Capra hircus (goat): 102191052 Help Entry 102191052         CDS       T02910                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism chx  Capra hircus (goat) Pathway chx04020   Calcium signaling pathway chx04371   Apelin signaling pathway chx04713   Circadian entrainment chx04921   Oxytocin signaling pathway chx04970   Salivary secretion chx05010   Alzheimer disease chx05012   Parkinson disease chx05020   Prion disease chx05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:chx00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102191052 (RYR3)    04020 Calcium signaling pathway     102191052 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     102191052 (RYR3)   09154 Digestive system    04970 Salivary secretion     102191052 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     102191052 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     102191052 (RYR3)    05012 Parkinson disease     102191052 (RYR3)    05020 Prion disease     102191052 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     102191052 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:chx04040]     102191052 (RYR3) Ion channels [BR:chx04040]  Voltage-gated cation channels   Ryanodine receptor    102191052 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  102191052 NCBI-ProteinID:  XP_017909258 LinkDB All DBs Position 10:73851578..74313440 Genome browser AA seq 4887 aa AA seqDB search MAECERASGGPVERVPGRRDSRQLCLKWALLDVTEQQQEDEVVLQCIANVHKEQRKFCLA AEGLGNRLCFLEPTSEAKYVPPDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGG HRTLLYGHAILLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQR SEGEKVRIGDDLILVSVSSERYLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLL GGHVVRLFHGHDECLTIPSTDQNDSQHRRIYYEAGGAGTRARSLWRVEPLRISWSGSNIR WGQAFRLRHLTTGHYLALTEDQGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIE GMGVPEIKYGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQR CQREESQAARIIRNTTALFSQFVSGNSRTAAPVTLPIEEVLQTLHDLIAYFQPPEEGMQH EGKQSKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSIAHFAGIAREESGMAWKEILNL LYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEG HIKSIISLLDKHGRNHKVLDVLCSLCLCDGVAVRANQNLICDNLLPRRNLLLQTRLINDV TSIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEG WGGNGVGDDLYSYGFDGLHLWSGRIPRTVASISQHLLQSDDVVSCCLDLGAPSISFRING QPVQGMFENFNTDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPSGYAPCYEALLPKEKM RLEPVKEYKRDAEGIRDLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHEL WGMNKIELGWTFGKMRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAH VNPAAEDDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRI KQGWTYGIQQDLKNKRNPRLVPYSLLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELA DPAVEKVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGVDDQ AFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFA DYEIDNGFVPICSLGLSQIGRMNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSK RLPTFVNVPKDHPQIEVVRIDGTMDTPPCLKVTHKTFGTQNSSATMIYCRLSVPVECHSS FSHSPCLDSDAFQKRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKF DLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVATSQRASRSNVDLEIGCLVDLAM GMLSFSANGRELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEE KNPVPQCPPRLDVQTIQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEE NRCVDILELCEQEDLMRFHYHTLRLYSALCALGNSRVAYALCSHVDLSQLFYAIDNKYLP GLLRSGFYDLLISIHLASAKERKLMMKNEYIIPITSTTRKIRLYPDESKRHGLPGVGPRT CLKPGFRFSTPCFITTNEEHQKQSPEIPLELLKTKALGMLTEAVQCSGAHIRDPVGGSVE FQFVPVLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSGETEEGAEKEEVTQVEEKAV EAGEKASREAPIKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQE NQKFRYNELMQALNMSAALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDF HEDLLLHCGVPLEEEEEEEEDTSWTGKICALVQRIKGPPKPEKEQPTEEEERCPTTLKEL ISQTMIRWAQEDQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVSDTISLLA ALGQIRCLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGA EKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDV AASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFL RFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLP SQGYKREVMEDDEDEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSIL RSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTF LLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTS LIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYC KMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKRYDPDLFR MALPCLSAIAGALPPDYLDTRISATLEKQVSVDADGNFDPKPINTVNFSLPEKLEYIVTK YAEHSHDKWACDKSQNGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTML AVGWTVERTKEGEALVQQRENEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVA ENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSR GMKDMELDASSMEKRFAYKFLKKVLKYVDSAQEFIAHLEAIVSSGKNEKSPHDQEIKFFA KVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGS DSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTLENLKLGKFTHSR TQIKGVSQNINYTTVALLPILTSIFEHVAQHQFGMDLLLGDVQLSCYHILCSLYSLGTGK NIYVERQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEM CPDIPQLEGLMKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSAGPW CTKVTSEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLE KLKKKAIKTVQEEEQLRADSKGDTQEAELLILDEFAILCRDLYAFYPMLIRYVDNSRSNW LKSPDADSDQLFRMVAEIFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGG QDQERKKTKRRGDFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEE VKEHLRSNLHLQEKSDDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVE QPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFE EKLVQDLAKSPKVQEEEEEEVEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYASMMA KSCQSGEDEDEEEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMV VETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAE GLGMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVN VIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCI GNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGN VVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQ KAMEGQKQYTQSEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHM PNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESK RQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSADRPDEEDDEEGDSSHVL EVEGEEEEEEKSLECASAFAMACASAKRSVANFLKRATLKNLRKQYRKVKKMTFKELVKL LFSFFWTLFVGLFRLLFTIVGGIVQVLWGTVFGGGLIEGAKNIRVTKILGDMPDPTQFGI HDDAVEAERAEVLEPGITTELAHFVKGEKGDADIMSDLFGLHPKKEGGLKHGPEVGLGDL SEIIGKDEPPTLESTVRKKRKAQAAEMKAAHEAEGKIESEKADMEDGEKEDTAKEEEQAE ALWADVTKRKKRRCGQKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFA INFILLFYKVTEEPLEEETEDVANLWNSFNDEEEEEAVVFFVLQESTGYMAPALRALAII HTVISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTP SFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSS IDMKYHVWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSV THNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVG VRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQV REDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYV WKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14664 nt NT seq  +upstreamnt  +downstreamnt atggccgagtgcgagcgagcctcggggggacctgtggagagagttccaggaagaagggac agcaggcagctgtgcctgaaatgggccttgcttgacgtgacagagcagcagcaggaagat gaagtggtcctccagtgcatcgccaacgttcacaaggagcagaggaagttctgcctggca gccgagggacttgggaatcgcctgtgctttttggaacccacttcagaagccaagtatgtt cctccagatctctgcgtctgcaactttgtgctggagcagtccctctctgtcagagccctg caggaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacaagggggtggc cacaggaccctgctgtatggccatgcaattcttctgcggcactccttcagtggcatgtat ctgacatgtttgaccacatcaagatcccagacggataaacttgcctttgatgtaggtcta cgggaacacgccacaggagaagcctgttggtggaccattcatcctgcttccaagcagagg tctgagggagaaaaggttcgaattggtgatgacctcatcctcgtcagtgtgtcctctgaa agataccttcatctctcgatatcaaatggtaacatacaagtggatgcctcctttatgcag acactctggaatgtacatcctacgtgctcaggaagtagcattgaagaaggatacctgctt ggtgggcatgtagtacgtcttttccatggacatgatgagtgtttgacgataccatctaca gaccagaatgattcccagcacaggaggatatactatgaagctgggggagctggcacgaga gccagatcgctatggagagtggaaccccttcggataagctggagtggcagtaacatcaga tggggacaggctttccgcctccggcatctcaccacaggccactacctggccttgacagaa gaccagggccttatcctgcaagaccggggaaagtcagacaccaagtccacagccttctct tttcgagcatccaaggaaatcaaggagaaattggattccagtcacaagcgagatatagaa ggcatgggagtcccagaaatcaagtatggagactctgtctgctttgtccaacatatagcc agtggtctgtgggtgacctacaaagcacaagatgccaagacatcccgcctgggacctctg aaaagaaaggtcatactccatcaggaaggccacatggatgatgggttaacactgcagaga tgccagcgtgaggagtcccaggctgctcggatcatccggaacacgaccgccttattcagc cagtttgtaagtggaaacagtcgcacagctgccccggtcaccctgccgatagaagaggtc ctgcagaccttacatgacctgattgcctacttccagcccccggaggaggggatgcagcat gaaggcaagcagagcaagctccgctcactcaaaaacagacagaatcttttcaaggaggag ggaatgttagcccttgtgttaaactgcattgatcgcttaaatatctacaatagcatagca cacttcgcaggcatcgccagggaggagagtgggatggcctggaaagaaattctgaacctc ctgtacaaattgctcgctgctcttattcgtggaaacagaaacaactgtgctcaattctcc aataaccttgactggctgatcagcaaattggacagactagaatcttcctcaggtatcttg gaagttttgcactgcatcctcattgaaagcccagaagccttaaacctgatagcagagggc cacatcaagtccatcatctccctgttggataagcacggacggaatcacaaggttctggat gtgctgtgttccctctgtctctgcgatggggtcgcagtgagagccaaccagaatctcatc tgtgacaacttgctgccccggagaaacctgctcctgcagacacggctgattaatgacgta acaagtattcggccaaacatcttcctgggagttgctgaaggctcagcacagtacaagaag tggtacttcgagcttatcatcgaccaggtggaccccttcctcacagcagagcccacgcat ctgcgggtgggctgggcctcttcctctggctacgctccttaccccggaggtggagaagga tggggaggcaatggtgttggtgatgacctatactcctatggctttgatggacttcacctc tggtcaggtcgcatacccagaaccgtggcctccatcagccagcacctcctgcagtcagac gacgtggtaagctgctgcctggacctgggggcacccagcatctctttccgcatcaacggg cagcctgtgcaggggatgtttgagaacttcaacacggatgggctcttcttccctgtggtg agcttctcagcaggtgtcaaagtacgtttcctgctgggtggacgtcatggagaatttaag ttcctgcctccctctggctatgccccttgctatgaagccttacttccaaaggaaaagatg agattggagcctgtcaaagagtataaacgtgatgctgaaggaattcgagatctgttgggt accacccagttcctctcccaagcctctttcatcccatgccccatagataccagtcaggtt gttttaccacctcatctagagaaaatccgagacaggctggctgaaaacattcatgagctt tggggaatgaataaaatagagcttggctggacttttggcaagatgcgggatgacaataaa agacagcacccctgccttgtcgagttttcaaagctgcccgaaactgagaagaattataac ctacaaatgtcaactgaaaccctaaaaactctcctggccctggggtgccacattgctcat gttaacccagctgctgaggacgatctcaagaaggtcaaattgcccaaaaactacatgatg tccaatggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaa gaaattttagtggataagcttgcagaaaatgcacacaatgtctgggcaaaagacagaata aaacaaggatggacctatggcattcaacaggatttaaagaacaaaagaaatccacgtttg gtgccatattcactgctggatgagcgtaccaagaagtcaaacagggacagccttcgtgaa gctgtccggacgtttgttggttatggctataacattgagccatcagaccaagagctagct gacccagctgtggagaaagtcagcatagacaagatccgctttttccgggtagagcgctct tatgccgtgagatcgggaaagtggtatttcgagttcgaggtggtgaccggaggcgacatg cgtgttggctgggcccggccaggctgccgaccagacattgagctgggggtggatgaccaa gccttcgtgtttgaaggcagcaggggccagcggtggcatcaagggagtgggtatttcgga cggacctggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcaatg atcttcacgctgaatggggagctgctgatcaccaacaaaggctctgaacttgcctttgct gactacgagattgacaatggctttgtgcccatctgctctctggggctgtctcagatcggc cgcatgaatctcgggatggacgccagcaccttcaagttttataccatgtgcggtctccaa gagggctttgagccttttgctgtcaacatgaatcgcgacgtggccatgtggttcagcaaa cgcctcccaacatttgtcaacgtgcccaaggatcatccgcagatagaggtcgtcaggatc gacggcaccatggatacccctccatgcctcaaggtgacccacaagacattcggcacccag aacagcagtgccaccatgatctactgccgcctgagcgtgcccgtcgagtgccactcctcc ttcagtcacagcccctgtctggacagtgatgctttccagaaaaggaaacagatgcaagaa atactctctcacacaacaacacagtgctactatgcaatccgcatctttgccggacaggat ccttcctgcgtgtgggtcggatgggtgactccggattatcacttgtacagtgaaaagttt gacctgaataaaaactgtactgtgactgttactctgggggacgaaagaggccgagtccac gaaagcgtgaaacgcagcaattgctacatggtctggggtggggacatcgtggctacatcc caaagagcgagtcgcagcaatgtggacctggagatcggctgccttgtggatctggcaatg ggcatgttgtccttttcagccaacgggagggaacttggcacctgctaccaggtggagccc aataccaaagtgtttccagccgtcttcctgcagcccacaagcacctctctgtttcaattt gaacttgggaagctgaagaatgccatgcccctgtcggcagccatatttaagagtgaagag aagaaccccgtcccgcagtgcccgccacggctggatgtccaaaccatccagcctgtgctc tggagccgcatgcccagcagcttcctgaaggtggagacggagagggtgagcgagcgccat ggctgggtggtgcagtgcctggagcccctacagatgatggcactccacatcccggaagag aacaggtgtgtggatatcctggagctctgcgagcaggaggacctcatgcggttccattac catacgttgagactctacagcgccttgtgtgccctgggaaacagccgggtggcctacgcc ctgtgcagccatgtggacctctcccaactcttctatgccattgacaacaagtacctccct ggcctcctgcgctcaggcttctacgacctgcttatcagcatccacctggccagcgctaag gagaggaagctgatgatgaagaatgagtacatcatccccatcaccagcaccaccaggaaa atccgcctgtacccggatgagtccaagaggcatgggctccctggggtgggcccgagaacg tgcctcaagccagggttcaggttctccaccccctgcttcatcaccaccaacgaggagcac cagaagcagagccccgagattcccttggagcttctcaagacgaaggcgctgggcatgctg acggaggcagtgcagtgcagcggggctcacatccgggaccctgtcggggggtctgtggag ttccagtttgtgcctgtgctgaagctcattggaaccctgctggtcatgggggtgtttgat gatgatgacgttcggcagatcctcctcctcatcgacccctctgtgtttggggagcacagt ggggagacagaggagggagcagagaaggaggaggtgacgcaggtggaggagaaggctgtg gaggctggggaaaaggccagcagggaggctcccatcaaaggcttgttgcagacccgatta ccggagtccgtcaagctgcagatgtgtgagctgctcagctatctctgtgactgtgagctg cagcaccgggtggaggccattgtggccttcggtgacatctatgtctccaagctccaggaa aatcagaagttccgctacaacgagctcatgcaggcccttaacatgtctgcggccctgacc gcccggaagaccagggagttccgctcgcccccacaggaacagatcaacatgcttcttaac tttcaactgggggagaactgcccatgcccagaagaaatccgggaagagctgtacgacttc catgaggaccttctccttcactgcggggttcccctggaagaagaggaagaagaggaagag gatacctcctggactggaaaaatctgtgccttggtgcagagaatcaaaggccctcccaag ccagagaaggagcaaccaacggaggaagaagagagatgccctacgaccctgaaggagctc atctcacagaccatgatccgctgggcccaggaggaccagatccaggatgcagagctggtc cggatgatgttcaaccttctgcggcggcagtacgacagcatcggggagctgctgcaggcg ctgcgcaagacctataccatcagccaggcctccgtgagcgacaccatcagcctgctagct gccctgggccaaattcgctgcctgctcagcgtcaggatgggcaaggaggaggagctactc atgatcaacgggctgggagacataatgaacaacaaggtgttttaccagcaccccaacctc atgagagtcctcggcatgcatgagacagtcatggaggtgatggtgaacgtgctgggtgca gaaaagtctcagattgcctttccaaagatggttgctagctgttgccgcttcctatgctat ttctgtcgaatcagccgacaaaatcagaaggccatgtttgagcatctaagttacctgttg gagaacagcagtgttggcctagcttccccctcgatgagaggatccaccccgctggatgtg gccgcttcctccgtgatggacaacaatgagttagcgctgggcttagaggagccagacctc gagaaggtggtgacctacttggcaggctgtggcctgcagagctgccccatgcttctagcc aaaggataccctgatgtcggctggaaccccattgaaggggagcgctacctgtccttcctg aggtttgccgtcttcgtgaacagtgaaagtgtggaagaaaatgctagtgtggtggtcaag ctgctcatcagacgccccgagtgcttcggccccgccctgcggggtgaaggaggaaacggc ctgttggcggccatgcaaggtgccattaagatctccgagaacccggccctcgacctcccc tcacagggctacaagagggaagtcatggaggacgatgaagatgaagaagagattgtgcac atgggcaatgcaatcatgtcgttttattcggcccttatagacctgctgggccgctgtgct cctgagatgcaccttatccagacaggaaagggagaagccatccggatcaggtccatcctg cgctccctggttcccactgaggacttggttggaatcatcagcatccccttgaaactgcct tccctgaacaaagatgggtcggtcagtgagccagatatggcagccaacttctgccctgac cacaaggcgcccatggtactgttcttggaccgtgtgtacggcatcaaggatcaaactttt ctgctccacttgctggaagttggatttttacctgacctaagagcctctgcctctctagat acagtttccctaagcaccaccgaggctgcactggcactgaacaggtacatatgttctgca gtgctcccactcctcacaagatgcgcccctctctttgccgggacagagcactgcacttct ttgattgactctacactgcagacaatatacaggctttccaaggggcgatccctcaccaaa gctcagagggacaccatagaggagtgtttgctggccatctgcaatcacttgaggccttcc atgttacagcaactcctgcgacgtctagtttttgatgtgccccaactcaatgaatactgc aaaatgcctcttaagcttctgacaaatcactacgaacagtgctggaagtattattgtctg ccttcgggctgggggagctacggtctggctgtggaggaagagctacatctgacagagaag ctcttctgggggatttttgactccctctcccataagaggtatgacccagatcttttccgg atggccctgccctgtctcagtgcaatagcgggggccctgccaccagattatttagatacc agaatctcagccacattggagaaacaggtctcagtggacgcagatggcaactttgacccc aaacccatcaacactgtgaacttctccttgcctgaaaaattggaatacatcgtcaccaag tatgctgagcactcccatgataaatgggcctgtgacaagagtcagaatggatggaaatac ggcatttccctggatgaaaatgtgaagacccatccattgatccggcctttcaagacatta accgagaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaaccatgctg gctgtgggctggactgtagagaggaccaaagagggagaagctctggttcaacagcgggaa aatgagaagcttcgaagcgtgtcccaggccagccagggcaacagctacagccctgcccct ctggatctctccaatgtcgtgctctccagagagctccaggggatggtggaggtggtagct gagaattatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggc ggcagtcaccctcttttggtaccctatgataccttaactgccaaggagaagttcagagac cgagagaaggcccaggacctgtttaaattcctccaagtgaatggcattgtggtttccaga ggtatgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataagttt ttgaagaaggttctgaaatatgttgattcggctcaagagtttattgcccatttggaagcc attgtcagcagtgggaaaaatgaaaagtctccccatgaccaggagatcaaattctttgcc aaagttctcctcccactggttgaccagtacttcaccaatcatcgcctctacttcctgtcc tcccctctgaagccccttagcagcagcgggtatgcctcccataaggagaaagaaatggtg gccagcctgttctgcaaacttgctgctctggttcgacacaggatttccctcttcgggagc gattcgacaacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggacg gtcatgaagtcaggctcagagctggtgaaagctggattacgggcgttctttgaaaatgca gcggaagacttagagaagactttggaaaacctgaagctcggcaagtttacccattccaga acgcagatcaaaggtgtctctcaaaatattaactacaccacggtggctctgctccccatc ttgacatccatctttgagcacgtggctcagcatcagttcgggatggacttactcttgggt gatgttcagctttcgtgctaccatatactgtgcagcctctactccctcgggacaggaaag aacatctatgttgaaaggcagcgtcctgcccttggagaatgcctggcctcactggcagcc gccataccagtggcattcctggagcctacccttaaccgctacaacccgctctccgtcttc aacaccaaaacccccagggagaggtctattctggggatgccagacacagtggaggagatg tgccccgacatcccccagctggaaggcctgatgaaggaaatcaacgacctggctgagtca ggggcccggtacacagagatgccccacgtcattgaggtcatcttgcccatgctgtgcaac tacctatcctattggtgggagcgggggcccgagcacctgccccccagtgcagggccctgg tgcaccaaggtcacgtctgaacacctcagtgtcatcctgggcaacattctgaaaatcatc aacaacaacctgggcatcgacgaggcctcttggatgaagcgcattgcagtgtacgcccaa ccgatcatcagcaaagccaggccagacctgctgagaagccacttcatcccgaccctggag aagctgaagaagaaggccatcaagaccgtgcaggaggaggagcagctgcgagcggacagc aagggcgacacgcaggaggccgagctgctcatcctggacgagtttgctatcctctgcaga gacctctatgccttctaccccatgctcatccgctacgtggacaacagcagatctaactgg ctcaaaagccccgatgcagactcggaccagctcttccgcatggtggcagagatcttcatc ctgtggtgtaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaacgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcgaaatctggagga caggaccaggagcggaagaagacaaagcggaggggagacttttattccatccagacctcc ctcatcgtggctgcgctcaagaaaatgctgcccattggtctgaatatgtgcaccccaggc gatcaggagctgatctccctcgcaaaatcacggtacagctatagggacacagatgaagag gtgaaggagcatctgcggagtaacttgcacttgcaggaaaagtctgatgatccagctgta aagtggcagctgaacctatacaaggatgttttaaagagtgaagaaccttccaacccagaa aagacagtggagcgtgtgcagagaatttcagcagctgtcttccacctagagcaggtggaa cagcctttgaggtccaagaaggcggtctggcacaaactgctatcaaagcagcggaaacgg gcagtggtggcctgtttcaggatggcccctctctacaacttgcccaggcaccgctctatt aacctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaa gagaaactagtacaggatttggctaaatctcccaaggttcaagaagaggaggaggaggag gtggaaaagcagccagacccgcttcatcagatcatcctccactttagccgcaacgctctc acggagaggagcaaactggaagacgaccctttgtacacctcctatgccagcatgatggcc aagagttgtcagagtggggaagatgaagacgaggaggaagacaaggagaaaacatttgaa gagaaagaaatggaaaagcagaaaaccctctatcagcaagcccggctgcatgagcgtgga gccgccgagatggtccttcagatgatcagcgccagcaaaggtgagatgagccccatggtg gtggagactctgaagctggggatcgccattctgaatgggggcaatgccggtgtgcagcag aaaatgctagattacctaaaggagaaaaaggatgctgggttctttcaaagtctttctggt cttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagctgaa ggcctggggatggttactgaggaaggaacactcattgttcgtgagcgtggtgaaaaagta ctccagaatgacgagtttacacgagatctctttagattcctacagttactttgtgaagga cacaacagtgatttccagaacttcctgaggactcagatgggcaacaccaccaccgtgaat gtcatcatcagtaccgtggactaccttctgcgtctgcaggaatcaatcagtgatttctac tggtattactcagggaaggacatcattgatgaatctggacagcacaatttttccaaagcc ctggcggtcaccaagcagatcttcaattcgcttacagaatacatccagggcccctgcatt gggaaccagcagagcctggctcacagcaggctgtgggacgcagtggtcggcttcctccat gtgtttgctaacatgcagatgaaactctcccaggattccagtcagatcgagctgctgaag gaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaat gtggtaaatgggaccattggcaagcagatggttgacacactggtagagtcatctaccaat gtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagacttaaccagctca gacaccttcaaagaatatgaccccgacgggaaaggaatcatttccaaaaaggaattccag aaggccatggaagggcaaaagcagtacacacagtcggagatagactttctcctttcgtgc gcagaagctgatgaaaacgacatgtttaattacatcgattttgtggaccggttccatgag ccagccaaggacatagggtttaatgtggcagtgttattgacaaacctctctgagcatatg ccaaacgattctcgcctgaagtgtctgttggacccagcagaaagtgtactcaattacttc gaaccatacctgggacgcattgagatcatgggtggggccaagaaaattgagcgtgtttat tttgagatcagtgagtccagccgaactcagtgggagaagccccaggtgaaggagtctaag cgacagttcatctttgacgttgtcaacgaaggcggggagcaagagaagatggagctgttc gtgaacttctgtgaggacaccatcttcgagatgcagttagcatcgcagatctcggaatct gactcagccgacaggcccgacgaggaggacgacgaagagggagactcttcgcacgtgttg gaagtggagggcgaggaggaggaggaggagaagtctttggagtgtgcctctgcatttgcg atggcttgcgcctcagcgaagagaagcgtggccaactttctgaagagggccaccctgaag aacctcaggaagcagtacaggaaggtgaagaagatgaccttcaaggagctggtgaagctg ctcttctctttcttctggacgttgttcgtggggctcttccgcttgctcttcactatagtg ggagggatcgttcaggtcctctggggcacagtgttcggagggggactcatagaaggggca aagaatataagagtcaccaagatcctgggcgacatgcctgacccaacccagtttggcatc cacgatgatgctgtggaagctgagagggcagaagtgctggagccaggcatcaccacggaa ctggcgcacttcgtaaagggggagaagggagatgcggacatcatgtcagacctctttgga ctccacccaaagaaagaaggtggcctaaagcatgggcccgaagtgggtttgggtgacctt tctgagattattggcaaagacgaaccccctaccttagagagtactgtccggaagaaaagg aaagcacaggcagcagaaatgaaagcagctcatgaagcagaagggaaaatagagtctgag aaggcagacatggaagatggggagaaagaggacacagccaaagaagaagagcaggccgag gccctgtgggcagacgtgaccaaaaggaagaagcgacgatgtggccagaaggttgagaag cctgaagccttcatggccaatttctttaaagggctggaaatctatcagaccaagttgctg cactacctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttcgct atcaacttcatcctgctcttttacaaggtcaccgaagaacctttagaagaagagacagag gatgttgcaaacctgtggaattccttcaatgacgaggaagaggaagaggcggtggtgttc tttgtcctgcaggagagcactgggtacatggcgccagccctgcgggccctggccatcatc cacaccgtcatctctttggtctgcgtggtgggctactactgcctaaaggtccctttggtc gtattcaaaagagaaaaagaaatcgccaggaagctggagtttgatggcctgtatatcact gaacagccttctgaagatgacatcaaggggcagtgggatcgcttggtcatcaacacgcca tcttttcctaataactactgggacaagtttgtaaagagaaaggtgatcaacaaatatgga gatctctacggagcagagcgcattgctgaactcctgggtttggacaaaaatgcccttgac tttagcccagtggaagagaccaaagcagaggcggcctccctggtgtcatggctaagttcc atcgacatgaagtaccatgtctggaagctgggagttgtttttactgacaattcctttctc tacctcgcctggtacacaaccatgtcagtcctgggccactacaacaactttttcttcgct gctcatcttctggatatcgcaatgggcttcaagactctgaggactattctgtcatctgtc actcacaatggcaaacagctggtcctgaccgtcggtctcctggccgtggtggtttatctc tataccgtggtggccttcaacttcttccgcaagttctacaacaaaagtgaagacgacgac gagcccgacatgaagtgtgatgacatgatgacgtgttacctgttccacatgtacgtggga gtgagagctggaggtggcatcggggatgaaattgaagaccctgctggggacccatatgaa atgtatcgcatcgtttttgacattaccttcttcttcttcgtcattgtcatcctgctagcc atcatccaaggtcttattattgatgcttttggggagctgagagaccagcaggaacaagta cgagaggatatggagactaaatgtttcatctgtgggattggcaatgactactttgacacg acccctcatggttttgaaacacacacgctgcaagagcacaacttagccaactacctgttc ttcctcatgtatttgattaacaaagatgagacagagcacacgggacaggaatcttacgtc tggaagatgtaccaagaaaggtgctgggatttcttcccagctggtgactgcttccggaaa caatatgaagatcagcttggataa

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