Ciona intestinalis (yellow sea squirt): 100178148 Help Entry 100178148         CDS       T01056                                  Name (RefSeq) ryanodine receptor 3   KO K04962   ryanodine receptor 2 Organism cin  Ciona intestinalis (yellow sea squirt) Brite KEGG Orthology (KO) [BR:cin00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cin04040]     100178148    04990 Domain-containing proteins not elsewhere classified [BR:cin04990]     100178148 Ion channels [BR:cin04040]  Voltage-gated cation channels   Ryanodine receptor    100178148 Domain-containing proteins not elsewhere classified [BR:cin04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    100178148 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 COP9_hel_rpt EF-hand_6 Motif Other DBs NCBI-GeneID:  100178148 NCBI-ProteinID:  XP_018669433 Ensembl:  ENSCING00000021152 LinkDB All DBs Position 11:1779251..1842995 Genome browser AA seq 5002 aa AA seqDB search MAESCDNDEEVHFLRTDDAIYLQCVRQKDQGKVCLAAEGFGNRLCYVEPSQDTVDAEPTD APRCVFVLSQALSVRALQELLASEEVGIDMDDDREIRPDLMSTESQAEGGATHSRTLLYG NAIQLKHELSGMFLTCLTTASSANDQLAFDVGLGEEETGETSWWTVHPTSKQRSEGEKVR IGDDLILISISSERYLHLSCGDGDDSSVQASFQQSMWTVGPVASGGSKAQGYLTGGDAIR LFHGHMDDCLTMHTMDENKSHSRSIIYESGSAGSHARSLWRLELMQIKWFGSHVSWGCPF RLRHITSGLYLCMLDDRSLMLMGPENASYRMSAFCWQSSKDKAEPLTEHEIDGMGVPVIK YGDSVCYLQHVETGLWVSYQVVDTKSVRVGPKQRKAVLHHEGHMDDGLALSRAQSGESRT ATIIRRTAQIFLSFISALDSHQPKKLGRRPDHPNVAEMEQCVNDLIDYFIEQEDKADDGS TDEHEVRQIRKQELKNRQDLFQEEGAISRILQCIDKLGAYGDTGNFAQIVGSEAAASYEF LLNSMYVLLAATVRGNRDNCAKFARHLDWLISQFDGQQASMGILEVLSAVLSDSQEALNM IKPDHIKSIISLLEKHGRNAKVLEVLCSLCVCNGVAVRSNQNLICETLLPGRDLLLQTTV LGYITNVQPNIFMGVSASCAQYKKWYYELLVEKIDPVCSSSGPHLRVGWGNTVGFSPYPV GGDYFGEAGVGDDIYSYGYDGLNLWTSHRACSVGSNNRHLLAANDIVSCCMDLSIPSISF RINGQPVQGMFEDFNLNGLFFPVVSFSAGIKVRFLFGGPHGEFKFLPPVGYAPTYEALLP GRRLFLSPCKSYGNLSRGYIMGPGSSWEHTVFVPNAVNTQNVILSHFLQAVVPKLAESIH ELWAMTRIQGGWSYGTVRDEAKKQNPCLVEFARLPAQERSFNLTMSYETLRTIIALGYHV GIADEEAEYNLRKLKLPRSYIMASGYKPSPIDLSHIKLTQQMEDLVEKLANNAHNVWARE RVKQGWTYGVNLDVGKKRNPRLVPFSLLDELAKQSNRNSIRELIRTLIGHGYMIEPPDDR LKDKDTKKKNQVQCNKMRIFRAERTHAVQSDKWYFEFTVESKGEIRVGWATPDCLASTDL GADAKAFVFDGHNALKWNNGAESFGRRWNAGDVVGCLLDFNEGVISFTLNGELLIDGHGQ ETAFENLSSDISLVPVVSLAVDQRGFLNFGRDSGTFKFYSSIGQQEGFQPFAFGMRSPIA MWFTKNLPSFCNIDETDQNIEVKRLPANNHRPPRLKVIHKQIGGTGSHDFTPDWFYTRLN LPITMATVFTKSPGHIINLFNESESVMEEDIDNDFEVLRKTARGGLSPPLPAVDLKNERH HHHHHGNSNTLPIPGLKVSKFHFSKPKSSMVQGNNGVNNTAKSRLTEEVLPDQYADVLYK NDIDQLLQSTQYSFSVRIFPEQDPGSVFVGWVTSDFHWNAEKFQQEFIPTVTITLGDDKG KVSESVKRSNCFVLWGGDLHQQTSATPPPANQSSPGILVTCIIDISTGLLTFTANGKNLN TFYQVEPNVRLYPAVFSFPTTHSVFQFELGRSKNCMPLSAAVLECERKNVIPQCPPRLVV QSLRKVTWTRMPSKLPHPECRRESVRSKGWTSELKPSNTDAYNAAILHVPEENRCIDLLE LTENEELLHFHEQTLKLYRSMCALGNHRVSHALCSYVDQKQLMHVVRNNDLIGSIRATYH NLLIEMHLAPHANARKNTQHEYMFPLNEMTRSIGLFANPETKDPTLPGVGSTSSLRPSMH WSQVNFVMHPSLIHERPLHVPEFPLDELCYNVILQLQDAVVCCYKNCKDIMGKNQQYVLV PLIRLTTTLLEMGVFVDEDVKKILILLDPNFFGSFMKDMDGVEALIKNAHSGLLCLDLVE SVKLVLCDLLEHLMNLVLRHRVEALVSFSCLVVDHLQQNQRNRYQRVMESVNMSAAMTAK MTREFRSPPMDQMAILLKFKNEELEEECPLPPSIKDLIWNFHMDMLIHCGETIEDVETNE TEIPLRSRLVAFISHILNRKNDKADETGEEQIEVITSLRDLITSTMVRWAQGSRLNNPQL VRSIFQLLYRQFNGVAIQCINKTYCISEISEVDTMGLLDSLSRLRSLLSVKLGEEEETLI IKELNTIMNNKVFYQHPNLMRVLCMHETVMEVMVSVLGGEDDETNSNEVQFPRMVAACCR FLCYFCRISRLNQGALFEHLGFLLEHSAVGLASPSMRGSTPLDVAAASVMDNNELALALK ESDLAKIVEQLGTCGVESCQLLLRKGYPDIGWNPVEGERYLDFLKNAVFVNGESVEENAN LVVRQLIRRTECLGPSLRGEGGHGLLSAITSALQICRDRSKDGPDNNVLRNDFDDENDIH MGFSILAFYSTLIDLLGRCAPEQCLIMQGKSDAIRIRSILRSLVPLEDLIGVISLPFELP RLERDGSTNVREPDLSACFIPDHKASMVLFLERVYGVDDPKLMLRLLEVGMLPDMKAAAQ LDTPLLHTTDMALSLNRYMCYSLLPMLVKHVELLEQWQHRVVLIDQLLHTIYRMSQAQAL TKAQKEMISNCLVAVAGVLRPSLLQGLLRKLTFDVPALTEETYVPIRLLTQHYARCWKYY YLHDGCSEFGRATDEEKHITMVLFWGIFDSLAKKPYQQELFSKVLPCLCSIANALPADYA LSPALEQLKEPSITAHGKFVPRPVDTKCIMLPEKLDTFVNKYSEQWHDTWALERFTAGWT YDSHYNDHFKHHPMLKPYRLLNDREKDVYRPTVREGIKTLLAWGWTIRKARDATEQLPAK VRCSSQSNISASEAHGYLPRPYDLSGVILSREMMRTAEMLAENFHLVWAKKKFNEMEAKM AANSSQPSSPTMTTNPMLVPYDRLTAKEKEKDRSKSYDLLKFFQFNSYMLTKDEKEELDI KSSVEKRFSSMMLVRLLNYVEKSTVYVNGMIQAAETVKQRRQEHAAFGNSQHDAALQLEL TGDHDIKFFAKVGMPFIESYFKTQEIYYVTVSGSLNEGMSVASNKEKEAVTLLFCKMALL IRQRTAMFGVDASVAINCIKVLAECIDASTITKSCPEHIKQALITFFNNAAEDLKKMLNH IRSGRMKHLRKMMLGAQTTNYVTHCILPVLTILFRHLGRHNFGKDLLLDEIQVSCYKILN GLYSLGTGKGAFIDRHRSQVGECLAAFASAFPVPFLEPRLNKFNSCSIYNILSIKDRKLL GLPPKLEQLTPLLPTLNNLLSDISHLAESGAKYEEAPEMIDIILPMICRYLPMWWKQGAC VAQQTNDKRIPIEESSGCGTAVSGEILNNILRDVLRLIQNNLGSDEADWMKRIAVYAQPI LVQSDPDLLTSHFLPILNKSLKRIQQIRDLEEQLAGHKGSMNDLLNIVKYEQRVNDVSDL ELLMLEDYGIIARDLYAFYPLLVRYIDLSKSLWIREKNQNAIALFKLLSEILVIWAKSVN FRREEQNFVVQHEIDNMSVLTADKSATPNAASALANRRIVKKRGDRYSPSTSLIVACVKR MLPVALNMGKVGDCNLLQEAKTRFLKKEMEDDVKEYLISALRENVNEDLTNEHGDITTRA DWLLEISRVQYHLHLTEHPPKSRRAVWKKLMSKQRKRAVVSCFRMVPLYNLPIHKVISMF VPSYSQHWVYTDQSNFAGKLINLVHKPNQEEGKTLHCDPLSQLIQVFSMSAVTSVVENDD LYLAYSELMTQSCHTGDDEEEDEGEESEKSFEEKEKEKQRLLYEQKRLATRGVAEMVLYM ISASGGDVSDTIVTTLQLGIALLTGGNVLVQKIMLDHLKAKKDVRFFTSVAGLMDQCSVL DLNAYERSLKSESLGHVNECTITGEKTMSDAELTCALFRFLQLLCEGHNADFQNYLRTQV GNNTTVNIIISTVDYLLRLQEAISDFYWYYSAKETIDAPGQENFSKAIAVAKQVFNTLTE YIQGPCEGNQQALAHSRLWDAVVGFLHVFANMQMKLSQDSKRQLSLLKELLDLQQDMIVM LLSMLEGNVVDGTIGRQLVDTLIESSHNVELILRFFNMFLRLKDITSSDKFLEYDAEHTG FVSRKDFQRAMEASKIYSSEEIDFLLACAVSTDDKLNYDEFTEQFHEPAADIGFNMAVLL TNLAEHMPRDTRLKKFLEMAEAMLEYFQPNLGRIEIIGSAKRIERVYFNIKPSSLDQWHK PQVQESKRQFFFDVINDEGDNGRMEEFVNFCEDTIFEMQLASEISEAGFGASSSSAVNDE EGDDKDEEDAAASGEILPSFNFKVVKSYVRQFRAMTWIEVITSLVFLFFTFNIKLCKLSI ELLQIFGNFLYVLFFSNFLVVEVKKKSLTEIIDEMPCPTHERIQHSVENLSDSGTDDTGQ DQTKGDKEDFISDVFGMDIKKSKELIKAVVHTKPEAGFGDFTVDEAADTFSLIASDYESG INTPRTSKIKKRRKLLRKGKQIGQTASTTSTILSSLENSSTSEQRLSNLKSAMSFDERSG EDNISPWYTCMKECGRPARYKHEEKTEDRNAMYLDTWNAFCMGTMGLFARNFYKFKILAL GLTFCINFILLFYKWHSINNDLKVDSESSEDEVEESLILEDTSKYMEPTLRAFSIIHFIL SFSMLVSYYGLKVPLVIFKREKEVARKLEFDGLYVNEDPTDDDLSGRWDKLVISCPSFPS NYWDKFIKKKVLDKFGEQCGQDRIQDLLGMDHSNTSFLDEEEPPKGNILTQLFLNVDIKY TVWKTGVIFSDQSFLYLLWYFVMSIFGQYNRFFFSLHLLDIAMCSKGLRTILTSVTHNGK QLVLTIGLLTVVVYLYTVIAFNFFKKFYNKGEGDDEDWKCNNMFTCFQFHFYSGVRAGGG IGDELEDPSGDAWEFYRIAFDISFFFFVVVILLAIIQGLIIDAFGELRDQQEQVKEDMDT KCFICTIGIDYFDQVPHGFETHTLQEHNLANYMFFLMHLINKDETEHTGQETYVWQQYQE RCWEFFPVGDCFRKQYENELSG NT seq 15009 nt NT seq  +upstreamnt  +downstreamnt atggcggaaagttgtgacaatgacgaggaagttcattttctacgaactgatgatgcgata tatcttcaatgtgttcgtcagaaggatcaaggcaaagtttgtcttgcagcagaaggattt ggaaacagattatgttacgtggaaccatctcaggataccgtggatgctgaaccaacagat gcgcctcgttgtgtgtttgttttatctcaagcattgtcagtgagagcattacaggaactg ttagcaagtgaagaggttggtattgacatggacgatgacagagaaataagacccgattta atgagcaccgagtcccaggcggaaggcggggcaactcacagcagaacgttgttgtatgga aatgccattcagttaaagcatgaacttagcggaatgtttctcacttgtctgacaacggcg agctctgcaaatgatcaattggcgtttgacgttggattgggggaagaggaaacaggtgag acatcatggtggacagttcatccaacttcaaaacaaagatcggaaggggagaaagtgaga atcggagatgatttgattctaatcagcatttcttctgagcgatacttgcatctttcatgt ggtgatggggatgatagcagtgttcaggcttcatttcaacaaagcatgtggactgttgga cctgtggcaagtggtggatccaaagctcaaggttaccttactggtggagatgcaattcga ctgttccatggtcatatggatgattgcttaaccatgcatacaatggatgaaaacaaatca cattccagatcaatcatttatgaatctggatcagccggaagccatgcaaggtcgctatgg cggttagaactaatgcaaattaagtggttcggatcacatgtctcctgggggtgcccgttt cgtttacgtcacatcacttcaggtttgtacttgtgtatgttggacgaccgaagcttaatg ttgatgggacctgaaaacgcaagttatagaatgtctgcgttttgctggcaatcatcaaag gacaaagctgaacctttaactgaacatgagattgatggtatgggtgtgccagtaatcaag tatggtgattcagtgtgttatcttcaacatgtggaaacaggtttatgggttagttatcag gtagttgacacgaaatctgtaagagttggtccaaaacaaagaaaggctgtattgcatcat gaaggccatatggatgatggacttgcattatctcgtgctcaatcaggagagtcacgcacc gcaaccatcatacgaagaactgcacaaatctttctgagctttatcagtgctttggattcc catcaacctaaaaagttgggtaggagaccagatcatccaaatgtagcggagatggaacaa tgtgtgaatgatcttattgattattttattgaacaagaagataaagctgatgatgggagc actgatgagcatgaagttagacaaataaggaaacaggaattaaaaaacaggcaagacttg tttcaagaggaaggagccatatctcgtatattacaatgcattgataagttaggagcttat ggggatactgggaactttgcccaaattgtcggttctgaagctgctgcttcttacgagttt ttactcaactcaatgtatgttctacttgctgccactgtacggggaaaccgagacaattgt gcaaagtttgcgcgtcatcttgactggcttatcagtcagtttgacggacagcaggcgtca atgggtatccttgaagttctcagtgcagtattaagtgacagccaggaagcattaaatatg ataaaacctgatcatattaagtccattatatcgttacttgaaaaacatggaagaaatgca aaggttttagaagttttgtgttccctttgtgtatgcaatggagttgcagttcgttcaaat caaaatttgatttgcgagacattgttgccaggaagagacttacttctacaaacaactgtt ttgggatatattaccaatgtccaacccaatattttcatgggtgtgagtgcttcatgtgct cagtataagaaatggtattacgaacttcttgttgagaagattgatcccgtttgttcttct tctggaccccacctaagggttggttggggaaatactgttggtttctccccctaccctgtt ggtggtgactattttggtgaagctggagtgggtgatgacatatactcatatggatatgat ggattaaatctatggacaagtcacagagcttgttctgttggatctaataatcgtcatctg ttagctgccaatgatattgttagttgttgcatggacctcagtataccaagtatatcattt cgtataaatggccaaccagttcaaggaatgtttgaagacttcaacttaaatggattgttt ttccctgttgtcagcttttctgcaggcatcaaagtccggtttctatttggaggaccacac ggtgaatttaaattccttccccctgttggatatgctcctacatatgaagctttgttacct ggaagaagattgtttctatccccatgcaaatcatatgggaatctatccaggggttatatc atggggccagggtcatcatgggaacacactgtatttgttccaaatgcggtgaatactcaa aatgttattctttcacatttcttgcaagcggttgttcctaagctcgctgaaagtattcat gaactgtgggcaatgacacgtatacaagggggttggagttatggaacggtgcgcgatgaa gcaaagaaacaaaatccctgtttggttgaatttgctcgacttccagctcaagaaagatca tttaatttaacgatgtcgtatgaaaccttaaggacaataattgcgcttggttatcatgtt ggaatcgcagacgaagaggcggaatacaatttaaggaaactcaaactaccacgaagttac ataatggcaagtggctacaaaccctcacctattgatctctcccatataaaactcacacaa caaatggaagatttggtggaaaaacttgcaaataacgctcacaatgtgtgggcacgtgag cgagttaaacaggggtggacttacggtgtgaatctggatgttgggaaaaaacggaaccca agacttgtcccgttttcccttcttgatgaattagcaaagcagagtaacagaaattctatt cgagagttgataagaacactgattgggcatggctacatgattgaaccaccagatgataga ttaaaagacaaagacacaaaaaagaaaaatcaggttcaatgcaacaaaatgagaatattt cgcgcagaacgaactcatgctgtccaatcagacaagtggtactttgagtttactgttgaa tcaaaaggagagatcagagttggttgggcaactcctgattgtttggcttctactgacctg ggtgctgatgcaaaagcatttgtatttgatggacataatgcattaaaatggaataatgga gctgaaagttttggtcgaagatggaatgctggagatgtggttggttgtctgcttgacttc aatgaaggagtcatttcgttcactttgaatggtgagttactcattgacggacatggtcag gagacagcattcgaaaatttatcttcagatatatctctggttcctgttgttagtttagct gttgaccagagaggatttcttaattttggccgggattcgggaacttttaagttttattct tccattggccagcaagaagggtttcaaccgtttgcttttggtatgagatccccaattgca atgtggtttacaaagaacttaccaagcttctgcaatattgatgaaactgatcaaaatatt gaagttaaaagacttccagcaaacaaccacaggccacccaggttgaaggtgattcataaa cagattggtggaactggatcacatgacttcacgcctgattggttctacactcgattaaat ttacccattactatggcaactgtatttacgaaaagtcccggacacatcatcaatttgttc aatgaaagtgaatcagttatggaagaagatatcgacaatgattttgaagttcttcgtaaa actgcccgaggtggtttgtcaccacctttacctgcagtcgaccttaagaatgagcgtcac catcatcatcatcatgggaattccaatacactaccgataccaggtttgaaagtttccaag tttcattttagcaaacctaaatcttcaatggtgcaaggaaataatggggtgaacaacaca gccaagtcacgactaacagaggaagtgttaccagatcaatatgctgatgttttgtacaag aatgacattgaccagttgttgcagtcgacccagtattcattctctgtacgaatatttccc gaacaagacccaggaagcgtctttgtgggttgggtgacgtcagactttcattggaatgca gaaaaatttcaacaggaatttattccaactgtaacaattacattgggtgatgataaagga aaagttagcgagagtgttaaacgttccaattgttttgtcctgtggggtggtgacctacat cagcagacaagtgccacgccccctcccgctaaccaatcatctcctgggattttggtcaca tgtataatagacatatcaacagggttgctaacttttacagcaaatggaaaaaatctgaat acattttatcaggttgaacctaacgtacgcctctacccagctgtattcagttttcccaca acacattcagtattccagtttgaacttggaagatctaagaactgcatgccattatcagca gcggttcttgaatgtgaaagaaagaatgtaatcccacaatgtccgccacgtttggtggtc caatctttacgtaaagtaacatggacgaggatgccaagcaaacttccacatcctgaatgt agacgagagtcggttagatcaaagggttggacttcggagttgaaaccatctaatactgac gcttataatgcagcaatacttcatgtacctgaagaaaaccgatgtatagatcttcttgaa cttactgaaaatgaagaactcttacattttcatgaacaaactttgaaactttaccgctca atgtgtgcattgggtaaccacagagtctcccatgctttatgcagctacgtggatcagaaa caattgatgcacgttgtccgcaacaatgatctaatcggttcaattcgtgccacataccac aacttactcattgaaatgcatcttgccccacatgccaatgctaggaaaaacacccaacat gaatatatgtttccattaaatgagatgacgcgttctattggattgtttgcaaatcctgaa acaaaggatccaacattacctggagttggttcaacttcatcattgcgacccagcatgcat tggtcgcaagtcaactttgttatgcatccaagtttaatccacgagcgaccgttacacgtg ccagagtttccattagatgaactttgttacaatgttattcttcaactacaggatgcggtt gtatgttgctacaaaaactgcaaagatataatggggaaaaatcaacaatatgtgcttgtt cctttaatccgacttacaaccactttgcttgaaatgggagtttttgttgatgaagatgtc aagaaaattcttattttactcgatccaaatttttttggttcatttatgaaagatatggat ggtgtggaagcactaataaaaaatgctcactctggattactttgcctggacttggttgaa tctgtgaagttggttttatgcgatttgctcgaacatttgatgaaccttgtgttgcgccac cgtgtggaagctctcgtctctttctcgtgtctcgttgttgaccacctacaacaaaaccaa aggaacagataccagcgtgttatggagtctgttaacatgtcagcggcaatgacggcaaaa atgacgcgcgagtttcgttcgccacctatggatcagatggcaattttacttaagtttaag aatgaggaattagaagaggaatgtccactaccaccaagtatcaaggatctgatatggaac ttccacatggatatgttgatacattgtggggaaactattgaagatgtggaaacaaatgaa actgagattccactaagaagtagattggttgcttttatttctcacatcctaaaccggaag aatgataaagcagatgagacaggagaggaacaaattgaagtgataacttctttacgagat ttaataacttccactatggttagatgggcacaaggttcacgacttaacaatccacagttg gttcgttcaatatttcaacttttgtatcgacaatttaatggagttgctatacaatgcatt aacaagacgtattgcataagtgaaatatcagaggtcgataccatggggttacttgactca ctttcaagattaagatctctattgtcagtaaaactcggagaagaagaagaaactttaatt ataaaagaactaaacacaattatgaacaacaaagtgttttatcaacacccgaaccttatg cgggttctgtgcatgcacgaaactgtgatggaagtcatggttagtgtattgggtggtgaa gatgatgaaacgaattctaatgaagttcaattcccacgtatggtggcagcttgttgtcga ttcctttgttacttttgtcgcatcagtcggttaaaccaaggagctctttttgaacatctt ggattccttctggagcattctgcagttggacttgcttcaccttcaatgaggggatccaca ccactcgatgttgctgctgcatccgttatggataacaacgagctagcgttggcgctgaaa gaaagtgatctagcaaagatcgttgaacagcttggtacatgtggtgtggaaagttgtcaa ctgttgttgaggaaaggatatcctgatatcgggtggaatcctgtggaaggagagagatat ttagacttcttaaaaaatgctgttttcgtaaatggagaaagtgttgaagagaatgcaaat cttgttgttcgtcagttgattcggcgtacggaatgtcttggtccaagtttaagaggagaa ggcggacacggacttctttctgcaattacatccgctctacagatatgtagagacagaagt aaggatggtccagacaacaatgtcctaagaaatgactttgatgatgagaatgatatccat atgggattttcaattcttgcattttattcaactctgattgatctgcttggaagatgtgca ccagagcaatgcttgatcatgcagggcaaaagtgatgccattcgtatacgcagcatttta agaagcttggttcccctggaagatcttattggtgtcatcagtcttccatttgaactgcct cgattagaaagagatggttccaccaatgttcgagaacctgatctatccgcttgtttcatt cctgatcataaagcatccatggttttattccttgaaagagtatatggtgtagacgacccc aagctcatgcttcgattattagaagttggaatgttaccagacatgaaagctgcagctcaa ctagatacacctttacttcataccactgacatggcattgtcactcaatcgttacatgtgc tacagtcttctaccaatgcttgtaaaacacgtagaactattggaacaatggcaacatcgt gttgtgttgatcgaccaattgctgcatacaatttatcgaatgtcccaggctcaagcactt actaaagctcagaaagaaatgatcagtaactgccttgttgcagtagcaggtgtcttgcgt ccatctttattacaaggtctgctgagaaagttaacatttgatgttcctgcattaactgaa gaaacttacgttccaatacggttattaacacaacattatgcgagatgttggaagtattac tacctacatgatggatgtagtgagtttggcagagctactgatgaagagaaacacataact atggtcttgttttggggaatatttgattcacttgcaaaaaaaccctaccaacaagaactc ttctccaaagtcctcccatgtttgtgttcaattgcgaatgccctacctgctgattatgct ttgtctccagcacttgaacaattgaaagaaccttccataactgcccatggaaagtttgta cctagacctgtggacaccaaatgtataatgttaccagaaaagttggatacttttgttaac aagtattctgaacaatggcatgacacttgggctttggaaagatttactgcagggtggaca tatgattcacattacaatgatcattttaaacatcatccaatgttgaagccttatcgtctc ttgaatgatcgggaaaaagatgtttatcgaccaactgttcgtgaaggaattaagacattg cttgcgtgggggtggaccattaggaaagcaagagacgcaactgaacagttacctgctaaa gtcagatgttcatctcagtcaaacatttccgcttctgaagctcatggttaccttcctcgt ccttatgatttaagtggcgtaatactgagtcgtgaaatgatgcggaccgccgaaatgttg gcggaaaatttccacttggtttgggcgaaaaagaagtttaatgaaatggaagcaaaaatg gcggcaaattcttctcaaccgtcatcccctaccatgactacaaaccctatgctcgtccct tatgatcgactgacagctaaagaaaaagagaaagatagaagcaaatcttatgatctgctc aagtttttccagttcaacagctacatgttgaccaaagatgaaaaagaggaacttgatata aagtcatcggtggagaaaagattttcttccatgatgttggtcagacttctcaactatgtg gaaaagagtacagtttatgtgaatggcatgatccaagctgcagaaaccgtgaaacaacgc cgacaagaacacgcagcgtttggtaattcacaacatgatgctgcgttacaactcgagttg acaggagaccatgatattaagttctttgcaaaagttggtatgccatttattgaatcatat ttcaaaacacaagaaatatattatgtaacggtatccggaagtcttaatgaaggaatgtct gttgcatcaaacaaagaaaaagaagcagttactttgttgttttgcaaaatggcattgctg atacgacaaagaaccgctatgtttggtgttgatgcatcagttgcaataaactgcatcaaa gttcttgcagaatgtattgacgcatcaacaatcaccaaatcatgtccagaacatatcaag caagccttgattactttcttcaataatgctgctgaagatttaaagaagatgcttaaccat attagaagtggtcgaatgaaacatcttcgtaaaatgatgcttggtgctcaaaccaccaat tatgtcacgcactgcattctaccagttctaacaattctgtttcgacatttgggtcgccat aactttgggaaggatttgctgctggatgaaatacaagtgtcttgctacaaaattcttaat ggtttgtacagtcttggtacaggcaaaggagcttttattgaccgccaccgatcacaagtt ggagaatgcttagctgcatttgcaagtgcctttcctgtcccatttctggaacctcgtctc aacaaattcaattcttgttcaatttacaacattctcagcataaaagatcgaaaactactt ggcttgccaccaaaacttgaacagctcacacccctccttccaacattgaacaatctgctt tccgatataagtcacttggctgaatcgggggcaaaatatgaggaagctccagaaatgatt gacatcattcttcctatgatttgcagataccttccaatgtggtggaaacaaggtgcatgt gttgcccagcaaactaatgacaagagaattccaattgaagaatcatctggttgtggaact gcagtttcaggagaaattttaaacaacattctccgtgatgtactacgtctcatccaaaat aaccttggatctgatgaagcagattggatgaaaaggattgcagtttatgcacagccaatc ttggttcaaagtgatcctgatttattgacgtctcattttcttccaattttaaacaaatca ctgaaaagaatccaacagatcagagatttagaagaacaacttgctggccacaaaggatca atgaatgacctactgaacatagtaaagtatgagcaaagagtgaatgatgtttcggattta gaacttttaatgttggaagattatggaataattgctcgcgatctttatgcgttctaccca ctgctggttcggtatattgatcttagcaaatcactctggatccgagagaaaaatcaaaat gctattgcactttttaagttgttgtctgagattcttgttatttgggcaaaatctgttaac ttcagaagagaagaacaaaactttgtagttcaacatgaaatagataacatgtctgtacta acagctgataaaagtgccactccaaacgctgcttctgcattggcaaacagacgcatcgtt aaaaagcgtggtgatcgttattcgccatctacatcactcatagttgcatgcgtcaagcga atgctgcctgttgcactgaacatgggaaaagttggagattgtaatttattacaagaagct aagactcgatttctaaagaaagaaatggaagatgatgtgaaagaatatttaatttctgct ctaagggaaaatgtaaatgaagatttaacaaatgaacatggagatattacaacacgagct gattggttgttagaaatatcacgtgtacaatatcatctacacctgacggagcatccacca aaatctcgaagagcagtttggaagaaattgatgtcaaaacaaagaaagagggccgtagtg tcatgttttcgaatggttcctttatacaaccttccaatacacaaagtgatatccatgttt gttccctcctattctcaacactgggtttatactgatcagtcaaactttgctggaaagttg ataaatttggttcataagccaaaccaagaagagggaaaaaccttgcactgtgatccactt agtcaacttattcaagtattcagtatgtcagctgtcacctctgttgtcgagaatgatgat ttatacctggcatattctgaacttatgacacaaagttgtcacactggtgatgatgaagaa gaggatgagggggaagaaagtgaaaaatctttcgaggagaaagaaaaagaaaaacaaaga cttctttacgaacaaaagcgtcttgcaacccgtggagttgctgaaatggtcttatacatg atcagtgcaagtggtggagatgtttccgacaccatcgttacgacacttcagttgggaatt gctttactgactggtggaaatgttcttgtgcagaagatcatgcttgatcatttaaaagcg aagaaagatgttcgtttctttacaagtgttgctgggttaatggatcagtgcagtgtatta gatctgaatgcttacgaaagaagtcttaaatcggaaagtttgggtcatgttaatgaatgt actatcacaggtgaaaaaactatgagtgatgcggaactgacctgcgctttattccgattt cttcaattgctttgtgaaggtcacaatgcagattttcaaaattatcttcgaactcaagtt ggaaacaacaccacagtcaacattatcatatcaactgtggattatcttttgcggttgcaa gaagctatcagtgatttctactggtattattctgcaaaagaaaccattgatgctccaggt caagaaaacttctcgaaagcaatcgctgttgccaagcaagttttcaacactcttactgaa tatattcagggtccatgtgaaggcaaccagcaagcattagcacacagcaggttatgggat gctgtggtgggattcttacatgtgtttgcaaatatgcaaatgaaattatcacaagattca aagcgacaattatccttgttgaaggaattgcttgatttgcaacaagatatgattgttatg ttgttgtccatgttggaaggaaatgttgttgatggaacaattggtcgacaattagttgat acgttgattgaatcttctcacaatgttgaattaattcttcgtttcttcaacatgtttcta cgactcaaagacatcacgtcatccgataaatttttggaatatgacgcagaacacactggg tttgtttcaagaaaagatttccaacgagcaatggaagcttcgaaaatatattcaagtgaa gaaatcgatttcttacttgcttgtgctgtgtcaactgatgacaagttaaattacgatgaa tttaccgaacaattccatgaaccagcagctgatatcggcttcaacatggctgtgttactc actaatcttgctgaacacatgccaagggatacaagattaaagaaatttcttgaaatggcc gaagcaatgttggaatattttcaaccaaatcttggaagaattgaaattattggaagtgca aaaagaattgaaagagtttatttcaacattaaaccttcaagtttggaccaatggcacaaa cctcaagtgcaagaatcgaaacgtcaatttttctttgatgtgatcaacgatgagggagat aatggaagaatggaagaatttgtcaacttttgtgaagacacaatttttgagatgcaactt gcttcggagattagtgaagcggggttcggagcttcttcatcgtctgctgttaacgatgag gaaggtgatgataaagatgaggaggacgctgctgcgtcaggagaaattttacccagtttt aatttcaaggttgttaaaagctatgtgcgacagtttcgtgcaatgacctggattgaagta ataacttcccttgttttcttattcttcacatttaacatcaagctctgcaagctaagcata gaactattgcaaatttttggaaatttcttgtatgttcttttcttctcaaacttccttgtg gtggaagtgaagaaaaaaagtttaactgaaataatcgatgaaatgccgtgtcctacgcat gaaagaatacaacattcggttgaaaacctcagtgatagtggaactgacgatacagggcaa gatcaaactaaaggagataaagaagatttcatttccgatgtttttggaatggacataaag aaaagcaaagaacttataaaagcagttgtacatacgaagccagaagctggatttggtgac ttcactgtagatgaggcagctgatacgttcagtttaatcgcatcagattatgagagtggg attaacacacctcgtacttcaaagatcaagaaaagaagaaaacttcttcgcaaaggaaaa caaatagggcagactgcaagcactacaagcacaattttaagttcgctggaaaattcgtca acgagtgaacaacgtttatcgaatcttaaatctgcgatgtcgttcgatgaaagatcgggt gaagataatatatcaccgtggtatacttgtatgaaggaatgtggtcgaccagctcgatat aaacatgaagagaaaactgaagataggaacgcaatgtaccttgacacttggaatgcattt tgtatgggaactatgggtttgtttgcgcgcaatttttacaaattcaagattcttgccctt ggtcttacattctgcatcaactttatcttactcttctataagtggcacagcatcaacaat gatcttaaagtggattcggaatcaagcgaagatgaagttgaagaatctttaatattggaa gatacatcaaaatacatggaaccaacgttacgagctttttcaattattcattttattctc agtttttcaatgctggtgtcgtattatggattgaaggttcctcttgtcattttcaaacga gaaaaagaagttgcacgaaaattagaatttgacggactttatgtaaatgaagatccaact gacgatgacttgagcggaagatgggacaaacttgttatttcttgtccatcattcccttcc aattattgggacaaatttatcaaaaaaaaggttttggacaaatttggtgaacaatgtggt caagatagaatccaagatttacttggaatggatcattcaaacacaagttttctggatgaa gaagaaccacctaaaggaaacattttaacacagttgttcttgaacgtggatatcaaatac acagtatggaagactggtgttattttctccgaccaatctttcctatatctactgtggtat ttcgttatgtccatatttggtcaatacaacaggtttttcttctccttgcatcttcttgat atcgcgatgtgttcgaaaggtttacgaactattctaacatcggtaactcataatggaaag cagcttgtgctaacaattggattgctcactgtggtggtttacctttacactgtcattgct ttcaacttcttcaagaagttttacaacaagggggagggagatgatgaagattggaaatgc aacaacatgtttacttgcttccagtttcatttctactctggtgtgagagcaggtggtgga attggtgatgaacttgaagatccatcgggagacgcgtgggagttttatcgaatcgcattt gacatctcatttttcttctttgttgttgtaattcttcttgccattattcagggtttgatt attgatgcctttggagaacttcgtgaccagcaggagcaagttaaagaagacatggacaca aagtgtttcatatgtacaataggaattgattattttgatcaagttccacatggatttgaa acgcacacactgcaggaacacaatttagcaaattacatgttctttctcatgcatttgatc aacaaagatgaaactgagcatacaggacaagagacatatgtatggcagcagtatcaagag cgctgttgggagtttttcccagtaggagattgtttccgaaagcaatatgaaaatgaatta agtggttga

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