Canis lupus dingo (dingo): 112653516
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Entry
112653516 CDS
T08371
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
clud
Canis lupus dingo (dingo)
Pathway
clud00230
Purine metabolism
clud01100
Metabolic pathways
clud04927
Cortisol synthesis and secretion
clud04934
Cushing syndrome
clud05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
clud00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
112653516 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
112653516 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
112653516 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
112653516 (PDE8A)
Enzymes [BR:
clud01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
112653516 (PDE8A)
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Gene cluster
GFIT
Motif
Pfam:
PDEase_I
PDE8A_N
PAS
PAS_9
PDE8
PAS_4
PAS_3
PAS_8
DUF5894
Sina_ZnF
Response_reg
Motif
Other DBs
NCBI-GeneID:
112653516
NCBI-ProteinID:
XP_025293508
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Position
3:54263784..54421057
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AA seq
838 aa
AA seq
DB search
MGCAPSIHISEGRAVYHGGKEAEDAPAAAAPPPPPPPPAGPKTTASPRARGAGLAEPEPR
DGSGGKVAVTDVQFGPMRFHPDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAV
LACFLDKHHDIVIIDHRNPRQLDAEALCRSIRSSELSENTIIIGVVRRTDREESSVMPLI
AAGFTRRYVENPSLMACYNELLQLEFGEVRSQLKLRACNSIFTALEKSQEAIEITSEDRV
IQYANPAFETTMGYQSGELIGKELAEVPINEKKADLLDTINSCIRIGKEWQGIYHAKKKN
GDNVQQNVKIIPVIGQGGKIRHYVSIIRVCNGSNKAEKITECVQSDTHTDNQSGKHKDRR
KSSLDVRTLASRTSEVGSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALD
RVLEILRSTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNLQQVPSSII
TPISLHDVPPRIARAMENEEYWDFNIFELEAATNKRPLIYLGLKIFARFGICEFLNCSET
TLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLCKERIKISCLQQTLDPVDEVAALI
AATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTRDDKCNIFKNMER
NDYRTLRQGIIDMVLATEMTRHFEHVNKFVNSINKPLAALEVNGEVNRDEEAINTMLRSP
ENRTLIKRMLIKCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKRQDLPVVMPVFDRNT
CSIPKSQISFIDYFITDMFDAWDAFVDLPELMQHLDNNFKYWKGLDEMKLRSLRPPPE
NT seq
2517 nt
NT seq
+upstream
nt +downstream
nt
atgggctgcgccccgagcatccacatttccgagggccgggcggtgtaccacggcggcaag
gaggccgaggacgcgcccgccgccgccgcgccgccgccgccgccgccgccgcccgccggc
ccgaagaccaccgcctcgccccgggcccgcggcgccggcctcgcggagcccgagcctcgc
gacggcagcggcgggaaggtagcagtaactgatgtgcagtttggccccatgagatttcat
ccagatcaactccaggtacttttagtgtttaccaaagaagataaccagtgtaatggattc
tgcagggcatgcgaaaaagcagggtttaagtgcacagttaccaaggaggctcaggctgtc
cttgcctgtttcctggacaaacatcacgacattgtcatcattgaccacagaaacccccgg
cagctggacgcagaggcgctgtgcaggtctatcagatcctcagaactctctgaaaacaca
attattattggtgtagtacggaggacggatagagaagagtcctctgtgatgcccctcatt
gctgctggctttacaaggaggtatgtggaaaaccccagcctcatggcctgttacaatgaa
ctgctccagctggagttcggagaggtgcggtcccagctgaaactcagggcttgtaactca
atattcacggcattagagaaaagtcaagaagcaattgaaattacaagtgaagaccgcgtt
atacagtatgcaaatcctgcatttgaaacaaccatgggctatcagtcaggtgaattaata
ggaaaggagttagcagaagtgcctataaatgaaaaaaaggctgatttgctcgatactata
aattcatgcatcaggataggcaaggagtggcaaggaatctaccatgccaaaaagaaaaat
ggagataatgtgcaacaaaatgtgaagataatacctgtcattggacagggaggaaaaatt
agacactatgtgtccattatcagagtgtgcaatggcagtaataaggctgagaaaataact
gaatgtgttcagtctgacactcatacagataatcagtcaggcaaacataaagacagaagg
aaaagctcgctagatgtcagaactcttgcttctcgaacaagtgaagttggcagtcagaga
cgacactcctccatggcccggatacattccatgacgattgaggcgcccatcaccaaggta
atcaacattatcaacgctgcccaggagagcagccccatgcctgtgacggaagccttagac
cgtgtgctggaaatcctgagaagcactgaattatattcaccacagtttggtgctaaggat
gatgatcctcatgccaatgaccttgttgggggcttaatgtctgatggtttgcgaagactc
tctgggaatgagtatgttctttcgacaaaaaatcttcagcaggtgcccagcagtataatc
acccccatctcccttcacgatgtccccccacggatagctcgggccatggaaaacgaggag
tactgggacttcaatatttttgaactggaggctgccacaaataaaaggcctttgatttat
cttggtctcaaaatatttgctcgcttcggaatctgtgaattcttgaactgctccgagaca
acactgagatcgtggttacagattattgaagccaattaccactcttctaacccctaccac
aactccacacactctgctgacgtgcttcacgccactgcctactttctctgcaaagagagg
ataaagatctcttgtttgcagcaaactttagatccagttgatgaggtcgctgccctcatc
gcagccaccatccacgacgtggaccaccctgggagaaccaactccttcctgtgcaatgct
ggaagcgagctggccattttgtataatgacactgctgtgctggagagccaccacgcggct
ctggccttccagctgaccacccgggatgacaaatgcaatatcttcaaaaacatggagagg
aatgactatcggacgctgcgccagggtatcatcgacatggtcttagccacagaaatgaca
aggcacttcgagcatgtcaacaaatttgtcaacagcatcaacaagcctctggcagccctc
gaagtaaatggggaagtgaatagagatgaagaagccataaacactatgcttagaagtcca
gagaaccggactctgattaaacggatgctgattaaatgtgcggatgtgtccaatccctgc
cgacccctagagcagtgcattgagtgggccgcacgcatctcagaagaatatttttctcag
actgatgaggagaagcggcaggacttacctgtggtgatgccagtttttgacagaaacacc
tgcagcatccccaaatcccagatctcctttatcgactacttcatcaccgacatgttcgat
gcttgggacgcctttgtagacctgcctgagttaatgcagcatcttgacaacaactttaaa
tactggaaaggactggacgagatgaagctgcggagcctccgaccgccccccgaatag
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