Capra hircus (goat): 102180670 Help Entry 102180670         CDS       T02910                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism chx  Capra hircus (goat) Pathway chx01521   EGFR tyrosine kinase inhibitor resistance chx04062   Chemokine signaling pathway chx04081   Hormone signaling chx04148   Efferocytosis chx04151   PI3K-Akt signaling pathway chx04217   Necroptosis chx04550   Signaling pathways regulating pluripotency of stem cells chx04630   JAK-STAT signaling pathway chx04658   Th1 and Th2 cell differentiation chx04659   Th17 cell differentiation chx04725   Cholinergic synapse chx04917   Prolactin signaling pathway chx04920   Adipocytokine signaling pathway chx04933   AGE-RAGE signaling pathway in diabetic complications chx04935   Growth hormone synthesis, secretion and action chx05140   Leishmaniasis chx05145   Toxoplasmosis chx05152   Tuberculosis chx05161   Hepatitis B chx05164   Influenza A chx05167   Kaposi sarcoma-associated herpesvirus infection chx05168   Herpes simplex virus 1 infection chx05200   Pathways in cancer chx05207   Chemical carcinogenesis - receptor activation chx05235   PD-L1 expression and PD-1 checkpoint pathway in cancer chx05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:chx00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102180670 (JAK2)    04151 PI3K-Akt signaling pathway     102180670 (JAK2)   09133 Signaling molecules and interaction    04081 Hormone signaling     102180670 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     102180670 (JAK2)   09143 Cell growth and death    04217 Necroptosis     102180670 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102180670 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     102180670 (JAK2)    04659 Th17 cell differentiation     102180670 (JAK2)    04062 Chemokine signaling pathway     102180670 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     102180670 (JAK2)    04917 Prolactin signaling pathway     102180670 (JAK2)    04935 Growth hormone synthesis, secretion and action     102180670 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     102180670 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102180670 (JAK2)    05207 Chemical carcinogenesis - receptor activation     102180670 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102180670 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     102180670 (JAK2)    05164 Influenza A     102180670 (JAK2)    05168 Herpes simplex virus 1 infection     102180670 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     102180670 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     102180670 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102180670 (JAK2)    05140 Leishmaniasis     102180670 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102180670 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102180670 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102180670 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:chx01001]     102180670 (JAK2) Enzymes [BR:chx01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102180670 (JAK2) Protein kinases [BR:chx01001]  Non-receptor tyrosine kinases   JAK family [OT]    102180670 (JAK2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  102180670 NCBI-ProteinID:  XP_017907511 UniProt:  A0A452DQ72 LinkDB All DBs Position 8:complement(39245187..39360411) Genome browser AA seq 1132 aa AA seqDB search MGMACLTMTEMEGTSTSPVHQNGDISGNANSVKQIDPVLQVYLYHSLGKAEEDYLKFPTG EYVAEEICIAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRQNVLYRIRFYF PYWYCNGSNRTYRHGIARGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLG MAVLDMMRIAKEKNQTPLDIYSSISYKTFLPKCVRAKIQEYHILTRKRIRYRFRRFIEQF SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPDIIDISIKQANQEGANESRIVTIHKQDGKSLEIELKSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKTGNQT GLYVLRCSPKDFHKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTSGVSDVPTSPALQRHNNVNQMVFHKI RNEDLVFNESLGQGTFTKIFKGIRREIGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLILNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA MHFLEEKTLIHGNVCAKNVLLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRHNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLAVRVDQIRDNMTG NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcttgccttacaatgacagaaatggaaggaacatccacatcccctgtgcat cagaatggtgatatttctggaaatgctaactctgtgaagcaaatagatccagtcctacag gtctatctttatcattcccttgggaaagctgaggaggattatctgaagtttccaactgga gagtatgttgctgaagagatttgtattgctgcttctaaagcttgtggaatcacacctgta tatcatagtatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat gtcttccatatagatgaatcaaccaggcaaaacgtactctacagaatcagattttacttt ccttactggtattgtaatggcagcaacagaacctatcgacatggaatagctcgaggtgct gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat tttttacatggatggataaaagtgcccgtgactcatgaaacacaggaagaatgtcttggg atggcagtgttagatatgatgagaatagccaaagaaaagaatcaaacgccactggacatc tatagctctatcagctacaagacatttttgccaaaatgtgttcgagcaaagatccaagag tatcatattttgacaaggaagagaataaggtacagatttcgcagatttattgagcaattc agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttgtattgtgatttt cctgatattattgatatcagtattaaacaagcaaatcaagaaggcgcaaatgaaagcaga attgtaactattcataagcaagatggtaaaagtctagaaattgaacttaagtcattaaga gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat cattatctttgtaaagaagtagcacctccaatggtgcttgaaaatatacaaagcaactgt catggcccaatttcaatggattttgctatcagtaaactgaagaaaacaggtaatcagact ggactctatgtacttcgatgcagtcccaaggactttcataaatattttctgacttttgct gttgagcgagagaatgttattgaatataagcactgtttgattacaaaaaatgagaatgga gaatacaacctcagtggtactaagaagaacttcagtaatcttaaagatcttctgaattgc taccagatggaaactgttcgctcggacagtataattttccagtttactaaatgctgtccc ccaaagccaaaagacaaatcaaaccttctagtcttcagaaccagtggtgtttctgatgta ccaacctcaccagctttacaaaggcataataatgtgaaccaaatggtgttccacaaaatt agaaatgaagatttggtatttaatgaaagccttggccaaggaacttttacaaaaattttt aaaggtataagaagagaaataggagactatggtcagctgcatgaaacagaagttctttta aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg atgagccagctttctcacaaacatctgattttaaattatggagtatgtgtctgtggagag gagaacattctggttcaggaatttgtaaaatttggatcactagatacatatctgaaaaag aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc atgcattttctagaagaaaaaacccttattcatgggaatgtgtgcgccaaaaatgttctt cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaagacatcctgcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatctaaacctggcaacagacaaatggagttttggt accacattgtgggaaatctgtagtggaggagataagccgctgagtgctttggattctcaa agaaaactacaattttatgaagataggcaccagcttcctgcaccaaagtggacagaatta gcaaatcttattaataattgcatggattatgaaccagattttagaccttctttcagagcc attataagagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac atgttaccaaatatgagaataggtgccctaggattttctggtgcttttgaagaccgagac cctacacaatttgaagaaagacacttgaaatttctacagcaacttggcaagggtaatttt gggagtgtggagatgtgccggtatgaccctctacaagacaatactggggaggtggtggct gtgaaaaagctccagcacagtactgaagagcacctcagagactttgaaagagaaattgaa atccttaaatccttgcagcatgacaacattgtaaagtacaaaggagtctgctacagtgct ggccggcataatctaagattaattatggagtatttaccatatggaagtttacgagactat ctccaaaaacataaagaacggatagatcataaaaaacttctgcagtacacatctcagata tgcaagggcatggaatatcttggtacaaaaaggtatatccacagggatctggcgacaagg aatatattagtggagaatgaaaacagagttaaaataggagattttggattaaccaaagtc ttgccacaagacaaagagtactacaaagtgaaagagcctggtgaaagtcccatattctgg tatgcaccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagcttt ggagtggttctctatgaacttttcacatatattgagaagagtaaaagcccaccagcggaa tttatgcgtatgattggcaatgacaaacaaggacagatgatcgtgtttcatttgatagaa ctcctgaagaataatggaagattaccgagaccagatggatgcccagatgagatttacatg attatgacagaatgctggaacaataatgtaaaccagcgcccctctttcagagacctagca gttcgagttgatcaaataagggacaacatgactggatga

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