KEGG   Canis lupus dingo (dingo): 112671968
Entry
112671968         CDS       T08371                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X3
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
clud  Canis lupus dingo (dingo)
Pathway
clud01522  Endocrine resistance
clud04010  MAPK signaling pathway
clud04012  ErbB signaling pathway
clud04014  Ras signaling pathway
clud04024  cAMP signaling pathway
clud04068  FoxO signaling pathway
clud04071  Sphingolipid signaling pathway
clud04137  Mitophagy - animal
clud04140  Autophagy - animal
clud04141  Protein processing in endoplasmic reticulum
clud04210  Apoptosis
clud04215  Apoptosis - multiple species
clud04217  Necroptosis
clud04310  Wnt signaling pathway
clud04380  Osteoclast differentiation
clud04510  Focal adhesion
clud04517  IgSF CAM signaling
clud04530  Tight junction
clud04620  Toll-like receptor signaling pathway
clud04621  NOD-like receptor signaling pathway
clud04622  RIG-I-like receptor signaling pathway
clud04625  C-type lectin receptor signaling pathway
clud04657  IL-17 signaling pathway
clud04658  Th1 and Th2 cell differentiation
clud04659  Th17 cell differentiation
clud04660  T cell receptor signaling pathway
clud04664  Fc epsilon RI signaling pathway
clud04668  TNF signaling pathway
clud04722  Neurotrophin signaling pathway
clud04723  Retrograde endocannabinoid signaling
clud04728  Dopaminergic synapse
clud04750  Inflammatory mediator regulation of TRP channels
clud04910  Insulin signaling pathway
clud04912  GnRH signaling pathway
clud04914  Progesterone-mediated oocyte maturation
clud04917  Prolactin signaling pathway
clud04920  Adipocytokine signaling pathway
clud04926  Relaxin signaling pathway
clud04930  Type II diabetes mellitus
clud04931  Insulin resistance
clud04932  Non-alcoholic fatty liver disease
clud04933  AGE-RAGE signaling pathway in diabetic complications
clud04935  Growth hormone synthesis, secretion and action
clud04936  Alcoholic liver disease
clud05010  Alzheimer disease
clud05012  Parkinson disease
clud05016  Huntington disease
clud05017  Spinocerebellar ataxia
clud05020  Prion disease
clud05022  Pathways of neurodegeneration - multiple diseases
clud05132  Salmonella infection
clud05133  Pertussis
clud05135  Yersinia infection
clud05142  Chagas disease
clud05145  Toxoplasmosis
clud05152  Tuberculosis
clud05161  Hepatitis B
clud05162  Measles
clud05166  Human T-cell leukemia virus 1 infection
clud05167  Kaposi sarcoma-associated herpesvirus infection
clud05169  Epstein-Barr virus infection
clud05170  Human immunodeficiency virus 1 infection
clud05171  Coronavirus disease - COVID-19
clud05200  Pathways in cancer
clud05208  Chemical carcinogenesis - reactive oxygen species
clud05210  Colorectal cancer
clud05212  Pancreatic cancer
clud05231  Choline metabolism in cancer
clud05415  Diabetic cardiomyopathy
clud05417  Lipid and atherosclerosis
clud05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:clud00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    112671968 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112671968 (MAPK8)
   04012 ErbB signaling pathway
    112671968 (MAPK8)
   04014 Ras signaling pathway
    112671968 (MAPK8)
   04310 Wnt signaling pathway
    112671968 (MAPK8)
   04668 TNF signaling pathway
    112671968 (MAPK8)
   04068 FoxO signaling pathway
    112671968 (MAPK8)
   04071 Sphingolipid signaling pathway
    112671968 (MAPK8)
   04024 cAMP signaling pathway
    112671968 (MAPK8)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    112671968 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112671968 (MAPK8)
   04137 Mitophagy - animal
    112671968 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    112671968 (MAPK8)
   04215 Apoptosis - multiple species
    112671968 (MAPK8)
   04217 Necroptosis
    112671968 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112671968 (MAPK8)
   04530 Tight junction
    112671968 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    112671968 (MAPK8)
   04621 NOD-like receptor signaling pathway
    112671968 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    112671968 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    112671968 (MAPK8)
   04660 T cell receptor signaling pathway
    112671968 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    112671968 (MAPK8)
   04659 Th17 cell differentiation
    112671968 (MAPK8)
   04657 IL-17 signaling pathway
    112671968 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    112671968 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112671968 (MAPK8)
   04920 Adipocytokine signaling pathway
    112671968 (MAPK8)
   04912 GnRH signaling pathway
    112671968 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    112671968 (MAPK8)
   04917 Prolactin signaling pathway
    112671968 (MAPK8)
   04926 Relaxin signaling pathway
    112671968 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    112671968 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    112671968 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    112671968 (MAPK8)
   04722 Neurotrophin signaling pathway
    112671968 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    112671968 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112671968 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112671968 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    112671968 (MAPK8)
   05231 Choline metabolism in cancer
    112671968 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112671968 (MAPK8)
   05212 Pancreatic cancer
    112671968 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112671968 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    112671968 (MAPK8)
   05161 Hepatitis B
    112671968 (MAPK8)
   05171 Coronavirus disease - COVID-19
    112671968 (MAPK8)
   05162 Measles
    112671968 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112671968 (MAPK8)
   05169 Epstein-Barr virus infection
    112671968 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112671968 (MAPK8)
   05135 Yersinia infection
    112671968 (MAPK8)
   05133 Pertussis
    112671968 (MAPK8)
   05152 Tuberculosis
    112671968 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    112671968 (MAPK8)
   05142 Chagas disease
    112671968 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112671968 (MAPK8)
   05012 Parkinson disease
    112671968 (MAPK8)
   05016 Huntington disease
    112671968 (MAPK8)
   05017 Spinocerebellar ataxia
    112671968 (MAPK8)
   05020 Prion disease
    112671968 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    112671968 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112671968 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    112671968 (MAPK8)
   05415 Diabetic cardiomyopathy
    112671968 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    112671968 (MAPK8)
   04936 Alcoholic liver disease
    112671968 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    112671968 (MAPK8)
   04931 Insulin resistance
    112671968 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112671968 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    112671968 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:clud01001]
    112671968 (MAPK8)
Enzymes [BR:clud01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     112671968 (MAPK8)
Protein kinases [BR:clud01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   112671968 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH DUF530
Other DBs
NCBI-GeneID: 112671968
NCBI-ProteinID: XP_025322091
Ensembl: ENSCAFG00020025053
LinkDB
Position
28:396447..484019
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagattccacattt
acagtcttgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaaactaagccggcca
tttcagaatcagactcatgctaaacgggcttacagagagctagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggacgcaaatctttgccaagtgattcag
atggaactagatcatgaaagaatgtcctacctgctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcccagtaatatagtggtaaaa
tcagactgcactttgaagattcttgactttggactggccaggactgcaggaactagtttt
atgatgacaccttatgtagtgactcgctactacagagcacctgaggtcatcctagggatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgccctgaattcatgaagaaactacagccaacagtaaggacttatgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccccgatgtacttttc
ccagctgactcagaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgttggtaattgatgcatctaaaaggatctctgtagatgaagctctccagcacccatat
atcaatgtctggtatgatccttctgaagcagaagctccaccaccaaagatacctgacaag
cagttagatgaaagggaacatacaatagaagagtggaaagagttgatatacaaagaagtt
atggacttggaggagagaaccaagaatggagttatacgggggcagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcgtcatcatctgtcaatgatgtgtct
tcaatgtcaacagatccaactttggcctcagatacagacagcagtttagaagcatcagct
ggacctctgggctgctgtagatga

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