KEGG   Callithrix jacchus (white-tufted-ear marmoset): 100410075
Entry
100410075         CDS       T03264                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cjc  Callithrix jacchus (white-tufted-ear marmoset)
Pathway
cjc00562  Inositol phosphate metabolism
cjc01100  Metabolic pathways
cjc04015  Rap1 signaling pathway
cjc04020  Calcium signaling pathway
cjc04022  cGMP-PKG signaling pathway
cjc04062  Chemokine signaling pathway
cjc04070  Phosphatidylinositol signaling system
cjc04071  Sphingolipid signaling pathway
cjc04072  Phospholipase D signaling pathway
cjc04081  Hormone signaling
cjc04082  Neuroactive ligand signaling
cjc04261  Adrenergic signaling in cardiomyocytes
cjc04270  Vascular smooth muscle contraction
cjc04310  Wnt signaling pathway
cjc04371  Apelin signaling pathway
cjc04540  Gap junction
cjc04611  Platelet activation
cjc04613  Neutrophil extracellular trap formation
cjc04621  NOD-like receptor signaling pathway
cjc04713  Circadian entrainment
cjc04720  Long-term potentiation
cjc04723  Retrograde endocannabinoid signaling
cjc04724  Glutamatergic synapse
cjc04725  Cholinergic synapse
cjc04726  Serotonergic synapse
cjc04728  Dopaminergic synapse
cjc04730  Long-term depression
cjc04742  Taste transduction
cjc04750  Inflammatory mediator regulation of TRP channels
cjc04911  Insulin secretion
cjc04912  GnRH signaling pathway
cjc04915  Estrogen signaling pathway
cjc04916  Melanogenesis
cjc04918  Thyroid hormone synthesis
cjc04919  Thyroid hormone signaling pathway
cjc04921  Oxytocin signaling pathway
cjc04922  Glucagon signaling pathway
cjc04924  Renin secretion
cjc04925  Aldosterone synthesis and secretion
cjc04926  Relaxin signaling pathway
cjc04927  Cortisol synthesis and secretion
cjc04928  Parathyroid hormone synthesis, secretion and action
cjc04929  GnRH secretion
cjc04933  AGE-RAGE signaling pathway in diabetic complications
cjc04934  Cushing syndrome
cjc04935  Growth hormone synthesis, secretion and action
cjc04961  Endocrine and other factor-regulated calcium reabsorption
cjc04970  Salivary secretion
cjc04971  Gastric acid secretion
cjc04972  Pancreatic secretion
cjc04973  Carbohydrate digestion and absorption
cjc05010  Alzheimer disease
cjc05016  Huntington disease
cjc05017  Spinocerebellar ataxia
cjc05022  Pathways of neurodegeneration - multiple diseases
cjc05142  Chagas disease
cjc05143  African trypanosomiasis
cjc05146  Amoebiasis
cjc05163  Human cytomegalovirus infection
cjc05200  Pathways in cancer
cjc05415  Diabetic cardiomyopathy
cjc05417  Lipid and atherosclerosis
Module
cjc_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cjc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100410075 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100410075 (PLCB4)
   04310 Wnt signaling pathway
    100410075 (PLCB4)
   04371 Apelin signaling pathway
    100410075 (PLCB4)
   04020 Calcium signaling pathway
    100410075 (PLCB4)
   04070 Phosphatidylinositol signaling system
    100410075 (PLCB4)
   04072 Phospholipase D signaling pathway
    100410075 (PLCB4)
   04071 Sphingolipid signaling pathway
    100410075 (PLCB4)
   04022 cGMP-PKG signaling pathway
    100410075 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    100410075 (PLCB4)
   04081 Hormone signaling
    100410075 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100410075 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100410075 (PLCB4)
   04613 Neutrophil extracellular trap formation
    100410075 (PLCB4)
   04621 NOD-like receptor signaling pathway
    100410075 (PLCB4)
   04062 Chemokine signaling pathway
    100410075 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    100410075 (PLCB4)
   04922 Glucagon signaling pathway
    100410075 (PLCB4)
   04929 GnRH secretion
    100410075 (PLCB4)
   04912 GnRH signaling pathway
    100410075 (PLCB4)
   04915 Estrogen signaling pathway
    100410075 (PLCB4)
   04921 Oxytocin signaling pathway
    100410075 (PLCB4)
   04926 Relaxin signaling pathway
    100410075 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    100410075 (PLCB4)
   04918 Thyroid hormone synthesis
    100410075 (PLCB4)
   04919 Thyroid hormone signaling pathway
    100410075 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    100410075 (PLCB4)
   04916 Melanogenesis
    100410075 (PLCB4)
   04924 Renin secretion
    100410075 (PLCB4)
   04925 Aldosterone synthesis and secretion
    100410075 (PLCB4)
   04927 Cortisol synthesis and secretion
    100410075 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100410075 (PLCB4)
   04270 Vascular smooth muscle contraction
    100410075 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    100410075 (PLCB4)
   04971 Gastric acid secretion
    100410075 (PLCB4)
   04972 Pancreatic secretion
    100410075 (PLCB4)
   04973 Carbohydrate digestion and absorption
    100410075 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100410075 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    100410075 (PLCB4)
   04725 Cholinergic synapse
    100410075 (PLCB4)
   04728 Dopaminergic synapse
    100410075 (PLCB4)
   04726 Serotonergic synapse
    100410075 (PLCB4)
   04720 Long-term potentiation
    100410075 (PLCB4)
   04730 Long-term depression
    100410075 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    100410075 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    100410075 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    100410075 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100410075 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100410075 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100410075 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100410075 (PLCB4)
   05142 Chagas disease
    100410075 (PLCB4)
   05143 African trypanosomiasis
    100410075 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100410075 (PLCB4)
   05016 Huntington disease
    100410075 (PLCB4)
   05017 Spinocerebellar ataxia
    100410075 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    100410075 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100410075 (PLCB4)
   05415 Diabetic cardiomyopathy
    100410075 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100410075 (PLCB4)
   04934 Cushing syndrome
    100410075 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cjc04131]
    100410075 (PLCB4)
Enzymes [BR:cjc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100410075 (PLCB4)
Membrane trafficking [BR:cjc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100410075 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100410075 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 100410075
NCBI-ProteinID: XP_008993987
Ensembl: ENSCJAG00000021323
UniProt: A0A8J8YD73
LinkDB
Position
5:14175874..14575189
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIEMYEPDEDLKKRGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGEAASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFNVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALASGVEAKKGIELIPQIRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGNNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLNQQCELLKKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSM
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacctggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtattcggtcgggagccataccaaaggatcccaaaatcttg
gctgctcttgaagctgttggaaaatcagaaaatgatctggaagggcggatagtttgtgtc
tgcagtggcacagatctagtgaacattagctttacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaac
gtcagtccaatgacgtgcctcaaaaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccggttaggagtattactagaacctttgcatcgggaaaaacagaaaaa
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cctgcggcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacaccaacgagatcctcgattgaatgaaattttattt
ccattttatgataccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagat
ttgaagaaaagaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgccccagtcttcctagatcgtttagaactttaccaagaaatggaccaccctctggct
cactacttcatcagttcttcccataacacttacctcactggcagacagttcggcgggaag
tcttcagtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgctgaaacaagcacttgaatcacat
ccactggaaccaggcaggcctttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaacaagcggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatg
atggaagctggagaagctgcctccccagcaaacatcttagaggatgataatgaagaggag
atcgaaagtgctgaccaagaagaggaagctcaccccgaattcaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaacagcgtcaagaaggcctcagat
gaccttgaacatgaaaacaacaaaaagggcctggtcactgtagaagatgagcaggcgtgg
atggcatcttataaatatgtaggtgctaccactaatatccatccatatttatccacaatg
atcaactacgcccagcctgtaaagtttcaaggtttcaatgtggcagaagaacgcaatatt
cattacaacatgtcttcttttaatgaatcagtcggtcttggctacttgaagacacacgca
attgaatttgtcaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaattcgagtataat
ggatcatgcgggtaccttctcaaaccagatttcatgaggcggcctgatcgaacatttgat
cccttctctgaaactcctgttgatggcgttattgcagccacttgctcagtgcaggttata
tcaggtcaattcttatcagataagaaaattggcacctacgtagaagtggatatgtatggg
ttgcccactgacacgatacgtaaggaattccgaactcgcatggttatgaataatggactc
aatccagtttacaatgaagagtcatttgtatttcggaaggtgatcctgccggacctggct
gtcttgagaatagcagtgtatgatgataacaacaagctgattggccagaggatcctcccg
cttgatggcctccaagcagggtaccgacacatttcccttcgaaatgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacgtatgtgcctgatggattt
ggagatattgtggatgctctatcagatccaaagaaatttctctcaattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaaccagtgacatagccgatgtgcccagtgac
acttccaaaaatgacaagaaaggaaaggccaacaccgccaaagcaaatgtgacccctcag
agtagctccgagctcagaccaaccacgacagctgccctggcttctggtgtggaagccaag
aaaggtattgaacttatacctcaaataaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacagcagaaggagctaaattctttaaagaagaaacatgcaaag
gagcacagtaccatgcagaagttacactgcacacaagttgacaaaattgtggcacagtat
gacaaagagaagtcgactcacgagaaaatcctagagaaggcaatgaagaagaagggggga
aataattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagattgtagcacagcacacaaaggaatggtcagaaatgatc
aatacccacagtgctgaggagcaagaaatccgagacctgcacctcaaccagcagtgtgag
ctgctgaagaagctactcatcaacgcccacgagcagcagacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcgagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaagagactcgcaatgaag
cagtccaaagagatggatcagttgaaaaaagtccagcttgaacatctagaattcctagag
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatg
aaactccaaaatgcaaactga

DBGET integrated database retrieval system