Colletes gigas: 122397745 Help Entry 122397745         CDS       T07492                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism cgig  Colletes gigas Brite KEGG Orthology (KO) [BR:cgig00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cgig04040]     122397745    04990 Domain-containing proteins not elsewhere classified [BR:cgig04990]     122397745 Ion channels [BR:cgig04040]  Voltage-gated cation channels   Ryanodine receptor    122397745 Domain-containing proteins not elsewhere classified [BR:cgig04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    122397745 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 CFAP143 baeRF_family6 Serglycin DUF996 Motif Other DBs NCBI-GeneID:  122397745 NCBI-ProteinID:  XP_043253045 LinkDB All DBs Position Unknown AA seq 5120 aa AA seqDB search MADSEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGSETQQESLGKGTGSGHRTLLYGNAILLRHQNSDMYLA CLSTSSSNDKLAFDVGLQQHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENDLSVVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSSW STSTNQNIVIYEGGSVMSQARSLWRLELARTKWAGGFINWLHPMRIRHLTTGRYLGVKEN NELYLVDRNEGTIETSTFWLRQEKDDQKIILEDKDLEVIGMPIIKYGDSTVIMQHATTCL WVSYKSYETKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTQF ITGLETLQVDRRASMFFQNVNLNEMVMCLEDLINYFAQPEDDMEHEEKQNRFRALRNRQD LFQEEGILNLILEAIDKINVITSQGFLVALSGDESGQAWDQISGYLYQLLAAIIKGNHTN CAQFANSNRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEK HGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTQLVDHVASIRPNIFVGR VEGSALYQKWYFEVTVDHIEQTTHMMPHLRIGWANTAGYMPYPGGGEKWGGNGVGDDLYS FGFDGAHLWTGGRKTQVVLNATEPYIRKSDVIGCALDLTVPIITFTFNGAPILGSFRNFN LDGMFFPSISCSSKLSCRFLLGGDHGRLKFQPPEEFSPLVESLLPQQILSLDPCFYFGNM NKVVLAGPWLVEDDTAFVPAPVDTSMINLPSYVEQIRDKLAENIHEMWAMNKIEAGWIYG EHRDDLRKIHPCIVQFERLPAAEKRYDTQLAVQTLKTILALGYYITMDKPPSRIKTLRLP NEPFMQSSGYKPAPLDLTAISLTPKMEELVDQLAENTHNLWAKERISQGWTYALNEDSEM RRSPHLVPYPKVDEAIKKANRDTASETVRTLLVYGYMLEPPTGEQHEALLLEASRLRQSS FRTYRVEKHYAVSSGKWYFEFEVLTAGPMRVGWAKAECMPGSMLGSDENTWAFDGYNEEK VYSGTAETFGKQWQVGDVVGVFLDLIDRTISFSLNGELLMDALGGETSFADVQGDCFVPA FTLGVGQKAKLTFGQDVNTLKFFTTCGLQEGYEPFCVNMNRPVTFWFTKDQPIFENTDDM ADTRIDVARIPAGSDTPPCLKISHNTFETMEKANWEFLRLSLPVICQSTFVSESEKLRRW QEIKMRQNRLLSEQVEQAQQAAPSAHMEQIMKSGFSMSDIKGLQRNYSEDAVEADEMMKE SPLPMQRNKPTRPPRKGSLYGSRVGNMENAISETEMNGYGDMNGDVKDDKKKRGRSPFRK LSKEMEDAPFFSRKAKSPDAKSKTPEPPVRSDVSDKSTKTLQMNKASSRPPQVRISNTDL KVIPPQIPERNAPKAMSVLSGSGVEAIGNEIYDAECLKLMNEYFYGVRIFPGQDPTHVYV GWVTSQYHLHTKDFNLSRVRKGSVVITDDYERPVEQVDRQSCYMVRADELYNEVTQDASG KGASQGMFVGCFVDTATGWVSFTCEGKETSHKFKMEPDTKLFPAIFVEATSKEILQIELG RTSTTLPLSAAVLQNSERHVIPQFPPRLKVQCLKPHQWARVPNQSLQVHALKLSDIRGWS MLCEDAISMLALHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAAHALCQ HVDQKQLLYAIRAEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYIIPLGQELKELYE NEEMRHSLRYLETESVRPQMKMTDISDQTIENIRSLYSPHFPLDVVRDYVMEALNEAVEV NQVHNRDPIGGSNENLFLPLLKLVDRLLLVGMLRNEDIMKLLIMIHPETWDPTFDKEGKD EHKKGLLHMKMAEGAKLQMCYLLHHLNDIQLRHRVESIIAFSHDFVGDLQSDQLRRYIEI KQSDLPSAVAAKKTKEFRCPPREQMNSILSFKNMDFADDPDNVPCGEDLIGRMNEFHTNL MSYVSLHALQDAADAANEPEEDVQKPGAMKKLFNFINAVKELEEEPKPEPEPERKTPEEV FRKVLISTIVSWAEESQIETPKLVREMFSLLVRQYDTVGELIRALEKTYVINSKTRDDAA LMWVGLSQIRALLPVQMSQEEEELVRERLWKLVNNHTFFQHPDLIRVLRIHENVMAIMMN TLGRRAQAQSDAQTQPQTTEGEPASKEKDTSHEMVVACCRFLCYFCRTSRQNQKAMFDHF DFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSRCGLQSNS ELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPALRGE GEGLLRAIIDANKMSERIADRRKVHDEAEGTSMMQFEHPLPESDDDEDYIDTGAAILNFY CTLVDLLGRCAPDSSVIEQGKNESLRARAILRSLVPLDDLQGVLSLRFTLLNPAAGEEKP KSDMPSGLIPGHKQSIVLFLERVYGIETQELFFKILEEAFLPDLRAATMLDRNDGYESDM ALAMNRYIGNSILPLLIKHSKFYNEADNYASLLDATLHTVYRLSKNRMLTKGQREAVSDF LVALTSQMQPSMLLKLLRKLTVDVSKLSEYTTVALRLLTLHYDRCAKYYGSTGGQGAYGA SSDEEKRLTMVLFSNIFDSLSKMDYDPELFGKALPCLTAIGCALPPDYSLSKNYDDEWYG SKSASTQSPDGPYNPQPINTSSVVLNNDLNQIVQKFSEHYHDAWASRKLENGWTYGEQWS DANKTHPRLKPYNMLNDYERERYKEPVRESLKALLAIGWSVEHAEVDVPSTNRSSMRRSS KSQGDAANPFNYNPHPVDMTNLTLSREMQNMAERLADNAHDIWAKKKKEELITCGGGIHP QLVPYDLLTDKEKRKDRERSQEFLKYLQYQGYKLHKPNRGGESEVTTAGASVELRFAYSL LEKLIAYLDKATINMKLLKPSDTFSRRNSFKTSTRDIKFFSKVVLPLMEKYFSTHRNYFI AVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAAFGPDVRITVRCLQVLVKGIDAKS LVKNCPEFIRTSMLTFFNNTADDLGHTILNLQEGKYSHLRGTHLKTSTSLSYINSVVLPV LTAMFDHLAACEYGSDLLLDEIQVASYKMLASLYTLGVDSSLTHDRKYLKTEIERHKPNL GSCLGAFSSCFPVAFLEPHLNKHNQFSLLNRIADHSLEAQDIMSKMESSMPTLETILGEV DQFVESDKTYNDLPQVVDVILPLLCSYLPFWWSQGPDNVNPTEGTYVSMVTSDHMNQLLK NVLKLTKKNIGNENAPWMTRIAAYTQQIIINSSEELLKDPFLPLAERVRKRTDNMFHKEE SLRGFIKSSTDDTSQVEAQIQEDWQLLVRDIYSFYPLLIKYVDLQRNHWLRNNISEAEDL YNHVAAIFNIWSKSQYFLREEQNFISANEIDNMVLIMPTATRRPAAISDGTAPSGGGKKK KKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRFLKKMPEYDIAE FAKTQLTLPDKIDPADEMSWQHYLYSKLGQKKDSMEPVKAQQLEDVVARITDMAKVLYGL HMIDHPQQQSKGQYRSVVSIQRKRAVIACFRQTSLHSLPRHRAINIFARTYYELWLQDEN VGQEVMIEDLTQSFEDAELKKMDKAEDEGKPDPLTQLVTTFCRGAMTERSGALQEDPLYM SYAQIISKSCGEEEEEGEDEGGGGEEEGGASIHEQEMEKQKLLFHQTRLANRGVAEMVLL HISACKGLPSEMVMKTLELGISILRGGNIEIQRGMLNHLKEKKDVGFFTSIAGLMNSCSV LDLDAFERNTKAEGLGVGSEGAAGEKNMHDAEFTCALFRFIQLTCEGHNLDWQNYLRTQA GNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELIDPAGKANFFKAIGVASQVFNTLTE VIQGPCAQNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMM LSMLEGNVVNGTIGKQMVDTLVESAGNVELILKYFDMFLKLKDLVSSPSFLEVDLNSDGW VYPKDFKEKMEQQKSYTDEEIEFLLACCETNHDGKIDYVAFMDRFHEPAKEIGFNLAVLL TNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEILGGNKKIERVYFEIKESNIEQWEK PQIKESKRTYFYNTVVEAGEKEKLETFINFCEDAIFEMQHASALMAVEESGGIGKARESS YTYMTDDDEERNKDPIRRGIQTFKDSIYFFFSIFSPSNIKNKIAEMQQMTILELFIGFFK MIFYAFYYSGFGFGCILGYFMRLLLALMKGPHVEEPVVEVKEEEEKPSRHLPALPPTPDE SNLQVQAFGMDITKEEGGQIKIAPHESAASTPQSSIEETGESTPEEAAGEEGARAEAGTG DSEAPVSLADLLGGEQARAQAAAAAEAAAAQQAAMAAVEAEAKHETTTETSSSSIDFSEY THRIVSFLARNFYNLKYVALVLAFCINFMLLFYKVSSLAGDSDEEGSGQVMADILAEMSG EGPSGSGSGSGVEMGSGSGEDESEEEEDAYALEYVEVSEDFYYMAHVMRLMACLHSIVSL AMLVAYYHLKVPLAIFKREKEIARRVEFDGLYIAETPEEDDIKAHWDKMVISAKTFPVNY WDKFVKKKVRQKYSETYDFDYISNLLGMEKTSFSQQEEEGSGLIHFIVNIDWRYQVWKAG VTITDNAFLYSLWYFIFSILGNYNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTV MLLTIVVYIYTVIAFNFFRKFYIQEEDDEVDKKCHDMLTCFVFHLYKGVRAGGGIGDEIG EPDGDDYEVYRIMFDITFFFFVIVILLAIIQGLIIDAFGELRDQLENVKTNMESNCFICG LGKEYFDTVPHGFDTHVQQEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRCWDFF PVGDCFRKQNEAVEDEAKKK NT seq 15363 nt NT seq  +upstreamnt  +downstreamnt atggctgacagcgagggcggctccgagcaggatgacgtatccttcctccgcacggaggat atggtgtgtctgtcctgcaccgcaacgggcgaaagggtttgcctcgcggccgagggtttc ggtaacaggcactgcttcctcgagaacatcgcagacaagaatatacctccggatctgtcg caatgcgtattcgtgatagaacaagctctctcggtgagagcgctgcaggaattggttact gctgccggttccgagacgcagcaagaaagtttaggaaaaggcaccggatccgggcacaga acgttattgtacggcaatgctattctgttgaggcatcagaacagcgacatgtatttggct tgtctatcgactagttcgtccaacgacaagttggctttcgacgtcggtctgcaacaacat tctcaaggggaggcatgctggtggacggtgcatccagcgtcgaaacagaggtccgagggt gaaaaggtccgagtcggtgacgacctcattctagtatccgtggccaccgagagatacttg cacactacgaaagagaacgatctgtcggtggtgaacgcctcgttccacgtgacccattgg tcggtgcaaccgtacggtactgggatcagccgaatgaagtacgtcggttacgttttcggc ggcgatgttctccgatttttccacggcggtgacgagtgcctcactataccgtcgtcctgg agcacatcgaccaaccaaaatatagtgatctacgaaggaggaagcgtaatgagccaggcg cgatctttgtggaggctggagctggcgaggacaaaatgggcgggcggtttcataaattgg ctacacccgatgaggatcaggcacctcaccaccggacgttatctaggcgtgaaagaaaac aacgaactgtatctggtcgataggaacgaggggacgatcgagacgtcgacgttctggctg cgacaggagaaggatgaccagaagatcattctcgaggataaggacctcgaagtcatcggt atgccgattatcaagtatggtgactcgactgttatcatgcagcatgccactacttgtctc tgggtctcgtacaagtcgtacgagacgaagaagaagggcgtgggtaaggtagaggagaag caagcagtacttcacgaggaaggaaagatggacgacggtttggacttctcccggtcgcaa gaagaggagtcacgcacggcgcgagtaattcgaaagtgcagcagcttgttcacgcagttc atcacaggcctagagacgctgcaagtagatagaagagcgtctatgttcttccaaaatgtc aatctgaacgaaatggtgatgtgtctggaagacttgattaattattttgctcaacccgag gacgacatggaacacgaggagaaacagaacaggttccgtgctctgaggaatcgtcaggac ctgttccaagaggagggtatactgaatctcattctggaggccatcgacaagatcaacgta atcacatcgcaaggtttcctcgtggcgctttcgggcgacgagagcggccaggcctgggac caaatatccggatacctgtatcagctgctagccgccatcatcaagggaaatcacacgaac tgcgcgcaattcgccaacagcaatcgtttgaactggctgttcagtcgccttggctcgcag gcgtccagcgagggcactgggatgctggacgtcctccactgtgtcctcatcgactcgcca gaggctctgaacatgatgagggacgaacacatcaaagtcatcatctcgctgctggagaag cacggaagggacccaaaagtcttggacgtcctttgctcgctgtgcgtgggtaacggcgtc gcggttcgatcgtcgcagaacaacatatgcgacttcctgctgccagggaagaatcttctc cttcaaacccagctggtggaccacgtggccagcatcagaccgaacatattcgtcggcaga gtcgagggatcggcgctttatcagaagtggtacttcgaagtcaccgtcgaccacatcgag cagaccacgcacatgatgcctcatttgagaataggctgggcgaacacggcagggtacatg ccgtatccaggaggaggcgaaaaatggggtggcaacggcgtgggcgacgatctttactcg ttcggtttcgatggcgcgcacctgtggaccggtggcaggaaaactcaggtggtcctcaac gccacggagccttacatcaggaagagcgacgtgatcgggtgcgctttggatctgacggtt ccgatcatcacgttcaccttcaacggagcgcccatccttggatcgttcagaaacttcaac ctggacgggatgttcttcccctcgatcagttgctcctcgaaactgtcctgcagattcctc ctgggaggcgaccacggtcgtctaaagttccagccccctgaagaattttcgcccttggtg gagagtctgttgccccagcagatcctgtcgctggacccttgcttctatttcgggaacatg aacaaggtggtgttggctggcccgtggctggtcgaagatgacaccgctttcgtccccgcg ccggtcgacacgtccatgatcaacctgccgtcctacgtcgaacagatcagggacaaactg gcggagaacatccacgagatgtgggcgatgaacaagatcgaggccggatggatctacggg gagcacagggacgacctgaggaagattcatccctgcatcgtgcagttcgagaggctaccg gctgcggagaaacgctacgacacacaactggccgtgcagacgctgaagaccatcttggcc ctgggatattacataaccatggacaaaccaccgtccagaataaagaccttgaggcttccg aacgaaccctttatgcagagcagcggttacaagccagctcctctggacctcaccgccatc tcgctcactccaaagatggaggaactggtggatcagctggcagagaacacacacaatttg tgggcgaaggagaggatcagccaaggctggacttacgcgctgaacgaagactccgagatg aggaggagccctcatctggtgccgtatccgaaagtagacgaagccatcaagaaagctaat cgcgacaccgccagcgaaaccgtcaggacgctgttagtttacggatacatgctggaacca cccacaggggagcagcacgaagcgctactgctggaggcgagcagactacgacaatcgtcc ttcaggacctatcgagtcgagaaacactatgctgtaagcagcggaaagtggtacttcgag ttcgaggttctaaccgctggtccaatgcgcgtaggttgggccaaagctgagtgtatgcct ggaagcatgctgggaagcgacgagaacacttgggctttcgacggttacaacgaggaaaaa gtatactcgggcacagccgaaacatttggcaaacaatggcaggttggagacgttgtcggg gtattcctggatctaattgaccgaacgattagcttttctctcaacggagaattgctgatg gacgcgctcggtggtgaaacgtctttcgccgacgtgcagggcgactgttttgtcccagct ttcacgctcggggttggccaaaaagcgaaattaacattcggacaggacgtcaacactctc aagttcttcacgacttgcggtttgcaagaaggatacgagccattttgcgtaaatatgaat cgcccggtgacattttggttcacgaaggatcagccgatcttcgagaacacggacgacatg gccgacacgaggatagacgtcgccagaataccagccggttccgatactccgccatgcctg aagatctcccacaacaccttcgagaccatggaaaaagcgaactgggaattcctacgattg tcgttgccagtcatctgtcagtcgacgttcgtctccgagagtgagaagttacgaagatgg caagagatcaagatgcgtcagaacagactgctgtccgagcaagtggaacaagcgcaacag gccgcgccatcggctcacatggagcagatcatgaagtctggcttcagcatgagtgacatt aaaggattgcagaggaactattcagaggatgcagtggaagctgacgaaatgatgaaggag tcgccgttgcccatgcagagaaacaaacccaccagacctcctagaaaaggttccctttat ggttcgagggttgggaacatggagaacgccatcagcgagactgagatgaacggatacggc gacatgaacggcgacgtgaaggatgacaagaagaagcgtgggcgttcaccgttccgcaaa cttagcaaagagatggaggatgcaccgttcttctcgcgcaaagcgaagtccccggacgcg aaatcgaaaacgcccgaaccaccggtgcgctccgacgtctccgacaaaagcaccaaaact ctgcagatgaacaaagcaagtagccggccacctcaagttcgcatatcaaacacggacttg aaggtgataccaccgcagatcccggaacgcaacgctccgaaagcgatgtccgttttgagc ggatctggcgtcgaggcgattgggaacgaaatatacgacgcagagtgtctgaagctgatg aacgagtacttttacggggtgaggatcttccctggacaggacccaactcacgtttacgtt ggttgggtcacgtctcaataccacctacacaccaaggacttcaatttgtctcgcgtgaga aagggatcggtggtcatcaccgacgactacgaacgtcccgtggaacaagtggacagacag agttgttacatggtgagagcagacgagctctacaacgaagtcacgcaggatgcttccggt aaaggagcgtcccagggaatgttcgtcggttgtttcgtggacacagctacaggttgggtg tccttcacctgcgagggcaaggagaccagccacaagttcaaaatggaaccggacacgaag ctgttccccgccatcttcgtggaggccaccagcaaagagatacttcaaatcgagctaggc agaacctcgaccacgctgccgttgtccgcggccgttttgcagaactctgaacgccacgtt atcccgcagttcccgcccaggttgaaggtgcaatgcttgaaaccccaccagtgggccaga gtgcccaatcagtcgctccaggtgcacgctttgaagctctccgacatcagaggctggtcc atgctgtgcgaggacgcgatatcgatgctggccctgcacatccccgaggaggacaggtgc atcgacattttggagctcatcgaaatggacaaattactcagcttccacgcgcacaccctg acgctgtatgcagctctgtgctatcagtcgaactacagagcagcccacgctctgtgccaa cacgtcgaccagaaacaactgttgtacgctatccgagcagagtacatgtccgggccccta cgacaaggattctacgacctgctgatcgctctgcacctcgagtcgcacgcaacgacgatg gaagtgtgcaagaacgagtacattattcctctaggtcaggaattgaaggagttatacgaa aacgaagagatgaggcacagcctcaggtacctggagaccgagtccgttcgtccccagatg aaaatgacggacatcagcgaccaaacgatcgagaacataaggagcctctacagtccgcac ttcccgctggacgtggtgcgagattacgtgatggaggctttaaacgaagccgtcgaggtc aatcaagttcacaatcgagacccgatcggcggcagcaatgagaatcttttcctgccgctt ttgaaactcgttgatagactactcctagttggaatgcttaggaacgaagatatcatgaag cttctcatcatgattcatcctgaaacttgggaccctacgttcgacaaagagggaaaagac gagcacaagaagggactactccacatgaaaatggcggagggagcgaagctgcagatgtgc tacctgcttcatcatctgaacgacatccagctacgacatcgcgtcgagtccatcatcgcc ttcagccacgacttcgttggcgacctgcagtccgaccagcttcgtcgttacatcgagatc aagcagtccgatttaccgtcggcggtggccgccaagaagaccaaggagtttcggtgccct cctcgcgagcagatgaactcgattctgagcttcaagaacatggacttcgcggacgatccg gacaacgtgccctgcggagaggatctgataggcaggatgaacgaattccacaccaatctg atgtcttacgtgtccctgcacgcgcttcaagacgctgctgacgccgccaacgagccggaa gaagacgttcagaagcctggcgctatgaagaaactgttcaacttcatcaacgctgtgaaa gagttggaggaggagcccaagccagaacctgaaccggaaaggaagactccggaagaggtg ttccgtaaagtcctcatatcgaccatcgttagctgggccgaggaatcccagatcgagact ccgaagttggttcgagagatgttcagtctattggtgcgtcagtacgacaccgtgggcgaa ctgatcagagctctggagaagacgtacgtgatcaacagtaaaacgagagacgacgctgcc ctgatgtgggtcggtctgagccagattcgcgcgttgctgcccgtccaaatgtctcaggag gaagaggagctggtcagagagcgactctggaagttggtgaacaatcacaccttcttccag catccggatctgatcagagtgctgaggattcacgagaacgtgatggcgatcatgatgaac acgctgggcagacgcgcgcaggctcagtctgacgctcagacgcagcctcaaaccacggaa ggcgaaccagcttccaaggaaaaggacacgtctcacgagatggtggtagcctgctgtaga ttcctttgctatttctgtcgcacgtccaggcagaaccagaaggcgatgttcgatcatttc gactttctcttggagaacagtaatattttgctgtcgaggccatctttgagaggatccacg cccttggacgtggcttactcctcgctgatggagaacacggaactcgcgttggcgctcagg gaacactatctcgagaaaatcgccatctatttgtcccgttgtggcttgcaatcgaactct gaactcgtggagaaaggttaccctgatctgggatgggatccggtggagggtgaacgatat ttggacttcttgagattctgcgtttgggttaacggcgaaagcgtcgaggaaaacgcaaat ctggtgatacgtttgctgatcagaagaccagaatgtttgggaccagcccttcgaggtgag ggcgaaggtttattgagggccatcatagacgccaacaaaatgtccgaacgcatcgctgat cgacgaaaagtgcacgacgaagcggaaggtacatcaatgatgcagttcgagcatcccctc ccagaatcagacgacgacgaagactacatagacactggagcagcgatcttgaacttctac tgtaccctggtagatctattaggacgctgtgctcctgattcgtccgttatcgaacaaggg aagaacgagtctctgagagcaagggctattctgcgttctctggtgcccctcgacgaccta cagggtgtcctgtctctgaggttcaccctgctgaatccagcggctggcgaagaaaaacca aagagcgacatgccgtcaggtttgatcccaggacacaagcaaagcatcgtcctgtttttg gaacgcgtttacggcatcgaaacgcaggagctgttcttcaagatactcgaggaagctttc ttgcccgacctgagagccgccactatgctcgacaggaacgatggttacgaatccgacatg gccctggcgatgaaccgttacataggaaacagtattctgcctctgctgatcaagcattcc aaattctacaacgaggcggacaattacgccagcttactggacgccacgctgcacaccgtc tatagattgagcaagaacagaatgctaacgaagggtcagcgagaggctgtgtcggacttc ctcgtggcactgaccagccaaatgcaacccagcatgctgttgaagctactccgaaagttg accgtggacgtgtccaagctctcggaatacactacggtcgctctacggttgctgactctg cattacgatcgttgcgcaaaatactacggatcgaccggtgggcaaggcgcgtacggtgca tcgagcgacgaagagaaacgtttgaccatggttctcttcagcaacatattcgactcgctg tctaaaatggactacgatccggaattgtttggaaaggctctgccttgtctcacggccatt ggttgtgctctgccgcccgattattccttgtctaagaactacgacgacgagtggtacgga agcaaatccgcgtccacgcaatcgcccgatggaccctacaatccgcaaccaatcaacacc tctagcgtggttctcaacaacgatcttaatcaaatcgtacaaaagttctccgagcattat cacgacgcttgggccagccggaagctagaaaacggttggacttatggcgaacagtggtca gatgcaaataaaactcatcctagactgaaaccgtacaacatgctgaacgattacgagagg gaacgctacaaagaaccggtcagggagagcttgaaagctttgttggctataggatggagc gttgaacacgccgaggtggacgtaccttcgaccaatcgtagttctatgagacgatcatcg aaaagtcaaggtgatgctgcaaatccgtttaattacaatcctcatccggtcgatatgacg aacctgacgctgagcagagagatgcagaacatggccgagcgtctcgcagacaacgcacac gacatctgggccaagaagaagaaggaagagctcatcacttgcggaggtggcatccaccca cagttggtaccgtacgatctgctcaccgacaaagagaaacgaaaggatcgcgaacgttcc caggagttcctcaagtatttgcagtatcaaggatacaagcttcacaaacctaatcgaggc ggtgaatccgaggttactaccgctggtgcctccgtggaactacgattcgcctactcgttg ctggagaaactgatagcttatttggacaaagcgacgatcaacatgaaactgttgaaaccg tccgacacgttcagtcgacgcaacagtttcaagacatccacgcgggacatcaagttcttc agcaaggtggtcctgccgttgatggagaagtatttcagcactcacaggaattatttcatc gccgtggccacggctaccaacaacgtcggggcagcgtccttgaaggagaaggaaatggtg gcagcccttttctgcaaattggccagcttgctcaggtccagactcgctgctttcgggcct gacgttaggatcaccgtccgttgtcttcaggtgctggtcaaaggcatagacgcgaagagc ttggtgaagaactgccccgagttcattcgaacgtccatgttgaccttcttcaacaacacc gctgacgatctggggcacacgatcctgaatcttcaagagggcaaatacagccacctcaga ggcacgcacttgaaaacctcgacgtccttgtcgtacatcaacagcgtcgtcttaccggta ctcacagccatgttcgatcatctggctgcatgcgagtatggcagcgatctgttactggac gaaattcaagtggcgtcctacaaaatgctggcgtccctgtacaccctgggcgtggattcg tccctgacgcacgacagaaagtacttgaagacggagatcgaacgccacaagcctaacttg ggctcctgtctgggcgcgttttcgagttgcttccccgtagccttcctggagccgcatctg aacaagcacaatcagttttcccttctgaatcgtatcgccgaccattccttggaagcccag gacataatgtcgaagatggagtcgagcatgccaacgctggaaacgatcctgggagaggtt gatcagttcgtcgagtccgataagacctacaacgatcttccacaggtggtcgacgtcatt ctgcctctgctttgctcctatttgcccttctggtggtcacagggaccggacaacgtgaat ccaacggagggaacgtacgttagcatggtcaccagcgatcacatgaaccagcttctgaag aatgttttgaaattgaccaagaagaacattggcaacgagaacgctccgtggatgacacgt atcgccgcgtatactcaacagatcatcatcaactcgtcggaggagctgctgaaggatccc ttcttgccactcgctgaacgcgtcaggaaacgcaccgataacatgttccacaaagaagaa tctttacgaggttttatcaaatcgtccaccgacgatacgtcgcaggtcgaggctcagatt caggaggactggcaactcttggttcgcgatatctactcgttctatcctcttctgatcaag tacgtcgatctgcagaggaatcactggctgaggaataacatctccgaggccgaggacctt tacaatcacgtggcggcgatatttaacatttggtccaagtcccagtacttcttgcgggag gaacagaacttcatatccgcgaacgagatcgataacatggtgctcattatgccaacggcg accaggaggcctgccgctatttccgatggaactgcaccatccggcggaggcaagaaaaag aagaaacaccgtgacaagaagagggacaaggacaaagaggtgcaagcgtccttgatggta gcctgcttgaagaggctgctaccagtcggtttgaacttgttcgctggacgcgagcaggag ctggtgcagcattgcaaggacaggtttctgaagaagatgccggaatacgacatcgccgag ttcgccaagacgcagctgacgttgccggacaagatcgatccagccgatgagatgtcctgg cagcattatttgtattccaagttgggccagaagaaggactccatggaaccggttaaggcg cagcaattagaggacgtcgttgcaaggatcaccgacatggccaaagttctttacggtctt cacatgatagatcatccgcaacagcagagcaagggtcaatatcgatccgtggtgtcgata caacgtaaacgagcggtgatcgcttgtttccgtcaaacttccctacattccttgcccagg catcgggctataaacatttttgcgagaacgtactacgagctctggttgcaggatgagaac gtcggtcaagaagttatgattgaagaccttacgcaatctttcgaggacgcagaactgaag aagatggacaaagccgaggatgagggaaaaccagatcctctgacgcaactcgtaacaaca ttctgccgtggcgccatgacagaacggtccggtgctcttcaagaggatcccttgtacatg agttacgctcaaattatatcgaaatcttgcggcgaggaggaagaggaaggcgaagacgag ggtgggggaggtgaagaggaagggggtgcctcgatccacgaacaagaaatggagaagcag aagcttctcttccaccaaacgcgtctggcgaatcgcggtgtggcggagatggtgttgctt catatatcagcctgtaaaggattgcccagcgagatggttatgaagaccttggaactggga atctccattctacgcggcggtaacatagagatccaacgaggaatgctgaaccacttgaag gagaagaaggacgtgggattcttcacctcgatcgctggtttgatgaattcttgcagcgtc ctggacctggacgcgttcgaaaggaacacgaaagctgaaggactcggtgttggttctgag ggtgcagctggtgagaagaacatgcacgacgcagagttcacgtgtgctctgtttcgattc atccaactgacttgcgagggtcacaatcttgactggcagaactatctgagaacgcaggct ggtaacacgacaaccgtgaacgtggtcatttgtaccgtcgattaccttctgcgacttcag gagtccatcatggacttctattggcactactccagcaaggagctcatcgaccctgctggc aaggctaacttcttcaaagccataggcgttgccagtcaagtcttcaacaccctcaccgaa gtgatccagggaccttgtgcacagaatcaacaggcactggcgcactctcgattgtgggac gccgttggtggattcctcttcctgttctctcatatgcaagacaaactatcgaagcactcg agtcaagtggatcttctgaaggagttgttgaacttgcagaaagacatgatcaccatgatg ctgtctatgctggaaggtaacgttgtaaatggaacgatcggaaagcagatggtggacacg ttggtagagtctgcgggcaacgtggaattaattctcaagtacttcgacatgttcctgaag ctgaaggacctggtatcgtcccccagcttcctggaagtggacctcaacagcgatggctgg gtgtaccccaaggatttcaaggagaaaatggaacagcagaagagttacacagacgaggag atcgagtttctactggcctgttgcgagacgaaccacgacggcaagatcgactacgtggcc ttcatggaccgtttccacgagccagcgaaagagatcggcttcaatcttgccgttttgctc accaacttgtccgagcacatgcccaacgagcccagactggcgaggttcctcgaaacagct ggctcagtattgaattacttcgagcctttcctcggcaggatcgagatcctgggtggcaac aagaagatcgagcgtgtctacttcgagatcaaggagtcgaacatcgagcaatgggagaag ccgcagatcaaagagtcgaagcgaacgtacttctacaacaccgtcgtggaggcaggggag aaggagaagctggagaccttcatcaacttctgcgaggatgccatctttgagatgcaacac gcgagcgcgttgatggccgtggaagaaagtggaggaatcggaaaagcgagagagtcgtcc tacacttacatgacggacgacgacgaggagaggaacaaggatcctatcagaagaggcatt cagacattcaaggacagtatttacttcttcttctccatattctcgcccagcaacatcaag aacaagatcgccgagatgcaacagatgacgatactggaactcttcatcggattcttcaaa atgatattctacgcgttctactattccgggttcgggtttggctgtatacttgggtacttt atgaggctgctgttggcattgatgaagggaccgcacgtggaggagcctgtcgtcgaggtg aaggaagaggaagagaaaccctcgagacatctacccgccttgccaccgacgccggacgag tctaacttacaggtgcaagccttcggaatggatataacgaaagaggaaggcggccagata aagatcgcgccgcacgaatcggcagcttcgactccgcaatcgagcatcgaggaaactgga gagagcacgccggaagaggctgctggagaagaaggtgcgagggcggaagctggtaccggg gactcggaagctcccgtttccttggccgacttgctaggtggcgaacaggctagagctcag gctgcagcagctgcggaagcagcagccgcgcaacaagcagcaatggctgctgtagaagct gaggcgaaacacgaaacgaccacggagacgtcgtcctctagcatcgacttctccgagtac acgcatcgtatcgtatccttcttggctaggaacttctacaacttgaaatacgtcgctctg gtcctcgctttctgcatcaatttcatgttgctgttctacaaggtgtcgtctttggctggc gactcggacgaggagggcagtggtcaagtgatggcggacatattggcagagatgtctggc gagggtccatctggttccggaagtggcagcggggtggaaatgggaagcggtagcggggag gacgaatcggaggaagaggaggacgcgtacgcgttggaatacgtggaagtgtccgaggat ttctattacatggctcacgttatgaggctcatggcgtgtttacattcgatcgtctcgctt gctatgcttgtcgcctactatcacctcaaggtgccgctggccatctttaaacgggaaaag gaaatcgcgcgaagggtggaattcgacggtctgtacatcgccgagacaccggaagaggac gacatcaaggcacactgggacaagatggtgatatcggcgaaaaccttccccgtgaattac tgggacaaattcgtgaagaagaaagttcgacagaagtacagcgagacctacgacttcgac tacatcagcaatctgcttggtatggagaagacttcgttcagccaacaggaagaggagggt tctggtttgatacacttcattgtaaatatcgactggaggtatcaggtttggaaggccggt gtcaccatcacggacaatgcatttttgtacagtttgtggtacttcatcttctcgatcctc gggaattacaacaacttcttcttcgcggcccacttgctggacgtggcggttggattcaag acgctacgaacgatcttgcaatccgttacgcacaacggcaaacaattggtgctgacggtg atgttgctgactatcgtggtctacatatacacggtcatagcgtttaacttctttaggaaa ttttatatccaagaggaagacgacgaggtggacaagaagtgtcacgacatgttaacgtgc ttcgtgttccacttgtacaaaggtgtcagagctggtggtggtatcggtgacgagattgga gaacccgatggcgacgactacgaagtctatcgtatcatgttcgacatcactttcttcttc ttcgttattgttattttgctggctattattcaaggtttgattatcgacgcgttcggtgag cttcgagaccagctcgagaacgttaagacaaacatggagagcaactgcttcatatgtggc ttaggaaaggaatatttcgacacggttccccatggattcgatacgcacgttcaacaggag cataatcttgctaattatatgttcttcctcatgcacttaatcaacaaaccagacaccgag tacaccggtcaagagacgtacgtgtggaacatgtatcagcaaaggtgttgggacttcttc ccggtcggtgattgcttccgcaaacagaacgaagcggtagaggacgaggccaagaagaaa taa

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