Ctenopharyngodon idella (grass carp): 127523844 Help Entry 127523844         CDS       T08802                                  Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism cide  Ctenopharyngodon idella (grass carp) Pathway cide04020   Calcium signaling pathway cide04260   Cardiac muscle contraction cide04261   Adrenergic signaling in cardiomyocytes cide04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cide00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     127523844    04020 Calcium signaling pathway     127523844  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     127523844    04261 Adrenergic signaling in cardiomyocytes     127523844  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cide04040]     127523844    04990 Domain-containing proteins not elsewhere classified [BR:cide04990]     127523844 Ion channels [BR:cide04040]  Voltage-gated cation channels   Ryanodine receptor    127523844 Domain-containing proteins not elsewhere classified [BR:cide04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    127523844 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  127523844 NCBI-ProteinID:  XP_051770910 LinkDB All DBs Position 12:complement(30460776..30570041) Genome browser AA seq 4966 aa AA seqDB search MTDGEAEDEIQFLRTDDEVVLQCSATVQKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPD LSICTFVLEQSLSVRALQEMLANTEERAEGLIDMEKWKFMMKTAQGGGHRTLLYGHAVLL RHSYSGMYLCCLSTARSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDL ILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHM DECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHVT TGKYLSMMDDQGLLLMDKEKADVKSTAFCFRSSKEKLDFGLRKEVDGMGVPDIKYGDSVC YIQHVDAGLWLTYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRS TVFLFNRFIRGLDTLSKKGKTSTLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRA LKSRQILFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGQSWKSILNSLYELLAALI RGNRKNCAQFSSSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLL DKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFL GVSEGSAQYRKWYYELIVDHVEPFVTAEATHLRVGWASTQGYWPYPGGGEGWGGNGVGDD LYSYGFDGLHLWAGCVARSVSSPNQHLLRAEDVVSCCLDLSAPSISFRINGQPVQGMFEN FNSDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPSGYAPCFEAVLPREKLRVEHSQEYK HDHRNTRDLLGPTVTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIDLG WTYGTVRDDNKRQHPCLVEFSRLPEQERSYNLQMSQETLKTLLALGCHVGVADERAAEKV KNLKLSAKYELSSGYKPAPMDLSHIKLASTQEAMVDKLAENAHNVWARDRIRQGWTYGVQ QDIKNRRNPRLVPYVLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARADTGNLS AERFRIFRAEKTYSVSGGKWYFELEVVTAGEMRVGWARPGCLPDQELGSDEQAFVFDGFK AQRWHQGNEHFGRSWQSGDVVGCMVDMNERTMMFTLNGEVLLDDSGSELAFKDFEVWDGF IPVCSLGICQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDLTMWISKRLPQFIPA PLNHEHIEVTRIDGTVESPPCLKVTQRSFGSQNSNTDIMFYRLSMPIECSEAFLRSPGGT LAANGSFFSPKRDLEDFETVSDFEVLMKTPHSHVSSNGPDRDRDEFNNHKDHNQEKPSKI KQRFMLKRTKPDMNSSNSSARLSEEVLADERDDCENLIQTSTYYYSVRIFPGQEPASVWV GWVTSDFHQYDPAFELSKVRTVTVTLGDEKGKVHESIKRSNCYMVWGGECSSPSQGRNNN GLEIGCLVDTANGLLSFTSNGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKSI MPLSAGLFKSERKNAIPQCPPRLHVQFLTPVLWSRVPNQFLRSEVTRVNERLGWMVQSSE PLQFMTLHIPEENRSLDILELTEQRDLLKFHFHTLRLYSAICALGNNRVAHALCSHVDEA QLLYAIQNKYMPGLLRTGYYDLLIDIHLSSYATARLMMNSEYIVPMTAETKSITLFPNEK KKHGLPGIGLSTSLQPRMRFSSPSFVGHHGAVAGGDCFQYSPEFPLETLKSRTMEMLTEA VREGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKTILQLIEPSVFSQDGGGG TNEAEDSCGRGRLEGGGAEEHGLRGKMPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHR IEAVVAFSDDFVANLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKD EKQDCPCPEDIREQLLDFHEDLMTHCGIEMDDDKSGDGDDFTIRGRLMCLVEKVTYLKKK MTEIPKKKKSKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRAL PKTYTINAVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIHGLSDIMNNKVFYQHPNLM RALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLL ENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLMS KGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNG LLAAMEEAIKISEDPSRDGPSPTTEESRTLSDVLEEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLVGVISIPFLMPTLAKDGSVIEPDMSAGF CPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKL RPSMMQHLLRRLVFDVPVLNEHTKMPLKLLTNHYERCWKYYCLSGGWGSFGASSDEELHL SRKLFWGIFDALARKKYDVELFKLALPCLSAVAGALPPDYMESNYVAMMEKQSSMDAEGN FNPQPADTSSVVVPEKLDHFINKYAEYSHEKWSMEKFAVGWIHGEQMCESSKVHPLLKPY KCLSEKDKEVYRWPIRESLKTMLSWGWSIERTRESDASTLHSRTRRISLSSQRSIEGAHG FSPRPVDMSNVTLSRDLHSMAELLAENYHNIWAQKKKLELEAKGGGSHPLLVPYDTLTAK EKSKDREKAQDILKFFQINGYSVSRAMKEQDLDTPSIEKRFAYTFLQQLITYVDEAHGHM LEFDAGIRPKGEKIPHEQQVKFFGKVVLPLVDQYFKNHRLYFLSTAVRPISSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGQDSVKAALRAF FDNASEDLEKTMENLRQGQFTHTRMQPKGVTQIINYTTVALLPVLSSLFEHIGQNLFGED LILDDVQVSCYRILNSLYSLGTSKSIYVERQRPALGECLAAFSGAFPVAFLEPNLNKHNT YSIYNCKGSRERAALGLPAQVEEVCALVPSLERALQEIMELAESGMRYTQMPHVMEVLLP MLCSYMSHWWEHGPESDPERAESCCTSLTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIIGKAKSQLLKTHFLPLMEKLKKKAATVLQDEEHMKAEGRGEMSESELLILDEFT ILVRDLYAFYPLLIRFVDYNRAKWLKEPNTEAEELFRMVAEVFIFWAKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKGGVSDQERKKMKKRGDRYSLQTSLIVAALKRLLPVGLNI CAPGDQELIGLAKSRFTQKDTEDEVREIIRNNLHLQGKLEDPAIRWQMALYKDMPNRSED SSDPEKTVDRVLNIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLP RHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKAGGEELSEEDEMTKHIDPLHQLIQLF SRTALTEKCKLEEDHLYMAYADIMAKSCHDEEEDDEEEVKSFEEKEMEKQKLLYQQARLH DRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKRDVGFFQS LAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLL CEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNF SKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIE LLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDL TSSDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVER FHEPAKDIGFNVAVLLTNLSEHMPHDSRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIE RVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQM SDAAERSASKEESEREKPDEESPEMGFFSVTTVRTALFALRYNVMLLMKVLSMKSLKKQV KKAKKMTVKDMVTTLVSFYWSVLLGLLHFAFSVARGFFRITYNSFLGGSLVEGAKTMKVS ELLANMPDPTQDEVRGEMEEGEKKHLDKTSPEEDLADLTVATDDTDVLSDIFGLDLKREG GQYKLMPHNPNASLTDLLNTPVPQPPTPSPELRRRHQTKGSSSSTDNNEVAEETKSVPEK AERENGEKAQKKDEAVKRKVRLHYSRADEPDLQESAFWKKIIAYQRKLLNYFARNFYNMR MLALFVAFAINFILLFYKVSTSSAVTEGKEVLFSASSDTSVRWDPLAGSGTRPVTVHFVL EESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQP SEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSD AHEKKKPKRDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMSMSILGHYNNFFFAA HLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGES PDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAI IQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFF FMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14901 nt NT seq  +upstreamnt  +downstreamnt atgacggacggcgaagccgaagatgagatccagttcttacggaccgatgatgaggtggtc ctccagtgctccgccaccgtccagaaggagcagcagaaactctgtctggccgccgagggc ttcgggaacagactgtgtttcctcgagtccacgtccaactcaaagaatgttcctccggat ctgtccatatgtacgtttgtgctggagcagtcgctgtcagtgcgagcgctgcaggagatg ctggccaacactgaggagcgagcggaagggctcatagacatggagaaatggaaattcatg atgaagacggcgcagggcggaggtcaccggacgctgctctacggtcacgcggtcttactg agacactcctacagcgggatgtatctgtgctgtctgtctacggctcgctcgtccaccgac aaactggcttttgatgtggggcttcaggaagacacaacaggtgaggcatgttggtggaca atccaccccgcgtccaaacagaggtcagagggcgagaaggtgcgggtgggtgatgatctc atcctggtcagcgtgtcgtctgaacgttacctgcacttgtcgtatggtaacggcagtttg cacgtggacgcggctttccagcaaacgctctggagcgtcgcgccgatctgctccggcagt gaagtggctcagggcttcctaattggtggagatgttctgcggctgctgcacggtcacatg gacgagtgtttgaccgtcccgtcaggagaacatggagaggaacaacgcaggacggtgcat tacgagggtggagccgtgtccatccacgccagatccctgtggaggctggagacgctccga gtcgcgtggagcggcagtcacatccgctggggtcagccgtttcgcttgcgccacgtgacc accgggaaatatctcagcatgatggacgatcaagggctcctgctaatggacaaggagaaa gcggacgtcaaatctacggctttctgcttccgttcctcaaaagagaagctggactttggc ctgaggaaggaggtggatgggatgggcgtcccggacatcaaatacggagactcggtctgc tacatccagcacgtggacgccgggctctggctcacataccagtctgtagacgccaagtgt gctcgcatgggtggcgtccagaggaaggccatcatgcatcatgagggtcacatggatgac ggattgacgctctcgcgatcacaaaacgaggagtcgcgcaccgccagagtcatccgcagc acggtcttcctgttcaaccgcttcatcaggggtctagacactctgagtaagaaggggaag acatccaccctcgatctgcccatcgaatcggtcagtctgagtcttcaggatctgatcgga tacttccagcctcccgatgagcacctggagcacgaggacaaacaaaaccgactccgagcg ctcaagagcagacagatcctgttccaggaggagggaatgatcaacctggtgctggagtgt atcgatcgtttgcatgtctacagcagtgcggctcattttgcagacgtggccggtaaagaa gctggacaatcctggaagtccatcctgaactccctctacgagctcctcgctgctctgatc agaggaaacaggaagaattgtgcccagttctccagctctctggattggctgatcagtcgt ctggagaggttggaagcgtcgtctgggattctggaggttctgcactgtgttctggtggag agtccagaagctctgaacatcattaaagaaggacacatcaaatccatcatctcactgctg gacaaacatggacgcaaccacaaggttctggacgtcctgtgttctctgtgcgtgtgtcac ggtgtggcggttcgctccaatcagcacctgatctgtgataatctgctgcccggcagagac ctgctgctgcagacgcgtctcgtcaatcacgtcagcagcatgaggcccaatatcttcctg ggtgtgagcgaaggctccgcccagtacaggaagtggtattatgagctcatcgtggaccac gtggagccattcgtgacggctgaagccactcacctgcgggtgggttgggcgtccacacag ggctactggccgtatccgggcggaggagagggctggggcgggaatggtgtcggggacgac ctctactcatacggctttgatggcctccacctgtgggcaggttgcgtggcgcgatcggtc agctcacccaatcagcacttgctgcgggccgaggacgtggtcagctgctgtctggatctc agcgctcccagcatctccttccgcatcaacggccagccggtccagggaatgtttgagaac ttcaactcagatggactcttcttccctgtagtgtccttctctgctggagtcaaagtgcgc ttccttttgggcggtcgtcatggcgagttcaagttcctgcccccatccggttacgctccg tgtttcgaggcggttttaccacgagagaagctgagagtggagcacagtcaggagtataaa catgatcataggaatacacgtgacctcctcggacccacggtcacgctgtcacaagcggcc ttcacaccaacacctgtggacaccagtcagatcgtgttgccgccacatcttgagcggatc cgagagaaactggcagaaaacatccatgagctgtgggtgatgaacaagatcgatctcgga tggacttacggaacggtgagagatgataataaacggcagcatccgtgtctggtcgagttc tccagacttcctgaacaagagcgtagctacaaccttcagatgtctcaggagacgctcaag actctcttggcgctgggctgtcatgttggcgtggcggacgaacgagcggcagagaaagta aaaaatctcaagctttcagccaaatacgagctctccagcgggtataaaccggcgccgatg gacctgagccacatcaaactggcgtctacccaggaggccatggtggacaaactggcagag aatgctcacaacgtctgggccagagaccgcatacggcagggctggacctacggcgtacag caggacattaagaacaggagaaaccctcgcctcgttccgtacgttcttctggacgagagg accaagaaatcaaacaaggacagtctgcgggaagctgtgcggacactgctgggatacgga tacaacctggaggctccggatcaagaccacgcggctcgagcggacacaggtaatctgtct gccgaacgcttccggatcttccgagcggagaagacatacagcgtgagcggagggaagtgg tacttcgagctggaggtggtgacggcgggcgagatgcgggtgggctgggcgagacccggc tgtctgccggaccaggagctgggctcagacgagcaggccttcgtcttcgatggattcaag gctcagcgctggcatcagggcaacgagcactttggtcgctcctggcagtccggagacgtg gtgggatgtatggtggacatgaacgaacgcaccatgatgttcacgctcaacggcgaggtg ctgctcgacgactccgggtccgaactcgccttcaaagactttgaagtttgggacggtttc atcccagtctgtagtctgggcatctgtcaggtgggccgtatgaacttcgggaaggatgtg agcaccctgaagtacttcaccatctgcggcctgcaggagggctacgaacccttcgccgtc aacatgaaccgagatctgaccatgtggatcagcaaacggctgcctcagttcatccccgcc ccgctcaaccacgagcacatagaggtcacaaggatcgatgggacagtggagagcccgccg tgcctaaaggtcacacagaggtcgttcggctcacagaacagtaacacggacatcatgttc tatcgtctcagcatgcccatagagtgctcggaggcgttcttgcgatcgcccggtgggacg ctagcagccaacggcagcttcttctctcccaagagagatctggaggattttgagacggtg tcggactttgaggtcctgatgaaaacgccacacagtcacgtgagctcaaacgggcccgac agagatcgagacgagttcaacaaccacaaagatcataatcaggagaaaccttcgaaaatc aaacagaggtttatgctgaaaagaacgaagcccgacatgaacagcagtaactctagcgct cgcctgtcagaggaggttttggctgatgagagagatgattgtgagaatctcatacaaaca tcaacgtattactactcggtgaggatcttccctgggcaggaaccagccagtgtttgggtc ggatgggtgacctcagactttcatcagtacgatccagcctttgagctcagcaaggtccgt acggtcaccgttaccctgggagatgagaagggcaaagttcacgagagcattaagcgcagt aactgctacatggtgtggggcggcgagtgcagcagtcccagtcagggccgcaataataac ggcctggagatcggatgtttggtagatactgccaacggcctcctcagcttcacctccaac ggcaaagagctcagcacctactaccaggtggagcccagtactaaactcttccctgcagtg tttgcgcaggcaacaagtccaaacgtcttccagtttgaactgggacgcatcaagagcatc atgccgctctctgcagggctgtttaaaagtgaacggaagaacgcgattcctcagtgtccg ccacggttacacgtgcagttcctcacacctgtgttgtggagccgtgtgcctaatcagttc ctgaggtcagaggtcaccagggtcaacgagagactgggctggatggtgcagagttcagaa ccgctgcagttcatgaccctccatatacctgaggagaacaggtctctggacattctggag ctgacagagcagcgcgacctgctgaagttccacttccacacgctgcgcttgtattcagcc atctgcgcgctgggaaacaaccgtgtggctcacgcgctctgcagtcacgtggacgaggcg cagctcctctacgccatccagaacaaatacatgccgggcctcttgcgcaccggatactac gacctgctcatcgacatccacctgagcagctacgccaccgcgcgcctcatgatgaactct gagtacattgttcccatgacggccgagaccaagagcatcacactctttcccaacgagaag aagaagcacgggctgccgggcatcggcctgagcacgtcgctgcagccgcgcatgcgtttc tcctcacccagcttcgtgggtcaccacggcgccgtcgcggggggcgactgcttccagtac agccccgagttcccgctggagacgctgaagagccgtacgatggagatgttgacggaggca gtgcgggagggcagcttacacgtgcgcgatcccgtcggcgggagcactgagttcctgttc gttccgctcattaaactcttctacacgcttctgatcatgggcatcttccacaacggagac ctgaagaccatcctgcagctgatcgagcccagcgtgttctcgcaggacggcggcggcggg acgaatgaggcggaggacagctgtgggcggggccggctagaagggggcggggctgaagaa catggtctgagaggaaagatgcccaaagaaggacttttacagatgaagcttcctgaaccc gtcaaactccagatgtgtcacctgctgcagtacctgtgcgactgtcaggtgcgtcaccgc atcgaggctgtggtcgccttctccgacgactttgtggcgaatcttcaggataaccagcgt ttccgctataatgaagtgatgcaggcgctgaacatgtctgctgctctgacggcacgcaaa accaaagagttccgctcgcctccacaggaacagatcaacatgctgctgaattttaaggat gagaagcaggattgtccgtgtcctgaggacatccgtgaacagctgctagacttccatgaa gatctcatgacacactgcggcattgagatggatgatgataaatcaggagacggagatgat ttcaccatcaggggtcgtctgatgtgtctggtggaaaaggtgacctacctgaagaagaaa atgactgaaataccaaagaaaaagaaatcaaagaaacccagcacgcttcagcagctgatc tctgagaccatggtccgctgggcgcaggagtcggtcatcgaggatccggagctggtgcgg gccatgttcgtgttactccaccgtcagtacgacggcataggtgggcaggtgcgagcgctg cccaagacctacaccatcaacgctgtctccgtggaggacaccatcaacctgctggcatct ctgggacagatccgctctctgctcagcgtcaggatgggccgcgaggaggagaaactcatg attcatgggctcagtgacatcatgaataacaaggtgttttaccagcatccgaacctgatg agagcgctcgggatgcatgagaccgtcatggaggtgatggtgaacgtcctgggtggagga gagtccaaggaaatcacgtttccaaagatggtggccaactgctgccggttcctgtgctac ttctgtcgaatcagccgtcagaatcagaaggccatgttcgatcatctcagctacctgctg gagaacagcagcgtgggactcgcgtctccgtccatgcgaggttccactcctctggatgtg gccgctgcatctgtaatggataataatgaactggctctggcgctgagagaaccggacctc gagaaggtggtccagtatctggcgggctgtggtcttcagagctgtgtaatgctgatgtct aaaggatatcctgacatcggctggaacccggtggagggcgaacgatacctggacttcctt cgatttgcagtcttctgtaatggtgagagcgtggaggagaatgctaacgtggtcgtgcgg ctcctgattcggcggccggagtgttttggccccgccctgcgtggagagggcgggaacggg cttctggcggcgatggaggaagccataaagatctcagaagatcccagccgagacggaccg tcgcccaccacagaggagagcaggacacttagtgatgtattggaggaagaggaagatgac accattcacatgggaaacgccatcatgaccttctacgcagctctgatcgacctattgggc cgctgcgctcccgagatgcatctgatccacgccgggaagggagaggccatccgtatccga gccatcctgcgctctctcattcccattgaggatctggtgggagtgatcagcatcccgttc ctgatgcccacgctggctaaagacggttccgtgatcgagccggatatgtcagcagggttc tgtcctgatcacaaagcagccatggttctgttcctggaccgggtttacggcatcgaggac cagaacttcctcctgcacctgctggaagtgggtttcctgcctgacctcagagccgccgcc tcattggacacggcggctctgagcgccacagacatggcgctggctctgaaccggtacctg tgcacggcggtcctgcctctgctcaccaaatgcgctcctctgtttgcggggacggagccg ttcgcgtctctcatcgactctctgctgcacactgtctacagactgtctaaaggctgctgt ctcaccaaagctcagagagacgccatcgaggagtgtctgctggccgtgtgcgggaaactg cgtccgtcgatgatgcagcatctgctgcggcgtctggtgttcgacgttcctgtgctcaac gaacacacgaagatgcctctgaagctcctgaccaatcactacgagcgctgctggaagtac tactgtctgtccggagggtggggaagctttggcgcctcgtccgacgaggaactgcatctg tccagaaaactcttctggggaatctttgacgctctggcgagaaagaagtatgacgtggag ttgttcaagctggcgctgccgtgtctgagcgcagtggccggagctttacctcctgattac atggagtcaaactacgtggccatgatggagaaacagtcgtctatggacgccgagggaaac ttcaacccacagcccgccgacaccagcagcgtcgttgttcctgagaagctcgatcatttc atcaataaatatgcagaatattcccatgagaaatggtccatggagaagtttgccgtcggc tggattcatggagagcagatgtgtgaatcgtctaaagttcatccgctgctgaagccctac aagtgtctgtctgagaaggataaggaggtttaccgctggccaatcagagagagtttgaag acgatgctgtcttggggctggagcattgagcggacgagagagagcgacgcgtccacctta cacagccgcacccgccggatctctctgtccagtcagcgctccatagagggcgctcatggt ttcagcccgcggcctgtcgacatgagcaacgtgacgctgtccagagacctgcattcgatg gcggagctgctggccgagaactatcacaacatttgggctcagaagaaaaaactggagctg gaagccaaaggaggaggaagtcatccattactggttccttacgacactttaactgccaaa gagaaatccaaagaccgggagaaagcacaagacatcctgaagttctttcagatcaatgga tacagcgtctcaagggcgatgaaagaacaggatctggacactccgtccatagagaaacgc ttcgcgtacacgtttctgcagcagctgatcacgtatgtggacgaagctcacggacacatg ctggagtttgatgctggaattcgaccgaaaggggagaaaatccctcatgagcagcaggtc aaattcttcgggaaggttgtgttgccgctggtggatcagtacttcaaaaaccaccggctc tacttcctgtccaccgctgttcgaccaatcagcagcgggggccacgcctccaataaagag aaggagatggtgaccagcctgttctgcaaactgggcgttcttgtgcggcaccggatctca ttgtttgggaatgatgccacctccattgtgaactgcctgcacatcctgggacagacgctg gacgcccggactgtgatgaaaaccggtcaggactctgtcaaagcggctctgagggcgttt tttgataacgcatcagaagatttggagaaaaccatggaaaatctgcggcagggtcagttc acacacacgcggatgcaacccaagggcgtcacacagatcatcaactacacgacagtcgcg ctgctgccggtgctgtcctcgctgttcgaacacatagggcagaacctgttcggagaggat ctcatcttggatgatgtccaggtttcctgctatcggatattaaacagtttgtactcactt ggaaccagtaaaagtatttatgttgagaggcagcgtccggctctcggtgagtgtctggcc gcgttctcgggcgcatttcccgtggccttcctcgagcccaatctgaacaaacacaacaca tactccatatacaactgcaaaggctccagagagagagcagcgttaggtctgccggctcag gtggaggaggtgtgcgcgctggtgccgtctctggagcgggcgctgcaggaaatcatggag ctggccgagtcgggcatgcgctacacgcagatgccgcacgtgatggaggtgctgctgccc atgctgtgcagctacatgtcgcactggtgggaacacggacccgagagcgacccggagcgc gccgagagctgctgcacctcgctgacctcagagcacatgaacacgctgctgggaaacatc ctgaagatcatctacaacaacctgggtattgacgagggagcctggatgaagagactggca gtgttttctcagcccatcatcggtaaagccaagtctcagctgctgaagactcacttcctg ccgctgatggagaagctgaagaagaaggcggcgacggtcctgcaggacgaggagcacatg aaggcggagggccggggcgagatgtcggagtcggagctcctcatcctggacgagttcacc atcctcgtgcgagacctgtacgccttctacccgctgctcatacgcttcgtcgactacaac cgagcgaaatggctcaaggaaccgaacactgaggcggaggagttattccgtatggtggcc gaagtcttcatattctgggctaaatcacataactttaaacgagaagaacaaaactttgtg gttcaaaatgaaatcaacaacatgtccttcctcataactgataccaaatctaaaatgtcc aagggtggcgtatcagaccaggagaggaagaagatgaagaagcgaggggatcgatattcc ctccagacgtctctgatcgtcgccgctctcaagcgcttgcttccggtcggactgaacatc tgtgcgccgggagaccaggagctgatcggactcgccaagagccgcttcacgcagaaagac actgaggacgaggtccgagagatcatacgaaacaacctccacctgcaggggaagctggag gatcctgcgatccgctggcagatggcgctgtataaagacatgcccaaccgcagcgaggac tcgtcggaccccgagaagaccgtcgatcgagtgctgaacatcgcacatgtgctcttccac ctcgaccaggttgaacatcctcagcgcagtaagaaggccgtgtggcacaagctgctgtcc aaacagaggaagagagccgtcgtggcctgtttcaggatggcgccgctttacaacctgccc aggcacagagccgtgaacctgttcctccagggttacgagaagtcctggatcgagacggaa gaacactatttcgaggacaagctgatcgaggatttggccaaagcaggcggagaggagctg tcagaggaggacgagatgaccaaacacatcgatcccttacaccagctcatacaactcttc agcagaaccgcgctgacagagaaatgtaaactagaggaggatcatctctacatggcttac gctgatatcatggccaagagctgtcatgatgaagaggaagacgatgaggaagaggtgaag agttttgaggagaaagagatggagaagcagaagctgctgtatcagcaggccagacttcac gaccgcggcgccgcagagatggtgctacagaccatcagcgccagcaaaggagagatgggg ccgatggtggcctccacgctcaagttgggaatcgccatactcaatggaggaaactccaca gttcagcagaaaatgctggactacctgaaagacaaacgagacgttggatttttccagagt ctggcgggactcatgcagtcgtgcagtgttctggatctgaacgcgtttgagaggcagaat aaagctgaaggtctcgggatggtgacggaggaaggatcagtcatcactcatgagcgtggt gagaaggtcatgcaagatgacgagttcacctgcgacctcttccgcttcctccagctgctc tgtgagggacacaattcagattttcagaactacctgcgaacgcagacgggtaacaacacg acggtcaacatcatcatctcgacggtggattatctgctccgagtccaggagtccatcagt gatttctactggtactattctgggaaagacgtcatcgatgaacaaggccagcggaatttc tccaaagcaatcaatgtagccaaacaagtcttcaacactctcacagagtacattcagggc ccttgcacagggaatcagcagagtctggctcacagtcgcctgtgggatgcagttgttggt ttcctgcacgtttttgcacatatgcagatgaagctgtctcaggattcaagccaaatcgag ctgttgaaggagctcatggatcttcagaaggatatggttgtgatgctcttgtccatgttg gagggaaatgttgtgaatggcaccattggaaagcagatggtggacatgttggtggagtcc tcaaacaatgtagagatgattctgaagttctttgacatgttcctcaaactgaaagatctg acgtcgtcagatgccttcaaagagtacgatcctgatggcaaaggcgtcatctccaagagg gatttccacaaggcaatggagagccataaacattacacccaatctgagacagaattcctg ctctcctgtgcggaaacagatgaaaatgagctcttggactatgaagagttcgtcgaacgc ttccacgagccggcgaaggacatcggcttcaacgttgccgttctcctgaccaacctctca gagcatatgccccatgactctcgcctccagaccttcctggagctggccgagagcgtgctg aactacttccagccatacctgggccgcatcgagatcatgggcagcgccaagcggatcgaa cgagtgtactttgagatcagcgagtccagtcgcacccagtgggagaagccacaggtcaag gagtccaaacggcagttcatcttcgatgtggtgaacgaaggtggtgagaaggagaaaatg gagctctttgtcaacttctgtgaagacaccatctttgagatgcagttggcggcacagatg tccgacgccgccgagcgctcggctagcaaagaggaaagcgagagggagaaacccgacgag gagagtcccgagatgggcttcttctccgtcaccactgtgcgaacggctctcttcgcttta cgatacaacgtgatgctcttaatgaaggtgctgtccatgaaaagcctcaagaagcaggtt aagaaagccaagaagatgactgtgaaggacatggtgactacgctagtgtccttctattgg agcgtcctgctgggcctgctgcacttcgccttcagcgtcgctcgaggattcttccggatc acatacaacagctttcttggggggagtctggtggagggcgccaagaccatgaaggtgtcg gagctcctggccaacatgcctgacccgactcaggacgaagtgaggggagagatggaagag ggtgagaagaaacacctcgacaaaacctcacccgaggaagacctggccgatctaactgtg gccacagacgacaccgacgtcctgtctgatatattcggtttggatctgaagagagaggga gggcagtacaaactgatgcctcacaatccaaatgccagcctcacggatttgctcaatacg cccgtcccgcagccacccacaccctcacctgaacttcgcagacgacaccagacaaagggc tcgtcatcctcaactgacaacaatgaagttgcggaggagaccaaatcagtgcctgagaaa gcagaaagggaaaatggagagaaagcacagaagaaggacgaagcggtgaagcgtaaggtc agactgcactactccagagcagatgagcctgatctgcaggagtcagccttctggaagaag atcatcgcttatcaacgcaagctgctgaactattttgcacgaaatttctacaacatgaga atgttggctttgtttgtggcctttgcaatcaacttcattctgctgttttacaaggtgtcc acatcctcagctgtgaccgagggtaaggaggtgttgttcagcgcgtcctcagacaccagc gtgcggtgggaccctctggccggctccggcactcgcccggtcactgtgcactttgtgctg gaggagagcagcggatacatggagcccaccctgcggatcctagccatcctgcacacagtc atctccttcttctgtatcatcggctactactgcttaaaggttcctctggtgatttttaag cgagagaaggaagtggccagaaagctggagtttgacggcctgtacatcactgaacagccc tcagaagatgatattaaaggccagtgggaccggctggtcatcaatacacagtccttccca aacaattactgggataaatttgtgaagcggaaggtgatggataagtatggagagttttat ggacatgatcggatcagtgagctgctcgggatggataaagctgcgctggacttcagtgac gcccacgagaaaaagaaaccaaagagagacagttcactggccgcagtactgaactcaatc gatgtgaagtatcagatctggaagttgggtgtcgtcttcacagataactcgttcctgtat ctggcctggtacatgagcatgtccatcctcggtcactacaataacttcttctttgccgcc catctgctggacatcgccatgggcttcaagacgctcaggaccatcctgtcttctgtcacg cacaatggcaaacagctggtcctgactgtcggtctgctggcggttgtggtgtatctctac accgtagtggctttcaacttcttccgaaagttctacaataagagtgaagatggagaatca ccagacatgaagtgtgacgacatgctgacgtgctacatgttccacatgtatgttggcgtt cgtgccggcggtggcatcggcgatcagatcgaagatccggccggtgacgagtacgagatc tatcgcatcatctttgacatcaccttcttcttcttcgtcatcgtcatcctcctcgccatc attcagggtctgatcattgatgcgttcggtgagctgagagaccaacaggagcaggtgaaa gaggacatggagacgaagtgcttcatctgtggaattggaaacgattatttcgacacggtt cctcacggctttgagacgcacacgctgcaggaacacaatctggccaactatctatttttc ttcatgtatctcatcaacaaggatgaaaccgagcacaccggccaggagtcgtacgtttgg aaaatgtaccaggaacgttgctgggaattctttcccgctggcgactgtttccggaaacaa tacgaggaccagctcaattaa

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