Capra hircus (goat): 102180119
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Entry
102180119 CDS
T02910
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
chx
Capra hircus (goat)
Pathway
chx00310
Lysine degradation
chx01100
Metabolic pathways
chx05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
chx00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
102180119 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
102180119 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
chx03036
]
102180119 (DOT1L)
Enzymes [BR:
chx01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
102180119 (DOT1L)
Chromosome and associated proteins [BR:
chx03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
102180119 (DOT1L)
HMT complexes
Dot1-containing complex
102180119 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
102180119
NCBI-ProteinID:
XP_017906244
LinkDB
All DBs
Position
7:complement(89184931..89236978)
Genome browser
AA seq
1714 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVVFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAVPADTPVDSGAEEEKAGTAAVKKPSPSKARKKKLNKKGRKMVGRKRGRPKKMSAT
NPERKPKKTQSALDLLHAQTVSRAASPLPQDVHRPPHSPFYQLPPSVQRPTPEQLLLAPT
PPALHRLLESFRIQYLQFLAYTKTPQYKATLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EESKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNRELRSQSLRLL
KARCEELKLDWSTLSLENLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDEALALQLRGKPEAEPGRLHLELDCARFSLPPFSSLSPELSMNGHAAGYELCSAL
GRPSPKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSSLALPDYTRLSPAKLVLRRHLS
QDHAASGKAAASELHPRAEHAKENGLPYQSPGITNGIKLSPQDPRPSSPTALQMGEKGPE
KGVKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKARSTPSPGPPA
RESSSTLEKQVAANTHGAGGNAAGSKSLALAPTGFAYSGSVAISGALAGSPAPLGPGAEP
PALDESSSSGSLFATVGSRSSTPQHPPLLTQPRTCGSASPAPQLCASPRLGALGPLPDSG
KGDLPCDASFSDPESEAKRRIVFTISAGASSAKQSPSSKHSPLPSAARGDGGQGHGPDSR
KRGRRKRASAGTPSLSSSVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAIS
SPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEPGSEDEPGSARIERKI
ATISLESKSPPKTLENAGGSLAGRKAPLASEPVNSSKWKSTFSPISDLGLAKAADSPLQA
ASALSHNSLFAFRPGLEEPSTADGKLATHSRKSFPGTLPGAGGLSPNSLPASGFALGGGL
AADLSLHSFSDGASLSHKAPEAAGLGAPMSFPGPRGKEGGAAESGPFVNKRQLDGLGPKG
EGGLPTCGPPDKASTAHSKAGKGREREPDVKNGHNLFMAAAAAPPAGLLSGPGLAPAASS
AGGTAPSVQTHRPFLGAFAPGPQFALGPMSLQANLGPSVLQSLFSSVPAAGLVHVSTAAT
RLTNSHAMGSFSSGVAGGAVGGVFNHAVPPASAHPFGASFGSGAACRSTTLSLTPLQAVA
STPASSFQAPSSAEPRPPQPPPHLGRPPPGQPALHAPPHPNATLPPPPALLPANSEPVLL
QNLASLPANQAFLPAASAASLPPANASLSIKLASLPHKVSRPALTVHHQPLPGLALAQAA
PVNPQASSTGPPAVWVSLGMPPPYAARLAGVKPR
NT seq
5145 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtttacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atcagatgggtctgtgaggaaatcccggatctcaagctcgctatggagaattacgtttta
attgactacgataccaaaagctttgagagtatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacacagcccatgaagctgaacaca
cggccgtccactgggctcctgcggcacatcctgcagcaggtctacaaccactcggtgact
gaccctgagaagctcaacaactatgagcccttctccccagaggtgtatggggagacctcc
ttcgacctggtcgcccagatgatcgatgagatcaagatgaccgaagatgacctgttcgtg
gacctgggcagtggggtgggccaggtcgtgctgcaggttgccgcagccaccaactgcaaa
catcattatggtgtagagaaagctgacatcccagccaagtacgcggagacgatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagagg
ggggacttcctctcggaggagtggagagaacggattgctaatacaagtgttgtatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcaaacatg
aaggaaggtggcagaatcgtgtcctcgaagccctttgcgcctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgccgctaaaa
ggctcggtgtcatggacggggaagccagtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctaaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgggagaacaagagcaacacaaccacacccaccaaggtgccc
gagagcaaggcagctgtgccggcagacacccccgtggactccggtgctgaggaggagaaa
gccgggacggccgctgtcaagaagccatctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggtgggtcggaagcgtgggcgccccaagaagatgagtgccacc
aaccccgagcgcaagcccaagaagacccagagcgcactggacctgctgcacgcccagacc
gtgtcacgagcggcctcccccttgccgcaggacgtgcacaggccacctcacagcccattc
taccagctacctcccagcgtgcagcggcctacccctgagcagctgctgctggcacccacc
ccgcccgcgctgcacaggctgctagagtccttcaggattcagtatctacagttcctggca
tacacgaagacccctcagtacaaggccaccctgcagcagctgctggaccaggagaaggag
aagaatgcccggttgctaggcgcagcgcagcagctgtttggccactgccaagctcagaag
gaggaaagcaagaggctcttccagcagaaactggacgagctgggagtgaaggcgctgacc
tacaacgacctgatccaagcgcagaaggagatctcggctcacaaccaacagttgagggaa
cagacggagcagctagagaagggcaaccgggagctgaggagccagagcctgcggctgctc
aaggcacggtgtgaggagctgaagctggactggtccacgctgtccctggagaatctgctg
aaggagaagcaggccctgaagagccagatctcagagaagcagaggcactgcctggaactg
cagatcagcattgtggagctggagaagagccagcggcagcaggagttgctccagctcaag
tcctgcgtgccgcctgatgaggcactggccctgcagcttcgtgggaagccagaggccgag
cctggccggcttcacttggagctggactgcgcccgcttctccctgccacctttcagcagc
ttgagccccgagctctccatgaatggccatgcggccggctatgagctctgcagcgcactg
ggtcggccctcacccaagcagaacaccccccagtacctggcctctccgctagaccaggag
gtcgtgccctgcacccctagccacagcggccggccacggctggagaagctatccagcctg
gccctgcctgactataccaggctatcccctgccaagctggtgctgcggcgccacctgagc
caggaccacgcggccagtggcaaggcagctgccagcgagctgcacccacgagccgagcat
gccaaggagaacgggctcccttaccagagccctggcatcaccaacggcatcaagctgagc
ccacaagacccccgaccttcatcccccacagctttacagatgggagagaagggccctgag
aagggtgtgaaggagcgtgcctacgccagcagtggggaggccatcaccagcctgcctgtc
agcatcccgctgagcaccgtgcagcccagcaagctgcccgtcagcatccccctggccagc
gtggtgctgcccagccgcgccgagaaggcgagaagcacacccagccctgggccaccggcc
cgagagtcctcgtctacgctggagaagcaggtggctgctaacacccatggtgccgggggc
aacgctgctgggagcaagagcctcgccctggctcccacaggctttgcatacagcggctcg
gtggccatcagtggggccctggcaggcagcccagcaccccttggccctggagctgagccc
ccggccctagacgagtcctccagctctggaagcctctttgccactgtggggtcccgcagc
tccaccccgcagcacccacccctgctgacgcagccacgtacctgcggctcagcctcgccg
gccccccagctctgcgccagcccccggctaggcgccctgggcccgctccccgactctggc
aaaggggacctgccctgcgacgccagcttctcagaccctgagagcgaagccaaaaggagg
atcgtcttcaccatctcggcgggtgccagcagcgccaagcagtcaccttccagcaaacac
agccctctgccctcggctgcccgcggggacggtggccagggccatgggccagacagccgc
aagcggggccggaggaagcgggcatcagcggggacccccagcctgagctcgagtgtgtcc
cccaagcgccgggccttgccatctgtcgctgggcttttcacgcagtcttcagggtccccc
ctgaatctcaactccatggtcagcaacatcaaccagcccctggagatcacggccatctcg
tcccctgagagctccctaaagagctcacccgtcccctaccaggacaatgaccaaccacct
gtgctcaagaaggagaagcccctgagccagaccaatggtgcccactactccccactgacc
tcggacgaggagccaggctctgaggatgagcccggcagtgccagaattgagagaaaaatt
gcaacaatctccttagaaagcaagtctccaccaaaaaccttggaaaatgcaggtggcagc
ctagcaggaaggaaggcaccgctggccagcgagccggtcaacagcagcaagtggaagtcc
accttctcacccatctccgacctgggcctggccaaggcagctgacagcccgctgcaggct
gcctccgctctgagccacaactccctgttcgctttccggcctggcctggaggagcccagt
acagccgatggcaagctggccacccactccaggaagagcttcccaggcaccctgccgggg
gcgggcgggctgagccccaatagccttcctgccagtggcttcgccctgggcgggggccta
gcagctgacctcagtttacacagcttcagtgatggtgcttctctctcccacaaggccccc
gaggcagctggcctgggtgcccccatgagcttccctggcccacggggcaaggagggtggc
gctgcagagtctggccccttcgtgaacaagcggcagctggacggactgggcccaaaaggc
gaggggggccttcccacatgcggacccccggacaaggcctctacagcgcatagcaaggca
ggcaagggccgtgagcgcgagcccgacgtcaagaatggccacaacctgttcatggctgct
gccgccgcgccccctgcaggcctcctcagtggcccaggtcttgccccagcggcatcctcg
gcaggtggcacagccccgtccgtgcagacccaccgccccttcctgggcgccttcgcccct
gggccacagttcgcgctgggccccatgtcgctacaggccaacctgggcccgtctgtgctg
cagtccctgttcagttctgtgcccgccgccggcctggttcacgtctcgaccgccgccacc
agattgaccaactcgcacgccatgggcagcttctcctccggggtggccggcggcgcagtt
ggaggtgtctttaaccacgcggtgcctcccgcctccgcccatccgtttggagccagtttc
ggcagtggggctgcatgtcgcagcaccacgctgagcttaaccccgctgcaggcggtggcc
agcaccccggcctcttcctttcaggccccgtcctctgcggagccgaggccaccccaaccc
cctccgcacctgggccggccccctccggggcagcctgccctccatgcacccccccatcct
aacgccaccttgcctcctccccctgcgctgctcccagctaactctgagcccgtgcttctg
cagaacctcgcatccctccctgctaaccaagctttcttgcccgccgcctctgccgcctct
ctgccgcctgctaacgcctctctgtccatcaagctcgcctccctcccgcacaaggtgtcc
cggcccgccttgacggtgcaccaccagcccctgcctgggttggccctggcccaggccgcg
cccgtgaacccacaggccagctccacggggccgcccgccgtgtgggtttcccttggcatg
ccgcctccgtatgccgcgcgccttgcgggggttaagccgcgataa
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