Entry |
|
Symbol |
PLCB2
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
|
KO |
|
Organism |
|
Pathway |
chx04070 | Phosphatidylinositol signaling system |
chx04072 | Phospholipase D signaling pathway |
chx04261 | Adrenergic signaling in cardiomyocytes |
chx04270 | Vascular smooth muscle contraction |
chx04613 | Neutrophil extracellular trap formation |
chx04621 | NOD-like receptor signaling pathway |
chx04723 | Retrograde endocannabinoid signaling |
chx04750 | Inflammatory mediator regulation of TRP channels |
chx04919 | Thyroid hormone signaling pathway |
chx04925 | Aldosterone synthesis and secretion |
chx04927 | Cortisol synthesis and secretion |
chx04928 | Parathyroid hormone synthesis, secretion and action |
chx04933 | AGE-RAGE signaling pathway in diabetic complications |
chx04935 | Growth hormone synthesis, secretion and action |
chx04961 | Endocrine and other factor-regulated calcium reabsorption |
chx04973 | Carbohydrate digestion and absorption |
chx05022 | Pathways of neurodegeneration - multiple diseases |
chx05163 | Human cytomegalovirus infection |
|
Module |
chx_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:chx00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
102169966 (PLCB2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
102169966 (PLCB2)
04310 Wnt signaling pathway
102169966 (PLCB2)
04371 Apelin signaling pathway
102169966 (PLCB2)
04020 Calcium signaling pathway
102169966 (PLCB2)
04070 Phosphatidylinositol signaling system
102169966 (PLCB2)
04072 Phospholipase D signaling pathway
102169966 (PLCB2)
04071 Sphingolipid signaling pathway
102169966 (PLCB2)
04022 cGMP-PKG signaling pathway
102169966 (PLCB2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
102169966 (PLCB2)
04081 Hormone signaling
102169966 (PLCB2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
102169966 (PLCB2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
102169966 (PLCB2)
04613 Neutrophil extracellular trap formation
102169966 (PLCB2)
04621 NOD-like receptor signaling pathway
102169966 (PLCB2)
04062 Chemokine signaling pathway
102169966 (PLCB2)
09152 Endocrine system
04911 Insulin secretion
102169966 (PLCB2)
04922 Glucagon signaling pathway
102169966 (PLCB2)
04929 GnRH secretion
102169966 (PLCB2)
04912 GnRH signaling pathway
102169966 (PLCB2)
04915 Estrogen signaling pathway
102169966 (PLCB2)
04921 Oxytocin signaling pathway
102169966 (PLCB2)
04926 Relaxin signaling pathway
102169966 (PLCB2)
04935 Growth hormone synthesis, secretion and action
102169966 (PLCB2)
04918 Thyroid hormone synthesis
102169966 (PLCB2)
04919 Thyroid hormone signaling pathway
102169966 (PLCB2)
04928 Parathyroid hormone synthesis, secretion and action
102169966 (PLCB2)
04916 Melanogenesis
102169966 (PLCB2)
04924 Renin secretion
102169966 (PLCB2)
04925 Aldosterone synthesis and secretion
102169966 (PLCB2)
04927 Cortisol synthesis and secretion
102169966 (PLCB2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
102169966 (PLCB2)
04270 Vascular smooth muscle contraction
102169966 (PLCB2)
09154 Digestive system
04970 Salivary secretion
102169966 (PLCB2)
04971 Gastric acid secretion
102169966 (PLCB2)
04972 Pancreatic secretion
102169966 (PLCB2)
04973 Carbohydrate digestion and absorption
102169966 (PLCB2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
102169966 (PLCB2)
09156 Nervous system
04724 Glutamatergic synapse
102169966 (PLCB2)
04725 Cholinergic synapse
102169966 (PLCB2)
04728 Dopaminergic synapse
102169966 (PLCB2)
04726 Serotonergic synapse
102169966 (PLCB2)
04720 Long-term potentiation
102169966 (PLCB2)
04730 Long-term depression
102169966 (PLCB2)
04723 Retrograde endocannabinoid signaling
102169966 (PLCB2)
09157 Sensory system
04742 Taste transduction
102169966 (PLCB2)
04750 Inflammatory mediator regulation of TRP channels
102169966 (PLCB2)
09159 Environmental adaptation
04713 Circadian entrainment
102169966 (PLCB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102169966 (PLCB2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
102169966 (PLCB2)
09174 Infectious disease: parasitic
05146 Amoebiasis
102169966 (PLCB2)
05142 Chagas disease
102169966 (PLCB2)
05143 African trypanosomiasis
102169966 (PLCB2)
09164 Neurodegenerative disease
05010 Alzheimer disease
102169966 (PLCB2)
05016 Huntington disease
102169966 (PLCB2)
05017 Spinocerebellar ataxia
102169966 (PLCB2)
05022 Pathways of neurodegeneration - multiple diseases
102169966 (PLCB2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
102169966 (PLCB2)
05415 Diabetic cardiomyopathy
102169966 (PLCB2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
102169966 (PLCB2)
04934 Cushing syndrome
102169966 (PLCB2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:chx04131]
102169966 (PLCB2)
Enzymes [BR:chx01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
102169966 (PLCB2)
Membrane trafficking [BR:chx04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
102169966 (PLCB2)
Endocytosis
Macropinocytosis
Phospholipase C
102169966 (PLCB2)
|
SSDB |
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Motif |
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Other DBs |
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LinkDB |
|
Position |
10:67144238..67166117
|
AA seq |
1186 aa
MSLLNPVLLPPTVKAYLSQGERFIKWDDETTTASPVILRVDPKGYYLYWTYQSKEMELLD
ITSIRDTRFGKFAKMPKSQKLREVFNMNTPDNFLLKTLTVVSGPDMVDLTFHNFVSYKEN
VGKDWAEDVLALAKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRV
EAALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHL
AKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPENS
VLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDCW
KGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMA
EYCRTMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKEPDGEA
EGSSPPNGPVGEDTVWAGEEGAELEEEEVEEEEEESGNLDEEEIKKMQSDEGTAGLEVTA
YKEMSSLVNYIQPTKFISFELSAQKNRSYVISSFTELKAYDLLSKSSVQFVDYNKRQMSR
IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMR
RSDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKL
SPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPISALNSGYHHLCL
HNESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAHDKKAVKLKEAMGGQLE
GPFPLGNHPASQVNGASAPTSNGSAAAGAKAREEATKEVAEPQTASLEELRELKGVVKLQ
RRQEKELRELGRRGVRRWEELLQRGAAQLAGLGPPGAGVSGGCRGRKLGPGKGSRKKRTL
PGEDTAGAASAEGPEGEDVRLRELRDRLELELLQLGEEQCECVLKLKEQHAAQQMTKMME
LAREKQAAERKTLKETLETDTKEMKKKLEAKRLERIQAMMKVTTDKMAQERLKREINNSH
IQEVVQVINQMKENLERHQEKLEEKQAACLEQIQEMEKQFQQEAMAEYEVKMKGLEMEVK
ESVRTCLRACFPSEEEDKPERPCVVSRELCEQDILTEQAETQESHL |
NT seq |
3561 nt +upstreamnt +downstreamnt
atgtctcttctcaaccctgtcctgctgccccccacagtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggatgatgaaacgacgacagcctctccggttatcctccgtgtg
gatcccaagggctactacttgtactggacatatcagagtaaggagatggagcttctggat
atcaccagcatccgggacacccgctttgggaagtttgccaagatgcccaagagccagaag
ctccgggaagtcttcaacatgaacacccccgacaacttcctgctgaagacgctcacagta
gtatctggccctgacatggtggacctcaccttccataacttcgtctcctacaaggagaac
gtgggcaaggactgggctgaagacgtattggctctggccaagcacccgctgacggccaac
gcctcccgcagcaccttcctggacaagatccttgtgaagctcaagatgcagcttaaccct
gaggggaagattcccgtgaagaattttttccagatgttccctgctgaccgcaagcgggtg
gaagctgccctcagcgcctgccacctccccaaaggcaagaacgatgccatcaatcccgag
gacttcccagaatccgtgtacaagagcttcctcatgagcctctgtcctcggccggaaata
gatgagatcttcacttcctaccactccaaggccaaaccgtatatgactaaggagcacctg
gccaaattcatcaaccagaaacagcgtgactccaggctcaattccctgctgtttccgcca
gcgcggcctgaccaggtgcagggcctcatcgacaagtatgagcccagcggcatcaatgtg
cagcggggccagctgtcccctgagggcatggtgtggtttctctgcgggccggagaacagt
gtgctggcccaggacaagctgctgctgcaccacgacatgacccagccactcaaccattac
ttcatcaactcctcccacaacacctacctgacagctggccagttctcaggcctctcctct
gctgagatgtaccgccaagtgctgctggcaggctgccgctgcgtggagctggactgctgg
aaggggaagccccccgacgaggagcccatcatcacccacggtttcaccatgaccacagac
atctatttcaaggaagcaatcgaagccattgcagaaagtgcctttaagacctccccttat
ccggtcatcctgtcatttgaaaaccacgtggactcaccccgccaacaggctaagatggcc
gagtactgccggacgatgtttggggatatgctgctcacagaacccctggagaagttcccg
ctgaaacctggcatccccctgcccagccctgaggatctccgaggcaagatcctaataaag
aacaagaagaaccagttttctggccctgcatcccccagcaaggagccggatggggaggct
gagggtagcagcccacccaatggccctgtgggtgaggatacagtgtgggctggtgaggaa
ggggctgagttggaagaggaggaggtggaagaggaagaggaggagtcggggaacctggat
gaagaagagataaagaagatgcaatcagatgagggcacagcgggcctggaggtgacggcc
tacaaggagatgtccagcctagtcaattacatccagcccaccaagttcatctccttcgag
ctctctgcccagaagaaccgaagttatgttatctcctccttcacggagctcaaggcttac
gacctgctctccaagtcctcagtgcagtttgtggactacaacaagcgccaaatgagccgc
atctaccccaagggtacccgcatggactcctccaactacatgccccagatgttctggaat
gctggttgtcagatggttgccctcaacttccagacgatggacctgcccatgcagcagaac
atggcgcttttcgagttcaacgggcagagtggctacctcctcaagcatgagttcatgcgt
cggtcggacaagcagttcaatcccttctcagtggaccgcatcgacgtggtggtagccacc
accctttccattacggtgatctctgggcagttcctgtcagaacgcagcgtgcgcacctat
gtggaagtggagctgtttggccttccgggggatcccaagaggcgctatcgcaccaagctg
tcacccagtaccaactccatcaatccggtctggaaggaggagccctttgtctttgagaag
atcttgatgcctgagctggcttccctcagagtcgctgtgatggaggagggcaacaagttt
cttggacaccgcatcatccccatcagtgccctgaattctggataccaccatctctgtctg
cacaacgagagcaacatgccgctcaccatgcctgccctctttgtcttcctggagatgaag
gactatgtgcctgacacctgggcagatctcacggtggccctcgccaatcctatcaagttc
ttcagtgcccatgataagaaggctgtgaagctcaaggaagccatgggaggccagctcgag
ggtcccttccctcttgggaatcaccctgccagccaggtcaacggggcatcggctccaaca
agcaatgggtcagcagcagccggggccaaggccagggaggaggccacgaaagaagttgcg
gaaccgcagaccgccagcctggaggagctgcgggagctgaagggcgtcgtgaagctgcag
cggcgccaggagaaggagctgcgggaactggggcggcgcggcgtgcggcgctgggaggag
ctgctgcagaggggcgcggcgcagctggccgggctcgggccgccgggcgcgggagtcagc
ggcgggtgccggggccgcaagctcggcccgggcaagggatcccgcaaaaagaggaccctg
ccaggcgaggacaccgccggggcggcgtcggccgaaggccccgagggcgaggacgtgcgc
cttcgagagctgagggacaggctggagctggagctgctgcagctgggcgaggagcaatgc
gagtgtgtcctgaagctcaaggagcagcacgcggcccagcaaatgaccaagatgatggag
ctggccagggagaaacaggctgcagagcggaagaccctcaaggagaccttggagactgac
accaaagagatgaagaagaagctggaggccaagagactggagcggatccaggccatgatg
aaggtcaccacagacaagatggctcaggagaggttgaagagagagattaacaactcccac
atccaggaggtggtgcaggtgatcaaccagatgaaggagaacctggagaggcaccaggag
aagttggaggagaagcaagcagcctgcctggaacagatccaggagatggaaaaacagttc
cagcaggaggcaatggcagagtacgaggtcaagatgaagggcctggagatggaagtgaag
gaatcagtgaggacctgcctccgggcctgcttcccctctgaggaggaggacaagcctgag
agaccatgtgtggtctccagggagctgtgtgagcaggacatactcacagagcaggcagag
acccaggagagccacctctga |