KEGG   Canis lupus dingo (dingo): 112675721
Entry
112675721         CDS       T08371                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
clud  Canis lupus dingo (dingo)
Pathway
clud01521  EGFR tyrosine kinase inhibitor resistance
clud01522  Endocrine resistance
clud04010  MAPK signaling pathway
clud04012  ErbB signaling pathway
clud04014  Ras signaling pathway
clud04015  Rap1 signaling pathway
clud04022  cGMP-PKG signaling pathway
clud04024  cAMP signaling pathway
clud04062  Chemokine signaling pathway
clud04066  HIF-1 signaling pathway
clud04068  FoxO signaling pathway
clud04071  Sphingolipid signaling pathway
clud04072  Phospholipase D signaling pathway
clud04114  Oocyte meiosis
clud04140  Autophagy - animal
clud04148  Efferocytosis
clud04150  mTOR signaling pathway
clud04151  PI3K-Akt signaling pathway
clud04210  Apoptosis
clud04218  Cellular senescence
clud04270  Vascular smooth muscle contraction
clud04370  VEGF signaling pathway
clud04371  Apelin signaling pathway
clud04380  Osteoclast differentiation
clud04510  Focal adhesion
clud04540  Gap junction
clud04550  Signaling pathways regulating pluripotency of stem cells
clud04613  Neutrophil extracellular trap formation
clud04620  Toll-like receptor signaling pathway
clud04650  Natural killer cell mediated cytotoxicity
clud04660  T cell receptor signaling pathway
clud04662  B cell receptor signaling pathway
clud04664  Fc epsilon RI signaling pathway
clud04666  Fc gamma R-mediated phagocytosis
clud04668  TNF signaling pathway
clud04720  Long-term potentiation
clud04722  Neurotrophin signaling pathway
clud04725  Cholinergic synapse
clud04726  Serotonergic synapse
clud04730  Long-term depression
clud04810  Regulation of actin cytoskeleton
clud04910  Insulin signaling pathway
clud04912  GnRH signaling pathway
clud04914  Progesterone-mediated oocyte maturation
clud04915  Estrogen signaling pathway
clud04916  Melanogenesis
clud04917  Prolactin signaling pathway
clud04919  Thyroid hormone signaling pathway
clud04921  Oxytocin signaling pathway
clud04926  Relaxin signaling pathway
clud04928  Parathyroid hormone synthesis, secretion and action
clud04929  GnRH secretion
clud04934  Cushing syndrome
clud04935  Growth hormone synthesis, secretion and action
clud05010  Alzheimer disease
clud05022  Pathways of neurodegeneration - multiple diseases
clud05034  Alcoholism
clud05132  Salmonella infection
clud05135  Yersinia infection
clud05160  Hepatitis C
clud05161  Hepatitis B
clud05163  Human cytomegalovirus infection
clud05164  Influenza A
clud05165  Human papillomavirus infection
clud05166  Human T-cell leukemia virus 1 infection
clud05167  Kaposi sarcoma-associated herpesvirus infection
clud05170  Human immunodeficiency virus 1 infection
clud05200  Pathways in cancer
clud05205  Proteoglycans in cancer
clud05206  MicroRNAs in cancer
clud05207  Chemical carcinogenesis - receptor activation
clud05208  Chemical carcinogenesis - reactive oxygen species
clud05210  Colorectal cancer
clud05211  Renal cell carcinoma
clud05212  Pancreatic cancer
clud05213  Endometrial cancer
clud05214  Glioma
clud05215  Prostate cancer
clud05216  Thyroid cancer
clud05218  Melanoma
clud05219  Bladder cancer
clud05220  Chronic myeloid leukemia
clud05221  Acute myeloid leukemia
clud05223  Non-small cell lung cancer
clud05224  Breast cancer
clud05225  Hepatocellular carcinoma
clud05226  Gastric cancer
clud05230  Central carbon metabolism in cancer
clud05231  Choline metabolism in cancer
clud05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:clud00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112675721 (MAP2K1)
   04012 ErbB signaling pathway
    112675721 (MAP2K1)
   04014 Ras signaling pathway
    112675721 (MAP2K1)
   04015 Rap1 signaling pathway
    112675721 (MAP2K1)
   04370 VEGF signaling pathway
    112675721 (MAP2K1)
   04371 Apelin signaling pathway
    112675721 (MAP2K1)
   04668 TNF signaling pathway
    112675721 (MAP2K1)
   04066 HIF-1 signaling pathway
    112675721 (MAP2K1)
   04068 FoxO signaling pathway
    112675721 (MAP2K1)
   04072 Phospholipase D signaling pathway
    112675721 (MAP2K1)
   04071 Sphingolipid signaling pathway
    112675721 (MAP2K1)
   04024 cAMP signaling pathway
    112675721 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    112675721 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    112675721 (MAP2K1)
   04150 mTOR signaling pathway
    112675721 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112675721 (MAP2K1)
   04148 Efferocytosis
    112675721 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    112675721 (MAP2K1)
   04210 Apoptosis
    112675721 (MAP2K1)
   04218 Cellular senescence
    112675721 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112675721 (MAP2K1)
   04540 Gap junction
    112675721 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    112675721 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112675721 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    112675721 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    112675721 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    112675721 (MAP2K1)
   04660 T cell receptor signaling pathway
    112675721 (MAP2K1)
   04662 B cell receptor signaling pathway
    112675721 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    112675721 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    112675721 (MAP2K1)
   04062 Chemokine signaling pathway
    112675721 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112675721 (MAP2K1)
   04929 GnRH secretion
    112675721 (MAP2K1)
   04912 GnRH signaling pathway
    112675721 (MAP2K1)
   04915 Estrogen signaling pathway
    112675721 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    112675721 (MAP2K1)
   04917 Prolactin signaling pathway
    112675721 (MAP2K1)
   04921 Oxytocin signaling pathway
    112675721 (MAP2K1)
   04926 Relaxin signaling pathway
    112675721 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    112675721 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    112675721 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    112675721 (MAP2K1)
   04916 Melanogenesis
    112675721 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    112675721 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    112675721 (MAP2K1)
   04726 Serotonergic synapse
    112675721 (MAP2K1)
   04720 Long-term potentiation
    112675721 (MAP2K1)
   04730 Long-term depression
    112675721 (MAP2K1)
   04722 Neurotrophin signaling pathway
    112675721 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112675721 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112675721 (MAP2K1)
   05206 MicroRNAs in cancer
    112675721 (MAP2K1)
   05205 Proteoglycans in cancer
    112675721 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    112675721 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    112675721 (MAP2K1)
   05230 Central carbon metabolism in cancer
    112675721 (MAP2K1)
   05231 Choline metabolism in cancer
    112675721 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112675721 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112675721 (MAP2K1)
   05212 Pancreatic cancer
    112675721 (MAP2K1)
   05225 Hepatocellular carcinoma
    112675721 (MAP2K1)
   05226 Gastric cancer
    112675721 (MAP2K1)
   05214 Glioma
    112675721 (MAP2K1)
   05216 Thyroid cancer
    112675721 (MAP2K1)
   05221 Acute myeloid leukemia
    112675721 (MAP2K1)
   05220 Chronic myeloid leukemia
    112675721 (MAP2K1)
   05218 Melanoma
    112675721 (MAP2K1)
   05211 Renal cell carcinoma
    112675721 (MAP2K1)
   05219 Bladder cancer
    112675721 (MAP2K1)
   05215 Prostate cancer
    112675721 (MAP2K1)
   05213 Endometrial cancer
    112675721 (MAP2K1)
   05224 Breast cancer
    112675721 (MAP2K1)
   05223 Non-small cell lung cancer
    112675721 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112675721 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    112675721 (MAP2K1)
   05161 Hepatitis B
    112675721 (MAP2K1)
   05160 Hepatitis C
    112675721 (MAP2K1)
   05164 Influenza A
    112675721 (MAP2K1)
   05163 Human cytomegalovirus infection
    112675721 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112675721 (MAP2K1)
   05165 Human papillomavirus infection
    112675721 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112675721 (MAP2K1)
   05135 Yersinia infection
    112675721 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112675721 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    112675721 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    112675721 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    112675721 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112675721 (MAP2K1)
   01522 Endocrine resistance
    112675721 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:clud01001]
    112675721 (MAP2K1)
Enzymes [BR:clud01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     112675721 (MAP2K1)
Protein kinases [BR:clud01001]
 Serine/threonine kinases: STE group
  STE7 family
   112675721 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 112675721
NCBI-ProteinID: XP_025328198
Ensembl: ENSCAFG00020008392
UniProt: A0A8C0QXB7
LinkDB
Position
30:30915947..30993806
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDVAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctcggcggtg
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgatgagcagcagcggaagcgccttgaggcctttctcacccagaagcagaaggtc
ggggaactgaaggatgacgacttcgagaagatcagtgagctgggtgctggcaacggtggc
gtggtgttcaaggtctcccacaagccgtccggcctagtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctacaggttctacatgag
tgcaactccccgtacatcgtgggcttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattctaggaaaagttagcatcgctgtaataaaaggtctgacatacctg
agagagaagcacaagattatgcacagagatgtcaagccttccaacatcctcgtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcattgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tccgtgcagtcggacatctggagcatggggctctctctggtggagatggcagttgggagg
tatcccatccctcctccggatgccaaggagctggagctgatgtttgggtgccaagtggag
ggagacgtggctgagaccccacccagaccaaggaccccgggaagaccccttagctcttat
ggaatggacagccgaccgcccatggcaatttttgagctgttggattacatagtcaacgag
ccccctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaacccagcagagagagcagatctgaagcaactcatggttcatgccttc
atcaagagatctgacggtgaagaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacgccgacccacgcagctggcgtctaa

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