Columba livia (rock pigeon): 102091036 Help Entry 102091036         CDS       T02912                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism clv  Columba livia (rock pigeon) Pathway clv04020   Calcium signaling pathway clv04260   Cardiac muscle contraction clv04261   Adrenergic signaling in cardiomyocytes clv04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:clv00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102091036 (RYR2)    04020 Calcium signaling pathway     102091036 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     102091036 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     102091036 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:clv04040]     102091036 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:clv04990]     102091036 (RYR2) Ion channels [BR:clv04040]  Voltage-gated cation channels   Ryanodine receptor    102091036 (RYR2) Domain-containing proteins not elsewhere classified [BR:clv04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    102091036 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  102091036 NCBI-ProteinID:  XP_021151855 LinkDB All DBs Position Unknown AA seq 4973 aa AA seqDB search MGTIAKRDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVL EQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKSAQGGGHRTLLYGHAILLRHSYSGMY LCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSE RYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPS GEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITTGKYLSLL DDKSLLLTDKEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSICFIQHVDTG LWLTYQSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRSTVFLFNRF IRGLDALSKKAKSSTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLF QEEGMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNRKNCA QFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHGRNHK VLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISEGSAQ YRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSYGFDG LHLWSGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFF PVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREYKQDRSYTRD LLGPTISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRD DNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKN YQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRN PRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHAMKLDVCSGIMEKFRIFR TEKTYAVKTGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRWHQGN EHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGDGFLPVCSLGP SQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNHEHIE VMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAGGLPGSGLFG PKNDLEDYDADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEKPSRLKQRFM LRRTKPDYSMSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWITSD FHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGETMSPGQGRNNNGLEIGC LVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAG LFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQCLNPLQFMA LHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHVDESQLLYAI ENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKKHGLP GIGLSTSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQEGSLHVRDP VGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFKEAISQEDEADFSEKELS SDELKSEEGEEETRREQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIVAFSD DFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNDCPCPE EIRDQLLDFHEDLMTHCGIELDEDGTLDGNSDLTIRGRLLHLMEKVTYLKKKQTEKPVDD DDKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINS VSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHET VMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLA SPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLICKGYPDIGW NPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEA IQISEDPTRDGRSPSNGSSKTLEMEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIH AGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFCPDHKAAMVL FLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTR CAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQHLLR RLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFD ALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMVEKQSSMDSDGNFNPQPVDTSN ITIPEKLEYFINKYAEHSHDKWSMEKFANGWTYGETYSESAKVQPLMKQYKLLSEKEKEI YRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGYTPRAIDMSN VTLSRDLHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAKEKAKDREKA QDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRG KGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEKEMVTSLFC KLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRAFLDNAAEDLE KTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILDDVQVS CYRILASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYNTKNA RDRAVLNLPTSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVILPMLCSYMSHW WEHGPENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISK VKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARDLYAF YPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMS FLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELI ALAKNRFSMKDTEDEVRDIIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDSSDPEKTVE RVLDIANVLFHLEQRSACVGRGYFFWVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLY NLPRHRAVNLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPAEEDESLKRVDPLHQLIL LFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEK QKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYL KDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVITYERGEKVMQDDEF TCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGK DVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQ MKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILK FFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDEN ETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDSRLQTFLELSESVLNYFQPFLGR IEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCED TIFEMQLAAQISESDLNERSANKEENEKDKPEEQDPRMGFFSLMTMKSALVALKYNIVTL MKMLSMKSLKKQMKKVKKMTMKDMVMALFSSYWSVLMGLLHFAYSVVRGFFRIICSLLLG GSLVEGAKKIKVAELLANMPDPTQDEVRGEGEEGERKPTEAALPTEDLTDLRTLSDESDL LSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSIAPMPEVQEKVQEQVKEDEKEEKEE TKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVQESAFWKKIIAYQQKLLNY FARNFYNMRMLALFVAFAINFILLFYKVSTSAVTEEKDIPVVSADESTKLDSLESDNQRV IAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDG LYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDK AALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHY NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYN KSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFV IVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHN LANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14922 nt NT seq  +upstreamnt  +downstreamnt atggggacaattgcaaaaagggatgatgaggtggttctgcagtgcactgcaactgttcac aaggagcaacagaaattgtgtctggctgcagaaggatttggcaacaggctttgctttttg gaatccacatcaaattctaagaatgttccacctgatttgtccatctgcacctttgtgctg gagcagtctctgtcagtacgggccctccaggaaatgctggctaacacggaagaaaaggca gaagggctagttgatgtggaaaaatggaaatttatgatgaagtccgcacaaggcggtggc catcgaacgctcctctatgggcatgccatcctgctgcgccattcctacagcggcatgtac ctatgctgcctctctacatcccgatcttcaatggataagctggcatttgatgtaggattg caggaggacacaacaggtgaggcgtgctggtggaccatccatcccgcttccaagcaacga tcagaaggagaaaaagtgcgtgttggagatgaccttattttagtcagtgtctcttcagaa agatacttgcatctctcttacggcaatggtagcttacatgttgatgcagccttccagcag acactctggagcgtagcaccaatcagttcaggaagtgaagctgcccaaggatatctgata ggaggggatgttctgaggttattgcatggtcacatggacgaatgtttgacagtcccttca ggtgaacatggagaagagcagagaagaactgtccattacgaaggtggggctgtgtcaatt catgctcgttccctttggcgactagagactctaagagttgcgtggagtggcagccacatt agatggggacagccattcagactaagacatataacaacaggaaaatatttaagtctcctg gatgacaagagtcttcttcttacagacaaagagaaagcggatgtaaaatctacagcattc tgttttcggtcttccaaggaaaagttggacatagggacaagaaaagaggtggatggaatg ggagcacctgaaataaaatatggggattcaatatgcttcatacaacatgtagacacaggc ttatggctcacataccagtctgctgatgcaaagtctgtgagaatgggttccgtgcagcgg aaggcaataatgcaccatgaaggtcacatggatgatggtttaacattgtccagatctcag aatgaagaatcccgtacggcacgtgtcatccgtagtactgtcttcctcttcaacaggttt ataaggggccttgatgctctcagcaagaaagcaaagtcttccaccgtcgatttgcctatt gagtcagtcagtctgagccttcaggacttgattggctattttcacccccctgatgaacat ttggagcatgaagacaaacaaaacaggctccgagcactgaagaatcgccagaacctcttc caagaagagggtatgatcaaccttgttcttgaatgtattgatcgcttgaatgtatacagc agtgcagctcattttgcagatgtagctgggaaagaagctggagaagcatggaaatctatt ctgaattccttgtatgaattgctagccgctctgattcgagggaatcgtaaaaactgtgct cagttttctggatctcttgattggctgatcagcagattagaaagactagaagcttcttct ggaattctagaggttttacactgtgtgttggtggaaagcccagaagctctaaacattatt aaggaaggacatattaaatcaatcatctgtcttttggacaaacatggaagaaaccataag gttttggatgttttgtgttctctctgtgtttgtcatggagtagctgtgcggtctaatcaa catctaatctgtgataatcttctgccaggaagagatctgctcttacagacacgccttgtc aaccacgtgagcagcatgcgacccaacatcttcttggggattagtgaaggctctgcccaa tacagaaaatggtactatgaacttatggtggaccatctagagccctttgtgactgcagaa tcaactcacctacgagttggctgggcttcaacagagggctactcaccatatccaggtgga ggagcagagtggggaggaaatggtgttggtgatgacttgtactcctatggctttgatggt ctacatctgtggtcaggttgtgtagcacgaacagtaaattctcccaaccaacatctctta agaactgatgatgttattagctgctgtttggacctgagtgcacccagcatctctttccgg ataaatggtcagccggttcaaggaatgtttgagaatttcaacatagatggcctcttcttc ccagttgtcagcttctctgcaggaataaaggtacgttttttgcttggaggtcgtcatgga gagttcaagttccttcctccacctggatatgccccttgctttgaagctgttctgccgaaa gagaagctgaaagtggagcacagccgagagtacaagcaggatcgcagctatacaagagac ctgctgggtcccactatctctctctctcaagcagctttcactccagttcctgtagatacc agccagattgttttgcctccccacctggaaaggattagagaaaaattggcagaaaacatc catgaactttgggttatgaataagatcgaacttggctggcagtatggaccagttcgagat gacaacaaaagacaacacccatgcttagtggagttctcaaaattgccagagcaggaaaga aattataacttgcaaatgtcacttgaaacactgaaaacgttgctggcgttaggctgccat gttggcattgctgatgaacatgctgaagaaaaagtgaaaaaaatgaaactgccaaagaac taccagttgttaagtggatataagcctgctcccatggatctgagttttatcaagctgacc ccctctcaagaggctatggtggataaactagcagagaatgcgcacaatgtgtgggcaaga gaccgcataagacaaggctggacatatggtattcaacaggatgtgaaaaatagacggaat cctcgccttgtaccttatgctcttctggatgatcggacaaagaagtcaaacaaagacagt cttcgggaagcagtccgcacccttctaggctatggttaccacctggaagctcctgatcaa gatcatgcaatgaaactggatgtgtgcagtgggataatggaaaaattcaggatcttccgc acagaaaagacttatgcagtgaagactgggaagtggtactttgagtttgaggcagttact gcaggcgacatgagagttggctggaccaggccaggttgccttccagatcaggaacttggt tcagacgaagaagcttttgtttttgatggctttaaggcacagcggtggcatcaaggtaat gagcattttggccgctcttggttggcaggagatgttgttgggtgtatggttgacatgaat gagcacactatgatgttcactttaaatggtgaaatcctacttgatgactcaggttcagaa cttgcattcaaggactttgaggttggtgatggatttctacctgtgtgcagcctgggacca tctcaagtgggaagaatgaactttggaaaagatgtcagcactctaaaatatttcactatc tgtggcttacaggaagggtatgagccctttgctgttaatacaaatagagacatcaccatt tggctgagtaaaagactccctcagtttctaccagtgccacaaaatcatgaacatattgag gtgatgagaattgatggcaccatagacagctgcccctgcctgaaggtcacacagaagtcc tttggttcacagaacagtaaaacagacgtcatgttttttcgattaagcatgcccattgaa tgtgctgaggtgttctccagatcagctgcaggagggttaccaggctctggtctttttggc ccaaagaatgacttggaggattatgatgctgattctgattttgaggttctaatgaaaact gctcatggtcatctagttcctgaccggacagaaagagaaaaagatgcgacaaaaccagag ttaaacaaccataaagattatgttcaagaaaagccttcacgtcttaaacaaagatttatg ctcaggaggacaaagccagattatagcatgagtcactctgcacggcttactgaggatgta ctagcagatgatagggatgactatgattatttgatgcaaacttccacgtactattattca gtgaggatatttcctggtcaagaacctgctaacgtctgggtgggctggattacatctgac tttcaccagtatgatacaagctttgacttggacagagtgcgtactgtcacagttactctg ggagatgaaaaagggaaggttcatgagagtataaaacgcagcaactgctatatggtgtgc gcaggagagaccatgagccctggacaaggacgtaataataatggtctggagattggttgc ttggttgatgctgccagtggcctgctgacgttcacagctaatggcaaggaactaggcacg tattatcaggttgaacccagtacgaagttatttcctgctgtatttgctcaagctacaagc cctaatgttttccaatttgaactgggaagaataaagaatgtaatgccattatctgctggc ttattcaaaagcgaacacaaaaacccagtttctcaatgtcctccacgtctccatgtccaa tttctgactcatgtgctttggagcagagtgccaaaccacttcttgaaggttgatgtctct cggatcagtgaacgtcaaggctggatgatacagtgcctgaatcctttgcagttcatggcc cttcatattcctgaagaaaacagaacaattgatattttagagctgacagaacaggaagaa ttgctgaaatttcactaccataccctccgattgtattcagctgtttgtgctttaggcaac aatcgagtggcccatgctatgtgtagccatgtggatgaatctcagctcctgtacgctatt gagaacaaatatatgccaggattattacgcgcaggatattatgacttactcattgacatc catctcaatacctatgcaactgccaggttaatgatgaataatgaatttatagttccaatg acagatgagaccaagagtattactttgtttcctgatgaaaacaaaaaacatggcctccct ggtataggacttagcacttcattaaggccaagaatgcagttctcctctccgagttttgtt agcattagcagtgaatgctttcagttcagccctgaattccctctggaaatcttaaaggcc aaaaccatagagatgctgactgaagctgttcaggagggcagcctccatgtcagagaccca gttggaggttctacagaatttctgtttgtccctctcattaagctcttttataccctgcta attatgggaatcttccacaatggggatctgaaacacattttgcagttgattgagccccgg gttttcaaggaggcaataagccaggaggatgaagctgatttctcagagaaggagctgagt tcagatgagctcaagtcagaagaaggagaggaggaaaccagaagggagcaagtgccaaag gaaggactccttcagatgaaacttccagaacctgttaaattacagatgtgtcatctactc cagtacttgtgtgattgtcaagtacgacaccgaatagaagccattgtagcattttcagat gattttgtggccaagcttcaagaaaatcaacgcttccggtacaatgaagtgatgcaggcc ttgaacatgtctgctgccctgacagctagaaaaacaaaagaatttcgatccccacctcag gagcagattaacatgctgctgaactttaaagatgataagaatgattgtccttgccctgaa gaaattcgggatcaactcctggatttccatgaagacctaatgacacactgtggaattgaa ctagatgaagatggaaccttggatggaaacagtgatttaaccattagaggtcgcctccta caccttatggaaaaagttacatatctgaagaagaagcaaactgaaaagccggttgatgat gatgataagacatcctctactcttcagcagttgatttcagacacaatggtacgctgggcc caggagtcagtaatagaagacccggaattagtgagggccatgtttgtattgctacatcgc caatatgatggtattggtggcctcgttcgagccctgccgaagacctacaccataaatagt gtgtctgtggaagatacaatcaatcttctggcatcccttggccaaatccgttccttactg agtgtcagaatgggaaaggaggaagagaaacttatgattcgtggattaggagacatcatg aataataaagtattttaccaacatccaaatctcatgagagctttaggcatgcatgaaact gtcatggaagtgatggtaaatgttcttggtggaggagaatccaaggaaatcactttccca aagatggtggcaaactgctgtcgatttctctgttatttttgccgcatcagcaggcagaat caaaaagctatgtttgatcatcttagctacttattggaaaacagcagtgttggccttgcc tctccttctatgcgaggatcaactcctttagatgttgcagcagcctctgtgatggataac aacgaacttgcgctggctttaagggagcctgatttggagaaggttgttcgctacttggct ggatgcggattgcagagttgtcctttgttgatttgtaaaggatacccagacattggatgg aatccagttgaaggagagcgatatttggattttcttcgctttgcagttttttgcaatgga gaaagtgtagaggagaatgctaatgttgtagtcagactgcttatccgtcgacctgaatgt tttggtcctgctctaagaggagaaggaggcaatgggttacttgctgccatggaggaagct atacaaatatccgaagatccaacaagagatggacgttctccaagtaatggatctagtaaa acccttgaaatggaagaacaagaagatgacactattcacatgggaaatgcaatcatgacc ttttatgctgccttgattgatctcttaggacgctgtgcccctgaaatgcatctaatccat gctggtaagggggaagccattagaatcagatcaattcttcggtctttgattccgctggaa gatttggtgggagtaattagtattcctttccacatgccaaccatagctaaagatggtact gtggtggaacctgacatgtctgcggggttttgcccagatcacaaggcagccatggttttg ttccttgacagggtctatggaattgaggaccaggattttcttctacaccttcttgaagtt ggctttctgccagatcttcgtgctgctgcttctttagatacggctgctttgagtgctacg gatatggctttggctctgaatcgatacctttgcacagcagtcttgcctctgttgacccga tgcgctcctctttttgctggcacagagcaccacgcttccctcatcgattccttgttacat actgtgtacagactctcaaagggatgctctcttaccaaagctcagcgagattctattgag gagtgtttgctgtctatctgtgggcagttgcggccttccatgatgcagcatttgctgaga agattagtatttgatgttcctctattaaatgaacatgcaaagatgcctctcaagttgctg acaaatcattatgaaagatgctggaagtattattgtttgccaggtggatggggtaatttt ggtgctgcctcagaagaagaacttcatttatccagaaagttgttctggggtatttttgat gctttgtctcaaaagaagtatgaacaagaactgtttaaattggctttgccttgcttgagt gcggtagcaggggccttacctccagactatatggaatcaaattatgtcagtatggtggaa aaacagtcttcaatggattcagatgggaacttcaatcctcaacctgtcgatacatcaaac attacaatccctgaaaagctagaatatttcattaacaagtatgcagaacactctcatgac aaatggtcaatggaaaagtttgccaatggatggacatatggtgaaacatattctgaatct gcaaaagtgcaaccattaatgaaacagtataagttactatctgaaaaggagaaagaaatt tatcgatggccaatcaaagaatcgctgaaaactatgctggcatggggatggcgaattgaa agaacacgggagggagattccatggcactgtataaccggacacgtcgcatatctcaaact agtcaaatctctgtagatacagcccatggttacactcctcgagcaattgacatgagcaat gtcaccctctccagagacttacatgctatggctgagatgatggctgaaaactaccataac atatgggcaaagaaaaagaaaatggagcttgaagcaaaagtaggaggaggcaaccatcct cttcttgttccttatgatacactcacagccaaagaaaaagccaaagacagagaaaaagca caggatattctgaaatttctacagattaatggatatgttgtctccagaggacttaaggac ctggaattagacacaccttccattgagaaacgctttgcttacagtttccttcagcaactt ataagatatgtggatgaagcacatcagtacattttggagtttgatggtggcagcagaggc aaaggagagcacttcccatatgaacaagaaatcaagttttttgccaaagttgtgctccct ttgattgatcagtattttaaaaatcatcgcctgtatttcttgtctgcagcaagtaggcct ctcagcagtggaggccatgcctctaataaagagaaagaaatggtgacaagcctgttctgc aaacttggagttcttgtcaggcataggatttcactgtttggaaatgatgcaacatcaata gtcaactgtcttcacatactgggccagaccttggatgcaaggactgtgatgaaaactggt ttggaatctgtcaagatggcattgagagcctttttggacaatgctgctgaggatctggaa aaaacaatggaaaatcttaagcaaggccagtttacacacagcagaaaccagccaaagggt gttacacaaatcattaattataccacagttgctctcctgccagtgctatcttcattattt gagcatattggacagcaccagtttggggaagatttgatattggatgatgttcaggtctcc tgttacagaatattggccagcttatatgctctgggaaccagcaagagtatctatgtagag cggcaacgatcagcactaggagaatgcttggccgctttctcaggtgcctttcctgtggct tttttggaaactcatttgaacaaacataatatctactcaatttacaataccaagaatgcg agagacagagcagttctcaatttgcctactagtgtggaagaggtttgtccaaatattcct tccttggtgaagctaatggaagaaattgtggaactggcagagtctggtattcgttacaca caaatgccacatatcatggaagttatactgcctatgctgtgtagttacatgtcacactgg tgggagcatgggccagaaaacaaccctgacaaggctgaaatgtgttgcacagccttgaca tcagagcacatgaacactctgttgggtaatatattgaaaatcatctataacaaccttggt attgatgaaggagcctggatgaaaagactagcagtgttttcccagcccatcataagcaaa gtgaagccacagctcttaaagacacacttcctgccactgatggataagctaaagaaaaaa gcagcagtggttgtgtcggatgaagaacatctaagagcagaaggcagaggtgacatgtcg gaggctgaactgctcatcctagatgagttcaccactttggcacgggacctctatgccttc taccctttgttgattagatttgtggactataacagggcaaaatggctgaaagagcccaat cctgaagcagaagaattgttccgcatggtggccgaggtcttcatttactggtcaaaatct cataatttcaaaagggaagagcagaactttgtggtacaaaatgaaatcaacaacatgtct ttcctcatcagtgacaccaaatctaagatgtccaaggcagcagtttctgaccaggagagg aagaagatgaagcgaaaaggtgaccggtactctatgcagacctctctcattgtggcagca ctgaaaagattacttcccattggcctaaatatttgtgctcctggagaccaagagctaatt gcactggccaaaaatcgattcagcatgaaagatactgaagatgaagtacgagatatcatc cgcagtaatcttcatctccagggcaagcttgaggatccagccattaggtggcagatggca ctttacaaagatttgcctaacaggactgaagattcctcagatcccgagaagactgtggaa agggtccttgatatagctaatgtactgtttcacctggaacagagatctgcttgtgtaggc cgaggctatttcttttgggttgagcatcctcagcggtccaaaaaagcagtgtggcataag ctgctatctaaacagaggaaaagagcagtagttgcctgctttagaatggcacctttgtat aatctgccaaggcaccgagctgtcaatctctttcttcaaggctatgataaatcttggatt gaaacagaagaacactattttgaagacaaactgatagaagacttagcaaaacctggagag gaaccagcggaagaagacgaaagccttaaaagagttgatcctttacatcaacttattcta ctattcagtcgaacagccttaactgaaaaatgcaaattagaagaagatttcctgtatatg gcttatgctgatattatggcaaagagctgccacgatgaagaagatgacgatggtgaagaa gaagtgaagagttttgaagtgacaggatcacaacgcagcaaggaaaaagaaatggagaag caaaaacttctgtatcaacaagccagactgcatgaccggggtgctgctgagatggttctg cagacaatcagtgcaagtaaaggtgagatggggccaatggttgcagctaccctaaagcta gggattgccatcttaaatggaggaaattctaccgttcaacagaaaatgcttgactacctc aaggataaaaaggatgtgggattctttcaaagccttgctggtcttatgcagtcctgtagt gttcttgacctgaatgcatttgaacgtcagaacaaggcagaaggccttggcatggtgact gaagagggatcagtcatcacttatgagcgtggagaaaaggtgatgcaggatgatgagttc acctgtgacctcttccgtttccttcagttgctttgtgaaggacataattcagattttcag aattacctgagaactcagactggtaacaacacaactgttaatattatcatttccactgtg gattacttgttaagagttcaggaatctattagtgatttctattggtattattctgggaaa gatgttattgatgagcaaggacaacgaaatttttccaaagccatccaggttgcaaaacaa gttttcaatactctcacagagtatatccaggggccctgtactgggaatcagcaaagtcta gctcacagcaggctatgggatgccgtagttggttttcttcatgtgtttgcccacatgcag atgaagctgtctcaggattccagtcaaattgaattactgaaggagttaatggatcttcag aaggatatggttgtcatgttgctgtctatgctggaaggtaatgttgtgaatggaaccatt ggcaagcagatggtcgatatgcttgtggaatcatccaacaatgttgagatgattctgaag ttttttgatatgttcttgaagctgaaagatttgacttcttctgatgcattcaaagaatat gaccctgatggtaaaggggtcatttcaaagagggattttcataaggcaatggaaagccat aagcattacacccagtctgaaactgagtttctgctatcgtgtgctgaaacagatgagaat gagactctggactatgaggagtttgtgaaacgattccatgaacctgccaaagacattggc ttcaatgtcgctgttctcctgaccaacctgtcagaacacatgccccatgacagccgcttg caaactttcctggaactatcagagagtgtgctgaactactttcagcctttccttggacgc atagaaatcatgggcagtgcgaagcgcatcgaacgagtttattttgaaataagtgagtca agtcgaactcagtgggagaaacctcaggtgaaagagtcaaagagacaatttatatttgat gttgtaaatgaaggaggggagaaagaaaagatggagctttttgtgaatttctgtgaggat accatctttgaaatgcaactggctgctcagatctctgagtcagatctgaatgaaaggtca gcaaataaagaggagaatgagaaagataagcctgaggaacaggaccctagaatgggtttc ttctctctcatgaccatgaagtcagcattagtagctctcaagtataatatagtgactctc atgaaaatgctcagcatgaagagcctaaagaaacagatgaaaaaagtaaagaaaatgacc atgaaggacatggtcatggctttgttttcttcctattggagcgttttgatgggcctacta cattttgcttatagcgttgtccggggcttctttcgcatcatatgcagtttgctgcttgga ggaagcctagtagaaggagcaaagaaaatcaaggtggctgaactattagctaatatgcca gatcccactcaggatgaggtgcgtggggaaggagaagagggcgagaggaagccgacagag gctgcattgcctacagaagacttgacagatctgagaactttatcagatgagagtgatctc ctctcagatatatttggtttggatttgaaacgagaaggtggacagtataaattgatccct cacaatccaaatgctggtttgagtgatttactgagcactccctccatagctccaatgcct gaggtgcaggaaaaagtccaggagcaggtgaaagaagatgaaaaggaagagaaggaggaa acaaaatctgaacctgaaaaagcagaaggagaagatggagaaaaagaagaaaaagccaag gaagacaaagggaagcagaaattaagacaacttcatactcacagatatggagaaccagaa gttcaagaatcagctttctggaagaaaatcattgcataccaacagaagcttcttaactat tttgcgcgaaacttttataacatgaggatgttggcattgtttgttgcttttgccatcaac ttcatcctgcttttctataaggtctccacctctgctgtaacagaagaaaaggacattcct gtggtatctgctgatgaaagtaccaagttggacagcctggaaagcgacaaccagagggtc attgcggtgcattatgtcctagaagaaagcagtggctacatggagcccacactgcggatt ctggccatcctacacacagtcatctcattcttctgcatcatagggtattactgtttgaaa gttccactggttatttttaagagagaaaaggaagtggcaaggaaattggaatttgatggg ctgtatataactgaacagccatcagaagatgatattaaagggcagtgggatagacttgta atcaacacacagtcttttccaaacaactattgggacaaatttgtgaaaagaaaggtcatg gataaatatggtgagttctatggccgtgacaggatcagcgagttactaggaatggacaaa gctgctcttgattttagtgatgctcgagaaaagaagaaaccaaagaaggatagctcctta tctgctgtgctaaattccattgatgttaagtatcagatgtggaaattaggagttgttttc actgataactctttcctttacctagcttggtacatgaccatgtcagtccttggccattac aacaattttttctttgctgctcatctccttgatattgcgatgggattcaagacattgcga actatcctgtcatcagtgacccacaatggcaaacagcttgtcctaacagtgggattgctg gcagtagttgtatacttgtatacagttgtggcattcaattttttccgcaagttctacaac aagagtgaagatggtgatatgccagacatgaaatgtgatgatatgctaacatgctacatg tttcacatgtacgttggagtacgtgcaggtggaggcattggggacgaaatagaggatcca gcaggagatgaatatgaaatctatcggattatctttgatatcaccttcttcttctttgtg attgtcatcctgcttgcaattattcaaggtttaattattgatgcttttggtgagttaaga gatcaacaagagcaagttaaggaagacatggagacaaagtgctttatctgtggaatagga aatgactactttgatacagtgccccatggctttgaaacacacacacttcaggagcacaac ttggccaattatttgttttttctgatgtatcttattaacaaagatgaaacagagcataca ggacaggaatcctatgtatggaaaatgtatcaagaacggtgctgggagtttttccctgcc ggtgattgcttccgaaaacaatatgaagaccagctcaactaa

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