Cyclopterus lumpus (lumpfish): 117744291 Help Entry 117744291         CDS       T09199                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism clum  Cyclopterus lumpus (lumpfish) Pathway clum04020   Calcium signaling pathway clum04260   Cardiac muscle contraction clum04261   Adrenergic signaling in cardiomyocytes clum04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:clum00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117744291 (ryr2b)    04020 Calcium signaling pathway     117744291 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     117744291 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     117744291 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:clum04040]     117744291 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:clum04990]     117744291 (ryr2b) Ion channels [BR:clum04040]  Voltage-gated cation channels   Ryanodine receptor    117744291 (ryr2b) Domain-containing proteins not elsewhere classified [BR:clum04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    117744291 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 EF-hand_8 Motif Other DBs NCBI-GeneID:  117744291 NCBI-ProteinID:  XP_034408378 Ensembl:  ENSCLMG00005018671 LinkDB All DBs Position 15:8167729..8223401 Genome browser AA seq 4943 aa AA seqDB search MADTGEGDDEFQFLRTGDEVVLQSSFTSQEEHVKLCLAAEGFGSRLCRLEPTSNCKNVPP DLSVCGFVMAQCLSVRALQEMLAHSEHLAAESQVEAGGSHRTLLYGQAVLFLHSYSGMYL SCLSSSHASTDKLAFDVGLQEDKAGEACWWTVHPASRQRSEGEKVRVGDDLILVNVSSER YLHLSFGTALDNKSLSESLIVNAAFQQTLWSVAPICSGGGVAQGYLKGDDTLRLLHSHSD ACLTIPSTEQGEELQRIMHYETGSVSSHARSLWRLEILRVVWSGRHACWGQPFRLCHVTT GRYLGLTEEKGLHLVDRDKADINTTSFCFRSSKEKLDTGTKTHIDGMGIPEIKYGDSICY VQHVESGLWLTYQAIDAQSTRMGWAQRKAILHSEGHMDDGLTLSRCQREESHTARLIRSA TLLFTRFIRKLESFRQQGNLTSVSLPMEKVTCSLQDLIHYFQPPLEGLGHEAKQNNMTAL KNRQNMFQEEGVIDLVLDCIDRLHQYSSVSQSDRGEEWVHILNNLYELLAALIRGNRLSC AHFSTSLDWLISRLDRVEASCGVLEVLHCVLVESPEALNVIKEGHILSIISFLDKHGCNH KVLEVLCSLCVCHGVAVRSNQNLICDNLLPGRDLLLQTRLANQATSMRPNIFLALGEESA QHRRWYYELVVDHVDSFLTSEPTHLRVGWASSEGYQPKPTGGEGWGGNGVGDDLYSYGFD GLHLWSGCVGRRVSSPFPHLLKEDDVVSCCLDIRATCISFRVNGQPVQGMLENFSAYGLL YPVVSFSAGVKVRFLFGGQHGEFRYLPPPGFASCSDALLPRVKLKLEPCQKYILDRGEGT QELIGPLVPVTPLTFTPTPVDISKVVLPPQLEDIREKMAENIHELWTMDRIDLGWTHGPV RDEVKRHDQCLVEFSKLSDQEKNQNLQVTQDTLRTLIALGFHIGLTDDHTEESVKYMRLS NKYEQPGGYRPVPVDSSQVFLSPAHEEVVNLLAENDHNVWARERIKQGWTYGAQQDVKVK RSPYLVPYSLLDERRRRVGRESVREAVCTLLVYGYSLEPLNQERTTLSIACLFSTEKCRV FRPDKSYSVTRGKWYFELEIVTAGNMRVGWARPGCTPDKELGSDNQAFVFDGFEAQWYHQ GVEPLGRRWQSGDVAGCLVDVAERTMIVTLNGEVLFNERGSELAAKDFDIRDGLLPVVSV GVNQVGRLNLGHQVSSLQYFTVCGLQEGYEPFAVNMARDPALWMSWKQPQFTSIQPDDQN LQVTRVSGSKDSLSSLRVSQRLFAHQGGGSEMGFYRLSMSIECEAVLTSPAGGVLPVASR RKEQEEVDSDFEVLMKSAHSFAGSRDELNHKDHSHDKTSRLKQRFMLKRTKPELVGSNSS ARLLEDVVVDKDNYDHLLQSSRYHYSVRVLPGQQPFNVWAGWVTSDFHQHDMTFDPDGIL TVTVTLGDDSGKVQESVKRCNCYMVCAGEATGLSQSRRSTGLEIGCLIDTATGLLTFTSS GVEMTTFYQVEASTKLFPAVFVKPTTSNMFQFEMGRMKNVMPLSAGLLHSQRRNATPQCL PRLQVQHLNPVSWIRVPDRALKVTVDRPDERHGWRVQCHEPLQVMTLHIPDENRSVNILE LSELDDLLTFHHHTLLLYCSLCALGNTRVCHALCSHVDQSQILHAIQNPHLPGPLRSAFY QLLTQVHLSSHTTACHMMNHEYIVPMTDQTREITLYPSPVNGENGLPPEGISSNSLSTSL KPQMHFSSPCFVRSDGMEGDGTGDITCTDSPEIPLDMLKNLTVEMLTAGVWAVGQGVRDP VGGSIELLLVPLIRLFYTLLVMGVFGDEDLGKVLRLIEPGVFSIDAGTIVKEEEEEEEEE EEAASDDDKESKGGHKKEDYTLKQGLLQMKLPEAVKLELCHLLSYLCDCQVRHRVEAVVA FSDNFVGQLQENQRFRYNQVMQALNMSAALTARKTKEFRSPPQEQINMLLRFREKEQQEN CPCPVEVQQLLQDFHHLLRTHCGIELDSDTEDEEDAEMSLKDRLLSLVARVIGLMKTPIE VEGSRPQSTSKCIHSLKTLISETMVRWAQETEMEDPELVRAVFSLLHRQYQGLGGQMTQH LCRAYTISQASVEDTMALLSSLSQIRSLLSVRMGKEEERLMIRRLGDIMNNKVFYQHPNL MRALGIHETVMEVMVNVLGEGESKEITFPKMVASCCRFLCYFCRISRHNQGALFDHLSYL LENSSVGLASPSMRGATPLDVAAASVMDNNELALALREPNLEKVVQYLAGCGLRSCPMLV AKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENAYVVLRLLIRRPECFGPALQGDEGN GLLAAMEEAIRISEDPSMDGPLTASQSNRTLDVVQDNDDDLIHMGHAIMTFYSALIDMLG RCAPEMHLIQRGKGEAIRIRAILRSLVPIQDLEGVISISFQIPSVSQGGLEVEPDLSTVF CPDHKAAVLLFLDRVYGIENPSFLLHLLEVGLLPDLQAAVSLDTAELGSTDMALALNRYL CTSVLPLLTKCSALLCPLEDRALLVDSLIQVIYNLSRALSLTKAQRDTIEECLLAVCSEL QPSMMQPLLRRLVFDVPHLTEHSKMPLKLLTGHYEQRWKYYSLAGGPDDHGLASEEELHL SRKLFWGVFKALAKKPYEAQLFRLAVQCLAAVAMALPPDHMDCASHPERKASMDIEGTFD PQPVNTSNVSVPERLEFVVNKYAEHTHEKWSLDKFANGWVHGEQLCENTKVHPLLKPYRA VAEKEKEAYRWAIKETIKSMLAFGWTIERTKEGDAFGTHTCTHRVSQSGQLSFEGASTFS PKPMDMSSITLSWDQCAMAEQLAENYHNAWAKRRKLELESKGGGGHSMLAPYDTLTAKEK NKFRERAKDILKFLQLNGYTVWRDRKTVETDFPATANCFGYTLLQRLLSHTEDAQEHMLE LEVMQARGQMSKGEKAPQQQAIHFFPKVILPLLEQFVKSHCLYFLSTSLCSRSYASKKEK EMIASLFCKLAALVRHRISLFGNEVSSIASCLHVLSRALDVRSLMNSAPESIQASLHSFF EAAATDLEMTVENLSVTLVCLPQSRNQSARGVAKVLGFTTAVLLPTLTSLFQHLGNQNYG VDLLVGSIQLSCYRILNSLLSLGTSSSIYMEGQRTAAGACLAALAGTFPVCFLEPSLNQD NPYSIYNTMTASQREDHGLPDQVEDMCPLLPSLEQALGEVEKLAGAGAGARQAHYIQVTE VTLPMLCSYVSRWWYWGPEGQPDSPICTSVTPQHASDLLGHILRIIHNHVGASQGDWMKQ LAVFSQPITCKAGTELLKSHFLPLMEKLRKRAKCVLLEEEQMKAAGCDTSEAELQIQEKF TVLVRDLYAFYPLLIPFVDSNRASWLKQLNPDAEQLFSMVAEVFTFWAKSHNFKWEEQNF VVQNEINNLAFLVNNNMSKLSTVVEFDHEQRRMKRKGDRYSTHTSLIVASMKRLLPVGLR VCFPSDYSLIVLAKSGFTQKNTRDEIREHISNRLIHLQNQASDCLRQETLHAEHLSQLGA VPDAQKTVNRILEVAQVLYFLDQVDHPQRSKKPAWHKVLSKQRKRAVVACLRMAPLYNLP RHRAVNLFLQGYNKSWISAEDHNFEEKLVEDLAVSDGEEKKNVEESAKPIDPLLQLITHF SRSALMEKCVKLEHDGLYKSYAAIMAKSCHREDDDDEEQEVESFEEKEMEKQKLLYQQAR LHRRGASEMVLQTISSSKGAMGSMIAPTLKLGIAVLNGGNAAVQQRMLDYLREKQDVGFF QSMAGLMRSCSVLDLNAFERQNKAEGLGMAKDESSGEKVMPDKDVTCDLFRFLQLLCEGH NSDFQNYLRTQTGNNTTVNIIITTVDYLLRVQESISDFYWYYSGKDVIDAHGQQNFSKAI EVAKQVFNTLTEYIQGPCSGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSRQIELLKE LMDLQKDMVVFLLSMLEGTVVNGTIGKQMVDMLVESSGNVKMILRFFDIFLKLKDLTSSD AFKEYDPDHKGCISRKDFQKAMENCKRFSQSEIHFLLSCMKTNDSDIVDYEAFVDRFHEP AKDIGFSIAVLLTNLSEHMPNDSRLQAFLELAECVLTYFQPYLGRIEILGGGKRIERVYF EISESSRTQWEKPQVKESKRQFIFDVITEGGEKEKMEMFVNFCEDTIFEMQLAAQISGSD TGERYADKGAEEKSEDEDLGNKGMFPLHHCFLLLISLLSVNNLKTLMKMTLKDILMSAVL LFRFILMAQVRCLRAIIGSISYVLYMAFISGGLIEGAKRMRMSDLLGGILEPTLDEVMEV PSGVGQLRKYSASFSSQRELREMGHVAAVTSPREMDGLSDIFGLKVKKEGGQYRLITHLT ASLTDLFNTTSNTISSADISEKHQATEDKNSDETMPELQNTKGKETEKKTVKEKAEARWK VEGYNKSEEPESQHSAFWEKIITHNKSLLNYFARNFYNMRLLALFVAFAINFILLFYKVA SLPVSREEEGVVTSVDNDGLDSAGSDHNKGGDYFVLEESSGYMEPSLRFLAVAHTIISFC CIIGYHCLKVPLVIFKREKDVARKLEFDGLYVIEQPPEEDIKGQWDRLVINTPSFPSNYW DKFVKRKVMDKYGDFYGCEKISELLGLDRAGLDFSSERNERRRLKRQAAWSALFNSVDMK YQVWKLGVVFTDNSFLYLAWYMAMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNG KQLALTVGLLAVVVYLYTVVAFNFFRKFYNKSDDKDTRDMKCNDMLTCYMFHMYVGVRAG GGIGDEIDDPAGDDFEVERIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDM ETKCFVCGIGSEYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMY QERCWEFFPVGDCFRKQYEDQLG NT seq 14832 nt NT seq  +upstreamnt  +downstreamnt atggccgacaccggagagggcgatgacgaattccagtttctacgaacgggagacgaggtg gtgttgcagagtagcttcacctcccaggaggaacatgtgaaactctgtcttgcagcagag ggatttggcagcaggctctgccggcttgagcccacttccaactgcaagaatgttccccca gacttgtcagtctgtggcttcgtcatggcccagtgtctctctgttcgagccctgcaggag atgctggcccatagcgagcacctggctgcagagtcacaggtggaagctggaggaagccat cgcacccttctatatggccaggcagtgctgttcctacactcctacagtggcatgtatctc agctgcttgtcctcatctcacgcttcaacagacaagctggcttttgatgtcggtttgcaa gaggataaagcaggcgaggcttgttggtggactgtccacccagcctccagacagaggtca gaaggggagaaagtgcgagttggagatgacctcatactagtcaatgtatcctcggaaaga tatctgcacttgtcctttggcactgcattggacaacaaaagcttgagtgaaagcctgatt gttaatgcagccttccagcagactctctggagtgttgctcccatttgctctggtggtggg gttgctcaaggatacctgaagggggacgacacattgcggctactccacagccatagtgac gcatgtctgactatcccgtccacagagcagggagaggaactgcaaaggataatgcattat gagactggatcagtttccagccatgcccgctctctctggaggctggagattctgcgagtt gtttggagtggcagacatgcctgctgggggcagcctttccggctctgccatgtgactact gggcggtacctgggccttacagaggagaaaggcctgcatctggtcgaccgagacaaggct gatatcaacacaacctccttctgctttcgatcatcaaaggagaagcttgacactggcacg aagactcatattgatggcatggggatcccagagatcaaatatggagactccatctgttat gttcagcatgtagagtctgggctctggctcacctaccaagctattgatgcccaatctaca cgcatgggatgggctcagcgaaaggccattttgcacagcgagggtcacatggacgatggg ctgacgctgtctcgttgtcagagggaagaatctcacactgccagactcatccggagtgct actctcctcttcactcgctttatcaggaaactggagagttttagacaacaaggaaacctc acatctgtcagcctgccaatggagaaagtgacatgtagtctgcaggatctaatacactat ttccagcctccattggagggccttggccatgaagcgaaacagaacaacatgacagcactg aagaatcggcagaacatgtttcaagaagagggtgtgatagatttggtcctagattgtatt gaccgtctacaccaatatagtagtgtctctcagagtgacagaggagaagagtgggtgcac atcctcaacaatttatacgagttactggctgctctgatccgaggaaaccgtctgagctgt gcacatttctcaacttctctcgactggctgattagcaggctagaccgtgtggaggcctct tgtggagtcttggaggttctacactgtgtcttagtggaaagtcctgaagcactcaacgtc atcaaagaaggacacattctttctatcatctcttttctagacaagcatggatgcaaccac aaggtgctggaggtgctatgctccctgtgtgtgtgtcatggtgtcgctgtgcgatccaat cagaacctcatctgtgacaacctgctgccaggcagagacttgctgcttcaaacacgtctg gctaatcaggccacaagcatgagacccaacatctttctggctctgggcgaagaatcagcc cagcatcggaggtggtactatgagcttgttgtagatcatgtcgactccttcctcacatcc gagcccacccatctgcgtgttggctgggcaagctctgagggctaccagcccaagcccaca ggaggggaaggctgggggggcaatggagtgggagacgacctctactcgtatggctttgat gggcttcacctctggtcaggctgcgtgggccgcagggtgagctctcccttccctcacctg ctgaaagaagacgatgtggtcagctgctgccttgacatcagagctacctgcatctccttc cgagtcaacggtcagcctgtgcagggcatgttggagaacttcagtgcttacggacttctc taccccgtggtcagcttctctgcaggagtcaaggttcgttttctgtttgggggacagcat ggagagtttcgctacctgcccccaccaggttttgcttcgtgctctgacgctctgctcccg agagtcaagctgaagttggagccatgtcagaaatacatcttggatcgtggagaggggaca caagagctcattggccccttagtacctgtaactccattgacctttactcccacaccagta gacatcagcaaggtggtattgcccccacaacttgaggatatcagagaaaaaatggctgag aatatccatgaactctggacaatggataggattgatcttggatggacacatggacctgtg agagatgaagttaagcggcatgatcagtgtctggtggagttctccaagctgtcggaccag gagaagaaccaaaaccttcaagtgactcaggacaccctcaggactctcattgcccttggt ttccacattggtttgactgatgaccacacggaggagagcgtcaaatacatgagactatcc aacaagtatgagcagcccggtggctatagaccagtcccagtagactcgagccaggttttt ctgagcccagcccacgaggaagtggttaacttgttggcagagaatgatcacaatgtatgg gccagagagcgcatcaagcagggatggacctatggagcccaacaggacgtgaaagtgaag cgtagcccgtatctcgtgccctacagcctccttgatgaaaggaggaggagagtgggaagg gagagtgtcagagaggctgtctgtacgctgctggtttacggttacagcttggagcctctc aaccaggaacggaccacattatcaatcgcatgtctcttctctaccgagaagtgcagagtg tttcgaccagataaatcatactctgtgacccgggggaagtggtactttgaacttgaaata gtgaccgctgggaatatgcgagtgggctgggcccgaccaggctgcaccccggataaagag ctcggctcagataaccaggcattcgtcttcgatggatttgaggctcagtggtaccatcag ggcgttgagcccctgggacggcggtggcagagcggcgatgtggcgggctgcttggtggac gtggctgaacgcaccatgattgtcacgcttaatggggaggtgctgtttaatgaaagagga tcagagctggctgccaaggactttgatattagagacggcctgttgcctgtagtcagtgtg ggggtgaaccaggtgggaaggctgaacctgggccaccaagtgagctctctgcagtacttt actgtgtgtggcttgcaggagggatatgaaccctttgctgtcaacatggccagagaccca gccctgtggatgagttggaaacagcctcagtttacctccatacagcctgatgatcaaaac ctacaggtcaccagagtcagtggctcaaaggattccttatccagtctgagggtttctcag cggttgtttgcacaccaaggtggaggcagtgagatgggcttttaccggctcagcatgtcc atcgagtgtgaagccgtcctcactagccctgctggcggcgtgcttcctgtggcctccaga aggaaagagcaggaggaggtggactctgactttgaagtgctgatgaagtcagcccacagc tttgccggctcaagagatgagctcaaccataaggatcatagtcacgacaaaacatcaaga ttgaaacaacggttcatgcttaagaggacaaaaccagagctagtcggcagcaactcatct gcacgtcttctagaagatgtcgtagtcgataaggataactatgatcaccttctccagagc tccagatatcactactctgtgagggttcttccaggccagcagccatttaatgtgtgggca ggctgggtgacctctgactttcatcaacacgacatgacctttgaccctgacggcatcctc actgtgaccgtcacccttggagacgacagcggaaaagtccaggaaagtgtgaagcggtgt aactgttacatggtgtgtgctggagaggcaacaggcctgtcgcagagtcgcagaagtaca ggtttggaaattggctgtttaattgacacagcgactgggctgctcaccttcacctccagt ggagtggagatgaccaccttctaccaagttgaagccagtacaaagctgtttccggctgtt tttgtcaagcccactacgagcaacatgtttcagtttgagatgggacgcatgaagaatgtg atgccactgtcagcaggtttgcttcacagccaaagaagaaatgcaacccctcagtgtctt ccaaggcttcaggtccaacatctgaacccggtttcttggatcagagtaccagaccgggca ttaaaggtgacggtggatcggccagatgagcgccacggctggagagtccaatgccatgag cccctacaagtcatgacccttcatattcctgatgaaaacaggtctgttaacattttggag ctgtcggaacttgatgacctcttgacctttcaccaccacactctccttctctactgctct ttgtgcgcccttggaaacaccagagtttgccacgccctctgcagtcacgtggaccaatcc cagatccttcatgccattcagaatccccacctccctggcccccttcgctctgcattttat cagctcctcactcaggttcacctcagcagccacaccacagcatgtcacatgatgaaccac gaatatattgtgcctatgactgaccagaccagagaaatcacactgtatccaagccctgtt aatggggagaatggtctacctcctgaaggcatttccagcaatagtctcagcacatccctt aaaccacagatgcatttctcatctccttgctttgtcaggagtgatgggatggaaggagat ggaacaggggatataacctgcacagacagcccagaaatcccgctggacatgttaaagaac ctgactgtggagatgctgactgctggagtatgggctgtgggtcagggtgtgagggatcct gtagggggcagcattgagcttctgctggttcctctaataagactgttctacaccctactg gtaatgggggtgtttggagatgaggacctcgggaaggttctgagactgatagagccggga gtcttctccatagatgcaggaaccatcgtgaaggaagaggaagaggaagaggaggaggaa gaagaggcggctagtgatgatgacaaagaatccaaagggggccacaaaaaagaagattac accctgaaacaaggacttcttcaaatgaagcttcctgaagctgtcaaacttgagctctgc catctgctgtcctacctgtgtgattgccaggtgcgccacagggtagaagctgtggttgcg ttttctgacaactttgtgggtcagctgcaggagaaccaacgctttcgctacaaccaggtc atgcaagcactcaacatgtctgccgctctcaccgcccgcaagaccaaggagttccgctca cctccacaggaacagatcaacatgctgctgcgcttcagagagaaggagcaacaggaaaac tgtccgtgtccagtggaagtccaacagcttctccaagacttccatcaccttctcagaaca cactgtggcatcgagttggacagtgacacagaggacgaagaggatgcagagatgtctctt aaagaccgacttctcagtctagtagcgagagtcattggactgatgaagacaccaatagaa gtggaagggagtagaccgcagagcaccagtaagtgcatccattccctcaaaacgctgatc tctgagacgatggtgcgttgggctcaggagactgagatggaggaccctgaactggttagg gctgtcttctcattgctgcaccgccagtatcagggtctggggggccaaatgacacaacac ctctgcagagcctacacgatcagccaggcttcggtagaagacaccatggctcttctctcc tccctgagccaaatccgctcgctcctcagtgtccgcatgggaaaagaagaggagaggctg atgatcagaagactaggagacatcatgaacaataaagtcttctaccagcaccctaaccta atgagggcattggggatacatgagaccgtgatggaggtgatggtcaatgttcttggagaa ggggaatcaaaggagattacctttccaaagatggtggccagctgttgtcgattcctgtgt tatttttgccgcatcagccgtcacaatcagggagccctgtttgaccatctcagttatctg ctggaaaacagcagtgttggtctagcatcgccatccatgcgtggagccactcctctggat gtggcagcagcctctgtgatggataacaatgaactggccttagcgctgagggaacctaac ctggagaaggtggtacagtaccttgctggctgcggtctccggagctgtccgatgctcgtg gctaaaggctatcctgatattggatggaaccctgtggagggcgagcgttacctggacttc ttacgttttgccgtcttctgcaatggtgagagtgtagaggagaatgcttacgtggtgttg aggttactgattcgtcgacctgagtgttttggccctgcactgcaaggggatgagggaaat ggcctcctggcagccatggaggaagccatccgaatctcagaggacccttctatggacgga cctttgaccgcctcccagtccaacagaacactagacgttgtccaggacaatgatgacgac ctcattcacatggggcacgccatcatgaccttctactcggcccttatcgacatgctgggg cgctgtgctccagaaatgcatttgattcaacgaggcaaaggagaagctatccggatcaga gccatcctgaggtcgctcgtccccattcaggatcttgagggagtcatcagcatctccttt caaatcccctcagtgtctcaaggtggtctggaggttgagcctgacctgtctacagtgttc tgcccggaccacaaggcagcagtgcttcttttcctggaccgggtttacggcattgagaac ccgagctttcttctccacctactagaagttggcttgctgcctgaccttcaggcagcggtc tctcttgacactgctgaattaggatccaccgatatggccctggccctcaacagatacttg tgcacatctgttcttcctctgctcaccaaatgttcagcgcttctttgccctttagaggac cgcgctctcctggtggattctctcatccaggtcatctacaacctttccagggctctcagc ttgaccaaggctcagagagacactattgaagagtgtttgctagctgtgtgcagtgaactc caaccatctatgatgcagcctcttcttcgacgtcttgtcttcgatgttccccatctcaca gaacacagcaagatgccattaaagctcttgaccggtcactacgaacagaggtggaagtac tactcactagctggagggccggatgaccacggtttggcctctgaagaggagctccatctg tctagaaagttgttctggggtgtgtttaaggccctggcaaagaagccctacgaggctcag ttgttcaggctggctgtccagtgcctggctgcagtggccatggctctgccccctgaccac atggactgtgcgtcccatccggagagaaaggcctcgatggacatagaaggaacctttgac ccccagcctgtaaatacctccaatgtgtcagtgccagagagactggagtttgtagttaac aagtatgcagagcatactcacgagaagtggtcactggacaagtttgccaatggctgggtt catggggagcagctctgtgagaacaccaaggttcaccctctcctaaagccatacagggcc gtggctgagaaggagaaggaggcataccgctgggcaattaaagaaacaataaagagcatg ctggcctttggatggaccatcgagagaaccaaagaaggagatgcatttggcacgcatacc tgtacacacagagtatcccagtctggacagctgtcttttgaaggagcatcgaccttcagc cccaaacctatggacatgagcagcatcaccttatcatgggaccagtgtgctatggctgaa cagttggctgaaaactaccacaacgcctgggctaagaggaggaaattagaacttgagagt aaaggagggggtggccattcaatgctggcaccctatgataccctgactgccaaggagaaa aacaaattcagagagagagcaaaggatatcctcaagttccttcagctcaatggctacacg gtgtggagggatcggaagacagtggagacggactttccagccacagccaactgctttggc tacactctccttcagcggctgctgtctcacaccgaggacgcccaagagcacatgttggag ctggaggtgatgcaagccagaggacagatgtccaagggagagaaagctccacaacagcaa gcgatacatttttttcccaaggttattcttcctcttttggaacaatttgtgaagagccac tgtctgtatttcctgtccacttctctctgctcgagaagctatgcttcgaaaaaggaaaag gagatgattgcgagcctcttttgtaagctcgcagctctggtaagacacaggatttcactc tttggaaacgaggtctcatccattgcaagctgcctccatgttttgtctcgggctctggat gtcaggtcattgatgaactcagccccggagtctatccaagcatctctgcattcattcttt gaggcagccgccactgatctggagatgactgtggaaaacctgtctgtgactttggtctgt ttacctcagagtaggaatcaatcggctagaggagtagccaaggttctcggcttcacaacc gccgtcctccttcccaccctcacttccctctttcagcatcttggcaaccaaaactatggc gtggacctcctggtggggagtatccagctgtcctgttacaggatcctcaacagcctcctc tctcttggcaccagtagcagcatctacatggaggggcagaggacagcagcaggtgcttgt cttgcagccttggctgggacctttcctgtgtgcttcctagagccatccttaaaccaagac aatccttactccatctacaacaccatgactgcttctcaaagagaagaccatgggcttcca gatcaggtggaggacatgtgtcccctgctgccctctctggaacaggcgctgggggaagtg gagaagttggccggcgctggtgctggagctcgccaggcccactacatccaggtcacggag gtcactttgcctatgctgtgcagctacgtgtcccgttggtggtactggggccctgagggc cagccagacagcccgatctgcacatctgtcacacctcaacatgctagtgaccttcttggc cacatcctccgaatcatccacaaccatgtgggagctagccagggagattggatgaaacag ctggcagttttttctcagccaattacatgtaaagccggcactgagctgttaaagagccac ttcctgccactgatggagaagttgaggaagagggccaaatgtgtgctactggaggaggag cagatgaaagcagctgggtgtgatacctccgaagcagagttgcagatacaggagaagttc actgtactggtgcgagacctctacgccttctatcccctcctcatcccttttgtggattct aatcgagccagctggctgaaacaattgaaccctgacgctgagcagctgttcagcatggtc gcagaggtctttacattctgggccaaatctcataatttcaagtgggaggaacagaacttt gtggtacaaaatgaaatcaacaacttggctttcttggtcaacaacaacatgtccaagttg tcaactgttgttgaattcgaccatgagcagaggaggatgaagaggaagggggatcgttat tccactcacacctctctcattgtggcctccatgaagagactgctccctgtgggactcagg gtttgttttccaagcgattacagcctcatcgtgttagcaaagagcggctttactcagaag aacactcgagatgagattcgagaacacatttccaatcgtcttatacatcttcagaatcag gcatccgactgtttgcggcaggaaacccttcatgcagaacacctgagccagctaggggcc gtccctgacgcccagaagactgtaaacaggattctggaagtagctcaagtcctttatttc ctggaccaggtggaccatccgcagagaagtaaaaagcctgcgtggcacaaggtcttatcc aaacagaggaaacgagcagtggtggcctgcctgaggatggctcccctctacaacttaccc aggcacagagctgtcaacctgttcctccaaggctacaataaatcctggatatcggctgag gaccacaactttgaggagaagcttgtggaggatttggctgtgagtgacggagaggaaaaa aagaatgtggaagaaagtgccaaaccaatcgatcccctcctccaactcattacgcacttc agtcgaagcgccctgatggaaaagtgtgttaagcttgaacatgacggcctctataagtcc tacgctgccattatggccaagagctgccacagagaggacgatgatgatgaagaacaggag gtggaaagctttgaagaaaaggagatggagaaacagaagttgctgtaccagcaggccagg ctgcatcgccgtggagcttctgagatggtcctgcaaaccatcagctccagcaaaggggct atgggctccatgattgccccgacattgaagctcggtattgctgttctcaacggagggaat gctgctgttcaacagcgaatgctggattatctgagagagaagcaagacgttggcttcttt cagagcatggctggactcatgcggtcatgtagtgttctggacctgaatgcgtttgagagg cagaacaaagcggaaggattaggcatggccaaggatgagagctcaggagagaaggtgatg cctgacaaagacgtcacctgtgacctattccgtttcctacagctgctttgtgaaggacac aactcagatttccagaattacttgagaacacaaacaggcaacaacaccactgtcaacatc ataataaccactgtggactatttactgagagtgcaggagtccatcagtgacttctactgg tactactcagggaaggatgtgattgatgcacacggacaacaaaacttctccaaggccatc gaagtggccaaacaggtcttcaacaccctcactgagtacatacagggcccatgcagtgga aaccaacaaagcctcgctcacagtcgcctgtgggacgctgttgtgggtttcctccatgtc tttgcccacatgcagatgaagctctctcaggactcaaggcaaatcgagcttctgaaagag ctcatggatttacaaaaggacatggtggttttcctgctttccatgttagaaggtactgtc gttaatggaactattggaaagcagatggtggacatgttggtggaatcatcaggcaacgtg aagatgattctcaggttttttgacattttcctcaaacttaaagacctcacctcctcagat gccttcaaagagtacgaccctgatcacaagggttgcatctccaggaaggacttccagaaa gccatggaaaattgcaagcgtttctcccaatctgagatccacttcctcctctcctgcatg aagacaaacgatagtgacattgtggactatgaggcctttgtggatcgcttccatgagcct gccaaagacatcggcttcagcatcgccgttctcctcaccaatttgtccgaacacatgccc aacgattccagacttcaggcattcctggaactggcagagtgtgtcttgacgtacttccag ccctatctaggacgtattgagatcctcggcggcgggaagcgcattgaacgtgtctacttt gagatcagtgaatccagccgtacacaatgggagaagccgcaggtcaaagagtccaagagg cagttcatttttgatgtgatcactgagggtggagagaaggagaaaatggagatgtttgtc aatttctgcgaggacaccatctttgagatgcaactggcagcccagatatccggctccgac actggagagaggtatgctgataaaggagcagaagaaaagagtgaagatgaagatttgggc aacaaaggaatgtttcccctgcatcattgttttttattgctgatatctttattgtctgtc aacaacctgaagacattgatgaagatgaccctgaaggatatcctcatgtcagctgttctc ctcttcagattcattttaatggctcaggtccggtgtcttcgtgctataattggcagcatc tcatatgtactgtacatggcctttattagtggtgggctcatagagggagccaaaaggatg aggatgtcggacttgctcggtggcatccttgagccgactcttgacgaggtcatggaggtg ccaagtggtgtgggtcagctcaggaagtactctgctagtttctcttcccagagagaattg agggagatggggcatgtggcagctgtgacctcccccagggagatggatggactgtcagac atatttggcctcaaagtgaagaaggagggaggtcaatacagacttataacacacctcact gcaagtttgactgatctgttcaacacaacctccaacacgatatcctctgctgatatttct gagaagcatcaggccacagaggataaaaacagcgatgagacgatgcctgaattacagaat acaaaagggaaggaaactgagaagaaaactgtgaaagagaaagcggaggcaagatggaaa gtcgagggctataataagtcagaggaaccagagagccaacactccgccttttgggagaag ataatcactcataacaaaagcctgctgaattactttgcaagaaatttttacaatatgcgc ttattggctctgtttgttgcctttgcaatcaacttcatcctcctcttctacaaggtagca tccttgcctgtatcacgagaagaggaaggagtcgtcacatctgttgacaatgatggactg gactctgctggtagtgaccacaacaagggcggagattattttgtgctggaggagagcagt ggatatatggaaccgtcgctccgtttcctggcagtagctcacacaatcatctccttctgt tgtattatcgggtaccactgcctcaaggtaccattggtgatcttcaaacgtgagaaggac gtggcacggaagctggagtttgatgggctgtatgtgatagagcagccccctgaggaggac atcaaagggcaatgggaccgactggtcattaacacgccgtcatttccaagtaattactgg gataaatttgtgaagagaaaggtgatggataagtatggtgacttctacggctgtgagaag attagtgaactccttggtttggaccgagctggattagactttagctctgagaggaacgag agaaggagactcaaaagacaagctgcctggagtgctctattcaactccgtcgacatgaag taccaggtctggaaactaggagttgtgttcactgacaattccttcctgtacttggcctgg tacatggccatgtccgttctgggtcattacaacaacttcttctttgctgcccaccttctg gacatcgccatgggcttcaagacacttcgtaccatcctttcctctgtcacacacaatgga aaacagttggccctcacggtgggcctgttggcggttgtggtgtatctctacaccgttgtg gccttcaacttcttcaggaagttttacaacaagagtgacgacaaggacacccgagacatg aagtgcaatgacatgcttacctgctacatgttccacatgtatgtgggcgtgcgtgcgggc gggggcatcggtgacgagatcgacgaccctgctggagacgactttgaggtggaacgcatc gtcttcgacatcacgtttttcttctttgtcatcgtcatcctcctggccatcatccaggga ttgataattgatgcctttggggagctgcgtgaccagcaggagcaggtgaaagaagatatg gagaccaaatgttttgtctgtggaataggaagtgagtactttgatacagtccctcatggc tttgagactcacactctccaggagcacaacttggccaactatctattttttctgatgtac ctcattaacaaggatgaaactgaacacacagggcaggaatcctatgtgtggaaaatgtac caggagcgttgctgggaattcttccctgtgggagactgtttccgtaagcaatatgaggat caactgggatga

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