| Entry |
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| Symbol |
EGFR
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| Name |
(RefSeq) epidermal growth factor receptor isoform X1
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| KO |
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| Organism |
cimi Cebus imitator (Panamanian white-faced capuchin)
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| Pathway |
| cimi01521 | EGFR tyrosine kinase inhibitor resistance |
| cimi04928 | Parathyroid hormone synthesis, secretion and action |
| cimi05207 | Chemical carcinogenesis - receptor activation |
| cimi05208 | Chemical carcinogenesis - reactive oxygen species |
| cimi05230 | Central carbon metabolism in cancer |
| cimi05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
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| Brite |
KEGG Orthology (KO) [BR:cimi00001]
09120 Genetic Information Processing
09125 Information processing in viruses
03272 Virion - Hepatitis viruses
108294535 (EGFR)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
108294535 (EGFR)
04012 ErbB signaling pathway
108294535 (EGFR)
04014 Ras signaling pathway
108294535 (EGFR)
04015 Rap1 signaling pathway
108294535 (EGFR)
04630 JAK-STAT signaling pathway
108294535 (EGFR)
04066 HIF-1 signaling pathway
108294535 (EGFR)
04068 FoxO signaling pathway
108294535 (EGFR)
04020 Calcium signaling pathway
108294535 (EGFR)
04072 Phospholipase D signaling pathway
108294535 (EGFR)
04151 PI3K-Akt signaling pathway
108294535 (EGFR)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
108294535 (EGFR)
09144 Cellular community - eukaryotes
04510 Focal adhesion
108294535 (EGFR)
04520 Adherens junction
108294535 (EGFR)
04540 Gap junction
108294535 (EGFR)
09142 Cell motility
04810 Regulation of actin cytoskeleton
108294535 (EGFR)
09150 Organismal Systems
09152 Endocrine system
04912 GnRH signaling pathway
108294535 (EGFR)
04915 Estrogen signaling pathway
108294535 (EGFR)
04921 Oxytocin signaling pathway
108294535 (EGFR)
04926 Relaxin signaling pathway
108294535 (EGFR)
04928 Parathyroid hormone synthesis, secretion and action
108294535 (EGFR)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
108294535 (EGFR)
05206 MicroRNAs in cancer
108294535 (EGFR)
05205 Proteoglycans in cancer
108294535 (EGFR)
05207 Chemical carcinogenesis - receptor activation
108294535 (EGFR)
05208 Chemical carcinogenesis - reactive oxygen species
108294535 (EGFR)
05230 Central carbon metabolism in cancer
108294535 (EGFR)
05231 Choline metabolism in cancer
108294535 (EGFR)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
108294535 (EGFR)
09162 Cancer: specific types
05210 Colorectal cancer
108294535 (EGFR)
05212 Pancreatic cancer
108294535 (EGFR)
05225 Hepatocellular carcinoma
108294535 (EGFR)
05226 Gastric cancer
108294535 (EGFR)
05214 Glioma
108294535 (EGFR)
05218 Melanoma
108294535 (EGFR)
05219 Bladder cancer
108294535 (EGFR)
05215 Prostate cancer
108294535 (EGFR)
05213 Endometrial cancer
108294535 (EGFR)
05224 Breast cancer
108294535 (EGFR)
05223 Non-small cell lung cancer
108294535 (EGFR)
09172 Infectious disease: viral
05160 Hepatitis C
108294535 (EGFR)
05171 Coronavirus disease - COVID-19
108294535 (EGFR)
05163 Human cytomegalovirus infection
108294535 (EGFR)
05165 Human papillomavirus infection
108294535 (EGFR)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
108294535 (EGFR)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
108294535 (EGFR)
01522 Endocrine resistance
108294535 (EGFR)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:cimi01001]
108294535 (EGFR)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:cimi04147]
108294535 (EGFR)
Enzymes [BR:cimi01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
108294535 (EGFR)
Protein kinases [BR:cimi01001]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
108294535 (EGFR)
Exosome [BR:cimi04147]
Exosomal proteins
Exosomal proteins of colorectal cancer cells
108294535 (EGFR)
Exosomal proteins of pancreatic cancer cells
108294535 (EGFR)
Exosomal proteins of bladder cancer cells
108294535 (EGFR)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
Unknown
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| AA seq |
1210 aa
MRPSGAAGAALLALLAALCPASLALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMFYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVDSIQWRDIVSSDFLSNMSMDF
QSHVAGCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEVEEDGVRKCKKCEGPCRKVCNGIGIGKFKDTLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPKELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSSQKTKIINNRGENSCKATGHVCHSLCSSEGCWGPDPRDCVSCRNVSRGRECVEKCN
VLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDSCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHSNCTYGCAGPGLEGCAMDRPKIPSIATGIVAALLLVLVV
ALGIGLFMRRRRIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSANSNNSTVACIDRNGLQTCPIKEDSFLQRYSSDPTGALTED
SIDDSFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNLAPSRDPHYQDPHSTAVGNPEYLN
TVQPTWVSSAVDSPDQWIQKAIHQISLDNPDYRQDFLPKEAKPNGMFKGPTAENAEYLRV
APQSSEFIGA |
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| NT seq |
3633 nt +upstreamnt +downstreamnt
atgcgaccctccggggcggccggggcggcgctcctggctttgctggctgcgctctgccca
gcgagtctggctctggaggaaaagaaagtttgccaaggcacgagtaacaagctcactcag
ctgggcacttttgaagatcattttctcagcctccagaggatgttcaataactgtgaggtg
gtccttgggaatctggaaattacctacgtgcagaggaattatgatctttccttcttaaag
accatccaggaggtggctggttatgtcctcatcgccctcaacacagtggagcggattcct
ttggaaaacctgcagatcatcagaggaaatatgttctacgaaaattcctatgccttagca
gtcttatccaactatgatgcaaataaaaccggactgaaggagctgcccatgagaaactta
caagaaatcctgcacggcgccgtgcggttcagcaacaaccctgccctgtgcaacgtggac
agcatccaatggcgggacatcgtcagcagcgactttctcagcaacatgtcgatggacttc
cagagccacgtggctggctgccaaaagtgtgatccgagctgtcccaatgggagctgctgg
ggtgcaggggaggagaactgccagaaactgaccaaaatcatctgtgcccagcagtgctcc
gggcgctgccgcggcaagtcccccagcgactgctgccacaaccagtgcgccgcgggctgc
acgggcccccgagagagcgactgcctggtctgccgtaaattccgagacgaagccacatgc
aaggacacctgccccccactcatgctctacaaccccaccacatatcagatggacgtgaac
cccgagggcaaatacagctttggtgccacctgcgtgaagaagtgtccccgtaactatgtg
gtgacagatcacggctcgtgcgtccgagcctgcggggccgacagctacgaggtggaggaa
gacggcgtccgcaagtgtaagaagtgtgaagggccttgccgcaaagtgtgtaacggaata
ggtattggtaaatttaaagacacactctccataaatgctacaaatattaaacacttcaaa
aactgcacgtccatcagcggtgacctccatatcctaccggtggcatttaggggtgactcc
ttcacacacaccccacctctggacccaaaggaactggatattctgaaaaccgttaaggaa
atcacagggtttttgctgattcaggcttggcctgaaaacaggacggacctccatgctttt
gagaacctggaaatcatacgcggcaggaccaagcaacatggtcagttttctcttgcggtt
gtcagcctgaacataacatccttgggattacgctccctcaaggagataagcgatggagat
gtgataatttcaggcaacaaaaatttgtgctatgcaaatacaataaactggaaaaaactg
tttgggacctccagccagaaaaccaaaatcataaacaacagaggtgaaaacagctgcaag
gccacaggccatgtctgccattccttgtgctcctccgagggctgctggggcccggacccc
agggactgcgtctcttgccggaacgtcagccgaggcagagagtgcgtggagaagtgcaac
gttctggagggcgagccgagggagtttgtggagaactctgagtgcatccagtgccacccg
gaatgcctgcctcaggccatgaacatcacctgcacgggacgggggccggacagctgcatc
cagtgtgcccactacatcgacggcccccattgtgtcaagacctgcccggcaggggtcatg
ggagaaaacaacaccctggtctggaagtacgcggacgccggccacgtgtgccacctgtgc
cattcaaactgcacctacggatgcgctgggccaggtcttgaaggctgtgcaatggatagg
cccaagatcccgtccatcgccaccgggattgtggctgccctcctcttggtgctggtggtg
gccctggggatcggcctcttcatgcgaaggcgccgcatcgtccggaagcgtacgctgcgg
aggctgctgcaggagcgagagctcgtggagcctcttacgcccagcggagaagctcccaac
caagccctcctgaggatcttgaaggaaactgaattcaaaaagatcaaagtgctgggctct
ggtgcattcggcacggtgtataagggactctggatcccagaaggtgagaaagttaaaatt
cccgtagctatcaaggagttaagagaagcaacgtctccgaaagccaacaaggaaatcctt
gatgaagcctacgtgatggccagcgtggacaacccccatgtgtgccgcctgctgggcatc
tgcctcacctccaccgtgcagctcatcacgcagctcatgcccttcggctgcctcctggac
tatgtccgggagcacaaggacaacatcggctcccagtacctgctcaactggtgtgtgcag
atcgctaagggcatgaactacctggaggaccggcgcttggtgcaccgcgacctggcagcc
aggaacgtgctggtgaagacgccgcagcatgtcaagatcacagattttgggctggccaaa
ctgctgggggcagaagagaaagaatatcatgcggaaggaggcaaagtgcctatcaagtgg
atggcattggaatcaattttacaccgaatttatacccaccagagtgatgtctggagttac
ggggtgaccgtttgggagttgatgacctttggatccaagccatatgatggaatccctgcc
agtgagatctcctccatcctggagaaaggagagcgcctcccccagccacccatatgcacc
atcgatgtgtacatgatcatggtcaaatgctggatgatagacgcagacagtcgcccaaag
ttccgtgagttgatcattgaattctccaaaatggcccgagacccccagcgctaccttgtc
attcagggggatgaacggatgcatttgccaagccctacagactccaacttctaccgcgcc
ctgatggatgaagaagacatggacgacgtggtggatgcggacgagtacctcatcccacag
cagggcttcttcagcagtccctccacgtcgcggactcccctcctcagctctctgagtgca
aacagcaacaattccactgtggcttgcattgatagaaacgggctacagacctgtcccatc
aaggaagacagcttcttacagcgatacagctcagaccccacaggagccttgactgaggac
agcatagatgactccttcctcccagtgcctgaatacataaaccagtctgttcccaaaagg
cctgcgggctctgtgcagaatcctgtctatcacaatcagcccctgaacctcgcgcccagc
agagacccacactaccaggacccccacagcaccgcagtgggcaaccccgagtatctcaac
actgtgcagcccacctgggtcagcagcgcagtggacagccctgaccaatggatccagaaa
gccatccaccaaatcagcctagacaaccctgactaccggcaggacttccttcccaaggaa
gccaagcccaacggcatgtttaagggccccacagctgaaaatgcagaatacctaagggtc
gcgccacaaagcagtgaatttattggagcgtga |
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