KEGG   Canis lupus dingo (dingo): 112645463
Entry
112645463         CDS       T08371                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
clud  Canis lupus dingo (dingo)
Pathway
clud01521  EGFR tyrosine kinase inhibitor resistance
clud01522  Endocrine resistance
clud01524  Platinum drug resistance
clud04010  MAPK signaling pathway
clud04012  ErbB signaling pathway
clud04014  Ras signaling pathway
clud04015  Rap1 signaling pathway
clud04022  cGMP-PKG signaling pathway
clud04024  cAMP signaling pathway
clud04062  Chemokine signaling pathway
clud04066  HIF-1 signaling pathway
clud04068  FoxO signaling pathway
clud04071  Sphingolipid signaling pathway
clud04072  Phospholipase D signaling pathway
clud04140  Autophagy - animal
clud04150  mTOR signaling pathway
clud04151  PI3K-Akt signaling pathway
clud04152  AMPK signaling pathway
clud04210  Apoptosis
clud04211  Longevity regulating pathway
clud04213  Longevity regulating pathway - multiple species
clud04218  Cellular senescence
clud04261  Adrenergic signaling in cardiomyocytes
clud04370  VEGF signaling pathway
clud04371  Apelin signaling pathway
clud04380  Osteoclast differentiation
clud04510  Focal adhesion
clud04517  IgSF CAM signaling
clud04518  Integrin signaling
clud04550  Signaling pathways regulating pluripotency of stem cells
clud04611  Platelet activation
clud04613  Neutrophil extracellular trap formation
clud04620  Toll-like receptor signaling pathway
clud04625  C-type lectin receptor signaling pathway
clud04630  JAK-STAT signaling pathway
clud04660  T cell receptor signaling pathway
clud04662  B cell receptor signaling pathway
clud04664  Fc epsilon RI signaling pathway
clud04666  Fc gamma R-mediated phagocytosis
clud04668  TNF signaling pathway
clud04722  Neurotrophin signaling pathway
clud04725  Cholinergic synapse
clud04728  Dopaminergic synapse
clud04810  Regulation of actin cytoskeleton
clud04910  Insulin signaling pathway
clud04914  Progesterone-mediated oocyte maturation
clud04915  Estrogen signaling pathway
clud04917  Prolactin signaling pathway
clud04919  Thyroid hormone signaling pathway
clud04920  Adipocytokine signaling pathway
clud04922  Glucagon signaling pathway
clud04923  Regulation of lipolysis in adipocytes
clud04926  Relaxin signaling pathway
clud04929  GnRH secretion
clud04931  Insulin resistance
clud04932  Non-alcoholic fatty liver disease
clud04933  AGE-RAGE signaling pathway in diabetic complications
clud04935  Growth hormone synthesis, secretion and action
clud04936  Alcoholic liver disease
clud04973  Carbohydrate digestion and absorption
clud05010  Alzheimer disease
clud05017  Spinocerebellar ataxia
clud05132  Salmonella infection
clud05135  Yersinia infection
clud05142  Chagas disease
clud05145  Toxoplasmosis
clud05152  Tuberculosis
clud05160  Hepatitis C
clud05161  Hepatitis B
clud05162  Measles
clud05163  Human cytomegalovirus infection
clud05164  Influenza A
clud05165  Human papillomavirus infection
clud05166  Human T-cell leukemia virus 1 infection
clud05167  Kaposi sarcoma-associated herpesvirus infection
clud05168  Herpes simplex virus 1 infection
clud05169  Epstein-Barr virus infection
clud05170  Human immunodeficiency virus 1 infection
clud05200  Pathways in cancer
clud05205  Proteoglycans in cancer
clud05207  Chemical carcinogenesis - receptor activation
clud05208  Chemical carcinogenesis - reactive oxygen species
clud05210  Colorectal cancer
clud05211  Renal cell carcinoma
clud05212  Pancreatic cancer
clud05213  Endometrial cancer
clud05214  Glioma
clud05215  Prostate cancer
clud05218  Melanoma
clud05220  Chronic myeloid leukemia
clud05221  Acute myeloid leukemia
clud05222  Small cell lung cancer
clud05223  Non-small cell lung cancer
clud05224  Breast cancer
clud05225  Hepatocellular carcinoma
clud05226  Gastric cancer
clud05230  Central carbon metabolism in cancer
clud05231  Choline metabolism in cancer
clud05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
clud05415  Diabetic cardiomyopathy
clud05417  Lipid and atherosclerosis
clud05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:clud00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112645463 (AKT2)
   04012 ErbB signaling pathway
    112645463 (AKT2)
   04014 Ras signaling pathway
    112645463 (AKT2)
   04015 Rap1 signaling pathway
    112645463 (AKT2)
   04370 VEGF signaling pathway
    112645463 (AKT2)
   04371 Apelin signaling pathway
    112645463 (AKT2)
   04630 JAK-STAT signaling pathway
    112645463 (AKT2)
   04668 TNF signaling pathway
    112645463 (AKT2)
   04066 HIF-1 signaling pathway
    112645463 (AKT2)
   04068 FoxO signaling pathway
    112645463 (AKT2)
   04072 Phospholipase D signaling pathway
    112645463 (AKT2)
   04071 Sphingolipid signaling pathway
    112645463 (AKT2)
   04024 cAMP signaling pathway
    112645463 (AKT2)
   04022 cGMP-PKG signaling pathway
    112645463 (AKT2)
   04151 PI3K-Akt signaling pathway
    112645463 (AKT2)
   04152 AMPK signaling pathway
    112645463 (AKT2)
   04150 mTOR signaling pathway
    112645463 (AKT2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    112645463 (AKT2)
   04518 Integrin signaling
    112645463 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112645463 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    112645463 (AKT2)
   04218 Cellular senescence
    112645463 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112645463 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    112645463 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112645463 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112645463 (AKT2)
   04613 Neutrophil extracellular trap formation
    112645463 (AKT2)
   04620 Toll-like receptor signaling pathway
    112645463 (AKT2)
   04625 C-type lectin receptor signaling pathway
    112645463 (AKT2)
   04660 T cell receptor signaling pathway
    112645463 (AKT2)
   04662 B cell receptor signaling pathway
    112645463 (AKT2)
   04664 Fc epsilon RI signaling pathway
    112645463 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    112645463 (AKT2)
   04062 Chemokine signaling pathway
    112645463 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112645463 (AKT2)
   04922 Glucagon signaling pathway
    112645463 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    112645463 (AKT2)
   04920 Adipocytokine signaling pathway
    112645463 (AKT2)
   04929 GnRH secretion
    112645463 (AKT2)
   04915 Estrogen signaling pathway
    112645463 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    112645463 (AKT2)
   04917 Prolactin signaling pathway
    112645463 (AKT2)
   04926 Relaxin signaling pathway
    112645463 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    112645463 (AKT2)
   04919 Thyroid hormone signaling pathway
    112645463 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112645463 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    112645463 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    112645463 (AKT2)
   04728 Dopaminergic synapse
    112645463 (AKT2)
   04722 Neurotrophin signaling pathway
    112645463 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112645463 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    112645463 (AKT2)
   04213 Longevity regulating pathway - multiple species
    112645463 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112645463 (AKT2)
   05205 Proteoglycans in cancer
    112645463 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    112645463 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    112645463 (AKT2)
   05230 Central carbon metabolism in cancer
    112645463 (AKT2)
   05231 Choline metabolism in cancer
    112645463 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112645463 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112645463 (AKT2)
   05212 Pancreatic cancer
    112645463 (AKT2)
   05225 Hepatocellular carcinoma
    112645463 (AKT2)
   05226 Gastric cancer
    112645463 (AKT2)
   05214 Glioma
    112645463 (AKT2)
   05221 Acute myeloid leukemia
    112645463 (AKT2)
   05220 Chronic myeloid leukemia
    112645463 (AKT2)
   05218 Melanoma
    112645463 (AKT2)
   05211 Renal cell carcinoma
    112645463 (AKT2)
   05215 Prostate cancer
    112645463 (AKT2)
   05213 Endometrial cancer
    112645463 (AKT2)
   05224 Breast cancer
    112645463 (AKT2)
   05222 Small cell lung cancer
    112645463 (AKT2)
   05223 Non-small cell lung cancer
    112645463 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112645463 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    112645463 (AKT2)
   05161 Hepatitis B
    112645463 (AKT2)
   05160 Hepatitis C
    112645463 (AKT2)
   05164 Influenza A
    112645463 (AKT2)
   05162 Measles
    112645463 (AKT2)
   05168 Herpes simplex virus 1 infection
    112645463 (AKT2)
   05163 Human cytomegalovirus infection
    112645463 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112645463 (AKT2)
   05169 Epstein-Barr virus infection
    112645463 (AKT2)
   05165 Human papillomavirus infection
    112645463 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112645463 (AKT2)
   05135 Yersinia infection
    112645463 (AKT2)
   05152 Tuberculosis
    112645463 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    112645463 (AKT2)
   05142 Chagas disease
    112645463 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112645463 (AKT2)
   05017 Spinocerebellar ataxia
    112645463 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112645463 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    112645463 (AKT2)
   05415 Diabetic cardiomyopathy
    112645463 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    112645463 (AKT2)
   04932 Non-alcoholic fatty liver disease
    112645463 (AKT2)
   04931 Insulin resistance
    112645463 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112645463 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112645463 (AKT2)
   01524 Platinum drug resistance
    112645463 (AKT2)
   01522 Endocrine resistance
    112645463 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:clud01001]
    112645463 (AKT2)
Enzymes [BR:clud01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     112645463 (AKT2)
Protein kinases [BR:clud01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   112645463 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Kinase-like PH_20 Seadorna_VP7
Other DBs
NCBI-GeneID: 112645463
NCBI-ProteinID: XP_048951127
Ensembl: ENSCAFG00020015563
LinkDB
Position
1:113473323..113523829
AA seq 557 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPDAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDERREWMRAIQMVANSLKQRGPGEDPM
DYKCGSPSDPSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKASGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQSFCHPSSLRSPLRLTPGTLTTSSLPSPSQ
SRPRTAMTAWAPSNWTSGPTSPSSPTRPASASEQCRPPPLMPSPQKTRTAAITAPGAFLC
VFKLLFCLFCLHPYPSPAHPHFQFFLQPSAKLTPAVPAALPPGSCPVLTFVPRPGFRRLS
TAHPRTRPLGGWRDSGF
NT seq 1674 nt   +upstreamnt  +downstreamnt
atgaacgaggtgtctgtcatcaaagaaggctggctccataagcgtggtgaatacatcaag
acctggaggccccggtacttcctgttgaagagtgacggctcctttattggatacaaggag
cggcctgacgcccctgaccagaccctgccccccctgaacaacttctctgtcgcagaatgc
cagctgatgaagactgagaggccacggcccaacacctttgtcatacgctgcctgcagtgg
accactgtcatcgagaggaccttccacgtagactctccagatgagaggcgagagtggatg
cgggctattcagatggtcgccaacagcctcaagcagcggggcccgggtgaggaccccatg
gactataagtgtggctctcccagtgacccttctgcggctgaggagatggaagtggcagtt
agcaaggctcgggccaaggtgaccatgaatgacttcgactatctcaaacttctgggcaag
ggcacctttggcaaagtgattctggtgcgggaaaaggccagtggccgctactacgccatg
aagatcctgcggaaggaagttatcattgccaaggatgaagtcgcccacacggtcaccgag
agccgcgtcctccagaacaccaggcacccattcctcaccgccctgaagtacgccttccag
acccatgaccgcttgtgcttcgtgatggagtatgccaatggtggtgagctgtttttccac
ctgtcccgggagcgtgtcttcacggaggagcgggctcgcttttatggcgcagagatcgtc
tctgccctcgagtatttgcattcgagggacgtggtataccgtgacatcaagctggaaaac
ctcatgctggacaaagatggccatatcaagatcactgacttcggcctgtgcaaagagggc
atcagtgatggggccaccatgaaaaccttctgtgggacgcctgagtacctggcacccgag
gtgctggaagacaacgactacggccgcgcggtggactggtgggggctgggcgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaggagatccgcttcccgcgcacactcagccccgaggccaagtccctg
cttgccgggctgcttaagaaggaccccaagcagagcttctgccacccttcaagcctcagg
tcacctctgaggttgacaccaggtactttgacgacgagttcactgcccagtccatcacaa
tcacgcccccggaccgctatgacagcctgggctccctcgaactggaccagcggacccact
tcccccagttctcctactcggccagcatccgcgagtgagcagtgccgcccaccgccactg
atgccgtcgccgcagaaaacacgcacggctgccatcaccgccccgggggcttttctctgt
gtttttaaacttttattttgccttttttgtttgcatccctatccctcacctgctcacccc
catttccagttttttcttcagccctctgccaaactcaccccagcggtcccagcggccctg
cctccaggatcctgtcctgtcctcacctttgtgcccagaccaggatttaggagactctct
accgcccaccccaggaccaggcctttgggcggttggagagattccggtttttaa

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