Cimex lectularius (bed bug): 106666716 Help Entry 106666716         CDS       T05603                                  Name (RefSeq) ryanodine receptor isoform X2   KO K04962   ryanodine receptor 2 Organism clec  Cimex lectularius (bed bug) Brite KEGG Orthology (KO) [BR:clec00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:clec04040]     106666716    04990 Domain-containing proteins not elsewhere classified [BR:clec04990]     106666716 Ion channels [BR:clec04040]  Voltage-gated cation channels   Ryanodine receptor    106666716 Domain-containing proteins not elsewhere classified [BR:clec04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    106666716 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  106666716 NCBI-ProteinID:  XP_014249566 UniProt:  A0A8I6RR23 LinkDB All DBs Position Unknown AA seq 5098 aa AA seqDB search MADSEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS TCVFVIEQALSVRALQELVTAAGTEEAQDSLGKGTGSGHRTLLYGNAILLRHQNSSMYLA CLSTSSSHDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENDQSIVNASFHVTHWSVQPYGTGISKMKYVGYVFGGDVLRFFHGGDECLTIPSTW SSEAGQNVVVYEGGSVLSQARSLWRLELARTKWAGGFINWYHPMRIRHLTTGRYLGVNEA NELHLVTRDEATTALSTFILRQEKDDQKVVMEDKDLEVIGAPIIKYGDSTVLVQHSESGL WVTYKSFETKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTQF IKGLEELQLNRRHSLFCATVNLNEMVMCLEDLINYFAQPEEDMEHEEKQNKLRALRNRQD LFQEEGILNLILEAIDKINIITSQGFLVNLAGDESGQSWDIISGYLYQLLAAIIKGNHTN CAQFANTNRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEK HGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTQLVDHVASVRPNIFVGR VEGSAVYQKWYFEVTLDHMEQMTHMTPHLRIGWANTAGYVPYPGGGEKWGGNGVGDDLYS FGFDGFALWTGGRSTVVSQLAQGPPYIKKGDVIGCALDLTVPIITFTFNGHAIKGSFRNF NLEGMFFPVISCSSKLSCRFLLGGDHGRLKYVPPEEFSPLVESLQPQQILSIDPCFYFGN LNKCVLSGPYTIEDDTAFVPIPVDTTMITLPNHVETIRDRLAENIHEMWAMNKIEAGWIF GENRDDIRRIHPCLVQFDKLPAAEKRYDTQLAVQTLKTIVALGYHISVDKPPSRIKNIRL PNEPFMQPNGYKPAPLDLSAITLTPKMEELVDQLAENTHNLWAKERIQQGWTYGLNEDPD YCRSPHLVPYSKVDELIKKANRDTASETVRTLLVYGYNLDPPTGEQTEALLAEASRLKHQ AFRTYRAEKTYAVNSGKWYFEFEILTAGPMKVGWATSDYCPGSQLGSDENSWAFDGYNEE KISSGVAESFGRQWTVGDVVGVFLDLLDHTISFSLNGELLMDTLGGETSFSDVQGEGFVP AFTLSVGQKAKLTFGQDVNALKYFTTCGLQEGYEPFCVNMNRAVTYWYTKDQPIFENTDD YADTRIDVTRIPPGSDSPPCLKISHNTFETMEKANWEFLRLSLPVICESSFIDETEKMRR WQEIRIRQHRLLAEQEQTTPAHIEQIMKSGFSMSDIKGLQRGYSEDAVEADEVIGPSSSP MMKSKLKSTPSRPPRKGSLSRQEDMTHLNGTLESGLGAMNRSTSELDFNRYNGEISDGKD DKKKRGRSPFRFFSRKRDASGERGKKGRTPEPASNNLLEPPRTPQMQRGGSLIRTPTKAL ADVKPPSPMADRGGPKTMSVPQGSGVESIGNEIYDAECLKLINEYYYAVRIFPGQDPTHV YVGWVTTQFHLHSNDFSQSKVLKSTVSVEDDYNRIIESIERQSCYMLRADELYNEVTQDA SGKVASQGMTIGCSIDTATGYMTFTCEGKETKHKYKMEPDTKLFPAIFVEATSKEILQIE LGRTPTTLPLSAAVLRNSERHVIPQFPPRMKVQCLIPHQWARVPNISLQVHALKLSDIRG WSMLCEDPISMLALHIPEEDRCIDILELIEMEKLLSFHAHTLTLYAALCYQSNYRAAHAL CQHVDQKQLQYAIRSEYMSGPLRLGFYDLLIALHIESHATTMEICKNEFIIPLGPELKEL YEDPEMGHSLRSLQMVSVLPQMKMTDINEPIESINTLYSPYFPLDAVRDYVMLAVQEAVE INQLHIRDPVGGSNENLFLPLLKLADRLLLVGMLRDEDVIKLLIMFDPETWDPNFEKDGK DEHRKGLLQMKMAEGAKLQMCYLLQHLCDIQLRHRVEDIINFSHDYVADIQTDQLRRYIE IKQTDLPASVAAKKTREFRCPPREQMNAIICFKNLDEDDSESCPCGPELRERLNSFHSGL MQKVSLVALQEPEEEGPTEEEKPNMFRKLYNFINAVKELDVPPKIIEEPEKKTPEEIFRK VLISTIVRWAEESQIETPKLVREMFSLLVRQYDSVGELQRSLGKTYVINYKTKDDVALMW IGLSQIRALLPVQMSQEEEGLMRMRLWKLVNNHTFFQHPDLIRVLRVHENVMAVMINTLG RRSQAQSDAPQGGQEGEPVAKEKDTSHEMVVACCRFLCYFCRTSRQNQKAMFDHLTFLLE NSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSRCGLQSNSELVEK GYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPALRGEGEGLL RAIIDANKMSERIADRRKVMDEAEGTTLGLQFEHPLPESDDDEDYIDTGAAILAFYCTLV DLLGRCAPDVSVIAQGKNESLRARAILRSLVPLEDLSGVLSLKFTLTNPAAGEERPKSDI PSGLIPSHKQSVVLFLERVYGIEHQDLFFRILEDAFLPDLRAATMLDRSDGQESEMALAM NRYIGNSILPLLIKHSQFYGNADNYASLLDATLHTVYRLSKNRMLTKGQREAVSDFLVAL TSQLQPSMLLKLLRKLTIDVSQLSEYTTVALRLLTLHYDRCAKYYGSSGGSTNSSDEEKR LTMILFSNIFDSLSKMDYDPELFGKALPCLSAIGCALPPDYSLSKNYDDELYGTKNMGPV DGPYNPQPINTSSVSLDNDMNSIVQKFSEHYHDAWASRKMENGWVHGDQWSDSSKTHPRL KPYNMLNDYEKERYKEPVRESLKALLAIGWTIEHTEVDIPSNNRGSSVRRQSKGAMDSGS PFNYHPNPIDMTNLTLSREMQNMAERLAENSHDIWAKKKKEELTTCGGAIHPQLVPYDLL TDKEKKKDRERSQEFLKYLQYQGFKLHKPNRGGGDIDQQIAAAATGESRFAYSLLEKLIQ YTDKASINMKLLKPSTTFSRRSSFKTCTRDIKFFFKVVLLLVEKYFSTHRSYFIAIATAT NNIGAASLKEKEMVASLFCKLANLLRTRLSAFGPDVRITVRCLQVLVKAIDAKSLVKNCP EFIRTSMLTFFNNTADDLGQTIQCLTDGRYSHLRGTHLKTSTSLFYINDVVLPVLTSMFD HLAACDYGIDLLLDEIQVASYKMLGSLYTLGIDPTLTHDRKYLKTEIERHRPAIGSCLGA FSSTFPVAYLEPHLNKHNQYSLVNRIADHSLEAQDVLNRMEQTMPTLDTILAEVDQFVES DKSHSAAPHVIDVILPLLCAYLPVWWVQGPDNVSLTAGNYVTMVTSEHMNKLLKNVLKLI KSNIGNENAPWMTRIAAFTQQIIINSSEELLKDPFLPLTLTVKKRIDSMCHKEESLRGFL KSSAEDTSQVEAEIQEEWNLIVRDIYSFYPLLIKYVDLQRNHWLRNNIPEADELYNHIAD IFNIWSKSQYFLKEENNFISANEIDNMALIMPTATRRTVTMSEGAAPAGGSGKAKKKKKN RDKKRDKNKELQASLMVAALKRLLPVGLNLFAGREQELVQHCKDRYLKKLPEYEIVDFAK TQLTLPDKIDPGDEMSWQHYLYSKLGNKKEISTEKPQQIDEVVDRIVAMAKVLFGLHMID HPQLQSKQQYRSCVSTQRKRAVIACFRQLSLHALPRHKVVNIFARTYCDLWLQEENIGQE VMIEDLTQSFEDAELKKQEKEEEEGKPDPLTQLVTTFCRGAMTERSGALQEDPLYMSYAE ITAKSCGEEEEEGGGDEEGGEEEGGASIHEQEMEKQKLLFHQARLANRGVAEMVLLHISA CKGVPSEMVQKTLNLGISVLRGGNLDIQMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLD AFERNTKAEGLGVGSEGAAGEKNMHDAEFTCTLFRFIQLTCEGHNLEWQNYLRTQAGNTT TVNVVICTVDYLLRLQESIMDFYWHYSSKELIDPAGKANFFKAIGVASQVFNTLSEVIQG PCTQNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHTSQVDLLKELLNLQKDMITMMLSML EGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLADLTSSPSFLELDPNHEGWVMPK DFKEKMEQQKSYTPEEIEFMLQCCETNHDGKLDYVGFTERFHEPSKEIGFNLAVLLTNLS EHMPNEPRLARFLETAGSVLNYFEPFLGRIEIMGSSKRIERVYFEIKESNIEQWEKPQIK ESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASGLMAVDDGSGGGGERRKTSYSY IGDEDEERKSPLKRAWQTIKDGVGAFFSMLSPANIKAKIAEMQQMTVLELVVAFFKLYFY AFYYSGYGVSLVLKYIGGIIYSLMSGPQAEEPVVEVKEEEKHHLRLMPALPPAEESPPPA PDVPKEGSQPPKAIEGRGEGTEEGGEKTDEGEKSEVVPEQQITLADILGGEAARKEAAQT AEVVAQQEAVMAAFDAESKQEKVSSEPSAVSQIDFNKYTHRAVSFLARNFYNLKYVALVL AFCINFILLFYKVTTLGEDEDDGGSGAASAAKSMEELLVELSGEAKSGEVENVSGVGSDG GGSGEEDEDPLELVHVNEDFFYMEHVMRLAALLHSLVSLAMLIAYYHLKVPLAIFKREKE IARRLEFDGLFIAEQPEDDDIKSHWDKLVISAKSFPVNYWDKFVKKKVRQKYSETYDFDS ISNLLGMEKTSFSSQEEEGSGFVHFILNIDWRYQLWKAGVTITDNAFLYSFFYFIFSILG NFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKF YVQEEEDEVDKKCHDMMTCFVFHLYKGVRAGGGIGDEIEPPDGDDYEVYRIMFDITFFFF VIVILLAIIQGLIIDAFGELRDQLESVKEDMESNCFICGIGKDYFDKVPHGFDTHVQQEH NLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRCWDFFPVGDCFRKQYEDELGGGGG NT seq 15297 nt NT seq  +upstreamnt  +downstreamnt atggctgacagcgaaggaggatccgaacaggatgacgtttccttcttgcgtacggaagac atggtttgtctatcctgtacagcaacaggggagagagtctgcttggctgctgaaggattt ggtaacaggcattgttttctggaaaatatagctgataagaatatccctccagatttatca acatgtgtatttgtgatagaacaggcactttcagtcagagctctccaagagttggtcacc gcggctggaacagaagaggctcaggattctttagggaaaggaacaggctccggtcataga actttgctgtatggtaatgctattttactgagacatcaaaacagttccatgtacctggct tgcctatcaacaagttcatcccatgataagttatcatttgatgttggtcttcaagaacat tcccaaggagaggcttgctggtggactgttcacccagcttcaaaacagagatcagaaggt gagaaagtcagagtaggtgacgatctaattttggtatcagtggcgacagaaagatacctg catacgacaaaagaaaatgaccagtcaattgtaaacgcttcatttcatgttacacattgg tcagttcaaccgtatggaacgggcattagtaaaatgaaatatgttggttatgtttttggc ggcgatgtcttaagattttttcacggaggagatgaatgtttaacaatcccttcgacatgg tcttcagaagctgggcaaaacgttgtggtttatgaaggtggtagtgttctaagccaagcc agatcgctatggaggctggaactggcaaggacaaaatgggccggagggtttatcaattgg taccatccgatgagaattcgacatctgaccactgggcgatatttgggcgttaatgaagcc aacgagttacatttagtaacacgtgatgaagcaacaactgccttatcaacttttattttg cgacaagagaaagacgatcaaaaagttgtcatggaagacaaagatctcgaagtaatcggt gcgccaattataaagtacggtgacagtactgttcttgttcaacattcagaaagtggatta tgggtcacatacaagtcattcgagacgaagaaaaaaggcgtaggaaaagtagaggaaaaa caagcagttcttcatgaagaagggaaaatggacgacggtttggacttcagcagaagtcaa gaggaagagtcaagaactgcaagagtcattaggaagtgttcatctctttttacacaattt atcaaagggctggaagagttgcaattgaaccgtagacattccctcttctgcgccaccgtg aatcttaacgaaatggtcatgtgtttagaagatttaatcaattactttgctcaacctgaa gaagacatggaacacgaagaaaagcaaaataagctaagggctcttagaaacaggcaggat ctatttcaagaggagggcatcctcaatctgatccttgaagctatcgacaaaatcaacatt ataacatcgcaagggtttttggtcaatttggctggtgacgaatctggacaaagttgggat atcatttcaggctatttgtaccagctcttagctgctatcataaagggaaatcataccaat tgtgcacaatttgccaacacaaacagactcaactggcttttcagccgacttggctctcaa gcctccagcgaaggtactggaatgttggatgtacttcactgtgtccttattgattcacca gaagctctgaacatgatgagagatgaacatataaaagttatcatttctcttcttgagaaa catggaagggatccaaaagtactcgacgtcctctgttcactttgtgtgggtaatggtgtc gccgtgaggagttcacaaaacaatatatgcgacttcttacttcctgggaagaatctcttg cttcaaacacagcttgtcgaccatgtagccagtgtccgtccaaacatatttgtcgggaga gttgaaggatcagcggtgtatcaaaaatggtattttgaagtgacacttgaccacatggaa caaatgacacacatgacaccgcatttgcgcatcggctgggcgaacactgctgggtatgtt ccttaccctggaggaggagaaaaatggggtggcaacggtgttggtgatgacttgtactca ttcggtttcgacggatttgccttatggactggtggaagaagtaccgtcgtaagtcaactt gctcaaggaccaccttacatcaaaaaaggagatgttattggctgtgctcttgatctcact gttcctattataacatttacgttcaatggccatgctattaaaggttcatttagaaatttt aatcttgaagggatgtttttcccagtaatcagttgttcatcgaaattaagttgtcgattt ctgcttggtggtgatcatgggagacttaaatatgtgcctcctgaggagttttctccatta gttgaaagtcttcagccgcagcaaattctttctattgatccatgcttttactttggcaat ctgaacaaatgtgttttgtctggcccttacaccatcgaagacgatactgcctttgttcct atcccagttgacactacaatgataacactcccaaaccatgttgaaacaattcgagatcgt ttggcagaaaacattcatgaaatgtgggctatgaacaagatcgaagctggatggattttt ggtgaaaatagagatgacatcaggaggatacatccatgccttgtacagtttgacaaactc cctgctgcagaaaaaagatacgatacccaattagctgtgcaaactttgaaaacaatagta gcattaggatatcacatcagcgtcgacaagccgccatcacgtataaaaaacatccgtctt ccaaatgagccatttatgcaaccgaacggatacaaaccagcccctcttgatttaagcgcg ataactctaactccaaaaatggaagaactggttgaccagttagctgagaacacgcacaat ctctgggccaaggaaagaatccaacaaggatggacatacggcctaaatgaagatcctgac tattgcagaagtccacatttagtgccttattccaaagtagatgaattgatcaaaaaagcc aacagagatactgccagtgaaactgtaagaactttgcttgtctatggatacaatttagat ccaccaactggagaacaaacagaagctttgttggccgaggcgagccgcttgaaacatcaa gcttttagaacatacagagcagaaaaaacttatgcagttaatagcggcaaatggtacttc gagtttgaaattctaacagctggaccgatgaaagttggttgggctacgtcggattactgt cccggatcacaacttggaagcgatgaaaactcttgggcttttgatggttacaatgaagaa aaaatttcttcaggtgtagcagaatcgtttggtcgacaatggacagtcggtgatgttgta ggagttttcctggatcttttagaccacactattagcttttcattaaatggtgaacttctt atggacacattaggaggagagacatcgttttccgacgtccagggtgaagggtttgtgcca gcttttactctcagcgttgggcagaaggcaaagctgactttcggccaggacgtgaacgca ctaaagtattttacaacatgtggacttcaagagggctatgagcctttttgtgtgaacatg aaccgtgctgtgacatattggtacaccaaggaccagccgatctttgaaaataccgacgac tatgccgatacgagaattgatgtcacacgtatccctcctgggtcggattctccaccttgc ctcaaaatcagccacaacactttcgagaccatggaaaaggccaactgggagttcttgcgt ctttccctacctgtcatatgcgagtcttctttcatcgacgaaacagaaaagatgagacgt tggcaggaaattcgaattagacaacatcgcctccttgccgaacaagagcagacgacccca gctcatattgagcaaataatgaaatctggatttagtatgagtgatatcaaaggtttacaa agaggatattctgaagatgcagttgaagctgatgaagttatcggaccgagttcttctccc atgatgaaatcaaaactcaagtcaacaccatccagaccacctaggaagggttcactttcc agacaggaagatatgactcacttgaatggaactttagaatcaggcttaggagcgatgaac agatcgacaagtgaactcgactttaatcgttacaatggggaaatctcagatggaaaggat gacaagaaaaaacgtggaagatccccgtttaggtttttctcgcgtaaaagagatgcaagt ggcgaaagagggaagaaaggtagaactcccgagccagcttctaataatctgttggaaccg ccaaggacaccacagatgcagaggggtggaagcctgataagaacacctacaaaagctctt gctgatgtcaaaccaccgtctcctatggcagaccgagggggaccaaaaacaatgtccgtc ccacaaggatcaggagtcgaatccatcggaaacgagatttatgatgctgaatgcttaaaa cttattaacgaatattactatgccgtgagaatattcccaggacaagacccaactcatgtt tatgtcggatgggtgacaacgcagtttcaccttcacagcaatgacttcagccagagcaaa gtcctgaaaagcacagtgtctgtcgaagatgactacaaccgcattatcgagagtatcgaa aggcagagctgttacatgctcagggccgatgaactttacaacgaagtcactcaagatgca tcaggaaaagtggcttctcaaggcatgaccattggatgttccatcgatacggctactggc tacatgaccttcacctgtgaaggaaaagaaacaaaacacaagtacaagatggaaccagac accaaactattcccagcaatttttgttgaagcgacaagcaaagaaatccttcagatcgag cttggaaggacacccacaactttgcccctttcggcagctgtacttcgcaattccgaacgg catgtgattccacagtttcccccaaggatgaaagtacagtgtctgattccacatcaatgg gcgagagtgccgaacatttctctgcaggtccacgctctcaaactgtccgatatcaggggt tggagtatgctctgtgaagacccaatttcaatgctcgcgcttcacatccccgaagaggat aggtgcattgatattctcgagctgatcgaaatggaaaaacttttgtcattccatgcccac actttgacactttatgcggctttgtgttaccaatcgaattacagagcagcacatgcactt tgccaacatgtagatcagaaacagctccagtatgccatcagatctgaatacatgtctgga ccactgagattgggcttttatgacctgttgattgccctccatatcgaatctcatgcaaca acaatggaaatttgtaaaaatgagtttattattccacttgggcctgagttgaaggagctt tacgaagacccagaaatggggcacagcttgagatccttgcaaatggtgtcagttcttccc cagatgaaaatgacggatataaatgaacccattgagagcattaatacgctgtacagccct tatttccctcttgatgctgtcagggattatgttatgttggctgtgcaagaagcggtcgag ataaaccaacttcacatcagagatcctgttggaggctcaaatgaaaatcttttcttacca cttttgaagctggctgacaggctgcttttagtaggaatgctcagggatgaagatgtgata aaacttctgataatgttcgatcctgaaacctgggatccaaattttgaaaaagatggaaag gatgaacacagaaagggtcttcttcaaatgaaaatggccgaaggggctaaacttcagatg tgctatttgttacaacacttgtgcgacattcagttgagacatcgggttgaagacattatt aatttcagccatgattacgtcgcagacattcaaactgatcagttgagaagatacattgaa atcaaacagacagatctaccagcgtcagtagcggcgaaaaagacaagagagttccgttgt cctcctagggaacagatgaatgcaattatttgtttcaaaaacctggacgaagatgacagc gaaagttgcccatgtggtcccgaattaagggaaagattgaattctttccattctgggctt atgcagaaagtatcattggttgctttacaagaacctgaagaggaaggtccaactgaagaa gagaaaccgaacatgtttcgaaaattgtacaatttcattaacgccgtgaaagagctcgat gttccaccaaagatcattgaagagcctgaaaagaaaactcccgaagagatatttcgcaaa gtacttataagcacaatcgtcagatgggctgaagaatcacagattgaaacaccaaaattg gttagggaaatgttcagtctactagtcaggcagtacgatagtgtgggagaacttcaaaga tcattgggaaagacctacgttattaactataagaccaaagatgatgttgctttgatgtgg attggcctgagtcagataagggcacttctacctgtgcagatgtctcaagaggaagaaggc ttgatgagaatgcgtttatggaagcttgtgaacaaccatactttcttccaacaccctgat ctaattcgagttcttagggtgcacgagaacgttatggctgtaatgatcaatacactgggc aggagatcacaagctcaatcggatgcacctcaaggcggacaagaaggcgagcctgtggct aaagagaaggatacttctcatgaaatggttgtggcgtgttgtcgtttcctttgttatttc tgcagaacgtcaaggcagaaccaaaaggctatgtttgaccatttgactttcctccttgaa aacagtaatatcctgctctcgagaccttctctcagaggtagtacaccactcgacgttgct tattcctctcttatggaaaacacagaactcgctcttgcactcagagaacattatttagag aaaatagctatttatctgagtcgttgcggtctccaatcgaattcagagttggttgaaaaa ggatatcccgatcttggttgggatcctgttgagggtgaaaggtatctggatttcttacgc ttctgtgtctgggtcaatggtgaaagtgtggaagaaaacgcaaacttggtgatcagactt ctaatcaggcggcctgaatgtcttggaccggctttgaggggtgaaggtgagggtctgctg agagcgattattgatgctaacaagatgtcagaaagaatagcagacagaagaaaagtaatg gatgaagctgaaggaaccacattaggcttgcagttcgaacatcctttgcccgaatctgac gatgatgaagactacatcgacactggagctgcgattttagccttttactgtacgcttgtt gacctactcggaagatgtgcacctgatgtttccgtcattgcacagggaaagaatgagtct ttgagagccagggcaattctgagatcactggttccgcttgaagatttatcaggagttctc agtctgaagtttactttgaccaacccggctgccggagaagagaggccaaagagcgacatc ccgtctggcttgattccgtctcacaagcagagcgtagtactttttctagaaagggtttac ggcattgaacatcaagacctgttcttcagaattctcgaggatgcatttttgccagatctt cgtgcagcgactatgctcgacaggagtgacggccaagaatctgaaatggctcttgctatg aatcgttacattggaaattcgattcttccgttgcttataaaacactcgcagttttacggc aatgctgacaattatgcaagtcttttggatgcaacactgcacactgtctacaggctttca aaaaatcgaatgttgaccaaaggtcaaagagaagcagtttcagattttcttgtagctctt acaagccagttgcagccaagtatgttgcttaaattgcttcgaaagttgactattgatgta tctcagctttcagagtacactacagtcgctttgaggttgttgactcttcactatgatcgt tgtgccaagtattacggatcttctggaggatcaaccaactcaagcgatgaggaaaagagg ctgacgatgattctcttcagcaatatattcgattcattatcaaagatggattatgatcct gaactgtttggaaaagctctgccctgcctttctgcaattggatgtgctctcccacctgat tattctttatctaagaactatgatgatgaactgtacggcactaagaatatgggacctgtt gatggaccgtacaatccacaacctattaacacatcatcagtatcacttgataatgatatg aactcaattgttcagaaattttctgaacactatcatgacgcgtgggctagcagaaaaatg gaaaatggatgggtgcacggtgatcaatggtctgacagttcaaaaacgcatcctcgtctg aaaccatacaatatgttgaatgattacgaaaaagaaaggtacaaagaacccgtaagggaa tctcttaaagcactattggccattggatggaccatagaacacactgaagtcgacatcccg tcaaacaacagaggaagctcagtgagaagacagtcgaaaggtgccatggatagcggctct cctttcaactatcatccaaatcctatcgacatgacaaatcttacactcagcagggaaatg caaaacatggctgaacgtcttgcagaaaactcacatgacatttgggcaaaaaagaaaaaa gaagaactcactacttgcggaggagcgattcatcctcaattagtcccatatgatctcctt actgacaaagaaaagaaaaaagacagggagaggtcacaagaattcctcaagtatttgcag taccaaggcttcaagctgcataaaccaaaccgaggtggtggtgacattgatcaacaaatt gcagcagcagccacaggcgagtccaggtttgcctacagtcttctggaaaagctcatccag tatacggacaaagcttcgatcaacatgaaattactcaagccgtccacgactttcagtagg cggtcaagtttcaaaacgtgtacaagagacatcaaatttttcttcaaggtggtgctactt cttgttgagaaatatttcagcacacacagaagttatttcattgcaattgctactgccaca aacaatattggagcagcgtcgttgaaagagaaggaaatggtcgcgagtcttttctgtaaa ttggcaaatttgttaagaacgaggttgtccgcttttggcccagatgttaggataactgtt aggtgccttcaagttttagtgaaagccatagatgcaaagtccttggttaaaaactgtccc gaatttataagaacttcaatgctcacatttttcaataacaccgccgatgacttaggccag actatccagtgcttaacagatggaaggtacagccatctaagagggacacatctcaagacg tcaacttccttgttttacataaatgatgttgtgttgcctgtcttgacatcaatgtttgac caccttgccgcttgtgactatggaattgatttgctgcttgatgaaattcaagtagcatct tataaaatgctcggaagcctttacacactcggcatagacccaacactcacgcatgatagg aagtatttgaagacagaaattgaaaggcatagacctgcaatcggaagttgtctgggtgct ttttcatctactttccctgtcgcttacctcgagcctcacctcaacaaacacaaccagtac tcgttggtcaatagaatcgcagatcattccttagaagctcaagatgtactaaaccgtatg gaacagacgatgccgaccctggacacgattcttgctgaagttgaccagtttgtcgaatct gataagagtcacagcgcagcacctcatgtcatcgatgttatccttccacttctctgtgcc taccttccggtctggtgggtccaagggccagataatgtatcccttacagctggaaattat gttacaatggtaacaagtgaacacatgaataagttgcttaaaaatgtgctgaagttgatc aaaagcaacattggcaatgaaaatgccccatggatgacaagaattgcagcctttactcag caaattatcataaattcttctgaggaacttctcaaggaccctttcctacctctgacgctc actgtcaaaaagcgtatcgatagcatgtgccacaaggaagaatcgctgagaggattttta aagtccagcgcagaagacacgtctcaagttgaagctgaaattcaagaagaatggaacctc attgttagagacatctattcgttttatcctctcctgatcaagtacgtcgatctgcagaga aatcactggctccggaacaacatacccgaggctgatgagttgtacaatcacatcgcggat atattcaacatctggtcaaaatcgcagtatttcttgaaggaagaaaacaatttcatttct gccaacgagatagataatatggcattaatcatgcctactgcgacaagaaggacagttaca atgtctgaaggtgcagcaccggctggtggaagtggaaaagccaagaagaaaaagaagaac cgggataagaaaagagacaagaacaaggaacttcaggccagtttaatggttgcagcttta aaacggttattacctgttggtttgaatctatttgccggaagagaacaagaacttgttcag cattgtaaagacagatatcttaaaaaattacccgagtatgaaatagttgattttgcgaaa acccagctcacacttcctgacaaaattgatccaggcgacgagatgtcttggcaacattac ttatattccaagcttggcaataaaaaagaaattagcacagaaaagcctcaacaaattgat gaagtcgtcgatagaattgtggccatggcaaaagttcttttcggcctgcacatgattgac catccacaactgcaaagtaagcaacagtatcgatcatgtgtctcgacacaaagaaagaga gccgttattgcttgtttccgtcaactatctcttcatgctcttccaaggcataaagtggtg aacatttttgcaagaacgtactgcgatctttggctccaagaagaaaatattggacaagaa gttatgattgaagatttgactcaatcgtttgaagacgcggagttgaagaagcaggaaaaa gaagaagaagaaggcaagccagacccattgacgcaacttgtaacaactttctgcagaggt gccatgacagaaagaagtggagcgcttcaagaagacccactgtacatgtcatacgctgaa atcactgcaaaatcttgtggtgaagaagaggaagaaggaggtggcgatgaagaaggcgga gaagaagaaggaggcgcttctattcatgaacaagaaatggaaaagcagaaattgctattt caccaagcaaggctggcgaacagaggagtcgccgagatggttcttctccacatttcagcc tgcaaaggagtaccaagtgaaatggtgcagaaaacgttgaatctaggaatttcagtgctt agaggaggcaaccttgatatacaaatgggcatgttgaatcatttgaaggagaaaaaagat gtaggatttttcacatccattgccggattaatgaactcatgcagtgtcttggatctagat gcttttgaaagaaacaccaaagctgagggtcttggagtcggatcagaaggtgctgcaggt gagaaaaatatgcacgatgctgaattcacctgcacccttttccggttcatccaactcacc tgtgaaggccataatcttgaatggcaaaattatctcaggacacaagcaggaaatacgacg acagtcaatgttgttatttgcacagtagattatcttcttcgcctccaggaatcaatcatg gatttctattggcactactcgagcaaagagctcattgatcctgccggaaaagcaaacttc ttcaaagctatcggtgtggcaagtcaagtgttcaacacactgtctgaagtcatccagggg ccttgtacccaaaatcagcaggcgctggcacattccaggctgtgggatgctgttggtggt ttcctcttcctcttttcgcacatgcaggacaaactctcaaagcacactagtcaggtcgac cttcttaaagagttgctcaaccttcagaaggacatgatcaccatgatgctgtccatgctt gaaggaaatgtcgtcaatggaacgattggaaaacagatggttgacaccttggttgaatcc gcatccaatgttgagttgattttgaaatactttgacatgttccttaaactggctgacctc acaagttctcccagttttctggaattggatccaaatcatgaaggttgggttatgcctaaa gacttcaaagaaaaaatggaacaacagaagagctacactccggaagagatcgaatttatg cttcagtgctgtgagacaaatcatgatggcaaactcgactatgtcggattcacagaaaga ttccatgagccgtcaaaagaaattggttttaatcttgcagtgcttcttacaaatttatct gaacacatgccaaatgagcctagattggcccggtttttggagacagctggtagtgtactg aactactttgagccattcctcggtcgcattgaaatcatgggtagcagcaaacgtattgag agggtatattttgagatcaaagaatccaacatcgagcagtgggagaagccgcagatcaaa gaatcaaagagagcgtttttctattcaattgtcactgagggaggagacaaagagaagcta gaggcattcgttaacttttgtgaagatgccatttttgaaatgactcatgccagtggcttg atggctgttgatgatggctctggtggaggaggagaacgacggaaaacatcttattcttat atcggtgatgaagatgaagaaagaaaatctcctctgaagcgagcttggcagacgattaaa gacggtgtaggtgcattcttttcaatgctgtcgcctgcaaatatcaaggcaaaaattgca gaaatgcaacagatgactgtgttggaacttgttgtcgcctttttcaagttgtacttttac gctttctactattctggttatggcgtgtcattagttctcaagtatatcggtggtatcatt tattcgcttatgtctggcccgcaagcagaagaacctgtagttgaggtgaaagaggaagaa aaacatcacttgcggctcatgccagcactacctcctgcagaagaaagtcctccaccagcg ccagacgttcccaaagaagggagtcaaccgccaaaagcaattgaagggagaggagaaggc acagaagaaggtggcgagaagacagatgaaggagaaaaatcggaagtggtccctgagcaa caaattactcttgctgatatcttgggtggtgaggcagctcggaaagaagcggctcaaacg gcagaagtcgttgcccaacaagaagcagttatggctgcatttgatgccgaatcgaaacaa gaaaaagttagcagtgaaccttctgcagtatcacagattgatttcaacaaatatactcac agggctgtcagctttcttgctcgcaacttttacaatttgaaatacgttgctcttgttttg gccttctgcatcaatttcattttacttttctacaaggtgacaacgttaggagaggatgaa gatgatggtggaagtggagctgcttctgcggccaaatcaatggaggaacttttagtcgaa ttaagcggagaggcgaaaagcggtgaagtggaaaatgtcagtggagtaggaagtgatggg ggtggtagcggcgaagaagacgaagacccacttgagcttgttcatgtcaacgaagatttc ttttacatggagcatgtcatgaggctagctgctcttctccactctttggtatcactcgct atgctaatagcttactatcatctcaaagtacctttggccatatttaaaagggaaaaggaa atcgcgagaaggctggaatttgatggccttttcattgccgaacagccagaagacgacgat ataaaatcacattgggataaactcgtcatttctgctaaatcatttcctgtaaactactgg gataaatttgtaaagaagaaggtcagacagaagtacagcgaaacttatgattttgattca ataagcaatcttctcggaatggaaaaaacatcattcagctcacaagaagaagaaggatca ggatttgtacacttcattttgaatattgactggagatatcaattatggaaagcaggagtc acgatcactgataatgccttcctgtacagttttttctacttcattttctcaatccttggc aacttcaataactttttctttgctgctcacttgctcgatgttgctgttggatttaagaca ctgcgtacgatcttgcagtctgtaacgcacaatggaaaacagcttgtcctcacagtcatg ttgttgacgattatcgtatatatctatactgtgatagctttcaacttcttcagaaaattc tatgtccaagaagaggaggacgaagtagacaaaaaatgtcacgatatgatgacttgtttt gtcttccatttatacaaaggtgtaagagccggtggtggtattggtgatgaaattgagccc cctgatggcgatgattatgaagtttatagaatcatgttcgacatcacattcttcttcttc gttattgtcattcttttggctattattcagggtttgatcattgatgcttttggagagcta agagatcaactggagagtgttaaagaagacatggaatccaactgcttcatatgcggcata ggaaaggattattttgataaagtaccacacggttttgacactcacgtccagcaggagcat aatttggcaaattacatgttctttcttatgcatctaatcaacaaaccggatactgaatat acaggccaagagacatacgtttggaacatgtatcaacagagatgttgggacttcttccca gtcggagactgtttcaggaagcaatatgaagatgaattgggtggcggtggtggataa

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