KEGG   Canis lupus dingo (dingo): 112659377
Entry
112659377         CDS       T08371                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
clud  Canis lupus dingo (dingo)
Pathway
clud00562  Inositol phosphate metabolism
clud01100  Metabolic pathways
clud04015  Rap1 signaling pathway
clud04020  Calcium signaling pathway
clud04022  cGMP-PKG signaling pathway
clud04062  Chemokine signaling pathway
clud04070  Phosphatidylinositol signaling system
clud04071  Sphingolipid signaling pathway
clud04072  Phospholipase D signaling pathway
clud04081  Hormone signaling
clud04082  Neuroactive ligand signaling
clud04261  Adrenergic signaling in cardiomyocytes
clud04270  Vascular smooth muscle contraction
clud04310  Wnt signaling pathway
clud04371  Apelin signaling pathway
clud04540  Gap junction
clud04611  Platelet activation
clud04613  Neutrophil extracellular trap formation
clud04621  NOD-like receptor signaling pathway
clud04713  Circadian entrainment
clud04720  Long-term potentiation
clud04723  Retrograde endocannabinoid signaling
clud04724  Glutamatergic synapse
clud04725  Cholinergic synapse
clud04726  Serotonergic synapse
clud04728  Dopaminergic synapse
clud04730  Long-term depression
clud04742  Taste transduction
clud04750  Inflammatory mediator regulation of TRP channels
clud04911  Insulin secretion
clud04912  GnRH signaling pathway
clud04915  Estrogen signaling pathway
clud04916  Melanogenesis
clud04918  Thyroid hormone synthesis
clud04919  Thyroid hormone signaling pathway
clud04921  Oxytocin signaling pathway
clud04922  Glucagon signaling pathway
clud04924  Renin secretion
clud04925  Aldosterone synthesis and secretion
clud04926  Relaxin signaling pathway
clud04927  Cortisol synthesis and secretion
clud04928  Parathyroid hormone synthesis, secretion and action
clud04929  GnRH secretion
clud04933  AGE-RAGE signaling pathway in diabetic complications
clud04934  Cushing syndrome
clud04935  Growth hormone synthesis, secretion and action
clud04961  Endocrine and other factor-regulated calcium reabsorption
clud04970  Salivary secretion
clud04971  Gastric acid secretion
clud04972  Pancreatic secretion
clud04973  Carbohydrate digestion and absorption
clud05010  Alzheimer disease
clud05016  Huntington disease
clud05017  Spinocerebellar ataxia
clud05022  Pathways of neurodegeneration - multiple diseases
clud05142  Chagas disease
clud05143  African trypanosomiasis
clud05146  Amoebiasis
clud05163  Human cytomegalovirus infection
clud05200  Pathways in cancer
clud05415  Diabetic cardiomyopathy
clud05417  Lipid and atherosclerosis
Module
clud_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:clud00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    112659377 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    112659377 (PLCB3)
   04310 Wnt signaling pathway
    112659377 (PLCB3)
   04371 Apelin signaling pathway
    112659377 (PLCB3)
   04020 Calcium signaling pathway
    112659377 (PLCB3)
   04070 Phosphatidylinositol signaling system
    112659377 (PLCB3)
   04072 Phospholipase D signaling pathway
    112659377 (PLCB3)
   04071 Sphingolipid signaling pathway
    112659377 (PLCB3)
   04022 cGMP-PKG signaling pathway
    112659377 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    112659377 (PLCB3)
   04081 Hormone signaling
    112659377 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    112659377 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112659377 (PLCB3)
   04613 Neutrophil extracellular trap formation
    112659377 (PLCB3)
   04621 NOD-like receptor signaling pathway
    112659377 (PLCB3)
   04062 Chemokine signaling pathway
    112659377 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    112659377 (PLCB3)
   04922 Glucagon signaling pathway
    112659377 (PLCB3)
   04929 GnRH secretion
    112659377 (PLCB3)
   04912 GnRH signaling pathway
    112659377 (PLCB3)
   04915 Estrogen signaling pathway
    112659377 (PLCB3)
   04921 Oxytocin signaling pathway
    112659377 (PLCB3)
   04926 Relaxin signaling pathway
    112659377 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    112659377 (PLCB3)
   04918 Thyroid hormone synthesis
    112659377 (PLCB3)
   04919 Thyroid hormone signaling pathway
    112659377 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    112659377 (PLCB3)
   04916 Melanogenesis
    112659377 (PLCB3)
   04924 Renin secretion
    112659377 (PLCB3)
   04925 Aldosterone synthesis and secretion
    112659377 (PLCB3)
   04927 Cortisol synthesis and secretion
    112659377 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112659377 (PLCB3)
   04270 Vascular smooth muscle contraction
    112659377 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    112659377 (PLCB3)
   04971 Gastric acid secretion
    112659377 (PLCB3)
   04972 Pancreatic secretion
    112659377 (PLCB3)
   04973 Carbohydrate digestion and absorption
    112659377 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    112659377 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    112659377 (PLCB3)
   04725 Cholinergic synapse
    112659377 (PLCB3)
   04728 Dopaminergic synapse
    112659377 (PLCB3)
   04726 Serotonergic synapse
    112659377 (PLCB3)
   04720 Long-term potentiation
    112659377 (PLCB3)
   04730 Long-term depression
    112659377 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    112659377 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    112659377 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    112659377 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    112659377 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112659377 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    112659377 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112659377 (PLCB3)
   05142 Chagas disease
    112659377 (PLCB3)
   05143 African trypanosomiasis
    112659377 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112659377 (PLCB3)
   05016 Huntington disease
    112659377 (PLCB3)
   05017 Spinocerebellar ataxia
    112659377 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    112659377 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112659377 (PLCB3)
   05415 Diabetic cardiomyopathy
    112659377 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    112659377 (PLCB3)
   04934 Cushing syndrome
    112659377 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:clud04131]
    112659377 (PLCB3)
Enzymes [BR:clud01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     112659377 (PLCB3)
Membrane trafficking [BR:clud04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    112659377 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    112659377 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 112659377
NCBI-ProteinID: XP_025301866
Ensembl: ENSCAFG00020014131
UniProt: A0A8C0KN21
LinkDB
Position
18:complement(52738356..52753581)
AA seq 1230 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDSNGFFLYWTGPNME
VDTLDISSIRDTRTGRYSRLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTAKVWAEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHQPSTGVPNS
SVRKRPLEQSNSALSESSATTDPSSPQLGSPSSESCPGLSNGEEVGLEKPSLEPQKSLGE
DGLPRGPNTLGSADREDEEEEEEEEEQADPKKPTSDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASPETCQETPSQQP
GSQLTPNPTPSPLDTPPRRPPGPATAPTSPSLSSPGQRDDLIASLLSEVAPIPLEELRGH
KALVKLQNRQERELRELHKKHQRKAVALTRRLLEGLAQARAESRCRHRPGVLGGENEKEE
GEEVKRYQEFQKRQVQSLLELREAQVDTEAERRLEHLRQAQQRLREVVLDAHTTQFKKLK
EINEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRQERLVAGQQQVLQQLAEEEPKLLAQLAQECQEHRARLPQEIRQSLLGETPEGLGDRHL
VACASNGHAPGSSGHLSGADSESQEENTKL
NT seq 3693 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagcaagttcatcaaatgggacgaggagacctccagtcggaacctg
gtaaccctgcgtgtggattccaatggcttctttctatactggactggacccaacatggag
gtggacacactggacattagttccatcagggacacgcgaacaggtcgttactcccgcctg
ccaaaggaccccaagatccgggaggtgctgggctttgggggccctgatacccgactagag
gagaagttgatgacggtggtggccgggccagacccggtgaatacaacattcttgaacttc
atggctgtgcaggatgacacagccaaggtctgggccgaggagctgttcaagctggctatg
aacatcctggctcagaacgcctccaggaataccttcctgcggaaagcatacaccaagctg
aagctgcaggtgaaccaggatggacggatcccggttaagaatatcctgaagatgttttca
gcagataaaaagcgagtggagaccgcactagaatcctgtggcctcaatttcaaccggagt
gaatccatccggcccgatgagttttccttggaaatctttgagcggttcctgaataagttg
tgtctgcggccggacattgacaagatcctgctagagataggtgctaagggcaagccatac
ctgacgctggagcagctcatggacttcatcaaccagaagcaacgggacccaaggctcaac
gaagtgctgtacccacccctgcggccctcccaggctcggctgctcattgagaagtatgag
cccaaccagcagttcctggagcgagatcagatgtccatggagggcttcagccgctacctg
ggaggtgaagagaatgggatcctgcccctggaggccctggatctgagcgctgacatgacc
cagccactcagtgcctatttcatcaactcctcacacaacacctatctcacagcggggcag
ctggctgggacctcgtcggtggagatgtaccggcaggcgctgctgtggggctgccgctgt
gtggagctggatgtgtggaaagggcggccgccggaggaggagcccttcatcacccacggc
ttcaccatgaccactgaggtgccgctgagagacgtgctcgaggccattgcagaaaccgcc
ttcaagacctcaccctatccagtcatcctctccttcgagaatcacgtggactcagcgaag
cagcaggccaagatggccgagtactgccgttccatctttggggacgcgctgctcatcgac
ccactggacaagtacccgctggccccaggtgtccccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagcgacaccagcccagcactggtgtccccaacagc
tctgtgcgcaagcggccgctggagcagagcaactcggccctgagcgagagctctgccacc
actgacccctcctcacctcagcttgggtcccccagctctgagagctgcccaggcctgagc
aatggggaagaggtgggcctggagaagcctagcctggagcctcagaagtctctaggcgag
gatgggctcccacggggccccaacactcttggatctgctgaccgtgaggatgaggaagaa
gaggaggaagaggaggaacaggcagatcctaaaaagccaacctcagatgagggcactgcc
agcagtgaggtcaatgccactgaggaaatgtcaacactcgtcaactacattgagcctgtc
aagttcaagtcctttgaggctgctcgaaaaaggaacaaatgctttgagatgtcatccttc
gtcgaaaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaat
aaacagcagctcagccgcatctaccctaagggtacccgcgtggactcatccaactacatg
ccccagctcttttggaacgtgggctgccagcttgttgcactcaacttccagaccctggat
gtggcaatgcagctcaacgcaggcgtgttcgagtacaatgggcgcagtggctatctgctc
aaacctgagtttatgcggcggccagacaagtccttcgatcctttcaccgaagtcattgtg
gatggcattgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggcatctatgtggaggtggacatgtttggcctccccgttgacacgcggcgc
aagtaccgtactcggacctctcaagggaactcattcaaccctgtgtgggatgaggaacct
tttgacttccccaaggtggtgctacccacgctggcttcgctgcgcatcgcggcctttgag
gaaggcggcaagtttgtggggcatcggattctgcccgtctctgccatccgctcagggtac
cactacatctgtctgcggaacgaggccaaccagccactttgcctgccagccctgctcatc
tacactgaagcctccgactatattcctgatgaccaccaggactacgcagaggccctgatc
aaccccatcaagcatgtcagcctgatggaccagagggccaagcagttggccgccctcatt
ggggagagtgaggctcaggccagcccagagacatgccaggagactccgtctcagcagccg
gggtcccagctgaccccaaaccctacacctagccccctggacacacccccgcgccggccc
ccaggccctgccacagcccctaccagcccctccctcagcagcccagggcagcgggatgac
ctcatcgccagcctcctctcagaggtggccccaatcccgctggaggagctccgaggccat
aaggcgctggtgaagctccagaaccggcaagaacgagagctgcgggagctacataagaag
caccagcggaaggccgtcgccctcacccgccggctgcttgagggcctggctcaggcccgg
gcggagagcaggtgccggcatcggccaggtgtcctaggcggggagaacgagaaggaagag
ggagaagaggtaaagcggtatcaggagttccagaagagacaggtgcagagtctgttggag
ctacgggaggctcaggtggacacagaggccgagcggaggctggagcacctgagacaggct
cagcagcggctcagggaagttgtcctggatgctcacacaactcagttcaagaagctgaag
gagataaatgagagggagaagaaggaattgcagaagattttagacaggaagcgccacaac
agtatctcagaggccaagactagggagaaacataagaaggaggcggaactgacagagatt
aaccgtcggcacatcactgagtcggtcaactccatccgtcggctggaggaggcccagaag
cagcggcaggaacgcctggtggctgggcagcagcaggtcctacagcagctggctgaagag
gagcccaagctgctggcccagctggcccaggagtgtcaggaacatcgagcaaggctgccc
caggagatccgccagagcctgctgggcgagacaccggaggggctgggggacaggcacctg
gtggcctgtgccagcaacggtcacgcacctgggagcagcgggcacctgtctggcgctgac
tcagagagccaagaggagaatacgaagctctga

DBGET integrated database retrieval system