Coturnix japonica (Japanese quail): 107314933 Help Entry 107314933         CDS       T04297                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X3   KO K04963   ryanodine receptor 3 Organism cjo  Coturnix japonica (Japanese quail) Pathway cjo04020   Calcium signaling pathway cjo04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cjo00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     107314933 (RYR3)    04020 Calcium signaling pathway     107314933 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cjo04040]     107314933 (RYR3) Ion channels [BR:cjo04040]  Voltage-gated cation channels   Ryanodine receptor    107314933 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 EF-hand_8 TBK1_ULD DUF3671 Motif Other DBs NCBI-GeneID:  107314933 NCBI-ProteinID:  XP_015720267 UniProt:  A0A8C2U0P6 LinkDB All DBs Position 5:26253800..26427964 Genome browser AA seq 4869 aa AA seqDB search MAEGGEGGEDEIQFLRTDDEVVLQCVSSVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLSICNFVLEQSLSVRALQEMLTSTGDNASEGAAQGGHRTLLYGHAILLRHSFSEMYLT CLTSSRSQTDKLAFDVGLRENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERY LHLSMSNGSIQVDASFMQTLWNVHPTCSGSNITEGYLLGGHVVRLFHGHDECLTIPSTDQ NDSQQKKVLYETGGAGVRARSLWRVEPLRISWSGSNIRWGQPFRLRHITTGMYLALNDDE GLVMLDREKSDTASSAFCFRASKELKEKQDSTLKRDIDGMGVPEIKYGDSVCFIQHVASA LWLTYKAPDAKSARLGLLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTSLFSQF ISGNNRTLSPIALPVEEMAQTLQDLIKYFQPPGEDLEHEDKQNKLRSLKNRQNLFKDEGM LALVLNCIDRLNDYNSAAHFAEIAREEHGTAWKEILNLLYKLLAALIRGNRNNCTQFSSN LDWLISKLDRLESSSGILEVLHCILIESPEALNVIAEEHIKSIISLLDKHGRNYKVLDVL CSLCVCNGVAVRANQNLICDNLLPRRDLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWY FELIIDQVDPFLTAEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSFGFDGLHLWS GRVPRAVASVNQHLLSSDDVVSCCLDLGVPSISFRINGQPVQGMFENFCTEGFFFPVVSL SAGVKARFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMKLEPVKEYKRDSDGVRDLLGTT QFLSQASFIPCPIDTSQIALPFHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDDNKRH HPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIVHANPAAEEDLKKVKLPKNYVMSN GYKPAPLDLSEVKLLPSQEFLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVP YALLDERTKKSNRDSLREAVRTFAGYGYNVEPPDQEIADQTVEKVSIDKIRFFRVEQSYA VKSGKWYFEFEAVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSKGQRWHQGSGFFGRS WQPGDVVGCMINLEDKSIIFTLNGELLITSKGSELAFADFGIESGFVPICSLGLSQIGRM NLGMDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHPHIQIWRIDG TIESPPRLKVTHKTFGTQNSNSDMIYCRLSMPIEFRSSFNFGMGVENASSDALQKRKHSQ EFPSSSTTYFYSLRIFAGQDPSSVWVGWVTPDYHFYSENFDINKNCTVTVTLGDERGRVH ESVKRSNCYMVWGGDISANSQRSGRSNVDLEIGCFVDLATGMLSFTANGKELGTCYQVEP NTKLFPAAFVQPTSTNLIQFELGKLKNTMPLSAAIFKSEERNPVPQCPPRLDVQTITPVL WSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMKFHY HTLKLYSSVCALGNTRVAYALCSHVDISQLFYTIDNQYLPGLLRSGFYDLLISIHLDHAK QAKLMMNNEFIIPVTEETRTIKLYPDETKKHGLPGVGLSTCLKPSFNFSTPCFIVTSEDH QTSSPEIPLDTLKSKAISMLTEAVQCSGSHIRDPVGGHIAFQFVPVLKLIATLLIMGVFD DDDVKQVLILIDPNVFGDHKEETEERTEKEEVTQVEEKAVEAGEKAVKETKAPTKGLLQT RLPESVKLQMCHLLNYFCDCELQHRVEAIVSFADHYVSKLQYNQKYRYNELMQALNMSAA LTAKKTKEFRSPPQEQINMLLNFQLGEDCPCPEEIRDELYDFHDDLLIHCGIPLEEEEEE EEDSSLTGKLRSLIYKIKGPPKPEKIEPREEEDKSPTTLKELISQTMVRWSQEDQIQDPE LVRIMYTLLRRQYDSIGELLQALRKAYTISAASVKDTINLLAALGQIRSLLSVRMGKEEE LLMINGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGDKSQIAFPKMVASCCRFL CYFCRISRQNQKAMFEHLSYLLENSSVGLAFPSMRGSTPLDVAAASVMDNNELALALEEP DLDKVVTYLAGCGLQSCPVLLAKGYPDIGWNPIEGERYLSFLRFAVFVNSESVEENASVV VKLLIRRPECFGPELRGEGGNGLLAAMQEAIRISENPTRDLPSQGYKREGDEEEEEEEIV HMGNAIMSFYSALIDLLGRCAPEMHLIQSGKGEAIRIRSILRSLVPTEDLVGIISIPLKL STVNKDGTVNEPDMSANFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRASASL DTVSLSTTEAALALNRYICSAVFPLLKRCAPLFSGTEHHASLVDSMLHTIYRLSKGRSLT KAQRDTIEECLLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKYYC LPSGMGSYGIAAEDELHLTEKLFWGIFDSLSHKKYDPELFKMALPCLSAIAGALPPDYLD TRIRSTLEKQTSVDPEGNFDPKPVNTANLILPEKLEYIVSKYAEHSHDKWAFDKTNNGWK YGVSLDENTKTHPLIRPFKTLTEKEKEIYRWPVRESLKTMLAMGWSLERTKEGGEAMLHQ RENEKLRSISQSSQGNGYSPAPLDLTNVVLSRELQGMVEVMAENYHNIWAKKKKMELESK GGGSHPLLVPYDTLTAKEKSRDREKAQELFKFLQVNGIVISRGLNDMDLDASSMEKRFAF KFLKKILKYVDSAQEFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHCLYF LSSPTKTLSSSGYASNKEKEMVASLFCKLAALVRHRISIFGSDSTTMVSCLHILAQSLDT RTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALL PVLTSIFEHISQYHFGVDLLLGDVQVSCYRILCSLYSLGTGKNIYVERQRPALGECLASL AAAIPVAFLEPSLNHYNPLSVFNTKSARERAILGMPDTVEEMCPEIPQLDGLIKEINNLA ESGARYTEMPHVIEVILPMLCNYLSYWWERGSESVPESAGPFCTMITSEHLSIILGNILK IINNNLGIDEASWMKRIAVYAQPIISKARPDLLKTHFIPTLEKLKKKAIKIVMEEEQLKA DSKSDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRANWLKKPDADSDELFRMVAEV FILWCKSHNFKREEQNFVIQNEINNLAFLTGDTKSKMSKAMQVKSGGQDQERKKSKRRGD LYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYSHRDTDEEVKEHIRNNLHLQE KSDDPAVKWQLNLYKDILKSDEPSDPEKNVERVQRISAALYHLDQVEQPLRSKKAVWHKL LSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQNYWIETEEYSFEEKLVQDLATSPKK EEEEEEDTEKEQPDPLHQIILYFSRNALTERSKLEDDPLYIAYAAMMAKSCQEEEEEEEE DKEKTFEEKEMEKQRTLYQQARLHDRGAAEMVLQMISASKGHTGPMVVETLKLGIAILNG GNTIVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIV RERGEKVLQHDEFTRDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVDYLLRLQ ESISDFYWYYSGKDVIDESGQRNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWD AVVGFLHVFANMQMKLSQDSAQIELLKELLDLLKDMVVMLLSLLEGNVVNGTIGKQMVDT LVESSSNVELILKFFDMFLKLKELTNSDAFKEHDPDGKGIISKKDFQKSMEAQKQYIQSE IEFLLSCAEADENDMFNYIDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQSLLEPA ESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRMQWEKPQVKESKRQFIFDVVNEGGE QEKMELFVNFCEDTIFEMQLASQISETDSAERPEEEEEEEPCYVVDIRDDEEEEKSLESP SAFAMACAAVKKNVTNFVKMVTVKNLRKQYRKVRKMTVKELVKVFFSFFWILFIGVFQLF FTIVWGIFQILWSTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVTEGEKTEGAEHG IRDELVQFVKGEKGDTDIISDIFGIPTKKEGGSKHGHDAGLGDIAEMLGSDIQSSLENNV RKKKGLQISETAKESEAERKVEAEKADMEDGEKQDKAKEEQSEQPEEGKTKKKKRRHGQK TEKPEAVMANFFKALEIYQTKMLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLDE VEEDTNLWNSFEEEEEEEGMVFFVLEESTGYMAPTLRALAVIHTIISFVCVIGYYCLKVP LVVFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINK YGDLYGAERIAELLGLDKNALDFSPVEESEPEAASLVSWLSSIDTKYHIWKLGVVFTDNS FLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVV YLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDP YEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYF DTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESFVWKMYQERCWDFFPAGDCF RKQYEDQLG NT seq 14610 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggtgaaggaggggaagatgaaatacagttcctacgaactgatgacgaa gtagtacttcagtgtgtttccagtgttcacaaagaacaaaggaagttttgcttggcagct gagggacttggaaatcgcctgtgctttttggaaccaacatcagaagctaaatatgttcct ccagatctttccatctgtaattttgtccttgaacagtctctgtctgtcagagcccttcaa gagatgttgaccagcacaggagataatgccagtgaaggggcagctcaaggtggtcacaga actctcctgtatggccacgctatactacttcgacattcgttcagtgaaatgtatttaaca tgtttaacatcatcaagatcccagacagataaacttgcatttgatgtgggactacgagaa aatgcagcaggtgaggcatgctggtggacaatacaccctgcttctaaacaaagatcagaa ggagaaaaagttcgaataggtgatgatcttatcctggtcagtgtgtcctctgaaagatac ctgcatctctccatgtcaaatggaagtattcaggtagatgcctccttcatgcagacactt tggaatgtgcatcctacgtgctcaggaagcaatattactgaaggatatcttcttggtggg catgtagtacgcttattccatggtcatgatgaatgtttgacaattccttctacagatcag aatgattcacagcagaagaaagtgctttatgaaactggaggagcaggtgttcgagcgagg tctttgtggagagtagaaccccttcggataagttggagtggaagtaacatcagatggggt cagcctttccgtcttcgacatataacaacaggaatgtacttggctttgaatgatgatgaa ggtcttgtaatgttggacagagaaaagtcggacacagcatcttctgctttttgtttcaga gcatcaaaggaactaaaagaaaagcaggattctactcttaaacgtgacattgatggaatg ggagtcccagaaataaaatatggtgattcagtctgttttattcaacatgtggccagtgcc ttatggttgacttataaagcaccagatgctaaatcagcacgcttaggtctcctgaaaaga aaggttatattacaccaagaaggtcatatggatgatggtctaaccttacaaagatgtcag catgaagaatcgcaggctgctcgaatcattcgcaatactacaagcttattcagccagttt ataagtggtaataacagaacactatcacccattgccctgcctgttgaggagatggcacag actctgcaagacctgatcaagtacttccagcctcctggagaagacctggaacatgaggat aagcaaaacaagcttcggtccctcaaaaacagacaaaacctattcaaagatgagggaatg ctggcactagttttgaattgcattgatcgtttaaatgactacaacagtgcagctcatttt gcagaaattgcaagagaagaacacggtacagcatggaaagaaattttaaatctcctttac aaactgcttgctgctctcattcgtggcaacagaaacaattgtactcagttttccagtaac ctagattggctgataagcaaattggacagattagaatcttcctcaggtattttggaagtg ttgcactgtattttgattgaaagcccagaagctttaaatgttatagctgaagagcatata aaatctattatttcactgctggacaagcatgggcgaaattacaaggttcttgatgtgctt tgctctctttgtgtctgtaatggagttgcagttcgtgccaatcaaaacttgatctgtgac aatctactgccaagaagagacttacttctgcaaacacgtttgattaatgatgtgacaagc ataaggccaaacatatttttgggtgttgctgagggctctgcacagtacaagaagtggtac tttgaattaataattgatcaggttgatccattcttgacggcagaacccacccatttacgg gttggatgggcctccacttcaggctatgccccctatcctggaggtggagaaggatggggt ggcaacggtgttggagatgacctatactcttttggttttgatggccttcatctgtggtct ggtcgagtacccagagctgtggcatctgtcaatcaacacttgctgtcatctgatgatgta gttagctgctgcttggatttaggtgtacccagcatttcattccgcattaatggtcagcct gtacaaggaatgtttgagaatttctgtactgaagggtttttcttccctgttgtaagctta tcagcaggtgtaaaagctcgtttcttattgggtggacgtcatggagaatttaaatttttg cctcctgctggctatgctccctgttatgaagccttgcttccaaaagaaaagatgaaattg gaaccagtgaaagaatataagagagattctgatggagtaagagatttgctgggtacaaca cagttcctctcccaagcttcatttataccttgtcctatagacaccagtcagattgctctt ccttttcatcttgaaaagatcagggataaactagcagaaaatatccacgaactgtgggga atgaataaaatagaactgggctggacgtatggcaagatacgggatgataataaaaggcat catccctgtcttgtggaattctcaaagttacctgagacagagaagaattataatctacaa atgtcaactgaaactctcaaaacacttttggcccttggatgtcatattgttcatgctaat ccagcagctgaggaagatcttaaaaaagtcaagcttcctaaaaattatgtcatgtcaaat ggttataaacctgcccctcttgatctttctgaagtgaaattgttaccttctcaagaattt ctagttgacaaactagcagaaaatgctcataatgtctgggcaaaagacagaataaagcaa ggatggacctatggcattcagcaggatcttaagaacaaacgtaatcctcggctagtgcca tatgcattactagatgaacgtactaaaaaatcaaacagagatagccttcgtgaagctgtt aggacatttgcaggctatggttataatgttgagccacctgaccaagaaatagctgaccaa acagtggaaaaagtcagcattgacaagatacgttttttcagagtagaacaatcttatgca gtgaagtctgggaagtggtactttgaatttgaagctgtaacaggtggagatatgcgtgtt ggctgggccagaccaggctgtcgacctgacattgaactgggagctgatgaccaagcattt gtttttgaaggaagcaaaggccagcgttggcatcaaggcagtgggttctttggacggagt tggcaaccaggagatgtggttggctgcatgataaacttggaggacaaatcaattatcttt actctaaatggagagttgcttataaccagtaaaggctcagaacttgcatttgctgacttt ggaatagaaagtggttttgttccaatttgctcactgggtctatcccagattggtcgtatg aaccttggaatggatgctagtactttcaaatattataccatgtgtggccttcaagaaggt tttgaaccttttgcagtgaacatgaaccgagatgttgctatgtggtttagtaaacgctta ccaacatttgttaacgtaccaaaaaatcatcctcacatacagatatggagaattgatgga accattgagagtccacctcgtttaaaagttactcacaaaacatttggtacacaaaacagc aattctgatatgatatattgccgtttgagtatgcccattgagttccgttcatcattcaac tttggcatgggtgtggaaaatgcctcatctgatgctcttcaaaaacgaaaacacagccaa gaatttccttcttcttctactacatatttttattccttgcggatatttgctggccaagac ccatcctctgtctgggttggctgggtaacaccagactatcatttttacagtgagaatttt gacataaataaaaactgtacagtgacggttactttaggagatgagagaggcagggttcat gaaagtgtgaagcgcagtaattgctatatggtttggggaggagatatatctgctaattct cagagatcaggtcgcagtaatgttgatttagaaattggatgctttgttgacctggctact ggaatgttgtcattcactgccaatggaaaagagcttggcacttgttatcaggttgaacca aacacgaagcttttccctgcagcttttgtacagcctacaagcactaacttaattcagttt gaacttggtaaattaaagaataccatgcctttatcagcagcaatttttaaaagtgaggaa agaaatcctgttcctcagtgtccccctcgacttgatgtgcaaacaattacacctgtttta tggagtaggatgcctaacagctttctaaaagtagaaacagagcgcgtcagtgaacgtcat ggctgggttgtgcaatgtttggaacccctgcagatgatggcacttcacatcccagaggaa aacagatgtgttgatattttggaactatgcgaacaagaagatttgatgaagtttcactat catactttaaaactttatagctcagtttgtgctctaggtaacactagagttgcttatgca ctttgtagccatgtagatatatctcagttattttacacaatagataatcagtatttacct ggactcctacgttctggattctatgacttgctcattagtattcatttggaccatgccaag caagccaagctcatgatgaacaatgaatttatcattccagttacagaggaaactcgaact attaaattatatcctgatgagacaaagaagcatggtttacctggagtagggcttagcact tgtctcaaaccaagcttcaatttttctactccttgctttattgtgacctctgaagatcat cagacatccagtccagaaattccccttgacacacttaaatccaaagctataagtatgctg acagaggcagtacaatgtagtggttctcatatacgagatcctgttggaggacatattgca ttccagtttgttcctgttcttaaactcatagcaacattgcttataatgggagtttttgat gatgatgatgtgaagcaggtgttaatactcattgatcccaatgtcttcggagatcacaag gaagaaacagaagagaggacagagaaggaagaagttacacaagttgaagaaaaagctgta gaagctggagaaaaggcagtaaaagaaacaaaagctcctacaaagggcttattgcagaca agattaccagaatctgttaagcttcagatgtgccacttactcaattatttctgtgactgt gagctgcaacatagagtggaagcaattgtatcgtttgcagatcactatgtatcaaaattg caatataaccaaaagtacaggtataatgagcttatgcaagccctgaacatgtctgctgct ttgactgccaagaagactaaggaatttcgatctcctccacaagaacagattaatatgctg ctgaattttcaactgggagaggattgtccttgtccagaggagattcgggatgaactatat gacttccatgatgatcttctaattcactgtggtattccactagaagaggaagaagaggaa gaagaagattcttccttgactggcaaacttcgttcattaatatacaaaatcaaaggtcca ccaaaaccagaaaaaatagagcccagggaagaagaagataaatcccctactacactgaag gagctcatttcccagactatggtgcgctggtcccaagaagatcagattcaagatccagaa ttggttcggattatgtacactctcctgcgtaggcaatatgatagcattggtgagctactt caagctctgaggaaagcatacactattagtgctgcctctgtgaaggataccattaatctg cttgctgcactgggccagattcgctctcttctcagtgtcagaatgggaaaagaagaggaa ttgctaatgattaatggattgggagatataatgaacaacaaggttttttatcagcatcct aacttaatgagagctttaggcatgcatgagacagtcatggaagtgatggtgaatgtgctt ggaggcgataaatctcagatcgcttttcctaagatggtggcaagctgttgtcgattcctg tgctacttctgtcgaattagccgtcaaaaccaaaaagccatgtttgagcatctcagttac ttactggaaaacagcagtgttgggttggcatttccttcaatgagaggttcgacaccacta gatgttgcagcagcttctgtaatggacaacaatgagcttgcactagcactggaagaacca gatcttgataaagttgttacttacctggcaggttgtggcctgcagagttgtccagtattg ctagctaaaggatatccagatattgggtggaatccaatagagggtgaacgttacctgtca ttcctaagatttgcagtttttgttaacagtgaaagtgttgaagaaaatgcaagtgttgtt gtaaagctccttattcgacgaccagagtgctttgggccagagcttagaggagaaggagga aatggtttgctggcagctatgcaagaagcaatacggatttcagagaatcctactcgtgac cttccctcacaaggatataagagagaaggtgatgaagaggaggaggaggaggagatagta cacatgggcaatgcaatcatgtcattttactctgctctcatagatttacttggacgctgt gcaccagaaatgcaccttattcaaagcggaaaaggagaagccattagaattagatcaatc cttcgatctctagtgccaactgaagatttggttgggattataagtataccactaaagctg tcaacagttaacaaagatggcactgtaaatgagccagacatgtctgcaaatttctgtcct gatcataaggcgccaatggtactctttttggaccgtgtgtatggtattaaggaccaaagc ttcctccttcacttacttgaagttggatttttaccagatttaagagcttctgcctctctg gatacagtttccctaagtaccacagaagcagctcttgcactaaacagatatatttgctca gctgtgtttccattactcaaaagatgtgctcccctcttttctggaacagaacatcatgcc tctcttgttgactccatgcttcacacaatatataggttatccaaaggacgttcccttaca aaagcacaacgagacactattgaagaatgcctgcttgctatctgccaccacttacgtcct tctatgctccaacagctattgagaaggctagtttttgatgtgcctttactcaatgaatac tgtaaaatgccactcaagcttctgacaaatcactatgaacagtgttggaaatattattgt ctaccttcaggaatgggaagctatggaattgcagcagaagatgaattgcatttaactgaa aaacttttttggggaatatttgattccttgtctcataagaagtatgatccagagcttttt aaaatggccttgccctgtctaagtgctatagctggggctttgcctcctgattatttagat acacgaattagatcaacattggaaaagcagacctcagtggatccagaaggaaattttgat cccaaacctgtcaacacagcaaaccttattcttcctgaaaagctggagtatattgtcagc aaatatgctgagcattctcatgataaatgggcttttgataagactaataatggatggaaa tatggtgtttcactggatgaaaatacgaagactcatccattaattagacctttcaaaact ttaactgagaaggaaaaagaaatttatcgttggcctgtgagagaatcactgaaaaccatg ttggccatgggctggagcctagagaggaccaaggaagggggagaagcaatgctacatcag cgtgaaaatgaaaagctccgcagtatatctcagtctagccagggaaatggatatagccca gcaccacttgatctcactaatgtggtactttctagggaacttcagggaatggttgaggta atggcagaaaactaccataatatttgggcgaaaaagaagaaaatggagttggaaagcaaa ggtgggggcagtcatcctttattggtaccttacgacacattgacagccaaggagaaatca cgggaccgtgaaaaggcacaagagctgtttaaattccttcaagtgaatggcatagtcata tcacggggtctgaatgacatggatttggatgcttcatccatggaaaagaggtttgccttt aagtttctgaagaaaattttaaaatatgttgactctgctcaagagttcattgcacatttg gaagccattgttaccagtggaaaaactgaaaaatctccacatgatcaagaaataaaattc tttgccaaagttcttttgccattagttgatcagtactttacaaatcactgcttgtacttc ctgtcttctccaacaaaaacactcagtagcagtggatatgcatcaaataaagaaaaggaa atggtagcaagcctgttctgcaaactagctgctcttgttagacataggatctcaattttt ggtagtgattctacaacaatggtgagctgcctgcacatcttggctcagtctctggacact cgaactgttatgaaatcaggatctgagcttgttaaagctggattgagagctttttttgaa aatgcagctgaagatctggaaaaaacttcagaaaatcttaaacttggaaaatttacccat tcacgaacacaaatcaaaggtgtttcacagaatatcaattatactacagtagcattgcta cctgtcttgacatcaattttcgagcatatttcacagtatcattttggagttgatttgctt ttgggtgatgtacaagtttcatgttacagaattctttgtagcctctattcccttgggact gggaagaacatctatgttgaaaggcaacgtcctgcacttggtgagtgcttagcatctctt gcagcagccattccagtagcattccttgaaccttctctcaaccactacaacccattgtct gtcttcaacacaaaaagtgcaagagaaagagcaattttaggtatgcctgatacagtagag gagatgtgtccagagatccctcagctggatggactgataaaggaaattaataatttagca gagtctggagcaagatatactgaaatgcctcatgtaattgaggttatcttacccatgctg tgcaactatttgtcctactggtgggaacgagggtctgaaagtgttcctgaaagcgctggg cctttctgtacaatgataacatctgagcatctgagcatcattctgggaaatattctgaaa atcattaacaacaatttgggaatagatgaagcatcttggatgaaaagaattgcagtttat gctcagcctatcatcagcaaagccagacctgatctgctgaaaactcactttattccaaca ctggagaaattgaagaagaaagctataaagattgtgatggaagaggagcaactgaaagca gatagtaaaagtgacactcaagaagctgagctgcttatccttgatgagtttgccgttctt tgtagagacctctatgccttctatccaatgctgatacgttatgtagacaacaacagagcc aactggctaaagaaaccagatgcagattctgatgaactgtttcgaatggtggctgaagtt tttatcctctggtgcaaatcacataatttcaaaagagaagaacaaaattttgtcattcag aatgaaatcaacaatttggcatttttaacaggagataccaagagcaagatgtctaaagcc atgcaagtaaagtctggaggacaagaccaagagaggaagaaatcaaaacgcagaggggat ttgtactccatacaaacatccttgattgtagctgcacttaaaaagatgcttcctatcggc ttgaatatgtgtactccaggagatcaagagctcatctcattggctaagaccagatatagc catagggacactgatgaagaagtcaaagaacatatacgtaacaacttacatttgcaggaa aagtctgatgatccagctgtgaaatggcagttaaatctatataaagacattctgaagagc gatgagccttctgaccctgagaaaaatgtggaacgtgtgcagaggatatcagctgctctc tatcatctagatcaggttgaacaaccactgagatcaaagaaagctgtttggcacaaactt ctgtcaaaacaacgcaaaagagctgttgttgcttgttttagaatggcaccgttatacaac ctacccaggcaccgttctattaacctcttcctccatggctatcagaactattggatagaa acagaggaatattcatttgaggagaaactagttcaggatttggctacatctccaaaaaag gaggaagaagaagaggaagatacagagaaagaacaacctgacccacttcatcagattatc ctttatttcagtcgcaatgctctcacagagaggagcaaactagaagatgatcccttatat attgcctatgctgccatgatggcaaagagctgtcaagaagaagaagaggaggaggaggaa gacaaagagaagacatttgaggagaaagaaatggaaaagcagagaactctttatcagcaa gctcgcttgcatgatcgtggagctgctgagatggtccttcagatgatcagtgcaagcaaa ggtcatacgggacccatggttgttgaaacactaaaacttggtattgctattctaaatggt gggaatacaatagttcaacagaaaatgctagactacttgaaggagaagaaggatgctgga ttctttcagagtctttctggtttgatgcagtcctgcagtgttcttgacttgaatgcgttt gagagacaaaataaagcagaaggcctgggaatggttactgaagaaggaactctcatcgta cgtgagcgtggtgaaaaagtgttgcagcatgatgaatttactcgagatctatttagattt ttacaactgctctgtgaagggcataacaatgattttcaaaattacctacgtacacagatg ggcaacaccacaacagtgaatattatcattagtacggttgactacctcttgcgtcttcag gaatcaatcagtgacttctactggtactattcagggaaagatgttattgatgaatcagga caacgtaacttctctaaagctttggctgtcaccaaacaaatattcaattctctaactgaa tatatacagggaccttgcattggtaaccaacagagtctggctcatagtaggctgtgggat gcagttgttggatttcttcatgtattcgccaatatgcagatgaaactttcacaggactct gctcaaattgaactgcttaaggaactgctagatctgctaaaggatatggttgtgatgttg ttgtcactacttgaaggtaatgttgtaaatggaacgattgggaaacaaatggtcgatacg cttgtagaatcatcgagcaacgtcgaattgatcttgaagttttttgacatgtttctcaaa ttaaaagaattaactaattcagatgctttcaaagagcatgacccagatggtaagggcatc atttcaaagaaggatttccagaagtcaatggaggctcaaaaacaatatatacaatcggag attgaattcctgctgtcatgtgcagaagctgatgaaaatgatatgttcaactacattgat tttgtggaaagattccatgaaccagccaaagatattggctttaatgtagcagttttgcta acaaacctttcagagcatatgcctaatgactcacgccttcagagcttacttgaacctgca gaaagtgttcttaattactttgaaccataccttggccgtattgaaataatgggtggagcc aagaaaatagaaagagtttactttgaaatcagtgaatccagtagaatgcaatgggagaag ccacaggtgaaggaatccaaaaggcagttcatatttgatgttgtaaatgagggtggagag caagaaaaaatggagctttttgttaatttctgtgaagacacaatctttgaaatgcagtta gcatcccaaatctccgaaaccgattcagctgagagacctgaggaagaggaagaagaagag ccttgctatgttgtggatatccgagatgatgaggaagaagaaaagtccctggaatctcct tcagcttttgcaatggcctgtgctgcagtcaagaagaacgtaaccaactttgttaaaatg gtcactgtgaagaacctaagaaaacagtacaggaaagttagaaagatgacagtaaaagag ttggtgaaagtgtttttctcttttttctggatcctattcataggggtgttccaactgttc tttactatagtgtgggggattttccagattctttggagcaccgtatttgggggtggactg gttgaaggagccaaaaacattaaagttactaaaatactgggggacatgcctgacccaaca cagtttggaatccatgatgatgtaacggaaggagaaaaaactgaaggtgctgagcatggc attagagatgaacttgtgcagtttgtaaagggtgaaaagggagacactgatataatctca gatattttcggcattcctactaagaaagaaggtggctcaaaacatggtcatgatgctgga cttggagatattgcagaaatgctcggttctgatatccagtcttctctggaaaacaatgtt cgtaagaaaaaaggattacagatatctgaaactgcaaaagaaagtgaagcagaaagaaaa gtggaagctgagaaggctgacatggaagatggtgagaaacaggataaggcaaaggaagaa cagtctgagcagccagaagaaggaaaaacgaagaaaaagaagcgaaggcatggacaaaaa actgagaaacctgaggctgttatggctaatttcttcaaagctttggaaatatatcaaaca aaaatgcttcactacctggcaaggaatttttacaacttacggtttcttgctctgtttgtt gcatttgccatcaactttattctgctgttttacaaggtgacagaagagccacttgatgaa gtggaggaagacactaatctctggaactcttttgaggaagaggaagaggaggaaggaatg gtattttttgttttggaagaaagtacaggttacatggcacccactctcagagcactggca gttattcatactatcatctcctttgtctgtgtgattggatactactgcttaaaggtccct ttggttgtattcaagagagaaaaggaggtagctaggaagctggaatttgatggattatac ataactgaacaaccctctgaagatgatattaaaggacagtgggatcgcctggttataaac acaccgtcctttcctaacaattactgggataaatttgtaaaacgaaaggttattaacaaa tatggagacttgtatggagcagagcgtatagcagaacttctgggtttggataaaaacgcc cttgatttcagtccggtggaagagagcgaaccagaagcagcatctcttgtatcatggcta agttccattgatacgaagtaccacatttggaagcttggtgttgttttcaccgataattca tttttgtacttagcttggtacacaactatgtctatccttgggcactacaacaatttcttt tttgctgctcatctgctggacattgctatgggattcaagacattgcgaactattttgtcc tctgtcactcacaatggcaaacagcttgtgcttactgtaggactcctggctgtagttgtg tatctttacactgttgtggcgttcaacttcttccgcaaattctacaataaaagtgaagat gaagatgaaccagatatgaaatgtgatgacatgatgacatgttacctattccacatgtat gtaggtgtaagagctggtggtggcatcggggatgaaattgaggatcctgctggagaccct tatgaaatgtatcgaattgtcttcgacatcacatttttcttctttgtcattgttatccta ctggccattattcaaggtctgattattgatgcttttggtgaattaagagaccagcaagaa caagtgagagaagatatggagaccaaatgctttatttgtggaattggcaacgactatttt gacacaaccccacacggcttcgaaacacatactctgcaggaacacaacttggcaaactac ctgttcttcttaatgtacctcataaacaaggatgagactgagcatactggtcaggagtca tttgtgtggaagatgtaccaagaaagatgctgggatttcttcccagcaggagactgcttc cggaaacagtatgaggatcaacttggctaa

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