Canis lupus dingo (dingo): 112676192 Help Entry 112676192         CDS       T08371                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism clud  Canis lupus dingo (dingo) Pathway clud04020   Calcium signaling pathway clud04371   Apelin signaling pathway clud04713   Circadian entrainment clud04921   Oxytocin signaling pathway clud04970   Salivary secretion clud05010   Alzheimer disease clud05012   Parkinson disease clud05020   Prion disease clud05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:clud00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112676192 (RYR3)    04020 Calcium signaling pathway     112676192 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     112676192 (RYR3)   09154 Digestive system    04970 Salivary secretion     112676192 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     112676192 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     112676192 (RYR3)    05012 Parkinson disease     112676192 (RYR3)    05020 Prion disease     112676192 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     112676192 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:clud04040]     112676192 (RYR3) Ion channels [BR:clud04040]  Voltage-gated cation channels   Ryanodine receptor    112676192 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  112676192 NCBI-ProteinID:  XP_025329120 Ensembl:  ENSCAFG00020008970 LinkDB All DBs Position 30:complement(1331089..1841904) Genome browser AA seq 4864 aa AA seqDB search MAEGAEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLHGHAVLLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSICFVQHMAS GLWVTYKAQDAKNPRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPIALPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGTAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQSLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHINPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFIGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRVD GTVDSPPCLKVTHRTFGAQSGGASMVYCRLSMPVECHSSFSHGPCPDGDAVHKRKQMQEI LSPTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLHSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWCGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQEDLMHFHYH TLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLAHAKE RKLMMKNEYIIPITSTTRKIRLYPDESKRHGLPGVGLRTCLRPGFRFSTPCFVVTGEEHQ KQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDSSVFGEHGAETEDGTEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED TSWTGKLRALVYKIKGPPKPEKKQPIEEEERYPTTLKELISQTMIRWAQEDQIQDAELVR MMFTLLQRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVMEDSEDEEIVHMG NAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSL NKDGSISEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTV SLSTTEAALALNRYLCSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLTKAQ RDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLMNHYEQCWKYYCLPS GWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRI SAMLEKQISVDADGNFDPKPINTTNFSLPEKWEYIVTKYAEHSHDKWACDKSQNGWKYGI SLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEALAQQRENE KLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGS HPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGILVSRGMKDMELDASSMEKRFAYKFLK KILKYVDSAQEFIAHLEAIISSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSP LKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVM KSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILT SIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAI PVAFLEPTLNRYNPLSVFNTRTPRERSILGMPDTVEEMCPDLPQLEGLMKEISDLAESGA RYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTRVTSEHLSVILGNILKIINN NLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEEQLKADTKG DTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPNADSDQLFRMVAEVFILW CKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERRKTKRRGDLYSIQTSLI VAALKKMLPIGLNMCTPGDQELISLAKARYGARDTDEEVKEHLRNNLHLQEKSDDPAVKW QLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAV VACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKEEEEEEEETE KQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKEKTFEEK EMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKM LDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQ NDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWY YSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVF ANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVE MILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAE ADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEP YLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVN FCEDTIFEMQLASQISESDSADRPEEEEEEDEDSSYMLEIEGEEEDSKSLESASAFAMAC ASVKRNVANFLKKATLKNLRKQYRKVKKMTVKELVKVFFSFFWMLFLELFRLFFAILGGI FQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAMDSERAEVTEPGITPELIH FVKAEKGDTDIMSDLFGFHPKKEGGLKHGPEVGLGDLSEIIGKDEPPTLESTVRKKRKAQ AAEMKAAHDAEGKVEPEKMDLEDGEKEDMAKEEEQAEAPWAEVTKKKKPRRGQKVEKPEA FMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDIA NLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKVPLVVFK REKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLY GAERIAELLGLDKNALDFSPVEENKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLA WYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTV VAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYR IVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPH GFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYE DQLG NT seq 14595 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggggcagaaggaggcgaggacgagatccagttcctgcggactgaagatgag gtggttctccagtgcatcgcaaacgtccacaaggagcaacggaagttctgcctggcggcc gagggacttgggaaccgcctgtgcttcttggaacccacgtcagaagccaagtacgttcct ccagatctctgtgtctgcaattttgtgctggaacagtccctctctgtgagagccctgcag gagatgcttgccaacacaggtgaaaatggtggtgaaggggcggcccaaggcgggggccac cggacgctgctgcacggccacgcggtcctcctgcggcactccttcagcggcatgtatcta acttgtttgaccacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaacatgctacaggagaagcctgttggtggaccatacatcccgcttccaaacagagatcc gagggagagaaagttcgaattggtgatgacctcatccttgtcagcgtgtcctctgaaaga taccttcatctctcagtatcaaatgggaacatacaagtggacgcctcttttatgcaaaca ctctggaatgtacaccctacgtgctcaggaagtagcattgaagaaggatacctacttggt gggcacgtggtacgtctcttccatggtcatgatgagtgtttgacgataccatctacagac cagaatgattcccagcacaggaggatattctatgaagctgggggagctgggacgcgagcc agatctctgtggagagtggaaccccttcggataagttggagtggcagtaacatcagatgg ggccaggctttccgactccggcatctcacgacaggccactacctggccttgacagaggac caaggccttatactgcaggaccgggcaaagtcggacaccaagtccacagccttctctttc cgggcttccaaggaaatcaaggagaaattggattccagtcacaaacgagatatagaaggc atgggtgttccagaaatcaagtatggagattccatctgctttgtccagcatatggccagt ggtctgtgggtgacctacaaagcacaagatgccaagaacccccgccttggacctctgaag agaaaggtcattctccatcaggaaggccacatggatgatgggttaacactgcagagatgc caacgtgaggagtcccaggctgctcggatcatccggaacacgaccgccttattcagccag tttgtaagtggaaacaatcgcacagctgcccccatcgctctgcccatagaagaggtcctg cagaccttacaggacttgattgcctactttcagcccccagaggaggagatgcagcatgaa gacaagcagaacaagctccgctcactcaagaacagacagaacctttttaaggaagaagga atgttggcccttgtgttaaactgcatcgatcgcttgaatatctataacagcgtagcacac tttgcggggattgcaagggaggagagtggcacggcttggaaagagatcctgaaccttctg tacaaactgctggctgctctcattcgtggaaacagaaacaactgcgcccagttctctaat aaccttgattggctcatcagcaaattggacagactagaatcttcctcaggtattttggaa gttttgcactgcatcttgattgaaagcccagaagccttaaatctgatagcagagggccac atcaagtccatcatctccctgttggataagcatgggcggaatcacaaggttctggatgtg ctgtgctccctctgtctctgcaatggggtcgcagtcagagccaaccagaatctgatttgt gacaacttgctgccccggagaaacctgctcctgcagacacggctgattaatgatgtgaca agcattcggcccaacatcttcctgggagttgctgagggctctgcacagtacaagaagtgg tacttcgagctaatcatcgaccaggtggaccctttcctaacagctgagcccacacacctg cgggtgggctgggcctcttcctcaggctatgctccgtaccctggcggaggagaagggtgg ggaggcaatggtgttggcgatgacctgtactcctatggctttgatggacttcacctttgg tcaggccgcatacccagagccgtagcctccatcaaccagcacctcctgagatcagacgac gtggtgagctgttgccttgacctcggagtgcccagcatctctttccgcatcaacgggcaa cctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttctctgcaggtgtcaaagtgcgtttcctgatgggtggacgtcatggcgaatttaagttc ctgcctccatctggctacgcaccttgctatgaagccttacttccgaaagaaaagatgaga ctggagcctgtcaaagaatataaacgtgacgctgaaggagtcagagatctgctgggtacc acccagtccctctctcaagcctctttcatcccgtgtcccatagacaccagtcaggtggtt ttgccacctcacctagaaaagatccgagacagactggctgaaaacatccacgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga caacacccctgtcttgtggagttttcaaagctgcctgaaactgagaagaattataaccta caaatgtcaactgaaaccttaaaaaccctcctggcccttgggtgccacatcgctcatatt aatccagctgctgaggaggacctcaagaaggtcaaattgcccaaaaactatatgatgtcc aacggctataaaccagcccctttggacttgtctgatgtgaagctgttaccgcctcaagaa attttagtagataagcttgcagaaaacgcacataacgtttgggccaaagacagaataaag caaggatggacctatggcatccaacaggatttgaagaacaaaagaaatccccggctggtg ccatatgcattactggatgagcgtaccaagaagtccaacagggacagccttcgtgaagct gttcgcacgtttattggttatggctataacattgagccatctgaccaagaactagctgac ccagctgtggagaaagtcagcatagacaagattcgatttttccgggtagagcggtcttac gcagtaagatctggaaagtggtattttgagtttgaggtggtgacaggaggagacatgcgc gtcggctgggccaggccaggctgtcggcctgacattgagctgggggccgatgaccaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaaggcagtgggtattttggacgt acatggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcaatgatc ttcacactgaatggggagctgctgatcaccaacaaaggctctgaacttgccttcgctgat tatgagattgagaatggctttgtgcccatctgctccctgggactgtctcagatcggccgc atgaatctcgggatggatgccagcaccttcaagttttataccatgtgtggccttcaagag ggctttgagccttttgctgtcaacatgaaccgcgatgttgcaatgtggttcagcaagcgc ctcccgacgtttgtcaacgtgccaaaggatcatccacatatagaggtggtgagggtggac ggcaccgtggacagccccccctgcctcaaggtgacccacaggacgttcggcgcgcagagc ggcggcgccagcatggtctactgccgcctgagcatgcccgtcgagtgccactcctcgttc agccacggcccctgtccggacggcgacgcggtccacaagaggaaacagatgcaagaaata ctctctcctacaacaacgcagtgctactatgcaatccgcatctttgctggacaggacccc tcctgcgtctgggtcggttgggtcactccagactatcacttacacagtgagaagtttgac ctgaataagaactgtacagtgactgtgactctaggggatgagcgaggccgagtccatgaa agtgtaaagcgcagcaactgctacatggtctggtgtggggatattgtggccacttcccaa agatcaagtcggagcaacgtggacctggagatcggctgccttgtggatctggcgatgggc atgttgtctttctccgccaatgggagagaacttggcacctgctaccaggtggagcccaat accaaagtgtttccagcagtcttcctgcagcccacgagcacctccttgtttcagtttgaa cttgggaagctgaagaacgcgatgcccctgtcggcggccatatttaagagtgaagagaag aacccagttccacagtgtccccctcggctggacgtccaaaccatccagcccgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacagagcgggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatcccagaggagaac aggtgtgtggatgttctagagctctgcgagcaggaggacctgatgcacttccattaccac acgctgcgcctctacagtgccgtgtgcgccctgggaaacagccgagtggcctacgccctg tgtggccacgtggacctgtcccagctcttctatgccatagacaacaagtacctccctggc ctcctccgctccggtttctatgacctgctcatcagcatccacctggcccatgctaaggag aggaagctaatgatgaagaatgagtacatcattcccatcactagcaccactaggaaaatc cgcctgtacccagatgagtccaagaggcacgggctacccggagtgggcctcagaacatgc ctcaggccaggattcaggttctccaccccttgctttgttgtgactggcgaggagcaccag aagcagagccctgagatccccttggagattctcaagacaaaggcactgagcatgctgacg gaggcagtgcagcacagcggggctcatatccgggaccccgtcggcgggtctgtagagttc caatttgtgcctgtgctgaaactcatcgggaccctgctggtcatgggggtgtttgatgat gatgacgtccggcagatcctcctcctgattgattcctctgtgtttggggagcatggtgca gagacagaggatggcacagagaaggaagaggtgacccaggtggaggagaaggcagtggag gctggggaaaaggccagcaaggaggctccggtcaagggcttgttgcagacccgactgcca gagtccgtcaagcttcagatgtgcgagctcctcagctacctctgcgactgtgagctacag catcgagtggaagccattgtggcgttcggcgacatttacgtctccaaactccaggcaaat cagaagttccgctacaatgagctcatgcaggccttgaacatgtctgcagccctgactgcc cggaagaccagggagttccgctcacctccacaggagcagatcaacatgcttcttaacttt caactgggagagaattgcccctgcccagaggagatccgggaggagctatatgacttccat gaggaccttctcattcactgtggagttccactggaggaggaggaagaagaggaggaggac acctcctggactgggaaactccgtgccttggtgtataaaatcaaaggccctcccaagcct gagaagaaacagccgatagaagaggaggagagataccctacaaccttgaaggagctcatc tcacagaccatgatccgctgggcccaagaggaccagatccaggatgcggagttggtccgg atgatgttcaccctcctgcagaggcagtacgacagcattggggagctgctgcaagccctg cggaagacctataccatcagtcaggcctccgtgagcgataccatcaatctgctggctgcc ctgggccagatccgctgcctcctcagtgtcaggatgggcaaggaagaggagctgctcatg atcaatgggctgggagacattatgaacaataaggtgttttaccagcaccccaacctcatg agagtccttggcatgcacgagacggtgatggaggtgatggtgaacgtgttgggtgcagag aagtcccagattgcttttccaaaaatggttgctagctgctgccgcttcctttgctatttc tgtcgaatcagccggcaaaatcagaaggccatgtttgagcatctaagttacctgctggag aatagcagtgttggcttagcatccccttcaatgagaggatctaccccactggatgtggca gcttcctctgtgatggacaacaacgagttagcgctgggcttggaggaaccagatcttgag aaggtggtaacctacttggcaggctgtggcctgcagagctgccccatgcttctagccaaa ggataccctgatgtcggctggaaccccattgaaggggaacgttacctgtccttcttgagg tttgccgtctttgtgaacagtgaaagtgtggaagaaaatgctagtgtcgtggtcaagctg ctcatcagacgcccagagtgcttcgggccagccctgcgaggtgaaggaggaaacggccta ttggcagctatgcagggcgccattaagatctctgagaacccggctctcgacctcccctct cagggatacaagagagaagtcatggaggacagtgaggatgaagagatcgtgcacatgggc aacgcaattatgtccttttattcagctcttatagatctcctgggtcgttgtgctcctgaa atgcatcttatccagacgggaaagggggaagccatccggatcaggtcaatcctgcgctcc ctggtccccaccgaggacctggttgggatcatcagcatccccttaaagctgccctctctg aacaaagatgggtccatcagcgagccagatatggcagccaacttctgccctgaccacaag gctcccatggtgctgttcttggatcgtgtttatggcattaaggatcagacttttctgctc cacttgctagaggttggatttttacccgacttaagagcttctgcctctctagatacagtt tccctaagcaccacggaggctgcgcttgcactcaataggtatttgtgttctgctgtgctc ccgctcctcacaagatgcgccccgctctttgccggaacagaacactacacttctttgatc gattctacactacagacaatatataggctttccaagggacggtccctcaccaaagctcag agggacaccatagaagaatgtttgcttgctatttgcaatcacttgaggccttccatgtta cagcaactcttgcgacgtctggtttttgatgtgccgcagctcaacgaatactgcaaaatg cctcttaagcttctgatgaatcactatgaacagtgctggaagtactactgcctgccttca ggatgggggagctatggtctagctgtggaagaagaactgcacctgaccgagaagctcttc tgggggatttttgactctctctcccataagaagtatgacccagaccttttccgaatggcc cttccttgtctcagtgctatcgctggggccctgccaccggattacttagataccagaatc tcggccatgttggagaaacagatctcagtggatgcagatggcaactttgaccccaaaccc atcaacaccacgaatttctccttgcctgaaaaatgggaatacatcgtcaccaagtatgct gagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaagtacggaatt tccctggatgaaaacgtgaagacccatccactcataaggccttttaagacattaacagaa aaggagaaggagatttaccgctggcctgccagagagtctctgaaaaccatgctggctgtg ggctggtctgtggagaggaccaaagagggagaggccctggctcaacagcgggaaaatgag aaacttcggagcgtgtcccaggctagccagggcaacagctacagccctgcccccctggat ctctccaacgtggtgctttccagagagctccaggggatggtggaagtcgtggctgaaaac tatcacaacatctgggccaagaagaagaagctggaactggagagcaaaggtggcggcagt caccctctgttggtgccatatgacaccttgacagccaaggagaagttcagggaccgggag aaggcacaggacctgtttaaattcctccaagtgaacggcatcttggtttctagaggtatg aaggatatggagctggatgcctcctccatggaaaagaggtttgcctataaatttttgaag aagatcctgaaatatgttgattctgcccaagagtttattgcccatttggaagccattatc agcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaagtt ctcctcccgctcgttgaccagtacttcaccaatcaccgcctctacttcctgtcatcccct ctgaagccccttagcagcagcggctatgcctctcataaggagaaagaaatggtggccagc ctcttctgcaaactcgctgctcttgttcgacacaggatttccctctttgggagcgattct acaacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtcatg aagtcaggctcagagctggtgaaggctgggttacgagcattctttgaaaatgctgcagaa gacttagagaagacttcagaaaatctgaagctcgggaagtttacccattccagaacacag attaaaggcgtgtctcaaaatattaactataccacggtggctctgctccccatcctgaca tccatctttgagcatgttgctcagcatcagttcggggtggatttactcttaggtgatgtg caaatttcatgctaccacatactgtgcagcctctactcccttgggactggaaagaatatc tatgttgaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgccata ccagtagcattcctggaacccacccttaaccgctacaatccactctcagtcttcaacacc agaacccccagggagaggtctattctggggatgccggacacagtggaagagatgtgcccc gacctccctcagctggaaggcctgatgaaggaaatcagtgacctggccgagtcaggggcc cgatacacggagatgccccacgtcatcgaggtgatcttacccatgctctgcaactacctg tcctactggtgggagcgggggcctgagcacctgccccccagcacaggcccctggtgcacc agggtcacctctgaacacctcagtgtcatcctgggaaacattctaaaaatcatcaacaac aatctgggcatcgatgaggcatcctggatgaagcgcattgcagtgtacgcccagccaatc atcagcaaagcacggccagacctgctgaagagccacttcatcccaactctggagaagctg aagaaaaaggctgtcaagactgtgcaggaggaggagcagctgaaagccgacaccaaagga gacacccaagaggcggagctcctcatcttggacgagtttgcagtcctctgcagagacctc tatgccttctaccccatgctgattcgctacgtggacaacaacagatctaactggctcaaa agtcccaatgctgattctgaccagctcttccgcatggtggctgaggtcttcatcctgtgg tgcaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaaattaat aatttggcatttttaactggagacagcaaaagcaagatgtcaaaatctggaggccaggac caggaacggaggaagaccaagcggaggggagacttgtattccatccagacctctctcatc gtggccgcgctcaagaagatgctgcccattggtttgaatatgtgcacaccgggcgatcag gagctgatctcccttgccaaggcccgctacggcgctagggacacggatgaagaggtgaag gaacatctgcggaacaacttgcacctgcaggaaaagtctgatgacccagcagtaaagtgg cagctgaacctctacaaagatgttttaaagagtgaagaaccgttcaatccagaaaagact gtagaacgtgtacagagaatttcagcagctgtcttccacctggagcaggtggaacagcct ttgagatccaagaaggcggtctggcacaaactgttgtcaaagcagcggaaacgggcagtg gtggcctgtttcaggatggcccctctctataacctgcccaggcaccgctccattaacctc ttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaagagaaa ctagtacaggatttggctaaatcccccaaggaggaagaggaggaggaggaggagacagaa aagcaaccagacccacttcatcagattattctccattttagccgcaatgctctcacggag aggagcaaattggaagacgaccccttgtacacatcctattccagcatgatggccaagagt tgtcagagcggggaggatgaagaagaggaggaagacaaggaaaaaacatttgaagagaaa gaaatggaaaagcagaaaactctctatcaacaagcacggctgcatgagcgtggagctgca gagatggtccttcagatgataagtgccagcaaaggtgagatgagccccatggtggttgag actctgaagctggggatcgccattctgaatggtggcaacgctggtgtacaacagaaaatg ctagattacctaaaggagaaaaaggatgctggattctttcaaagcctgtctggtcttatg cagtcttgcagtgtccttgatttgaatgcctttgagaggcagaataaagctgaaggcctg gggatggttactgaggaaggaacactcattgttcgagagcgtggtgaaaaagtactccag aatgatgagtttacacgagacctctttagattcctgcagttactttgtgaaggacataac agtgactttcagaacttcctacggactcagatgggcaataccaccactgtaaacgtcatc atcagtaccgtggactacctcctacgtctacaggagtcaatcagtgatttctactggtat tattcagggaaggacatcattgatgaatctggacagcacaatttttccaaagctctggca gtcacgaagcagattttcaattctcttacagaatacatccagggcccttgcattgggaac caacaaagcctggctcacagcaggctgtgggacgcggtggtcggcttcctccatgtattt gctaacatgcagatgaaactctctcaggattccagtcagatcgagctgctgaaggaactc ttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtggta aatggaactattggcaagcagatggttgacacactggtagaatcatctaccaatgtagaa atgatcttgaaattctttgacatgttcttgaaacttaaagacctcaccagctcagacacc ttcaaagaatatgacccagatggtaaagggattatctccaaaaaagagttccagaaggcc atggaagggcaaaaacagtacacacagtcagagattgactttctcctttcatgtgcagaa gctgatgagaatgatatgtttaattacattgattttgtagaccggttccatgagccggcc aaggacatagggtttaatgtggcagtgttactgacgaatctctccgaacatatgccaaat gattctcgcctgaagtgtctgttggacccagcagaaagtgtactaaattactttgaaccc tacctgggacgtattgagatcatgggaggggccaagaaaattgagcgcgtttattttgaa atcagtgaatccagtcgaactcaatgggagaagccccaagtgaaggaatctaagcggcag ttcatctttgatgtggtcaatgaaggtggagagcaagaaaagatggaactgtttgtgaac ttctgtgaggataccatttttgaaatgcagttagcatctcagatctctgaatctgactca gctgacagacccgaagaagaggaggaagaagatgaagattcatcttatatgttagaaatt gagggtgaggaggaggacagcaagtctctcgagtctgcctctgcatttgccatggcctgt gcctcagtgaagagaaatgttgccaactttctgaagaaggcaaccctgaagaacctcagg aagcagtacaggaaggtgaaaaagatgactgtgaaggagctggtgaaggtgtttttctct ttcttctggatgttgtttctggagctgttccggttgttcttcgccatattgggaggaatc tttcagatcctctggaacacagtgtttggagggggcctagtggaaggggcaaagaacatc agagtgaccaagatcctgggtgatatgcctgacccaacccaatttggtatccatgatgat gccatggattctgagagggcagaggtgactgagccaggtattacacctgaattgattcac ttcgtgaaggctgaaaagggagacacagatatcatgtcagatctctttggattccaccca aagaaagaaggtggcttaaagcatgggcctgaagtgggtttgggtgacctctctgagatt attggcaaggatgagccacctacactagagagtactgtacggaagaaaagaaaagcacag gcagcagagatgaaagcagcacatgatgcagaaggaaaagtggaacccgagaaaatggac ctagaagatggggagaaggaggatatggccaaagaggaagaacaggccgaggccccgtgg gcagaagtgacaaagaagaagaagccacggcggggccagaaagtcgagaagcctgaagcc ttcatggctaatttcttcaaagggctggaaatctatcagaccaagttactgcattacctg gccaggaatttctacaacctgaggttcctcgctctgtttgtcgccttcgctatcaacttc attctgctcttttacaaggttactgaagaacctctagaagaagagacagaggacattgca aatctgtggaattcctttaatgatgaagaagaagaagaagcgatggtgttctttgttctg caggagagcactgggtatatggcaccgacgttgcgggctttggccattatccacaccatc atctctttggtctgtgtggtgggctattactgcctgaaggtccctctggtggtattcaaa agggaaaaagaaattgccaggaagctggagttcgatggcctgtacatcactgaacagcca tctgaagatgacatcaaggggcagtgggaccgcctggtaatcaacacaccatctttccct aataactactgggacaagtttgtcaagagaaaggtgatcaacaagtatggagatctctac ggagcagaacgcattgcggaactcctaggtttggacaaaaatgcccttgatttcagccca gtcgaagagaacaaagcagaggcggcctctcttgtgtcatggctgagctccattgacatg aagtaccatatctggaaactgggagttgttttcaccgacaactcgtttctctaccttgcc tggtacacaaccatgtcagtcctgggccactacaacaacttcttttttgctgctcatctg ctggacatcgcaatgggcttcaagacgctgaggactattctgtcatctgtaactcacaat ggcaaacagctggtcctgaccgtgggtctcctggctgtggtggtctacctctacaccgtg gtggccttcaacttctttcgcaagttctacaacaagagtgaagatgatgatgagccggac atgaagtgtgacgacatgatgacgtgttacctgttccacatgtacgtgggagtgcgagcc gggggcggcatcggtgacgaaattgaagaccccgccggtgacccctacgaaatgtaccgc attgtcttcgacatcacgttcttcttctttgtcatcgtcatcctgctggccatcattcaa ggtctcatcatcgacgcctttggagagctgagagaccagcaggaacaagtgcgcgaggac atggagactaagtgcttcatctgcgggattggcaacgactactttgacacgactcctcat ggcttcgagacacacaccttacaggagcacaacttggccaactatctgttcttcctgatg tatctgattaataaagatgaaacggaacacacgggtcaggaatcttatgtctggaagatg taccaagaaaggtgttgggatttcttcccagctggtgactgctttcggaaacagtatgaa gatcagcttggataa

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