Ctenopharyngodon idella (grass carp): 127498223 Help Entry 127498223         CDS       T08802                                  Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism cide  Ctenopharyngodon idella (grass carp) Pathway cide04020   Calcium signaling pathway cide04260   Cardiac muscle contraction cide04261   Adrenergic signaling in cardiomyocytes cide04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cide00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     127498223    04020 Calcium signaling pathway     127498223  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     127498223    04261 Adrenergic signaling in cardiomyocytes     127498223  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cide04040]     127498223    04990 Domain-containing proteins not elsewhere classified [BR:cide04990]     127498223 Ion channels [BR:cide04040]  Voltage-gated cation channels   Ryanodine receptor    127498223 Domain-containing proteins not elsewhere classified [BR:cide04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    127498223 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY RR_TM4-6 MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_8 EF-hand_1 EF-hand_6 SK_channel Motif Other DBs NCBI-GeneID:  127498223 NCBI-ProteinID:  XP_051723294 LinkDB All DBs Position 17:24491202..24631598 Genome browser AA seq 4892 aa AA seqDB search MDIVEVEDEIQFLRTRDELVLRCCSSGPHQKKLCLAAEAFGDQLCYLESTSNSKNVPADL SVCVLVLDQCLSVRALQEMLANHEDQCAGSHEATGRRTLLYGQAVLFRHAFSDMYLCCLS TSGLSSDKLAFDVGLLEETKGEVCWWTVHPASKQRSEGEKVRVGDDLILVSVSSERYLHV SWINGESNDNGIGRVDAAFQQTLWSVAPVSSGTVETQSHVRGGDTVRLLRGHTDECLTIP AAEHRREERRSVHFEGGLVSLQARSLWRLEMLHVVWSSSHIHWGQPFRLRHLTTGSYLGL THDQGLQLVERERADVKSTAFSFRASKEESQESSRFVKRRDGMGTPEIKYGDSLCFIQHI DTGLWLTYQTTDFKRQKESVPQRQAVLQAEGHMDDGITLSRSQREESQAACLIRSSALLF SQFIRGLDDVSQKENITDLVLPIEMVHLTLQNLLGYFQWPEMGQDHKVRQGDIRALKNRQ NLFQDEGIITLLLDCIDHLHVYNSVTHFTEAAGKEARESWEKILNSFYELLAALIRGNRN NCAQFSGSLDWLVSRLERLEASSGILEVLHCVLVESPEALNVIKESHIKSIISLLDKHGR NHKILDVLCSLCVCHGMAVRSNQHLICDTLLPERDLLLQSRLVNQVFSVRPNIFLCARDD CAQYRKWYYEVVVEKVEPFVTAEPTHLRVGWASTEGYHPSPTGGHGWGSNGVGDDLCSYG FDGLQLWTGGVGRKVTSPNQHLLREDDVISCCLDLCATCISFRVNGQPVQGMLENFSVDG LLFPVVSFSAGVQVRVLFGGRQGEFRFLPPAGFSPCTEALLPKTCCKLELCQELTRNHTE GQRDLLGPVAPISPVTFTPIPVDSSQVENPPQLEQIRERLSENLHELWLIDKIEQGWNYG PVKDESKKIHTCLVEFSKLPDQERIHNLQSSEDILRTLLALGAHIGLSDEHAEKNVKYVR LSNKYELWNGYKPAPVDQSRVVLTASQEELVEKLAENEHNIWARERIRQGWSFGPQQDVK SKRSTQLVPFSLLDEKNKQAGRDAMRDALGTLLGFGYTVEPLEQEHASSSNIKSVAAERF RFFRLEQAFAVHYGKWYFEFEAVTNGQMRVGWARPGCKPDVDLGSDDQAFVFDGSKGQWW HGGKEQLGGRWKRGDVIGCLLDLTTCTMMVTLNGELLLNSRGSELAVKDFNISDGFLPVC SIGINQVGRLNLGRQVNSLRYFGVCGLQEGYQPFGLNMSKDLPLWMSWREPLFISIPDDH PNIQVIRVGTVDNTPCLKVTQRFFGQQERVTSYVGFYRLSMPIECAQVFSGPGEATVPPS SGVVCHLKDPEEGEAESDFELLMKAHRYAGSRDELNYHKDHSQEKPSRLKQRFLLKKKTD LNTSHSSARLLEDVLAIEKDEDNHLIHCTTYYYSVRIPFSQEPSYVWVGWVTSKFHHNDV TFDLDSICKVTVTLGDEWGKVHESVKRSGCYMVCAAEGSSLSHSRNSSSLEIGCLVDTST GLLTFTANGKEVATYYQVEPGTKLFPAVFAKPTSPDVFQFELGRIKNVMPLSAGVFRSER RNAKPQCPPRLCVQHLTPMRWTRVPDHSQPVEVTRLEERYGWRARCTQIRQIMTLHIPEE SRCVDILELSELRDLLKFHDHTLCLYSALSAHGNTHVSHALCSHVDQSQLLFALQCSRMP GHLRISYYNLLINTHLAAHASARQAMNHEYIVPITDATQSITLFRKNRKVQRFPGSDFST SLRPRMRFTSPCFIRAFKIDVMDGDNNRALWSNLRQDSPEFPLDVLKDVVIVMLKEAVTA VGQGVRDPAGGSIELLLVPLLGLLHTLLMIGVYQGTDLKAVFSLILPVSYMRGTCKTEEM DELEESDGEREEKEGRDWENNVPQQSLLQMKLPEAVKLQVCHLLKYLCDCQVRHRVEAVM SFSGEFVGRLQDNQRFRYNEVMAALNMSAALTARKTKEFRSPPQEQINMMLSFREECQDC PCPEDIQDLMWEFHQDLMTHCGIKIDRDLENENEDDLSIRNHLQGLVDKIIHLKRRMSGV PEEIVNKPVSLQQMISETMLHWAQEGTIENPDLVRAVFSLLLQQYAGLDGQMSAPLQKAY CISQASVEDTLNLQWALACIRSLLTARMGKEEEELMIRGLGDIMNNKVFYQHPNLMRTLG MHETVMEVMVNVLGAKESKEIMFPKMVAHCCRFLCYFCRISRHNQKAMFDHLSYLLDNSN VGLASPSMRGSTPLDVAAASVMDNNELALALTEADLEKVVQYLGGCGLCSCALLVSKGYP DIGWNPVEGERYLDFLRFAVFCNGESVEENAYVVVRLLIRRPECFGPALRGEGGNGLLAT MEEAIRISQQQDETSAASAHSSNQTLDMLDDEDDDVIHMGYAIMTFYSALIDLLGRCAPE MHLIEVGKGEAIRFRAILRSLVPREDLEGIINIPFTLPIVNTEDVVIEPDMSRIFCPDHK AAMVLFLDRVYGVQDQQFLLRLLEYGFLPDLQAAVNMDTMGLGGTDMALALNRYICVAML PLLSKYSSLLCDSSSLWTRLVDRLLEGVYSLSKASGLTKAQRDAIQDCLLAVCRKLNPSM LQFLLRNLVFDVPQLLENSKMPLKLLTNHYEQSRKHYCLNDGWGGFGSASEEELRLTRRL FWGIFSALAKKSYDAELFKLALGCLSAIAGAIPPDHLDLSCTGGRERHLVMDSERRFCPQ PLDTSNVTIPERLEFVVNKYAEHTHEKWSLDKFGNGWVHGEQLSESAKVHPLLKPYRALS EKDKEGYRGVIKETVKCMLFLGWTIERTNEGESQSFHNPARKISQSGKLSFEGASTFSPK PVDTSSVTLTWDQYAMAERLAENYHHIWAARKLQELESKGGGSHPLLVPYDALSVKDKSR VRDKAQDVLKFFQINGYSVKRNKKVADADSPAIASRFAYGLLQQALCLTEQAQEQLLELE VVQARGQIDRTERVPHDQQINFFIKVVLPLLDQYFKNHYLYFLSTTMSSFRDSCQSTNKE KEMATSLFCKLGALARRRLSLFGNDALALVSCLQILAQSLDGRTVMKTTSESVRVSLWSF FEAAAEDLELTVETVTWDEYGLNRAQSRGDSEVITYTTTALIPVLTALFQHDSQRQHGGG LFVDEVRSCYYRILSSLYILGTCSGTLIERQRSVFGECLAALSAAFPVCFLELSDLHSLS DTMSNEESEGVGVVFLAERACRLLPTLQEAFSEVEELAGAGSAARHALLTRVTEVTLPLL CSYVSRWGEAGNQASQEGHCSSVTPQHANALLGHILSIIHAHLGTADSAWMKRLAVFGQP IISKAEPHLLKSHFLPLMEKLRKRVETVLLEEEHLKTVGRGDVLEQELDIQERFTVLVQD IYAFYPLLIPFIDLHRMSWLREVDADAERLFSLVAEVFIFWAKSHNFKWEEQNFVVQNEI NNMTFLVNSSKSRMDKGGLCNQERRKVKRKGDHYSTHTSLIVAAPKKLLSVAMNGCCHGD QGLVTHAKNRFSQRDTEDEVRAFIQSNLQQDLCKNLVDPLSVERILGIACVLFHLDQVER PQKKKRAVWHKMLSKQRKRAVVACLRMAPLYNLPRHRAVNLFLRGYERVWLKAEHDSPED RLIEDLAKAAYVEILKEGAEQRNNMDPLHQLINLFSQSALTEKSKLEEDDLYMCYADIMA KSCQIEEDQDEDGLKSFEEKEMEKQRLLYQQARLHERGAAEMVLQNLSASRGDMGPMVAA TLKLGIAILNGGNTSVQQKMLDYLQQKRDVGFFHNLAGLMQSCSVLDLNAFERQIKAESL GVGAEDNSGDRVMADEQLTCDLFRFLQLLCEGHNTDLQNYLRTQTGNNTTVNIIISTVDY LLRVQESISDFYWYYSGKDVIDERGQHNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAH SRLWDAVVGFLHVFAHMQMKLSQDSSQLELLKALMDLQKDMVVMLLSMLEGNVVNGTIGK QMVDMLVESSSNVEMILKFFDMFLKLKDLTSSEAFREYDLEGRGLISKKDFHRAMEGFKR YSKSEIEFLLSCAEMAKSDLLDYPDFVMRFHEPAKEIGFNMAVLLTNLSEHMPSDARLQN FLELADSVLKYFHPHLGRIEILGSGKRIERVYFEISESTRTQWEKPQVKESKQQFIFDVV NKGGEKEKMELFVNFCEDTIFEMQLAAQISGSKSGDELKVKDDNEEKNKLELNENLAEDN RMTKDSRCFSLRNIRKHIKRITIRSIISAIFSFFHNVLLFITRAFLGLVWFCLYLLYHIF LSGWIIDVAKEMKLVDLLGDLRDPTMVEAIGLREGAVIESNACHTRAFSSRGNLRGMSLD LSAVSRDPQLLTDIFGLCLKKEGGKYTLSSGDTSKYQVEICEDFHEVQEEEDSETEKALD EDKNKSEKKSKRRVRKLSSSKPDETEIKESAVWNIICSQKTKLLNCFARNFYNMRLLALF LTFAINFILLFYKASSTIGDGENVEIALCDNRTKSAQEVYFELEENSGYMKMILRILAVL HTLISLCCIIGYYCLKVPLVIFKREKELARKLEFDGLYITEQPSEDDIKGQWDRMVINTP SYPSNYWDKFVKRKVMAKYGELYGSAHVSELLGLDKAALDFSSEAHERKRPVQKGAITAL FRLNTIDVKYQIWKLGVVLTDNSFLYLAWYMFVSVLGHYNNFFFAAHLLDIAMGFKTLRT ILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGEPVDMKCDDMLTCYMF HMYVGVRAGGGIGDEIEDPAGDEFEFYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRD RQEQVKEDMETKCFICGIGSEYFDTVPHGFESHTLQEHNLANYLFFLMYLINKDVTEHTG QESYVWKMFQERCWEFFPVGDCFRKQYEVQLS NT seq 14679 nt NT seq  +upstreamnt  +downstreamnt atggatattgtagaagtggaagatgaaatccagtttctgcgaactagagatgagctggtg ttgaggtgttgctcatcaggccctcatcagaaaaaactttgtttagctgcagaagctttc ggcgaccagttgtgttaccttgagtccacctccaactcaaagaatgttccagcagacctt tctgtgtgcgtgttagttcttgaccagtgtctgtctgtccgagcgctgcaggagatgctg gccaaccatgaagatcagtgtgcagggtcacatgaggcaactgggcgtcgtactctgctc tatggccaggcagtgttgtttcgacatgccttcagtgacatgtatctttgctgtctgtcc acgtcaggcctctcctctgacaaactggcttttgatgttggtttgctggaggaaacaaag ggtgaggtgtgttggtggacagttcaccctgcctccaaacaaaggtcagagggtgagaaa gtcagagtgggtgatgatctcatcttagttagtgtttcctctgagagatacctacatgtg tcatggattaacggtgaaagtaatgacaacggcattggccgcgtggatgctgcttttcag caaacattgtggagtgtggcccctgtttcttctgggactgtggagacacagagtcatgtg agaggaggggacactgtacgtctgctacgtggacacacagatgaatgtttgaccattcct gcagctgaacacagacgggaggagcgcagatctgtacatttcgagggaggcttggtatct cttcaggctcgatctttatggaggctcgaaatgttacatgttgtgtggagcagtagtcat attcactggggtcagccgttccgtcttcggcaccttaccaccgggtcatacctgggactg actcatgatcagggactacagctcgtggaaagagaaagagccgatgttaaaagtacagca ttctccttccgtgcatcaaaggaagagagccaggagagctcacgttttgttaagaggaga gatggcatgggcacacctgagatcaaatatggagactctctctgcttcattcagcacatt gacacagggctttggctcacatatcagaccactgacttcaagagacagaaggaaagtgtg ccacagagacaggctgttttgcaagcagaaggtcacatggatgatggaatcaccctttct cgctctcaacgggaggaatcacaagctgcttgtttaattcgtagctctgcccttctcttc tcacaattcattaggggactagatgatgtcagtcagaaggaaaacattactgatttggtt cttccaattgagatggtccatctgacactgcagaatttgcttggttattttcaatggcct gaaatggggcaagaccataaggttagacagggagatattagagcactgaagaacagacaa aatctcttccaagatgagggtataatcactctgttgctggactgcattgaccacctacat gtgtacaacagcgtgactcattttacagaggctgctgggaaagaggcaagagagtcatgg gaaaagattttgaattctttttatgagctgctagctgcccttatcaggggtaatcggaat aactgtgcccagttttctggatccttggattggctggtcagcagactggagaggctggag gcctcctctggaatattggaagtgttacattgtgttttagtagaaagtcctgaagctttg aatgttattaaggaaagccacataaaatctatcatctcacttctggacaaacatggaagg aatcataagattttggatgtgttgtgttcactctgtgtgtgtcatggcatggccgtccgc tctaatcagcatttgatttgtgacacactgctgccagaaagagacctgcttctacagtca agactggttaaccaagttttcagtgtacgtccaaacatcttcttgtgtgcaagagatgac tgcgcccagtacaggaagtggtattatgaggttgtagttgagaaggtggagccttttgtg acagcggagcctactcacctgcgagtgggttgggccagcactgaagggtaccatccatcc cccacaggcggtcacggatgggggtcaaatggtgttggagacgacctctgctcttatggc tttgatggactccagctctggacaggaggtgtaggtcggaaggtcacctcacccaatcag cacttgctaagggaggatgatgtcattagttgctgtcttgacctttgtgcaacttgcatc tcctttcgggtcaatggacagccagttcaaggcatgctggagaacttcagtgtggatggg ctgctgttcccagtggtcagcttctcagctggagtgcaggtgcgtgtgctgtttggaggt cgacagggggagtttaggtttcttcctcctgctggtttctctccgtgcactgaagctctc ctccccaaaacctgctgcaagctggagctgtgtcaggaactcacacggaatcacactgaa ggccaacgtgacctcctaggccctgtggcacctattagcccagtgacctttacccccatt ccagtggattccagccaggttgaaaatcctccacagctggagcagatcagagaaagatta tcagaaaatctccatgaactctggcttattgacaaaatagagcagggctggaactatgga cctgttaaagatgagagcaaaaaaatacacacgtgtctagttgagttttccaaacttcca gatcaggagcgaattcataaccttcagtcatctgaggacatcctcaggactcttctggct cttggtgcccatattggactctctgatgaacatgccgagaagaatgtgaaatatgttcgc ctttcaaataagtatgagctatggaacggatataaaccagcccctgtagatcagtcccgt gttgtgctaacagcttctcaggaagagctggtagaaaaactggctgagaatgaacacaac atctgggccagagagcgtatcaggcagggctggagctttggaccacagcaggatgtaaaa tctaagagaagtacccaactagtgccattttcccttttggatgaaaagaacaaacaggct ggaagagatgccatgagggacgctttaggtactcttcttgggtttggatacactgtggag cccctggagcaagaacatgcctcaagtagcaatattaagtctgtggctgcagagagattt cggtttttccgtctggagcaggcctttgcagtgcattatggcaaatggtactttgagttt gaggctgtaactaatggacagatgagagtgggctgggcacgacctggatgtaaacctgac gtggatcttgggtcagatgatcaggcctttgtctttgatggttctaaggggcagtggtgg catggtgggaaagagcaattgggtggccgctggaagaggggggatgtaattggctgtttg ttggacctgactacatgcactatgatggttactcttaatggagagctactgctgaacagt cgaggttctgaactggctgtaaaagactttaatatatctgatggtttcctgcctgtttgt agtatagggataaaccaggtgggtcgtctaaatttgggtcgtcaggttaactcactgaga tacttcggtgtttgtggcctacaagagggataccagccctttggtctgaacatgagcaaa gatctacctctgtggatgagctggagagaacctttgtttatttctatacccgatgaccat cctaacatacaggtgattcgtgttggaacggttgacaacaccccatgtctgaaagtaaca cagaggttttttgggcagcaggaaagagtcacaagctatgttggattttaccgtctgagc atgccaatcgagtgtgcacaggttttctctggccccggcgaggccactgtgccacccagc agcggtgtggtgtgccacctcaaagatccagaggaaggagaagcagagtctgactttgag ttactgatgaaagctcacagatacgcaggatccagagatgaactcaattatcacaaggac cacagtcaggagaagccatccagactcaaacagcggtttctgctgaagaagaaaacagat ttaaacaccagtcactcatcagctcgtctcttggaggatgtgctggccattgagaaagat gaagacaaccacctcattcactgcactacgtattattactctgtgagaatccccttcagt caggagccctcttatgtttgggtcggatgggtaacttctaagttccaccataatgatgtg acctttgacctggacagcatttgcaaggtcacagtcacacttggggatgaatggggcaaa gttcatgagagtgtcaagcgtagcggctgttacatggtgtgtgcagcagagggcagtagt ctgtctcacagtcgcaacagcagtagcctggagattggctgtctggttgacacatcaaca gggctcctgacattcaccgctaatggcaaggaggttgctacatactaccaggtggaacct ggcaccaagctcttccctgctgtatttgctaaacccaccagtcctgatgtcttccagttt gagctaggacgtatcaagaatgtgatgccactatcagcgggagtttttcggagtgaaaga agaaatgcaaaacctcagtgccctcccagactatgtgttcagcacttaacgcctatgcgg tggacccgagtacccgaccactctcagcctgtggaagtgacccgtctggaggagagatac ggctggagagctcgctgcactcagatccgacagatcatgaccctgcatatacctgaggag agcaggtgtgtggacattctggaactgtccgaattgcgtgatctcctgaagttccatgac cacaccctttgcctctactctgccctttcagctcatggaaacacgcatgtgagccacgcc ctctgcagccatgtggaccaatcacaactcttgtttgccttgcagtgctctagaatgcca ggtcacctgcggataagttactacaaccttctcatcaacacccaccttgctgcccatgcc agtgccaggcaggcaatgaaccatgaatacattgtacccataacggatgccacacagtct attacgcttttcagaaaaaacaggaaagtgcaaagattcccaggaagtgacttcagcact tccttgcggccgagaatgcgcttcacatcaccttgcttcattagagcttttaaaatagac gtgatggatggagataacaatagggctttgtggagtaatttgcgccaagacagcccggaa ttcccactggatgtattaaaggatgttgtcattgtaatgctgaaggaggcagtgacagca gttgggcagggtgtgagggatcctgcagggggcagcatagagctcctgctggttcctctg ctcggtttacttcacacgcttctgatgataggtgtgtatcaggggacagatctgaaggct gtgtttagtctcatcctgccagtcagttacatgagaggaacatgtaaaacagaggagatg gatgaacttgaagagagtgatggagaaagagaggaaaaggagggtagagattgggagaat aatgtccctcagcaaagtcttcttcagatgaagcttccagaagctgtcaaattacaggtg tgccaccttctgaagtacttgtgtgactgccaggtgcgtcacagagtagaagctgtaatg tcgttctcaggtgaatttgttggtcgtctccaagacaaccagcgcttccggtacaatgaa gttatggctgcgctcaacatgtctgctgccctcaccgcacgcaaaactaaagagttccgt tccccccctcaggaacagataaacatgatgctgagcttccgggaggaatgtcaggattgt ccttgcccagaggacatccaagatttgatgtgggaattccatcaggatctaatgacccac tgtggaattaagatagaccgtgatttagagaatgagaatgaggatgatctttcaatcagg aatcacctccaaggcctagtggataaaataattcatttaaagaggagaatgtctggcgtg cctgaggagattgtgaacaaacctgtctctctgcagcagatgatatcagaaaccatgctg cattgggcccaggaagggacgattgaaaaccccgatctggtgcgtgctgttttcagcctg ctgctacaacagtatgctgggctggatggccagatgtctgctccactacagaaggcttac tgtatcagccaggcatctgtggaagacactctgaacctacagtgggctctagcatgcatt cgttcattgctcacggccaggatgggcaaagaagaagaggaacttatgattagaggactg ggtgacatcatgaacaataaagttttctatcagcatcctaatctgatgagaactctgggg atgcatgagaccgtcatggaagttatggtgaatgtccttggtgctaaagaatccaaggaa atcatgttccctaagatggttgcgcactgctgtcgtttcctgtgttatttctgtcgaatc agtcgccataaccagaaggccatgtttgatcatctcagctacctgctggacaacagcaat gttggacttgcatctccttcaatgagaggatcgactcctctggatgtggctgccgcttct gtcatggacaacaacgagctggcacttgctcttactgaggcggatctagagaaagttgtg cagtatttgggaggctgtggtttgtgtagttgtgctttgctggtctccaaaggataccca gatattggatggaatcctgtagagggagaacgttacctggacttcctgcgctttgcagta ttttgcaatggtgagagtgttgaggagaacgcctatgtggtggtgaggcttctgattcgc cgacctgagtgctttggccccgctcttcgaggggaggggggaaatggtcttcttgcaacc atggaagaagcgatcagaatttcccaacagcaggatgaaaccagtgcagccagtgcacac agttccaaccagacacttgacatgcttgatgatgaagatgatgatgtcatccacatggga tacgccataatgaccttctactctgctctgatcgatctgttaggtcgttgcgcccctgag atgcatctcatagaagtggggaaaggtgaggccatccgattcagggcaatcttgaggtct ctcgttcccagagaggatctggagggcatcataaatattccttttactttaccaattgtt aacacagaagatgtagtgatcgagccagacatgtctcggatattttgtccggatcacaaa gcagccatggtgctgtttttggatcgagtttatggagttcaggaccagcagttcttgcta cgtctactggagtatggtttcctgccggacctgcaagcagctgttaacatggatactatg gggttaggtggaacagacatggcactggccctcaatcgatacatatgtgtggccatgctg ccactgctgagtaagtattcctctctgctgtgtgactcctcatctctttggaccaggctg gtggacaggctcttggagggtgtctacagcctctctaaagccagcggactgaccaaggcc cagagagatgccatacaggactgtctgctggcagtgtgcagaaaactgaatccttccatg ctgcagtttctgctgcgtaatcttgtgtttgacgtccctcaactgttggaaaactccaag atgccacttaagctgttgaccaatcattatgagcagagcaggaagcactactgtctgaat gatggatggggtggctttggctccgcctcagaggaagaacttcgtctaaccaggagactg ttttggggaatattcagtgctcttgccaaaaaatcttatgatgcagagctattcaaactg gccctcggttgtctgagtgccattgctggggcgattcctcccgaccaccttgacctgagc tgtactggtggacgagagagacacttagtgatggattcagagagacggttttgtcctcaa cccctggacacctcaaatgtgacaatcccagagaggctcgagtttgtggtaaacaaatat gcagaacatacacatgagaaatggtcactggacaagtttggtaacggttgggttcatgga gaacagctttctgagagtgctaaagttcatccactcctaaaaccttacagagctctatct gagaaggataaagaaggttatcgaggggtcattaaagagacggtgaaatgcatgctgttc ttgggctggaccattgagagaaccaatgagggggagtcacaaagctttcacaacccagct aggaagatctcacaatctggcaagctttcttttgaaggagcctccacgttcagtccaaag cctgtggacaccagcagtgtcactctgacctgggatcagtatgccatggcagagcgtttg gctgagaattatcatcacatctgggcagccaggaaactgcaggaactggagagtaaagga gggggcagtcaccctctgcttgtaccttatgatgctctgagtgttaaagacaagagccga gtcagagacaaagctcaagatgttctcaagttcttccaaatcaatgggtactcagtgaag aggaacaaaaaggtggcagatgctgattccccagcgattgcgagccgcttcgcttacggc ctgctccagcaagccctctgtctcactgaacaagcccaggaacagctactagagctggag gttgttcaagctcgagggcagattgacaggactgagagagttccccatgaccaacaaatt aatttcttcattaaggttgtattgccactgttagatcaatacttcaaaaatcactatctc tacttcctgtccactacaatgtcttcctttagagatagctgccagtctacaaataaagaa aaagagatggccaccagtttattctgtaaactcggagctctagccagacgcagactctct ctgtttggaaatgatgcccttgctttggtaagctgcctacaaatcctggcacagtccctg gatggaaggacagtaatgaaaaccactagtgaatccgtcagggtgtcattgtggtcattt tttgaagctgcggcagaggatcttgagctaacggtggaaactgtgacatgggatgagtat ggactgaaccgagcccagagcaggggagacagcgaggtcataacatacaccaccaccgcc ctgatcccagtgctcaccgctctatttcagcatgactcccagaggcagcacggaggggga ttgttcgtggatgaagtgcgctcctgttattacaggatcctcagcagtctctacattctt ggtacctgcagtggtaccttgattgagaggcagaggtcagtctttggggagtgtctggct gcattatctgcagcctttcctgtgtgtttcttggagctgagtgaccttcattccctctcc gacacgatgagtaatgaagagagtgaaggtgttggtgtggtctttctagctgagagagcc tgtaggctcctccccactttgcaggaggctttctcagaggtcgaagagctcgcaggagcg gggtctgcagcccgccatgcccttttaacaagggttactgaggtgactcttcctctgctg tgtagctatgtctctagatggggggaggctggtaaccaggcatctcaggagggccactgt tcctctgtcacacctcagcatgccaatgccttgctgggtcacatcctctccatcatccac gcccacctggggactgcagatagtgcttggatgaaacgcctcgcagtatttggccagcct atcatcagcaaggcagaaccacatctcttgaagagccactttctgcctctgatggaaaag ttaaggaagagggtggaaacagtgctgctggaggaggagcatttgaagacagtggggcgt ggcgatgtcttagagcaggagttagacatccaggaaaggtttaccgtgttggtccaagat atctatgctttttaccctttactcattccatttatagaccttcacagaatgagctggctg agagaggtggacgcagatgctgagaggcttttctccctcgtagctgaagtcttcattttt tgggctaaatctcataatttcaaatgggaagaacagaattttgttgttcaaaatgaaatc aacaacatgacattcctggtgaacagcagcaaaagcaggatggataagggagggttgtgc aaccaggagagaagaaaggtgaagaggaagggtgatcattactccacacacacctctctc attgtggccgccccaaaaaaactcctctcggtcgccatgaatggatgttgccatggcgat cagggcctggtcacccatgccaaaaaccgtttctctcagagggacacagaggatgaggtc cgagcattcattcaaagcaacctgcaacaggatctgtgtaaaaacttagtagatcccctc agtgttgagaggatcttaggcatcgcttgtgttcttttccaccttgatcaggtggagcgc cctcagaagaagaagagggcagtgtggcataagatgttgtctaagcagaggaaacgagct gtagttgcttgtttgagaatggctcctttgtacaatcttcccaggcacagagcagtgaac cttttcctccggggttatgagagagtctggctgaaggcagagcatgactcacctgaggat agactaattgaggatttggctaaagcagcttatgtagagatactaaaggagggagcagag cagagaaacaacatggatccactccatcagcttatcaatctcttcagtcaaagtgccttg actgagaagagtaaacttgaggaggatgacctgtacatgtgctatgctgacatcatggcc aagagttgccaaattgaggaagaccaggatgaagatggcctgaaatcatttgaggaaaaa gagatggaaaagcagaggctgctgtatcagcaggcccgacttcatgaacgcggagctgct gagatggtcttacagaacctcagcgccagcagaggtgatatggggcctatggtagcagcc acattaaagctgggcattgcaatcctgaatggaggaaacacgtctgtccagcagaaaatg ctggattacctgcaacagaagagagacgtgggcttctttcataatctggccggccttatg cagtcttgcagcgtgctggatttgaacgcatttgagaggcagatcaaagcagagagttta ggagtgggtgccgaggacaattcaggtgatagagtgatggcagatgaacagctaacctgt gatcttttcagattcctccagcttctttgtgaaggccataatactgatctccagaattac ctgaggactcaaactggaaacaacacaacggtcaacattatcatctccactgtggattat ctgcttagggtccaggagtccatcagcgatttctactggtattattcagggaaggatgtg attgatgagcgtggtcagcacaacttctccaaagccatcaacgtggccaagcaggtgttc aacacgctcactgaatacattcagggtccctgtacaggtaatcagcagagtttggcccac agtcgtctgtgggacgctgttgttggcttcctccatgtgttcgcccatatgcagatgaag ctttctcaggattccagccaattagagctactgaaggctttgatggacttacaaaaagac atggtggtaatgctgctgtccatgcttgaaggaaacgtggtgaatgggaccattggcaaa cagatggtagacatgttggtagaatcgtccagcaatgtggagatgatcctcaaattcttt gatatgttcctcaaactcaaagacctcacatcatctgaagcctttcgcgaatacgaccta gagggcagaggactcatttccaagaaggacttccacagagccatggaagggttcaagcgc tactctaaatcggagattgaatttctgttatcctgcgcagaaatggcgaaaagcgatttg ctggattaccctgactttgtgatgcgttttcatgaaccggccaaagagataggcttcaac atggcggttcttctgaccaatctgtccgagcacatgcccagtgatgcccgattgcagaat ttcctggagttggcggacagcgttcttaagtatttccatcctcacctgggaaggatcgaa atcctgggcagtgggaaacggatagaaagagtctactttgagatcagtgaatccacccgc actcagtgggagaaaccacaggttaaggagagcaaacaacagttcattttcgatgtcgtg aataaaggaggagagaaggaaaagatggagctatttgtcaacttctgtgaagacaccatc tttgaaatgcagcttgctgcacaaatatctggttcaaagagtggagatgaactgaaagtg aaagatgacaatgaggagaaaaacaaattagagttgaatgaaaaccttgcagaagacaac aggatgaccaaagactcaaggtgtttctccttaaggaacatcagaaaacacataaagagg ataaccattaggagtattatctcagcgatcttctctttcttccacaatgttctgctgttt atcactcgtgcctttttaggcctggtttggttctgcctttatctgctctaccacatcttc ttaagcggatggattattgatgtggctaaagagatgaagctagtcgaccttttaggtgac cttcgggatcctaccatggttgaggccatagggctcagagaaggagcggtcatagagagt aacgcgtgccatacacgtgcattttcgtctcgcggtaatcttaggggcatgagtctagat ctgtctgcagtgtccagggacccccagctcctcacagatattttcggcttgtgtctgaag aaggagggaggaaagtacacattgtcaagtggagacacctccaaatatcaggttgaaatc tgtgaggattttcatgaggtgcaagaggaggaggactcagagactgagaaagctttggat gaggataaaaataaaagtgaaaagaagtctaaacggagagttagaaagcttagctcttca aaaccagatgaaactgaaatcaaggaatcagctgtttggaatattatctgctctcagaag accaaactgctgaactgttttgcaagaaatttctacaacatgagattgctggctctgttc cttacttttgccatcaattttattcttctgttctacaaggcttcatcgaccattggtgat ggtgaaaatgtggagattgctctttgtgacaacagaaccaagagtgcacaggaagtttat tttgaactagaagagaacagtggctacatgaaaatgattcttcgcatcctggctgtcttg cacacacttatctcactctgctgtatcatcggctactactgtctgaaggttcctttagta atttttaagcgtgagaaggagctggctcgtaaactggagtttgacggactctacattaca gaacaaccttctgaagatgacattaaaggccagtgggacagaatggtcattaatacacca tcatacccaagtaattattgggataaatttgtgaaaaggaaggtgatggcgaaatatgga gagctgtatggatcggcacatgtcagtgagcttctaggtttagataaagctgctctggac ttcagctcagaggctcatgagaggaagagacctgtacaaaagggtgccatcactgcccta ttcaggttaaacaccattgatgtgaagtaccaaatatggaagctgggagtggttttaact gacaattccttcctttacctggcctggtatatgtttgtgtcagttctgggtcattataac aattttttcttcgctgcgcacctgctagacatcgccatgggcttcaaaacactgcgcacc atactgtcatctgttacacataatggcaaacagctggttttgacagtgggactgttggcc gtggtcgtgtatctctacactgtggttgcctttaacttcttccgcaagttttacaacaag agtgaggatggtgaaccagtggacatgaaatgtgatgatatgctcacatgttacatgttc cacatgtacgttggtgtgcgagccggaggagggattggagatgaaatcgaagacccagct ggtgacgagtttgagttctatcgtatcatcttcgacatcaccttcttcttcttcgtcatc gtcatcctcctagccatcattcagggtctgataattgatgcatttggcgagttgagagac cggcaggagcaggttaaagaggacatggagactaagtgttttatctgtggcattgggagt gagtattttgacacggtgccccatggcttcgagtcacacacactgcaagaacacaacctg gccaactatctgttctttctgatgtacctcatcaataaggatgttacagaacatactgga caggaatcatacgtgtggaagatgttccaggaacgctgctgggaattctttcctgttgga gactgtttccggaaacagtatgaggttcaactcagctga

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