Canis lupus dingo (dingo): 112655075 Help Entry 112655075         CDS       T08371                                  Symbol TOP2A Name (RefSeq) DNA topoisomerase 2-alpha   KO K03164   DNA topoisomerase II [EC:5.6.2.2] Organism clud  Canis lupus dingo (dingo) Pathway clud01524   Platinum drug resistance Brite KEGG Orthology (KO) [BR:clud00001]  09160 Human Diseases   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     112655075 (TOP2A)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:clud03032]     112655075 (TOP2A)    03036 Chromosome and associated proteins [BR:clud03036]     112655075 (TOP2A) Enzymes [BR:clud01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.2  DNA topoisomerase (ATP-hydrolysing)      112655075 (TOP2A) DNA replication proteins [BR:clud03032]  Eukaryotic type   DNA Topoisomerases    112655075 (TOP2A) Chromosome and associated proteins [BR:clud03036]  Eukaryotic type   Chromosome condensation proteins    Other regulators of chromosome condensation     112655075 (TOP2A)   Centrosome formation proteins    Centriole proteins     112655075 (TOP2A) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim Microp_apicomplexa_20 Motif Other DBs NCBI-GeneID:  112655075 NCBI-ProteinID:  XP_025295711 Ensembl:  ENSCAFG00020018681 LinkDB All DBs Position 9:23373389..23403393 Genome browser AA seq 1532 aa AA seqDB search MEVSPLQPVNENMQISKTKKNEDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQ MWVYDEDIGMNYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE TASREYKKMFKQTWMDNMGRAGEMELRPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKVDETGNPLKIIHEQVNPRWEVC LTMSEKGFQQISFVNSIATSKGGRHVDYIADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM WIFVNALIENPTFDSQTKENMTLQVKSFGSTCQLSEKFIKAATGCGIVESILNWVKFKAQ IQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSNECTLILTEGDSAKTLAVSGLGVVGRDK YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYDDEDSLKTLRYGKIMIMT DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS STPNHKKWKVKYYKGLGTSTSKEAKEYFANMKRHRIQFKYSGPEDDAAISLAFSKKQIDD RKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDQTLKFLYDDNQRVEPEW YIPIIPMVLINGAEGIGTGWSCKIPNFDIREVVNNIRRLMDGEEPLPMLPSYKNFRGTIE ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR GYDSDPVKAWKEAQQKVPDEEENEESDNENEAEKSDSVRDSGPTFNYLLDMPLWYLTKEK KDELCKLRNEKEQELETLKRKSPTDLWKEDLATFVEELEAVETKEKQEEQIGLPGKGGKG KGKKTQMAEVLPSPCGKRVIPRVTIEMKAEAEKKNKKKIKNENTEGSPQEESIEIEGLKQ RLEKKQKREPGTKTKKQTTLPFKPIKKGKKRNPWSDSESDMSSNESNFDVPPREVEPRRA ATKTKFTVDLDLDDSFSDFEERIQDEDSVPSDVSPHKTKASPKRTAKELKPQKSAPPVMD LDADDAKDSVPLSPGSTADFLAETEIVNPLPKKKVAVKKIAPKSQSSTSTTGAKKRAAPK GTKKDPGLNSDVSQKPDPPKTKNHRKRKPSTSDDSDSNFEKMISKAATNKKSKGESEDFH LDLDSGVAPRAKSGRARKPIKYLEESDEDDLF NT seq 4599 nt NT seq  +upstreamnt  +downstreamnt atggaggtgtcaccactgcagccggtaaatgaaaacatgcaaatcagcaaaacaaagaaa aatgaagatgctaagaaaagactgtctattgaaaggatctatcaaaagaaaacccaactg gaacatattttgctccgcccggacacctacattggctctgtggaattagtgacccagcaa atgtgggtttacgatgaagatattggcatgaactatagggaagtcacctttgtccctggg ttgtacaaaatctttgatgagattctggtcaatgctgcagacaacaaacaaagggaccca aaaatgtcttgtattagagtcacaattgacccggaaaacaatttaattagtatatggaat aatgggaaaggtattcctgttgttgaacacaaagttgagaagatgtatgtcccagcactc atctttggacagctcctaacttctagtaactatgatgatgatgaaaagaaagtaacaggt ggtcgaaatggctatggggccaaattgtgtaacatattcagtaccaagtttactgtggaa acagccagtagagaatacaagaaaatgttcaaacagacgtggatggataacatgggaagg gctggtgagatggaactcaggccatttaatggggaagattatacatgtattaccttccag cctgacttgtccaagtttaaaatgcaaagcctagataaagacattgttgcactgatggtt agaagagcatacgatattgctggatccactaaagatgtcaaagtctttctcaatggaaat aaactaccagtaaaaggattccgtagctacgtagatatgtatctgaaggataaggtagat gaaactggcaatccattgaaaattatccatgaacaagtaaaccccaggtgggaagtatgt ttaacaatgagtgaaaaaggctttcagcaaattagcttcgtcaacagcattgctacctcc aagggtggcagacatgttgattatatagctgatcagattgtgactaaacttgttgatgtt gtgaagaagaagaacaagggtggtgttgcagtaaaagcacatcaggtgaaaaatcacatg tggatttttgtgaatgccttgattgaaaacccaacctttgactctcagacgaaagaaaac atgactttacaagtcaagagctttggatcaacatgccaattaagtgaaaaattcatcaaa gctgcaactggctgtggtattgtggaaagcattctaaactgggtaaagtttaaggcccaa atccaattaaacaagaagtgttcagctgtaaagcataacagaatcaagggaattcccaaa cttgatgatgccaatgacgcagggggtcgaaactccaatgagtgtacacttatcctgact gaaggagactcagctaaaactttggctgtttcaggccttggtgtggttgggagagacaaa tatggagttttcccacttagaggaaaaatactcaatgttcgagaagcttctcataaacag atcatggaaaatgctgaaattaataatatcatcaagatcgtgggtcttcagtacaagaaa aactatgacgatgaagattcattgaagactcttcgttatgggaagataatgattatgaca gatcaggaccaagatggttcccatatcaaaggcttgctgattaattttatccatcataac tggccctctcttctacggcatcgttttctggaggaatttatcactccgattgtaaaggtg tctaaaaacaaacaagaaatggcattctatagccttcctgaatttgaagaatggaagagt tctactccaaatcataaaaaatggaaagtcaagtactacaaaggtttgggtaccagcaca tcaaaagaagctaaagaatactttgcaaatatgaaaagacatcgtattcagttcaaatac tccggtcctgaagatgatgctgccatcagcttggcctttagcaagaaacagatagatgat cgaaaggaatggttaactcatttcatggaagatagaagacaacggaagttacttggcctt cctgaggattacttgtatgggcaaactaccacatatctgacatacaatgactttataaat aaggaacttatcctgttctcaaattctgataacgagagatctatcccatctatggtggat ggcttgaaaccaggtcaaagaaaggttttgtttacctgtttcaaacggaatgacaagcga gaggtgaaggttgcccagttggctgggtcagtggctgagatgtcctcttatcatcatggt gagatgtcactaatgatgaccattataaatttggctcagaattttgtgggtagcaataat ctgaacctcttgcagcccattggtcagtttggtactaggctgcacggtggcaaggattct gctagtcctcgatacatcttcacaatgctcagccctttggctcggttattgtttccacca aaagatgatcagactttaaagtttttatatgatgacaatcaacgtgttgaacctgaatgg tacattcccattatacccatggtgctgataaatggtgctgaaggaattggtactgggtgg tcctgcaaaatccccaactttgatattcgtgaagttgtaaataatatcaggcgtttgatg gatggagaagaacctttgccaatgcttccaagttacaagaacttcaggggtactattgaa gagctggctccaaatcagtatgtgattagtggtgaagtggctatacttaattccacaacc attgaaatctcagagcttcctgtcagaacatggacccagacctataaagaacaggttcta gaacccatgttgaatggcactgagaagacaccacctctcataacagattatagggagtac catacagacaccactgtgaagtttgttgtgaagatgactgaagagaaactggcagaggca gagagagtggggctacacaaagtcttcaaactccaaactagtctcacatgcaactccatg gtgctttttgaccatgtaggttgtttaaagaaatatgacacagtgttggatattctaaga gacttctttgaactaaggcttaaatattatggattaagaaaagaatggcttctaggaatg cttggcgctgaatctgctaaactgaacaatcaggctcgctttatcttagagaaaatagat ggcaaaataattattgaaaataagcctaagaaagaattaattaaagttctgattcagagg ggatatgattcggatcctgtgaaggcttggaaagaagctcagcaaaaggtaccagatgaa gaagagaatgaagagagtgacaatgaaaatgaagctgaaaagagtgactctgtaagagat tctggaccaaccttcaactaccttcttgatatgcctctttggtatctcaccaaggagaag aaggatgaactgtgcaagctgagaaatgaaaaagagcaagaactagaaacattaaagaga aagagtccaacagatttgtggaaagaagacttggctacttttgttgaagagctagaggct gttgaaacaaaggaaaaacaagaagaacaaataggacttccagggaaaggagggaaagga aaggggaaaaaaacacaaatggctgaagttttgccttctccttgcggaaaaagagtcatc ccccgagtgaccatagagatgaaagcagaggcagaaaagaaaaataaaaagaaaattaag aatgaaaacactgaagggagccctcaagaagagagtatcgaaatagaaggtctgaaacaa aggttggagaagaaacagaaaagagaaccaggtaccaagacaaagaagcaaactacattg ccgtttaaacccatcaaaaaaggaaagaagagaaacccctggtctgattcagaatcagat atgagcagtaatgaaagtaactttgatgtccctccacgagaggtagagccacggagagca gcaacaaaaaccaaattcacagtggatttggatttagacgacagtttctcagattttgaa gaaagaattcaagatgaggattctgttccatcagatgtcagcccacataagaccaaagct tccccaaaacgtactgccaaagaactgaagccacagaaaagtgcccccccagtaatggac cttgatgctgatgatgccaaggacagtgtaccactttctccaggttctactgctgatttc ttggctgaaactgaaattgtaaacccccttcctaaaaagaaggtggccgtgaagaagata gcaccaaaaagtcagtcttccacctccactacaggtgcaaaaaaaagggctgcaccaaaa ggaaccaaaaaggatccaggcttaaattctgatgtctctcaaaagcctgatcccccaaaa accaaaaatcaccgcaaaaggaagccatccacttctgatgattccgactctaattttgag aagatgatttctaaagcagccacaaacaagaaatccaagggggagagtgaagacttccat ctggacctagactcaggtgtggctcctcgggccaaatctggacgtgcaaggaaacctata aagtaccttgaagaatcagatgaagatgatctgttctaa

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