KEGG   Capra hircus (goat): 102168391
Entry
102168391         CDS       T02910                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
chx  Capra hircus (goat)
Pathway
chx00562  Inositol phosphate metabolism
chx01100  Metabolic pathways
chx01521  EGFR tyrosine kinase inhibitor resistance
chx01522  Endocrine resistance
chx01524  Platinum drug resistance
chx04012  ErbB signaling pathway
chx04014  Ras signaling pathway
chx04015  Rap1 signaling pathway
chx04024  cAMP signaling pathway
chx04062  Chemokine signaling pathway
chx04066  HIF-1 signaling pathway
chx04068  FoxO signaling pathway
chx04070  Phosphatidylinositol signaling system
chx04071  Sphingolipid signaling pathway
chx04072  Phospholipase D signaling pathway
chx04081  Hormone signaling
chx04140  Autophagy - animal
chx04150  mTOR signaling pathway
chx04151  PI3K-Akt signaling pathway
chx04152  AMPK signaling pathway
chx04210  Apoptosis
chx04211  Longevity regulating pathway
chx04213  Longevity regulating pathway - multiple species
chx04218  Cellular senescence
chx04360  Axon guidance
chx04370  VEGF signaling pathway
chx04380  Osteoclast differentiation
chx04510  Focal adhesion
chx04517  IgSF CAM signaling
chx04518  Integrin signaling
chx04550  Signaling pathways regulating pluripotency of stem cells
chx04611  Platelet activation
chx04613  Neutrophil extracellular trap formation
chx04620  Toll-like receptor signaling pathway
chx04625  C-type lectin receptor signaling pathway
chx04630  JAK-STAT signaling pathway
chx04650  Natural killer cell mediated cytotoxicity
chx04660  T cell receptor signaling pathway
chx04662  B cell receptor signaling pathway
chx04664  Fc epsilon RI signaling pathway
chx04666  Fc gamma R-mediated phagocytosis
chx04668  TNF signaling pathway
chx04670  Leukocyte transendothelial migration
chx04722  Neurotrophin signaling pathway
chx04725  Cholinergic synapse
chx04750  Inflammatory mediator regulation of TRP channels
chx04810  Regulation of actin cytoskeleton
chx04910  Insulin signaling pathway
chx04914  Progesterone-mediated oocyte maturation
chx04915  Estrogen signaling pathway
chx04917  Prolactin signaling pathway
chx04919  Thyroid hormone signaling pathway
chx04923  Regulation of lipolysis in adipocytes
chx04926  Relaxin signaling pathway
chx04929  GnRH secretion
chx04930  Type II diabetes mellitus
chx04931  Insulin resistance
chx04932  Non-alcoholic fatty liver disease
chx04933  AGE-RAGE signaling pathway in diabetic complications
chx04935  Growth hormone synthesis, secretion and action
chx04960  Aldosterone-regulated sodium reabsorption
chx04973  Carbohydrate digestion and absorption
chx05010  Alzheimer disease
chx05017  Spinocerebellar ataxia
chx05020  Prion disease
chx05100  Bacterial invasion of epithelial cells
chx05132  Salmonella infection
chx05135  Yersinia infection
chx05142  Chagas disease
chx05146  Amoebiasis
chx05160  Hepatitis C
chx05161  Hepatitis B
chx05162  Measles
chx05163  Human cytomegalovirus infection
chx05164  Influenza A
chx05165  Human papillomavirus infection
chx05166  Human T-cell leukemia virus 1 infection
chx05167  Kaposi sarcoma-associated herpesvirus infection
chx05168  Herpes simplex virus 1 infection
chx05169  Epstein-Barr virus infection
chx05170  Human immunodeficiency virus 1 infection
chx05171  Coronavirus disease - COVID-19
chx05200  Pathways in cancer
chx05203  Viral carcinogenesis
chx05205  Proteoglycans in cancer
chx05206  MicroRNAs in cancer
chx05207  Chemical carcinogenesis - receptor activation
chx05208  Chemical carcinogenesis - reactive oxygen species
chx05210  Colorectal cancer
chx05211  Renal cell carcinoma
chx05212  Pancreatic cancer
chx05213  Endometrial cancer
chx05214  Glioma
chx05215  Prostate cancer
chx05218  Melanoma
chx05220  Chronic myeloid leukemia
chx05221  Acute myeloid leukemia
chx05222  Small cell lung cancer
chx05223  Non-small cell lung cancer
chx05224  Breast cancer
chx05225  Hepatocellular carcinoma
chx05226  Gastric cancer
chx05230  Central carbon metabolism in cancer
chx05231  Choline metabolism in cancer
chx05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
chx05415  Diabetic cardiomyopathy
chx05417  Lipid and atherosclerosis
chx05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:chx00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102168391 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102168391 (PIK3CA)
   04014 Ras signaling pathway
    102168391 (PIK3CA)
   04015 Rap1 signaling pathway
    102168391 (PIK3CA)
   04370 VEGF signaling pathway
    102168391 (PIK3CA)
   04630 JAK-STAT signaling pathway
    102168391 (PIK3CA)
   04668 TNF signaling pathway
    102168391 (PIK3CA)
   04066 HIF-1 signaling pathway
    102168391 (PIK3CA)
   04068 FoxO signaling pathway
    102168391 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    102168391 (PIK3CA)
   04072 Phospholipase D signaling pathway
    102168391 (PIK3CA)
   04071 Sphingolipid signaling pathway
    102168391 (PIK3CA)
   04024 cAMP signaling pathway
    102168391 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    102168391 (PIK3CA)
   04152 AMPK signaling pathway
    102168391 (PIK3CA)
   04150 mTOR signaling pathway
    102168391 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102168391 (PIK3CA)
   04517 IgSF CAM signaling
    102168391 (PIK3CA)
   04518 Integrin signaling
    102168391 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102168391 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    102168391 (PIK3CA)
   04218 Cellular senescence
    102168391 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102168391 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    102168391 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102168391 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102168391 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    102168391 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    102168391 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    102168391 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    102168391 (PIK3CA)
   04660 T cell receptor signaling pathway
    102168391 (PIK3CA)
   04662 B cell receptor signaling pathway
    102168391 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    102168391 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    102168391 (PIK3CA)
   04670 Leukocyte transendothelial migration
    102168391 (PIK3CA)
   04062 Chemokine signaling pathway
    102168391 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102168391 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    102168391 (PIK3CA)
   04929 GnRH secretion
    102168391 (PIK3CA)
   04915 Estrogen signaling pathway
    102168391 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    102168391 (PIK3CA)
   04917 Prolactin signaling pathway
    102168391 (PIK3CA)
   04926 Relaxin signaling pathway
    102168391 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    102168391 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    102168391 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102168391 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102168391 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    102168391 (PIK3CA)
   04722 Neurotrophin signaling pathway
    102168391 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102168391 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    102168391 (PIK3CA)
   04380 Osteoclast differentiation
    102168391 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    102168391 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    102168391 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102168391 (PIK3CA)
   05206 MicroRNAs in cancer
    102168391 (PIK3CA)
   05205 Proteoglycans in cancer
    102168391 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    102168391 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    102168391 (PIK3CA)
   05203 Viral carcinogenesis
    102168391 (PIK3CA)
   05230 Central carbon metabolism in cancer
    102168391 (PIK3CA)
   05231 Choline metabolism in cancer
    102168391 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102168391 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102168391 (PIK3CA)
   05212 Pancreatic cancer
    102168391 (PIK3CA)
   05225 Hepatocellular carcinoma
    102168391 (PIK3CA)
   05226 Gastric cancer
    102168391 (PIK3CA)
   05214 Glioma
    102168391 (PIK3CA)
   05221 Acute myeloid leukemia
    102168391 (PIK3CA)
   05220 Chronic myeloid leukemia
    102168391 (PIK3CA)
   05218 Melanoma
    102168391 (PIK3CA)
   05211 Renal cell carcinoma
    102168391 (PIK3CA)
   05215 Prostate cancer
    102168391 (PIK3CA)
   05213 Endometrial cancer
    102168391 (PIK3CA)
   05224 Breast cancer
    102168391 (PIK3CA)
   05222 Small cell lung cancer
    102168391 (PIK3CA)
   05223 Non-small cell lung cancer
    102168391 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102168391 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    102168391 (PIK3CA)
   05161 Hepatitis B
    102168391 (PIK3CA)
   05160 Hepatitis C
    102168391 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    102168391 (PIK3CA)
   05164 Influenza A
    102168391 (PIK3CA)
   05162 Measles
    102168391 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    102168391 (PIK3CA)
   05163 Human cytomegalovirus infection
    102168391 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102168391 (PIK3CA)
   05169 Epstein-Barr virus infection
    102168391 (PIK3CA)
   05165 Human papillomavirus infection
    102168391 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102168391 (PIK3CA)
   05135 Yersinia infection
    102168391 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    102168391 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102168391 (PIK3CA)
   05142 Chagas disease
    102168391 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102168391 (PIK3CA)
   05017 Spinocerebellar ataxia
    102168391 (PIK3CA)
   05020 Prion disease
    102168391 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102168391 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    102168391 (PIK3CA)
   05415 Diabetic cardiomyopathy
    102168391 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102168391 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    102168391 (PIK3CA)
   04931 Insulin resistance
    102168391 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102168391 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102168391 (PIK3CA)
   01524 Platinum drug resistance
    102168391 (PIK3CA)
   01522 Endocrine resistance
    102168391 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:chx04131]
    102168391 (PIK3CA)
Enzymes [BR:chx01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102168391 (PIK3CA)
Membrane trafficking [BR:chx04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102168391 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 102168391
NCBI-ProteinID: XP_005675346
UniProt: A0A452EUC1
LinkDB
Position
1:complement(87530725..87615654)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatgggatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttgaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtatgtgaattcgatatggttaaagatccagaagtacaggacttccga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtttatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaaacagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctctactctcaactgccaatggac
tgttttacaatgccatcgtattccagacgcatctccacagctacgccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatttatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgtttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaactggtccgta
tcccgtgaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgataaagaacagctccgagcaatttgtacacgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaactctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaagcctgaacaggctatggag
cttctggactgcaattacccagatcctatggttcgaggttttgctgttcggtgcttagaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtactaaag
tatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcgttaactaat
caaaggatcggtcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcatgtgggatgtatctgaag
caccttaataggcaagttgaggctatggaaaagctcattaacttgactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctccagggctttctgtctcctctaaaccctgctcatcag
ctgggaaatctcaggcttgaagagtgtcgaattatgtcttctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagaattactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaggatatgctaacccttcagattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggatgtctgtca
attggtgattgtgtgggacttattgaggtggtgagaaattctcacactataatgcagatt
cagtgtaaaggaggcctgaaaggtgcactgcagttcaacagccacacactccatcagtgg
ctcaaagacaagaacaagggagaaatatatgatgcagccatcgatttgtttacacggtca
tgtgctggatattgtgttgcaaccttcatcttgggaattggagatcgtcacaatagtaat
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagagcgcgtgccgtttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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