEEPSEEDEMTKHIDPLHQLIQ LFSRTALTEKCKLEEDHLYMAYADIMAKSCHDEEEEDEEEVKSFEEKEMEKQKLLYQQAR LHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKRDVGFF QSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLRDDEFTCDLFRFLQLLCEGH NSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKEVIDEQGQRNFSKAI NVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQVNIYRHVLET QRSFCKYTIRERGYCDVLLLQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQM VDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYT QSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLQTFL ELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNE GGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSASKEDSEREKPEEKSPEMGFFSVTTV RTALFALRYNVMLLMKVLSMKSLKKQVKKAKKMTVKDMVTTLVSFYWSVLLGLLHFGFSV ARGFFRIVYNSFLGGSLVEDAKTMKVSELLANMPDPTQDEVRGETEESEKKPTDKTSPEE DLADLTVATDDTELLSDIFGLDLKREGGQYKLMPHNPNASLTDLLNTPIPPPPTPSPELR RRHQTKSSSSSADVSEAADETKAVPEKAEGENGEKAQKKKEEVVKRKVRQHYEPDLQESA FWKKIMAYQRKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSAVSEGKEVLFGSS SDTSVRWDPLTDASARPDAVHFVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPL VIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKY GEFYGHDRISELLGMDKAALDFSDAHEKKKPKRDSSLAAVLNSVDVKYQIWKLGVVFTDN SFLYLAWYMSMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV VYLYTVVAFNFFRKFYNKSEDGESPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGD EYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDY FDTVPHGFETHTLQEHNLANYLFFFMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDC FRKQYEDQLN NT seq 14613 nt NT seq  +upstreamnt  +downstreamnt atgtatctgtgctgtctgtctacagctcgctcatccacagacaaactagcatttgacgtg gggcttcaggaagacacgacaggtgaggcgtgctggtggaccatccacccggcctccaag cagaggtcagagggtgagaaggtgcgagtgggcgatgacctcatcctggtcagcgtgtcg tctgaacgatacctgcacttgtcgtatggtaactgcagtctgcacgtggacgcagctttc cagcagacgctctggagcgtggctcccatctgctccggcagtgaagtggctcagggcttc ctgattggtggagatgttctgcggctgctgcacggtcacatggacgagtgtttgaccgtc ccgtcaggagaacacggagaggagcagcgcaggacggtgcattacgagggtggagctgtg tccatccacgccagatccctgtggaggctggagacgctgcgagtggcgtggagcggcagt cacatccgctggggtcagccatttcggctgcgtcacgtgaccacagggaagtatctcagc atgatggaggatcaagggctgctgctgatggacaaggagaaagcagacgtcaaatcaacg gctttctgcttccgttcctcaaaagagaagctggactttggtctgaggaaggaggtggat gggatgggcgtcccggacatcaaatacggtgactcggtctgtttcatccagcatgtggac accgggctctggctcacgtaccagtctgtggacgccaagtgtgcgcggatgggtggagtt cagaggaaggccataatgcatcatgagggtcacatggatgacggtttgacgctctcacga tcacagcacgaggagtcacgcaccgctagagtcattcgcagcacagttttcctcttcaac cgcttcatcaggggtctagacactctgagtaagaaggggaagacgtccagcctggatctg cccatcgagtcggtcagtctgagtcttcaggatctgatcggatacttccagccgccggac gaacacctggagcacgaggacaaacagaaccggctgcgagcgctcaagagcagacagaac ctcttccaggaggagggaatgatcaacctggtgctggagtgtatcgatcgtctgcatgtg tacagcagtgcggctcattttgcagacgtggccggtaaagaggccggagaatcctggaag tccatcctgaactccctctatgagcatctggctgctctgatcagaggaaacaggaagaat tgtgctcagttttccggctctctggattggctgatcagtcgtctggagaggctggaagcg tcgtccgggattctggaggttctgcactgtgttctggtggagagtccagaagctctgaac atcattaaagaaggacacatcaaatccatcatctcactgctggacaaacacggacgcaac cacaaggtgctggacgtcctgtgttctctgtgtgtgtgtcacggtgtggccgttcgctcc aatcagcacctgatctgtgataacctgctgcccggcagagacctgctgctgcagacacga ctcgtcaatcacgtcagcagcatgaggcccaacatcttcctgggtgtgagtgaaggcacc gcccagtacaggaagtggtattatgagctgatcgtggaccatgtggagccgttcgtgacg gccgaagccactcacctgcgggtgggctgggcgtccacacagggctatgggccgtatccg ggcggaggagagggctggggcgggaacggtgtcggggacgacctctactcatacggcttt gatggactacacctgtgggcaggttgtgtggcgcgttcggtcagctcacccaatcagcac gtgctgcgggccgaggatgtggtcagctgctgtctggatctcagcgctcccagcatctcc ttccgcatcaacggccagccggtccagggaatgtttgagaacttcaactcagacggactc ttcttccccgtcgtgtccttctcctctggagtcaaagtgcgcttcctgttgggtggtcgt catggagagttcaagttcctgcctccatctggttacgctccatgttttgaggctgtttta cctcgagagaagctgcgtgtggagcacagtcaagaatacaaacatgatcatgggagaaca cgtgacctcctgggacccacagtcacactgtcacaggcagccttcacgccaacaccggtg gacaccagtcagatcgtgttgcctccacatctcgagcggatccgggagaagctggcagag aacatccatgagctgtgggtgatgaacaagattgagctgggatggacgtacggagcggtg agggatgataataaacggcagcatccgtgtctggtggagttctccagacttcctgaacag gagcgcagctacaacctgcagatgtctcaggagacactcaagactcttctggcgttgggc tgtcatgttggagtggcggacgaacgagccgctgagaaagtcaaaaatctgaagctttca gcgaaatatgagctgtccagcgggtataaaccagccccaatggacctcagccacatcaaa ctggcatctacccaggaggccatggtggacaagctggcagagaacgctcacaacgtctgg gcacgagaccgcatacgacagggctggacctacggcgtccagcaggtcagtgtgtgtgga ctgtacagatttcaggacatcaagaacaagagaaaccctcgtctggttccttacgttctt ctggacgagagaaccaagaaatctaacaaggacagtctgcgggaagctgtacgcacgctg ctgggatacggatacaacctggaggccccggatcaggaccacgcggcccgagcagacgtg tgtaatctgtccgcggagcgcttccggatattccgagcggagaagacgtacagcgtgagc ggagggaggtggtacttcgagctggaggtggtgacggcgggggagatgcgggtgggctgg gcgagaccaggatgtcagccggacctggagctgggctcagacgaccaggccttcgtcttc gatgggttcaaggctcagcgctggcatcagggaaacgagcacttcggccgctcctggcag tctggagacgtggtgggctgcatggtggacatgaacgaacgcaccatgatcttcacgctc aacggagaggtgctgctcgacgactccggctcggaactcgccttcaaagacttcgaggtt tgggaaggattcatcccggtctgtagtctgggcgtgtgtcaggtgggccggatgaacttt gggaaggacgtgagcacgctgaagtacttcaccatctgcggcctgcaggagggatacgaa cccttcgccgtcaacatgaaccgtgatctgaccatgtggatcagcaaacgtctgccccag ttcatccccgtcccgctcaaccacgagcacattgaggtcacgcggatcgacgggacggtg gagagcccgccgtgtctaaaggtcacccagaggtcgttcggctcacagaacagcagcaca gacatcatgttctatcgtctcagcatgcccatcgagtgctcggaggcgttcctgcgctcg gccagcggaagcttcttctctcccaagagagatctggaggacttcgagaccgtgtcagac ttcgaggtcctgatgaagacgccacacagtcacatgagctcgaacggacctgacagagag cgagacgagttcaacaaccacaaggatcacaatcaggagaagccctcgaaactcaagcag aggttcatgttgaaaagaacgaagcctgagatgaccagcagtaactccagcagtaacgct cgtctgtcagaggaggtcttgtctgaggagagagacgactgtgagaatctcaaacagaca tcagcgtattattactcggtgaggatcttccccgggcaggagccgtccagcgtgtgggtc ggatgggtgacctcagactttcatcagcacgacccggccttcgagctcagcacggtccga acggtcaccgttaccctgggagacgagaagggcaaagttcacgagagcatcaagcgcagt aactgctacatggtgtgggggggcgagtgcagcagtcccagtcagggccgcagtaataac ggcctggagatcgggtgtgtggtggacacagccaacggcctcctcaccttcacctccaac ggcaaagagctcggcaccttctaccaggtggagcccagtactaaactgttccctgcagtg tttgcacaagcaaccagtccaaacgtcttccagttcgaactgggacgcatcaagagcgtc atgccgctttctgcaggtctgtttaaaagcgagcggaagaacacggttcctcagtgtccg ccgcggctacacgtgcagttcctcacacctgtgtcatggagccgtgtgcccaatcagttc ctgagggcagaggtcagcagggtcagtgagagactgggctggatggtgcagagttcagaa ccactgcagttcatgacgctccatatacctgaggagaacaggtctgtggatatcctggag ctgacggagcagagagagctgttgaagttccactatcacacgctgcgcttgtattctgcc atctgtgctctggggaacaaccgtgtggctcacgctctctgcagtcacgtagacgaggcg cagctgctgtacgccatccagaacaaatacatgccgggtcttctgcgcaccggatactac gacctgctgatcgacatccacctgagcagctacgccacggctcgcctcatgatgaactct gagtacatcgtgcccatgacccctgagaccaagagcatcacgctcttccccaacgagaag aagaagcacgggctgccggggatcggcctgagcacctctctgcagccgcgcatgcgcttc tcctcgcccagcttcgtgggtgccgtcgccggtcaccacggtaactgtttccagtacagc cctgagttcccgctggagacgctgaagagccgcacgatggagatgctgacggaggcggtg cgggagggaagcttgcacgtgcgtgaccccgtgggcggcagcaccgagttcctgttcgtc ccgctcattaaactcttctacacgctcctgatcatgggcatcttccacaacggagacctg aagaccatcctgcagctcatcgagcccagcgtcttctcgcaggacgggggggagagcgga ggcggggcctcggagccagaggacggctgtgggcggagccagctggagggaggcggggcc gagaagcacgacctgaaaggaaagatgcccaaagaaggacttctgcagatgaagcttcct gaacccgtcaaactccagatgtgtcacctgctgcagtacctgtgtgactgtcaggtgcgt caccgcatcgaggctgtggtggccttctctgacgactttgtggcgaatcttcaggagaac cagcgtttccgctataatgaagtgatgcaggcactgaacatgtcagccgctctgacggca cgcaagaccaaagagttccgctctcctccacaggaacagatcaacatgctgctgaatttt aaggatgagaagcaggactgtccgtgtccagaggacatccgtgaacagctgctggacttc catgaagatctgatgacacactgtggtattgagacggatgatgataaatcaggagatgga gatgatttcaccatcaggggccgtctgatgtctctggtggagaaggtgacctacctgaag aagaaaatgactgatataccaaagaagaagaagtcaaagaaacccagcaccttgcagcag ctgatctcggagacgatggtgcgctgggctcaggagtcggtcatcgaggatcccgagctg gtgcgggccatgtttgtgttgctccaccggcagtacgacggcatcggcggtcaggtgcga gcgctgcccaagacctacaccatcaacgccgtctctgtggaggacaccatcagcctgctg gcgtctctgggtcagatccgctctctgctcagcgtcaggatgggccgcgaggaggagaag ctcatgatccacggcctcagtgacatcatgaataacaaggtgttctaccagcatccgaac ctgatgagagcgctcggcatgcacgagaccgtcatggaggtgatggtgaacgtcctgggt ggaggagagtccaaggaaatcacctttccgaagatggtggccaactgctgtcgcttcctg tgctacttctgtcggatcagccgtcagaatcagaaggccatgtttgatcacctgagctac ctgctggagaacagcagcgtgggtctggcgtctccgtccatgcgagggtccactcctctg gatgtggccgctgcgtctgtgatggacaataatgaactggctctggcgctgagagagccg gacctcgagaaggtggtccagtatctggccggctgtggtctccagagctgtgtgatgctg atgtctagaggatatcctgacatcggctggaacccggtggagggtgaacgttacctggac ttcctccggttcgcggtcttctgtaacggggagagtgtggaggagaacgctaacgtggtg gtgcggctcctgattcgccggcccgagtgttttggccccgccctgcgaggagaaggcggg aacgggctgctggcggcgatggaggaagccatcaagatctcagaagatcccagcagagac ggaccatcacccagcacagaggagagccggacgcttaatgacatcatggaggaagaggag gatgacaccatccacatggggaacgccatcatgaccttctacgccgctctgatcgatctg ttgggccgctgcgctccagagatgcacctgatccacgcggggaagggagaggccatccgt atccgggccatcctgcgctcgctcattcccattgaggatctggtgggagtgatcagcatc ccgttcctgatgcccacgctggccaaagacggttctgtgatcgagccggatatgtcagca gggttctgtcctgaccacaaagctgccatggttctgttcctggaccgtgtttatggcatc gaggaccagaacttcctcttccacctgctggaggtgggctttcttcctgacctcagagcc gccgcctcattggacacggtgtctctgagcgccacagacatggctctggctctgaaccgg tacctgtgcaccgcggtcctgccgctgctcaccaaatgtgctcctctgttcgccgggacg gagccgttcgcgtctctcatcgactctctgctgcacaccgtctacagactgtccaagggc tgctgtctgaccaaagcacagagagacgccatcgaggagtgtctgctggccgtgtgcggt aaactgcgtccctcgatgatgcagcatctgctgaggcgtctggtgtttgacgttcctgtg ctcaacgaacacactaagatgcccctgaagctcctgaccaatcactacgagcgctgctgg aagtactactgtctgtccggaggatggggaagcttcggcgtggcctcggacgaggagctg catctgtccagaaagctcttctgggggatctttgacgctctggccagaaagaagtacgag gtggagttgttcaagctggcgctgccgtgtctgagcgctgtgggcggagctttacctcct gattacatggagtcaaactacatggccatgatggagaagcagtcttccatggacgccgag ggaaacttcaacccgcagcccgccgacaccagcagtgttgttgttcctgagaaactcgat catttcatcaataaatatgcagaatactcccatgagaaatggtccatggagaagtttgcc gtcggatgggttcatggagagcagatgtgtgaatcatctaaagttcatccggtgctcaag ccctacaaatgtttatctgagaaggataaggaggtgtaccgctggccaatcagagagagt ctgaagacgatgctgtcgtggggctggagcatcgagaggatgagagagagcgacgcttcc acgttacacaaccgcacgcgccgcatctctctgtccagtcagcgctccatagagggcgct cacgggttcagcccgcggccggtcgacatgagcaacgtgacgctgtccagagacctgcat acgatggcggagctgctggccgagaactatcacaacatttgggctcagaagaaaaaactg gagctggaatccaaaggaggaggaagtcatccactactggttccttatgacactctaact gccaaagagaaatccagagaccgagagaaagcacaagacatccttaagttctttcagatc aacggatacagcgtctcaagggctatgaaggaacaggatctggacgctccgtctatagag aaacgcttcgcctacacgttcctgcagcagctgatcacgtatgtggatgaagctcacaca cacatgctggagtacgatgctggaattcgacccaaagcagagaaaatcccccacgagcag cagttcaagttcttcgggaaggttgtgctgccactggtggaccagtacttcaaaaaccat cggctctacttcctgtccaccgccgttcgtccaatcagcagcggcggccacgcctccaat aaagagaaggagatggtgaccagtctgttctgtaagctggccgttctggtgcggcaccgg atctcactctttgggaatgatgccacgtccatcgtgaactgtctgcacatcctgggacag acgctggacgctaggaccgtgatgaaaaccggccaggactctgtcaaagcggctctgagg atgttttttgataacgcagcagaagatctggagaagacgatggagaacctgcgacagggt cagttcacacacacacggacgcagcccaaaggagtcacacagatcatcaactacaccacc atcgctctgctgcccgtcctctcgtcgctgttcgaacacatcggtcagaacctgttcgga gaggatctcatactggatgatgtccaggtttcctgctatcggattctcaacagtttgtac tcgcttggaaccagtaaaagtatttatgttgagaggcagcgtccggctctcggcgagtgt ctggctgcgttttcgggtgcgtttcctgtggccttcctggagcccagtctgaacagacac aacacattctccatatacaactgcaagagctctcgagaacgaacagcgctcggtctcccc gctcaggtggacgaggtgtgtgctctggtgccgtctctggagcgagcgctggaggagatc atggagctggccgagtctggcatgcgttacacacagatgcctcatgtgatggaggtgctg ctgcccatgctgtgcagctacatgtctcactggtgggaacacggacccgagagcgtcccg gagcgctccgagagctgctgcacctcgctgacctccgaacacatgaacacactgctggga aacatcctcaagatcatctacaacaacctgggcatcgacgagggagcctggatgaagaga ctcgcagtgttctctcagcccatcatcggtaaagcgcgctctcagctgctgaagactcac ttcctgccgctgatggagaagctgaagaagaaggcggcgacggttctgcaggacgaggag cacatgaaggcggagggacgaggagagatgtctgagtctgagctcctcatcctggatgag ttcacggtcctggtgcgagacctgtacgccttctacccgctgctcatacgcttcgtggac tacaacagagcgaagtggctgaaggagccgaacactgaggcagaggagttattccgtatg gtggccgaagtcttcatattctgggccaaatcacataactttaaaagagaagagcagaac tttgtggttcagaatgaaatcaacaacatgtccttcctcataactgataccaaatccaag atgtccaagggagccgtgtcggatcaggagaggaagaagatgaagaagcgcggtgacaga tactccctccagacatcgctgatcgtcgccgctctcaaacgcttacttcctgtgggactg aacatctgtgcaccgggagaccaggagctgatcggactcgccaagagccgcttcacacag aaagacactgaggacgaggtgcgagagaccatacgaaacaacctccacctgcagggaaag ctggaggatcctgcgatccgctggcagatggcgctgtataaagacatgcccaaccgcagc gagaacacgtctgaccccgagaagaccgtccacagagtgctgaacatcgcacacgtgctc ttccacctcgatcaggtggaacatcctcagcgcagtaaaaaggccgtgtggcacaagctg ctgtccaaacagaggaagagagccgtagtggcctgtttcaggatggcaccgctttacaac ctgcccaggcacagagctgtgaacctgttcctccagggctatgagaagtcctggatcgag acagaagagcattactttgaggacaagctgattgaggatttggccaaaccgggtggagag gagccgtcggaggaggacgagatgaccaaacacatcgacccgcttcaccagctcatacaa ctgttcagcagaaccgcgctgaccgagaaatgtaaactggaggaggaccatctctacatg gcttacgctgatatcatggctaagagctgtcatgatgaagaggaggaggatgaagaagag gtcaagagttttgaggagaaagagatggagaagcagaagctgctgtatcaacaggcccga ctgcacgaccgcggcgcggcggagatggtgctgcagaccatcagcgccagcaaaggagag atggggccgatggtggcctccacgctgaagctgggcatcgctatcctgaatggaggaaac tccaccgtccagcagaagatgctggactacctgaaggacaaacgggacgtgggctttttc cagagtctggcggggctgatgcagtcgtgcagtgttctagatctcaacgccttcgagagg cagaataaagctgaaggtctcgggatggtgacggaggagggatcaggtgagaaggtcctg cgagacgacgagttcacctgtgacctcttccgcttcctgcagctgctgtgtgagggacac aactctgacttccagaactacctgagaacacagacggggaacaacaccacggtcaacatc atcatctccaccgtggattacctgctcagagtccaggagtccatcagtgacttctactgg tattactccgggaaagaggtcatcgatgaacaaggccagcgcaacttctccaaagcaatc aatgtagccaaacaggtcttcaacacgctcacagagtacatccagggcccttgcacgggg aatcagcagagtctggctcacagccgtctgtgggacgcagtcgttggtttcttacacgta ttcgcacacatgcagatgaagctgtctcaggtaaacatctacagacatgttctagaaaca cagcgaagcttctgcaaatacaccatcagagaacgaggttactgtgatgttcttctgctg caggattcgagtcaaatcgagctgctgaaggagctcatggatcttcagaaggatatggtc gtgatgctcttgtccatgttggaaggaaatgttgtgaacggcaccattggaaagcagatg gtggacatgttggtggagtcctcgaacaacgtggagatgattctgaagttcttcgacatg ttcctcaaactgaaagatctgacgtcgtcagacgccttcaaagagtacgaccccgacggc aaaggagtgatctccaagagagacttccacaaggccatggagagccacaaacattacacc caatccgagaccgagttcctgctgtcctgcgccgaaactgacgaaaacgagctcttggat tatgaggagttcgtcgaacgcttccacgagccggcgaaagacatcggcttcaacgtagct gtccttctaaccaacctctcggagcacatgccccacgactcacgcctgcagaccttcctg gagctggccgagagcgtgctgaactacttccagccctacctgggccgcatcgagatcatg ggcagcgctaaacgcatcgagcgcgtctacttcgagatcagcgagtccagtcgcacacag tgggagaagccacaggtcaaagagtccaagcgccagttcatcttcgacgtggtcaacgaa ggaggcgagaaggagaagatggagctcttcgtcaacttctgtgaagacaccatctttgag atgcagctggcggcgcagatgtcggacgccggagagcgctcggccagcaaagaggacagc gagagagagaaacccgaggagaagagtcctgagatgggctttttctccgtcaccaccgtg agaaccgctctgttcgccttacgatacaacgtgatgctcttgatgaaggtgctgtctatg aagagcctgaagaagcaggtgaagaaagccaagaagatgacggtgaaggacatggtgacc acactagtgtccttctactggagcgtcctgctgggactcctgcacttcggcttcagcgtc gctcgaggattcttccggatcgtttacaacagctttctgggaggcagtctggtggaggac gccaagaccatgaaggtgtcggagctcctggctaacatgcctgacccgactcaagacgag gtgagaggagagacagaggagagcgagaagaaacccacggacaaaacctccccagaggaa gacctggccgatctgacggtggccacagacgacaccgagctcctctctgatatattcggt ttggatctgaagagagaaggagggcagtataaactgatgcctcacaatccgaacgctagc ctcacggatctgctcaacacacccatccctcctccacctacaccgtcaccagagctgcgc aggagacaccagaccaagagctcttcatcctcagcagatgtcagtgaagctgcggacgag accaaagctgtgcctgagaaagcagaaggggaaaacggagagaaagcacagaagaagaag gaggaagtggtgaagcgtaaggtcagacagcactacgagcctgatctgcaggagtcggcc ttctggaagaagatcatggcttaccaacgcaagctgctgaactacttcgcacgaaatttc tacaacatgagaatgttggctttgtttgtggcctttgcaatcaacttcattctgctgttt tacaaggtgtccacgtcctcggccgtctccgaggggaaggaggtgttgttcggctcgtct tcagacaccagtgtgcgctgggatcctctgacagacgcgagcgctcggcctgacgctgtg cacttcgtgctggaggagagcagcggctacatggagcccacgctgaggatcttagccatc ctgcacaccgtcatctccttcttctgcatcatcggctactactgcctgaaggttcctctg gtgatattcaagcgtgagaaggaagtggccaggaagctggagttcgacggtctgtacatc actgagcagccctcggaggacgatattaaaggccagtgggaccgactggtcatcaacaca cagtccttcccaaacaattactgggataagtttgtgaagcggaaggtgatggataagtat ggagagttttatggacatgatcggatcagtgagctgctggggatggataaagctgcgctg gacttcagtgacgcacatgagaaaaagaaaccaaagagagacagttcactggccgcagta ctgaactctgtggatgtgaagtatcagatctggaagctgggcgtggtcttcactgataac tcgttcctgtatctggcctggtacatgagcatgtccatcctcggacactacaacaacttc ttcttcgccgcccacctgctggacatcgccatgggcttcaagaccctcagaaccatcctg tcctccgtcacacacaacggcaaacagctggtcctgaccgtcggtctgctggcggttgtg gtctatctctacactgtggtggctttcaacttcttccgtaaattctacaacaagagtgaa gatggagaatcaccagacatgaagtgtgacgacatgctaacgtgctatatgttccacatg tatgttggcgtgcgagccggcggaggcatcggggatcagatcgaagatccagccggtgac gagtacgagatctaccgcatcatctttgacatcaccttcttcttcttcgtcatcgtcatc ctcctggccatcattcagggtctgatcatcgatgcgttcggagagctgagagaccagcaa gagcaggtgaaagaagacatggagacgaagtgcttcatctgtgggattggaaacgactac ttcgacacggttcctcacggcttcgagacacacacgctgcaggaacacaacctggccaac tatctatttttcttcatgtatctcatcaacaaggatgaaacggagcacacaggccaggag tcgtacgtttggaaaatgtaccaggaacgatgctgggaattcttccctgctggagactgt ttccggaaacaatacgaggaccagctcaattaa

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