Canis lupus dingo (dingo): 112660774 Help Entry 112660774         CDS       T08371                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism clud  Canis lupus dingo (dingo) Pathway clud04020   Calcium signaling pathway clud04024   cAMP signaling pathway clud04260   Cardiac muscle contraction clud04261   Adrenergic signaling in cardiomyocytes clud04371   Apelin signaling pathway clud04713   Circadian entrainment clud04911   Insulin secretion clud04921   Oxytocin signaling pathway clud04972   Pancreatic secretion clud05020   Prion disease clud05022   Pathways of neurodegeneration - multiple diseases clud05410   Hypertrophic cardiomyopathy clud05412   Arrhythmogenic right ventricular cardiomyopathy clud05414   Dilated cardiomyopathy clud05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:clud00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112660774 (RYR2)    04020 Calcium signaling pathway     112660774 (RYR2)    04024 cAMP signaling pathway     112660774 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     112660774 (RYR2)    04921 Oxytocin signaling pathway     112660774 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     112660774 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     112660774 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     112660774 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     112660774 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     112660774 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     112660774 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     112660774 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     112660774 (RYR2)    05414 Dilated cardiomyopathy     112660774 (RYR2)    05415 Diabetic cardiomyopathy     112660774 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:clud04040]     112660774 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:clud04990]     112660774 (RYR2) Ion channels [BR:clud04040]  Voltage-gated cation channels   Ryanodine receptor    112660774 (RYR2) Domain-containing proteins not elsewhere classified [BR:clud04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    112660774 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  112660774 NCBI-ProteinID:  XP_048964697 Ensembl:  ENSCAFG00020025276 LinkDB All DBs Position 4:complement(2439676..3167128) Genome browser AA seq 4975 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKSLLLMDKENADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVRASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLKTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDEHAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTERTMMFTLNGEVLLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTVAG GLPGTGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNECYQYSPEFPLDILKAKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPDEE TEALEKEPCPEDSKSEGAGEEEAKGVKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQAEKPIESDSKKSSTLQQLISETMVRWAQESVIEDPDLVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGGRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNI YSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYSLVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPPEEEESTKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQ RSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGGNST VQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQD DEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYY SGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFA HMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEM ILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAET DENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPF LGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNF CEDTIFEMQLAAQISESDLNERSVSKEESEKEKPEEQGPRMGFFSILTVKSALLALRYNV LTLMRMLSLKSLKKQMKRVKKMTVKDMVMAAFSSYWNIFMSLLHFVASVSRGFFRIICSL LLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDSEEGDRKPMEAALPSEDLTDLKELTEE SDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQEQKAKEEEKEEK EENKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLL NYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELSTRSSSENAKVSSLDSGSP RIITVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEF DGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGM DKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILG HYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKF YNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFF FVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQE HNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14928 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgtaccgcaaccatccacaaagaacaacagaagctgtgtttggcagcagaa ggctttggcaacagactttgtttcttggagtccacttcaaattccaagaatgttcctcca gacctctccatctgcacctttgtgctggaacagtctctctctgtccgggccctgcaagag atgctggctaacactgtggagaagtcagaagggcaagttgatgtggaaaaatggaaattc atgatgaagactgctcaaggtggtggtcatcgaacacttctgtatggacatgccatattg ctacgccattcctacagtggtatgtatctgtgctgcctctccacctcccggtcttcaact gataaactggcctttgatgttggcttgcaagaggacacaacaggtgaggcttgctggtgg actattcaccctgcctctaagcagcggtcggaaggagaaaaggttcgagttggagatgac ctcatcttagtcagtgtgtcctctgagaggtatctgcacttgtcttatggcaacggcagc ttacacgtggatgctgctttccagcagactctttggagcgtggccccaatcagctcagga agcgaagcagcccaagggtatctaattggtggtgacgtcctcaggttgctgcatggacac atggatgaatgcctcactgtcccttcgggagagcacggtgaagagcagcggagaactgtt cactatgaaggtggtgctgtatctgttcatgcacgttccctgtggaggctagagacacta agagttgcgtggagtggaagccacataagatggggccagcctttccgactacgccatgtc acaacaggaaaatacttgagtctcatggaagacaaaagccttctactcatggacaaagaa aacgcagatgtaaaatcaacagcatttaccttccgatcttccaaggaaaaattggatgtg ggtgtgagaaaagaagtagatggcatggggacatctgaaataaaatatggagactcagta tgctatatacaacatataaatacaggcctatggcttacctaccagtctgtggatgtaaaa tcagtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggtcacatggat gatggcttaaatttatccagatctcagcatgaagaatcacggactgcacgagtcattcgg agcacagttttccttttcaatagatttataaggggcctcgatgcgctcagcaagaaagtg agggcctccactgtggacctccctatagagtctgtgagtctaagtctgcaagacttgatt ggctacttccaccccccggatgagcacttggagcatgaagacaagcagaacagattgcga gctctcaagaaccggcaaaacctcttccaggaagagggaatgatcaacctcgtgctcgag tgtatagacaggctgcatgtgtatagcagcgcggcacactttgctgatgttgctgggaga gaagcaggcgagtcctggaagtcgattctgaattctctctatgagttgctagcggcttta attagaggaaatcgtaaaaactgtgctcaattttctggctcccttgattggttgatcagc cgactagaaagactggaagcttcttctgggattcttgaagttttacactgtgtgttagta gaaagtccggaagctctaaatattatcaaggaaggacacattaaatccataatctcactt ttagacaagcatggaagaaaccacaaggttctggatgtcttgtgctctctctgtgtctgc catggagtagcagtgcgttctaaccagcacctcatctgtgacaatctgctgccaggaaga gatctcctattacagacgcgccttgtaaaccacgtcagcagcatgagacccaatattttt ctgggcgtcagtgaagggtccgcccagtataagaagtggtactatgagctgatggtggac cacacggagccatttgtgactgctgaagccacgcacctgcgggtgggctgggcttccacc gaaggatactctccctatcccggaggcggtgaggagtggggtggaaatggagtcggagat gatctcttttcctacggattcgatggccttcacctctggtcaggttgcattgctcgtact gtaagctcaccaaaccagcacttgctgaaaactgatgacgtcatcagttgctgtttagat ctgagtgccccaagcatctcattccgaattaacggacaacctgttcaaggaatgtttgag aatttcaacattgatggcctcttctttccagttgttagtttctctgcaggaataaaggta cgctttctgcttggggggagacatggagaatttaaattcctccctccacctgggtacgct ccttgttatgaagccgttctgccgaaagaaaagttgaaagtggagcacagccgagagtac aagcaggaaaggacttacacacgggacctgctgggccccacggtttccctgactcaggct gccttcacaccaattcctgtggataccagccagattgtgttgcctcctcatctagagaga ataagagaaaaactggcagagaatatccatgaactttgggttatgaataaaatagagctt ggctggcagtatggtccggttagagatgacaataagagacaacacccctgtctggttgag ttctccaagctgcctgaacaagagcgcaattacaacttgcagatgtctctggagaccctg aagactttgctggcattaggatgtcatgtgggcatttcagatgaacatgctgaagaaaag gtgaaaaaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgcccca atggacctgagctttatcaaactcaccccatctcaggaagcaatggtggacaagttggca gaaaatgctcataatgtatgggcccgagatcgaatccggcagggctggacttacggcatc caacaggatgtaaagaacagaagaaaccctcgcctggttccctacactcttctagatgac cgcaccaagaaatccaataaagacagcctccgtgaagctgttcgcacgctgctggggtat ggctacaacctggaagcaccagatcaggatcatgctgccagagctgaagtgtgcagcggc acaggtgagagattcagaatcttccgtgctgagaaaacctacgctgtcaaggcaggaagg tggtattttgaatttgaggctgtcactgcaggcgacatgagagttggctggagcaggcca ggttgtcaacctgatcaagagcttggctccgacgaacatgcctttgcttttgatggcttc aaggctcagcggtggcaccagggcaacgagcattacgggcggtcatggcaagcgggagat gtcgtggggtgtatggtggacatgacagagcgtaccatgatgttcacgctcaatggcgaa gtccttctggacgattcgggctcagaactggcgttcaaggactttgatgttggtgatgga ttcattcctgtctgtagccttggagtggctcaagtgggcaggatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgaaccatttgct gtcaacacaaacagggatattaccatgtggttaagcaagaggcttcctcagtttctccag gtcccatcaaatcatgagcatatcgaggtgaccagaatagatggcaccatagacagttct ccatgtttaaaggtcactcagaagtcctttggttctcagaacagcagcaccgatatcatg ttctatcgcctgagcatgcccatcgagtgcgcagaagttttttccaagacggtagcagga ggactcccaggcactggcctctttgggcccaagaatgatctggaggactatgatgcagat tctgactttgaggttctaatgaagaccgctcatggccatctcgtgccagatcgagttgac aaagacaaggaagccacaaaaccagagtttaataaccacaaagattatgctcaagaaaag ccttctcgtctgaaacaaagatttttgcttagaagaaccaagccagattacagcacgagc cattctgcaagactcactgaagatgtccttgcagacgatagggatgattacgattacttg atgcaaacgtccacgtactattactcagtgagaatctttcctggccaagaacctgcaaac gtctgggtaggctggattacatcagatttccatcaatatgatacaggctttgacttggac agagttcgtacagtaaccgttaccctaggagatgaaaagggaaaagtgcatgaaagcatc aaacgcagcaactgctatatggtatgtgcaggcgagagcatgagccctgggcaaggacgc aacaacaatggcctggagatcgggtgtgtggtggacgccgccagtgggctgctcacattc accgccaatggcaaggagctgagcacgtactaccaggtggagccaagtacaaaattattt cctgcagtgtttgcacaagctacaagtcccaatgttttccagtttgagttgggaagaata aagaacgtgatgcctctgtcagcgggattgttcaagagtgagcacaaaaaccctgtgcca caatgtcccccacgtctccatgtgcaatttctatcccacgtcctgtggagcagaatgccc aaccagttcttgaaggtagatgtctctcgaataagtgagcgccaaggctggctggtgcag tgtttggatcccctgcagttcatgtctcttcatatcccagaggagaacaggtcagtggac atactggaattgacggagcaggaggagctgctgaagttccactatcacactctcaggctt tactctgctgtgtgtgcccttgggaaccaccgggtggcccatgccttgtgcagccacgtg gatgaacctcagctgctctacgccatcgagaacaaatacatgcctggcttgctgcgtgct ggctactacgacttgctcattgacatccacctcagctcctatgccactgccaggctcatg atgaacagtgagttcatcgtgcccatgacagaggagaccaagagcatcacccttttccct gatgagaacaaaaaacatggtctcccgggaattggcctcagcacttccctcaggccacgg atacaattttcctcccccagttttgtaagcattaataatgaatgttaccagtacagtcca gagttcccactggacatcctcaaggccaaaaccattcagatgctgacagaagctgtgaaa gagggcagccttcacgcccgggacccagttggggggacaactgagttcttgtttgtacct ctcatcaagcttttctatactctactcatcatggggatcttccacaatgaggacttgaaa cacatcttgcagttgatagagcccagcgtattcaaggaagctgccactccagatgaggag actgaggcactggagaaggaaccctgcccagaagactccaagtcagaaggagctggagaa gaagaagccaaaggggttaagaggcccaaggaaggcctgctccaaatgaaactgcctgag ccagttaaattgcagatgtgccttctgcttcagtatctctgtgactgtcaggtccggcac cggatagaagccattgtggccttttcagatgactttgtagctaagctccaagataatcaa cgcttccgatacaatgaagttatgcaagccttaaacatgtcagctgcactcaccgccagg aaaacgaaggaatttagatcaccacctcaagaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaggaaatccgtgaccaactcttagatttccat gaagatttgatgacacattgtggaattgagcttgatgaagatgggtctttggatggaaac agtgacttaacaattagaggacgcctgctgtccctggtagaaaaggtgacatacctgaag aagaaacaagctgaaaaaccaattgagagtgactccaagaagtcctccactcttcaacag ttgatttctgagaccatggtccgatgggcacaagagtctgtcattgaagaccctgacttg gtgagggccatgtttgtgttgctccatcgacagtatgatggcattgggggtctggtccgg gctctgccaaagacctacactataaatggtgtctccgtggaggataccatcaacctgctg gcatctcttggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtgttttaccagcaccctaat ctcatgagggcacttgggatgcatgagacagtgatggaggtcatggtgaatgtccttggc ggtggagagtccaaggaaatcacttttcctaagatggtggccaactgttgccgtttcctc tgttacttctgtcgtataagtaggcagaatcaaaaagctatgttcgatcatctcagctat ttattggagaacagcagtgttggtcttgcctcaccagctatgagaggttcgacaccgttg gacgtagcagctgcctcggtgatggataataatgagctggccttagctctgcgtgagcca gatctggaaaaggtagttcgatatttggctgggtgtggactgcagagctgccagatgctg gtgtctaagggttatccagacattggatggaatccagttgaaggagagagatatcttgac tttctcagatttgctgtcttctgtaatggggagagtgtggaagagaatgctaatgttgtg gtgaggttgctcatcaggaggcccgagtgttttggtcctgctttgagaggggaaggtggg aatggtctgcttgcagccatggaggaagccataaaaatagctgaagatccttctcgagat ggtccctcaccaactagcggatccagcaaaacacttgatacagaagaggaggaagatgac actatccacatggggaatgccatcatgacattttactcggctttgattgaccttttggga cgttgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccgg tcaattttgagatccctaattcccctgggagatttggtgggagtaatcagcattgctttt cagatgccaacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatgggattgaggtt caagatttcctcctccatcttcttgaggttggctttctgccagatctccgggctgctgct tctttagatacggctgctttgagtgctacagacatggccctggccctcaatcgttacctt tgcacagctgtgttgcctttgttaacaagatgtgcccctctttttgctggcacagagcac cacgcttccctcattgactcattacttcacactgtgtacagactttctaagggctgctct cttaccaaagctcagcgggattccatagaagtttgtttactctctatttgtggccaattg agaccttctatgatgcagcacttactccgaagattagtatttgatgtcccattattaaat gaacatgcaaaaatgccccttaagctgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtgggggaactttggagctgcctcagaagaagagcttcattta tcgagaaagttgttttggggcatttttgacgccctatctcaaaagaaatatgagcaagaa cttttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaatataacaattcctgagaagttggaatacttc attaacaaatatgcggaacattctcatgacaaatggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcatctaaagttcagccattaatgaagccatat aaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagagtctctaaaa accatgcttgcgtggggttggagaattgagagaacacgggaaggagacagcatggccctc tataaccggactcgtcgcatttctcagacaagccaggtttctgtagatgctgcccatggt tatagccccagagccattgacatgagcaatgtcacactgtccagagacctgcatgctatg gcagaaatgatggctgaaaactaccataacatatgggcaaagaaaaagaaaatggaactg gagtccaaaggaggtggaaatcatcccctgctggtaccttatgatacgctgacagccaaa gagaaagccaaggacagggaaaaagcacaggacatcctcaagttcttgcaaatcaatggc tatgctgtatccagggggtttaaggacctggaattggacacaccttccattgagaaacga tttgcctacagcttccttcagcaactcattcgctatgtggatgaagcccatcagtatatc ctggagtttgatggtggcggcagaagcaaaggagaacatttcccttatgaacaagaaatc aagttctttgctaaagtggttcttcctttaattgatcaatatttcaaaaaccatcgctta tacttcttatctgcagcaagcagacctctctgttctggaggacatgcatcaaacaaggag aaagaaatggtgacgagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatcaattgtcaactgtcttcatattttgggtcagactttg gacgccaggacagtgatgaagactggtctggaaagcgttaaaagcgccctccgagctttt ctagacaatgctgcggaggatctggagaagaccatggagaatctcaagcaaggccagttc acccacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggct ctgttgccgatgctatcatcattatttgagcatattggccagcatcaattcggagaagat ctaatattggaagatgtacaagtgtcatgttacagaattctgactagtttatatgctttg ggaaccagcaaaagtatttatgtggaaaggcaacgttctgcgttaggagaatgtctcgct gcttttgctggtgcctttcccatagcatttttggaaactcatctggacaaacataacatt tactctatctacaatactaagtcctcacgagaaagagcagctcttaatttgccaactaat gtggaagatgtttgcccaaatataccatctttggagaaactcatggaagaaattgtggaa ttagctgagtctggcattcgctacacacaaatgccacatgtaatggaagtcatactgccc atgctttgcagctacatgtctcgttggtgggagcatggacccgaaaacaatccggaaagg gctgaaatgtgctgtacagccctgaactccgagcacatgaacacacttctgggaaatata ttgaaaatcatatataataacttgggaatcgatgagggtgcctggatgaagaggttagca gttttttcacagcccattataaataaagtgaaacctcagctcctgaaaactcatttcttg ccattaatggagaaactcaagaaaaaagcagcaatggtggtgtctgaggaggaccatctg aaggctgaggccaggggggatatgtctgaggcagaacttctcattcttgatgagtttacc acactggctagagatctctatgccttctacccactcttgattagatttgtggactataac agggcaaagtggctaaaagagcctaacccagaagcagaggaccttttccgcatggtggcc gaagtatttatctattggtcaaaatctcacaatttcaaaagagaagagcagaacttcgtg gtacagaatgaaatcaacaacatgtctttccttatcactgacaccaagtcaaagatgtca aaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggagatcgatattcc atgcagacttctcttattgtggcagctctgaagcgcttgctgcccattgggttgaacatc tgtgcccctggggaccaggagctcatcgctctggccaaaaaccgattcagtatgaaagac actgaggatgaagtacgagatataattcgcagtaatattcatttacaaggcaagttggag gatcctgctatcagatggcaaatggctctctacaaagacttaccaaacaggactgaagac acatcagatccggaaaagaccgtagaaagagtattagatatagcaaatgtgctttttcat cttgagcagaagtctacatgtatgcgccggagatattacagtctggtggagcacccacag agatcgaagaaggctgtatggcacaaactgttatccaagcagaggaaaagagcagtggta gcctgtttccggatggctcctttatacaacctgccaaggcatcgggctgtcaatctcttt cttcagggatatgaaaagtcttggattgaaacagaagaacactactttgaagataaatta atagaagatttagcaaagcctggagccgaccctccagaagaagaggaaagcacgaagaga gttgatcccctccatcaactcatccttctgtttagtcgaacagctttaacagagaaatgc aaactggaagaagactttttatatatggcttatgcagatattatggcaaagagttgtcat gatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagtcacaggatcccaa cgcagcaaggaaaaagaaatggaaaagcaaaagcttctataccaacaagccaggcttcat gaccgaggggctgcggagatggtgctgcagaccatcagtgccagcaaaggtgatactgga ccaatggtagctgcgactttgaaacttggcattgctatcttaaatggcgggaactctaca gtacagcagaaaatgcttgactacctcaaggagaaaaaggatgtgggcttctttcagagc cttgctggcctgatgcagtcatgtagtgtcctcgacctaaatgcatttgagcgacaaaac aaagctgaaggacttggaatggtgaccgaggaaggatcaggagaaaaggttctccaggat gacgagttcacttgtgacctcttccgcttcctacaactgctttgtgagggacacaactca gattttcaaaattatctgagaacccagactggcaacaacacaactgtcaacataatcatc tctactgtagactacctcctgagagtccaggaatccattagtgatttctattggtattac tctgggaaagatgttattgatgaacaaggacaacggaatttttccaaagcaattcaagta gcaaagcaagtctttaacactctcacagagtatattcagggtccttgcactgggaatcag cagagcctggcccacagcaggctgtgggacgcagttgtgggctttcttcatgtatttgcc cacatgcagatgaagctatctcaggattccagtcaaattgagctattaaaagaattaatg gatcttcagaaggatatggtggtcatgttgctgtccatgttagaaggtaatgtcgtcaat ggaaccattggcaaacagatggtcgatatgcttgtggaatcttccaacaatgtggagatg attctcaagttttttgacatgtttttaaaattaaaagatttgacgtcctcagacacattt aaggaatacgatcccgatggcaaaggagtcatttccaagagggacttccataaagcgatg gagagtcataagcactatacacagtcagaaaccgagtttcttctgtcctgtgcagagacc gatgaaaacgagactctcgactatgaagagtttgtcaaacgcttccatgagcccgcaaag gacataggcttcaacgttgccgtcctcctgacaaacctgtctgaacacatgcccaatgac acccggctgcagacgtttctggagttggcagagagtgtgctgaattacttccagcccttt ctgggccgcatcgagatcatgggaagtgccaaacgcatcgagagggtctattttgaaatc agtgagtccagccgcacccagtgggagaagccccaggtcaaggagtccaaacggcagttc atatttgacgttgtcaatgaagggggagaaaaggagaagatggaactttttgtgaacttc tgtgaggacaccatatttgaaatgcagttggcggcacagatctcggagtcggatttgaat gagaggtcagtgagtaaggaggagagtgagaaggagaagcctgaagagcaggggcccagg atgggtttcttttccattctgacagtcaagtcagccctgttggctctcaggtacaatgtc ttgaccctcatgcgaatgctcagcctgaagagcctgaagaagcagatgaaaagagtgaag aagatgactgtgaaggatatggtcatggctgccttttcatcctattggaatattttcatg agcctcctgcacttcgtggccagcgtttccagaggctttttccgtatcatttgcagcctg ctgctggggggcagcctagtagaaggggcaaagaagatcagggtggcagagctcttagcc aacatgccggaccccacacaggatgaggtgaggggggatagcgaggagggggacaggaaa cccatggaagctgccctgccctcagaagacctgacagacctaaaggagctgacagaggag agtgaccttctttcggatatatttggcttggacctgaagagagaaggaggacagtacaaa ctcattcctcataatcccaatgctggcctcagcgacctcatgagcaacccggtccccatc cctgacgtgcaggaaaaatttcaggaacagaaggccaaagaggaagaaaaggaggaaaaa gaagaaaacaagtcggaacctgaaaaggctgagggagaagatggagagaaagaagaaaaa gccaaggaagataagggtaaacagaagctgaggcaactccacacacatagatatggagag ccggaagttcccgagtcagcgttctggaagaaaatcatagcatatcaacagaaacttcta aactattttgctcgcaacttttacaacatgagaatgttagccttatttgtcgcatttgca atcaatttcatcttgctgttttataaggtctccacttcttctgtggttgaaggaaaggag ctctccactcgcagttcaagtgaaaatgccaaagttagcagcctagacagtgggtcaccc agaatcatcacggttcactacgtcctggaggagagcagcggctacatggagcccacactg aggatcttagctattctccacacggtcatttctttcttctgcatcatcggatactactgc ttgaaagtcccattggttatttttaagcgagaaaaggaagttgctcgaaaattggaattt gatgggctttatattacagaacagccttcagaagatgatattaaaggccagtgggataga cttgtaatcaacacacagtcatttcccaacaactattgggacaaatttgttaaaagaaag gttatggataaatatggagagttctatggccgggacagaatcagtgagctccttggtatg gacaaagcagctctggacttcagcgatgccagggaaaagaagaagccaaaaaaagacagc tccctgtcggctgtactgaactctatcgacgtgaagtatcagatgtggaaactaggagtc gtcttcactgacaattcttttctctacctggcctggtatatgactatgtccattcttgga cactataacaactttttttttgctgctcatctccttgacattgctatggggttcaaaaca ctaagaaccatcttgtcatcggtaacgcacaatggcaaacagcttgtgttaaccgttggc ttattagctgttgttgtatacctgtatactgttgtggcattcaattttttccgaaaattc tacaataaaagtgaagatggtgatacaccagatatgaaatgtgatgatatgctaacgtgc tatatgttccacatgtatgttggggtacgtgctggagggggtattggtgatgaaattgaa gacccagcaggcgatgaatatgagatctatcgaatcatctttgacatcaccttcttcttc ttcgtgattgtcatcctcttggctataatacaaggtttaattattgatgcttttggagaa ctaagagaccaacaggagcaagtcaaagaagacatggagactaaatgcttcatctgtggg ataggcaatgattacttcgacacagtgccacatggctttgaaacccacactttacaggaa cacaacttggctaattacctgttttttctgatgtatctcataaacaaggatgaaacagag cacacaggacaggaatcttatgtctggaagatgtatcaagaaaggtgctgggaattcttc ccagcaggggactgtttccggaaacagtatgaggaccagctaaattaa

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