KEGG   Canis lupus dingo (dingo): 112673608
Entry
112673608         CDS       T08371                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
clud  Canis lupus dingo (dingo)
Pathway
clud00562  Inositol phosphate metabolism
clud01100  Metabolic pathways
clud04015  Rap1 signaling pathway
clud04020  Calcium signaling pathway
clud04022  cGMP-PKG signaling pathway
clud04062  Chemokine signaling pathway
clud04070  Phosphatidylinositol signaling system
clud04071  Sphingolipid signaling pathway
clud04072  Phospholipase D signaling pathway
clud04081  Hormone signaling
clud04082  Neuroactive ligand signaling
clud04261  Adrenergic signaling in cardiomyocytes
clud04270  Vascular smooth muscle contraction
clud04310  Wnt signaling pathway
clud04371  Apelin signaling pathway
clud04540  Gap junction
clud04611  Platelet activation
clud04613  Neutrophil extracellular trap formation
clud04621  NOD-like receptor signaling pathway
clud04713  Circadian entrainment
clud04720  Long-term potentiation
clud04723  Retrograde endocannabinoid signaling
clud04724  Glutamatergic synapse
clud04725  Cholinergic synapse
clud04726  Serotonergic synapse
clud04728  Dopaminergic synapse
clud04730  Long-term depression
clud04742  Taste transduction
clud04750  Inflammatory mediator regulation of TRP channels
clud04911  Insulin secretion
clud04912  GnRH signaling pathway
clud04915  Estrogen signaling pathway
clud04916  Melanogenesis
clud04918  Thyroid hormone synthesis
clud04919  Thyroid hormone signaling pathway
clud04921  Oxytocin signaling pathway
clud04922  Glucagon signaling pathway
clud04924  Renin secretion
clud04925  Aldosterone synthesis and secretion
clud04926  Relaxin signaling pathway
clud04927  Cortisol synthesis and secretion
clud04928  Parathyroid hormone synthesis, secretion and action
clud04929  GnRH secretion
clud04933  AGE-RAGE signaling pathway in diabetic complications
clud04934  Cushing syndrome
clud04935  Growth hormone synthesis, secretion and action
clud04961  Endocrine and other factor-regulated calcium reabsorption
clud04970  Salivary secretion
clud04971  Gastric acid secretion
clud04972  Pancreatic secretion
clud04973  Carbohydrate digestion and absorption
clud05010  Alzheimer disease
clud05016  Huntington disease
clud05017  Spinocerebellar ataxia
clud05022  Pathways of neurodegeneration - multiple diseases
clud05142  Chagas disease
clud05143  African trypanosomiasis
clud05146  Amoebiasis
clud05163  Human cytomegalovirus infection
clud05200  Pathways in cancer
clud05415  Diabetic cardiomyopathy
clud05417  Lipid and atherosclerosis
Module
clud_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:clud00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    112673608 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    112673608 (PLCB4)
   04310 Wnt signaling pathway
    112673608 (PLCB4)
   04371 Apelin signaling pathway
    112673608 (PLCB4)
   04020 Calcium signaling pathway
    112673608 (PLCB4)
   04070 Phosphatidylinositol signaling system
    112673608 (PLCB4)
   04072 Phospholipase D signaling pathway
    112673608 (PLCB4)
   04071 Sphingolipid signaling pathway
    112673608 (PLCB4)
   04022 cGMP-PKG signaling pathway
    112673608 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    112673608 (PLCB4)
   04081 Hormone signaling
    112673608 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    112673608 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112673608 (PLCB4)
   04613 Neutrophil extracellular trap formation
    112673608 (PLCB4)
   04621 NOD-like receptor signaling pathway
    112673608 (PLCB4)
   04062 Chemokine signaling pathway
    112673608 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    112673608 (PLCB4)
   04922 Glucagon signaling pathway
    112673608 (PLCB4)
   04929 GnRH secretion
    112673608 (PLCB4)
   04912 GnRH signaling pathway
    112673608 (PLCB4)
   04915 Estrogen signaling pathway
    112673608 (PLCB4)
   04921 Oxytocin signaling pathway
    112673608 (PLCB4)
   04926 Relaxin signaling pathway
    112673608 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    112673608 (PLCB4)
   04918 Thyroid hormone synthesis
    112673608 (PLCB4)
   04919 Thyroid hormone signaling pathway
    112673608 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    112673608 (PLCB4)
   04916 Melanogenesis
    112673608 (PLCB4)
   04924 Renin secretion
    112673608 (PLCB4)
   04925 Aldosterone synthesis and secretion
    112673608 (PLCB4)
   04927 Cortisol synthesis and secretion
    112673608 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112673608 (PLCB4)
   04270 Vascular smooth muscle contraction
    112673608 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    112673608 (PLCB4)
   04971 Gastric acid secretion
    112673608 (PLCB4)
   04972 Pancreatic secretion
    112673608 (PLCB4)
   04973 Carbohydrate digestion and absorption
    112673608 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    112673608 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    112673608 (PLCB4)
   04725 Cholinergic synapse
    112673608 (PLCB4)
   04728 Dopaminergic synapse
    112673608 (PLCB4)
   04726 Serotonergic synapse
    112673608 (PLCB4)
   04720 Long-term potentiation
    112673608 (PLCB4)
   04730 Long-term depression
    112673608 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    112673608 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    112673608 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    112673608 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    112673608 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112673608 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    112673608 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112673608 (PLCB4)
   05142 Chagas disease
    112673608 (PLCB4)
   05143 African trypanosomiasis
    112673608 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112673608 (PLCB4)
   05016 Huntington disease
    112673608 (PLCB4)
   05017 Spinocerebellar ataxia
    112673608 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    112673608 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112673608 (PLCB4)
   05415 Diabetic cardiomyopathy
    112673608 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    112673608 (PLCB4)
   04934 Cushing syndrome
    112673608 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:clud04131]
    112673608 (PLCB4)
Enzymes [BR:clud01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     112673608 (PLCB4)
Membrane trafficking [BR:clud04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    112673608 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    112673608 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 112673608
NCBI-ProteinID: XP_025325111
Ensembl: ENSCAFG00020027572
LinkDB
Position
24:complement(12890853..13313285)
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAIFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAAMGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSV
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcctttttgcaagaagga
gccatttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtgcta
gaatgctccctcatcaacagtattcgattgggagccaccccaaaggatcccaaaatcttg
gccgctcttgaggctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtc
tgcagtggcacagatctggtgaacatcagtttcacatacatggtggctgagaatccagaa
gtaactaagcaatgggtagaaggattgagatcaatcatacataacttcagagccaacaat
gttagtccaatgacctgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagtcaggagtattactagaacgtttgcgtcggggaaaacagaaaaa
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cctgcagcatttacttatgagaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc
ccattttatgatgcaaaaagggcaatgcagatcatcgagatgtatgagcctgatgaagat
ttgaagaaaaaaggcctcatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccaccctctggcc
cactacttcatcagttcttcacataacacctatctcactggccgacagtttggtgggaaa
tcttcagtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgttgggacggaaaaggtgaagaccaagaaccaataataactcatggaaaagctatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcatttgtcacatcc
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgtgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggcccttaccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaggttgaaaaaaaacagctcgaggctttgaaaagcatg
atggaagctggagaatctgctgccccagttagcatcctagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccctgaatacaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaggctgttgcaaatagtgtcaagaaggcgtcggat
gaccttgaacatgaaatcaacaaaaagggcctggttactgtagaagatgagcaggcatgg
atggcatcatataagtatgtaggtgctaccactaatatccatccatatttgtctacaatg
atcaactatgcacagcctgtaaagtttcaaggtttccatgtggctgaagagcgcaatatt
cattataacatgtcttcttttaacgagtccgttggtctaggctacttgaagacacatgca
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccgg
gttgattccagtaattacatgcctcaaattttctggaatgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgtgggtacctcctcaaaccagatttcatgagacggcccgatcgaacctttgat
ccattctctgaaacgcctgtcgatggggttattgcagccacttgctcagtgcaggtcata
tcaggtcagtttttatcagataagaagattggtacgtacgtagaagtggatatgtatggg
ttgcccaccgacactatccgtaaggaattccgaactcgcatggtgatgaacaatggactc
aatccagtttacaatgaagaatcatttgtgtttcggaaggtaatcctccctgacctggca
gtcttgagaatagcagtgtatgacgacaacaataggctgataggccagaggattcttcca
ctggatggcctccaagcaggctatcgacacatttcccttcgaaacgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagcgat
acttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaatgtgaccccacag
agcagctccgagctcagaccaaccaccacagcagccatggggtctggtgtggaagccaag
aaaggtatcgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ctgaagcacttaaagaagcaacagaaggagctaaattctttaaagaagaaacatgcgaag
gaacacagcaccatgcagaagttgcactgcacacaagttgacaaaattgtggcacagtat
gacaaagagaagtcgacacatgagaaaatcctagagaaggcgatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatagtggcccagcacacaaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagaaatccgggacctgcaccttagccagcagtgtgag
ctcctgagaaagctactgatcagtgcccatgagcagcagacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaacaaagcagaacgggaaaggcgagtcagg
gagttaaatagcagcaacaccaaaaagtttctggaagaaagaaagagacttgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctagagttcctagag
aaacagaatgagcagctattgaaatcctgccatgcagtgtcccaaacacaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtgtg
aaactccaaaatgcaaactga

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