Colossoma macropomum (tambaqui): 118814113 Help Entry 118814113         CDS       T09004                                  Symbol obscna Name (RefSeq) LOW QUALITY PROTEIN: obscurin   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism cmao  Colossoma macropomum (tambaqui) Pathway cmao04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:cmao00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     118814113 (obscna)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:cmao01001]     118814113 (obscna)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:cmao04131]     118814113 (obscna) Enzymes [BR:cmao01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      118814113 (obscna) Protein kinases [BR:cmao01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    118814113 (obscna) Membrane trafficking [BR:cmao04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     118814113 (obscna) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 Pkinase V-set PK_Tyr_Ser-Thr Ig_5 Ig_4 Izumo-Ig SOS1_NGEF_PH RhoGEF PH Lep_receptor_Ig IQ Kdo IQ_SEC7_PH RIO1 RHG20_PH Motif Other DBs NCBI-GeneID:  118814113 NCBI-ProteinID:  XP_036435667 LinkDB All DBs Position Unknown AA seq 6083 aa AA seqDB search MALKKVEVVKGLEDASLCEKESCSFEVTLSHSYVRGVWTRNGVPFKSKPTCRISAQGKTH CLTLTRVSLSDAGLISFQAEGAETSATLTVTARDIQIVKHLQDVSVTERESVTLVCEVNL EDVDGKWFKNDSRIKAGDNVKIRHECKTHSLTFKAIKPEDAGEIKFTAERVSSAAVLRVK ELPVHIVKPLRVKIGMYKHRALLECQVSRSNAEVTWYKRNREIVPNGKYQVISEGVYRQL TIDEVGSSDEDIFICDAGDDKTSCQLFVEEQAISIVRGLGSVEVTEPKEARFRVETSIKA ERAPKWTLNGELLASSPEVKIEREGTSHRLIFTSTDSSMCGTVQFSSGKSKSTAELTVTE RPLVVTQPISDVEVKENGSVTLTCEFCPSPRVVRWFKGRIPLLDTSKYRMRREKNRAQMT IMGVKAADSGEYRCLAGGAESRGRVNVEVKRLKIIRHLEQVEMEEDGTAVFSCELNHESP SVQWLLDDKVIHPSYLNKIQNSGKVYSLILKRLTPQDSRVTFKTIGLSESTTLRVKERPA VFLRSLEDVVAEEHGKACLQCEVSKQAVTAIWRKDGTVLTASEKQEILHLGRSLALIIHS LRKDDAGEYSCDVGTSQTKAKVIVRDLHITIIKRLKTVAALEGESCHFECVLSHDIIDEA SWTLNGELIVSNGRIQVDNKGRKYTMDIHEVVISDAGDVVFTIKDLSCRTMLFVKEKPVR VFRDMLNVKATPGEDAELSCEITKPQATIKWLKNGRLIRASPKYEISQKGHLVRLIILNT TVKDSGEYCCEADGIATRARLEVRDLQHTFAKELKDLRAEEKSMAILECETKRPASKVTW LKGMVVLTSGQKYLMRRKGVILSLTIFNLEKSDSDLYTCDVGTMQSRALLTVLGQKVLIL DELEDIECLEGNTVTFRCRICPSDFTEVKWYLDETLLYTNDLNEINMLPGGYHTLTIKQL ERKDTGTISFEAGDKRSYASLLVRERRPTIIKALEDTEAIEGGSLMLLCRTSKPCHIVWY KDGCLVWNSSNYLMSRAGNEARLTIREVKDTDAGVYECDAGSVSTKAVVTVKAVPAEFTK QLQSQDAEEGGSVTLSCEFSVPGVQYLWRKGPETLRSGEKYLTKQRKHHISLTIHNVKPE DSGTYTCVCRNQRTMATVTVHAVPITFVKELKNQESEEGWPVTLRCELSKAGVPVEWMRE EEVLSHGMKYLMRQIASIQELVIRNPAPEDSGTYSCVCTGQRTKASIKINAQPITFKQKL KTQTVEEGNSVILHCELSKPGLPVEWRKGNELLRSGEKYQMRQRGSAIELKIFSLRCDDS AVYSCSYGGVQTSAKVTVSRQHISFKETLKNQVVEEGKAVTMCCELSKAGVPVEWWNGEE LLQPGQKYQMRERDTTYELIINDTVPEDSGVYKCVCGDQKTKATIKIIGLPPTFKQNLKN QEASEEGSVVLRCELSKAGVPVEWWKGEEQLMPGGRYQMRQEGKVAEMEITNVHLNDAGK YSCVIGKQTSTAEVKIKALPITFKRELQDQVSKEGDSAVFTCELSKPGAPVEWRKGRVIL KPGEKYKMKLEGRLTKLVINNLEEGDSGKYICKTKDAQSAAELTVQALPLTFKTILKNLE AQEGNSLSLYCELSRAGAHVEWWKGEERLCTGERYQLRQRDVTTELLIRKAQPEDSGVYR CVCGEQSTEATIKVNAHPITFKQELKSQEVEEGNTVTLRCELSKAGAQVEWWKGEELLNS GEKFQMRQMATKVELVIKKAVPEDSGVYVCVCADQKSKATIKINALPVIFKQNLRNQETV EGNSVTLHCELSKPGASVKWWKGQEILTLGEKYHMKTEGRIAELIIRNAVLEDVGSYSCT VGDQKTTSEIKVQALPVTFKRELQNEVSKEGETALFSCELSKXGAQVDWRKGRVILKAGD KYDMKQEGRFAKLLIHNIEESDAGNYSCKTKDSESTAKLTVQVPPIVFKVKLKNQEVEEE STITLHCELSKAGISARWKKGEEVLKSGLKYQIRQQDAVMELIIRKAVPEDSGVYSCLCG DQKTKATVKVFATPVTFRQSLKNQEAPEGGVVVLHCELSKAGVPVQWWKGEEELNNGGKY KMKQEGSVAELHIKNVLPMDVGEYSCVIGDQKTTAEVNVRAAASAFFEKELQNREAMEGN SVVFSCLLSSSNAPVTWKKDSKQITQGGRFTLHQKGSTHELEIRQLKPEDAGVYTCNTRG KKSSATLRVIERVRIVRELRDITVTAGENARFVCELSHEDVTDGVWWLGSSILQENEMNQ MSCYGREHHLVLTMTTPEESGTVTFVVGEEKTSARLTVNSKPKVLIEEKLKDLVVFEGDT AILSCVTSDDCTPVTWKRNNVTLLAGEKYEPRKEGKRNQLLIHRVGKEDAGVYMCDTGDV QSAAALIIKERPLIFREELHNQQAEEGETAFLCCQLSKPGVAVQWKKGALLLTPGYKYKM KQDGCDLQLQIYNLTVEDSGSYRCCADSIETTARLDVKEQPLFFREELHSVEADEGETAL LCCELSKPGVTVQWKKGTVLLRPGSKYTMKQDGCELELQIHDLQRQDSGVYKCCAGSLEA KANIAVKEQPLFFREDLQNQQAEEGETAFLCCELSKPGVVVKWKKGAVLLSPGDKYEMKQ DGCKVQLKIHDLKGRDSGTYKCCAGSLVTTASVVVKEQPLFFREELQTVEVEEGGNALMC CELSKPAATVQWRKGTVLLRPGNKYEMKQNGCQLQLKILDLTTQDSGSYKCCASGIVTTA CLEVKEQPLLFCKELQSLEVEEGKSALLYCELSKPGVAVQWKKGTKLLRPGDKYETKENG CDIQLRIYDVSSQDSGTYRCCAGSLETTATLYVREQPLFFYKELRNQEVVEGETALLLCE ISKPGVPVQWKKGSMLLKVGDKYEMKQDGCKLQLKIYDLNGQDSGSYKCCAGSAVTTASI VVKEHPLFFCKELESQEGVEGETVLLCCELSKPAVTVQWKKGAVLLKHGNKYEIKQNGCE LQLKIHDLKSQDSGVYKCSAGNVETTASVVVKEISTEPKSNPQVPPRSKGRTFQEGSILD GQHSVLEQKQQSVDVVSGQTEDDHVNFGVKTRGARHPEENFSKTKDKGGWKTQKQSDKEQ EIFVVNAAEISAKQIQEKTEQVQMKAPCKDTTERKHEMQGKSTPQAPPRSKGRFTQPSVD PQGQHSILEPKKQVVVKKPSVETTFRDTSENEHLDLREEKREEILNVKEALLSQNLKDEK SVVPNETHPEPKKVPFSGEPEKKLPKHVQEKVDQRSKKQHVIVENVSEMSLKKVLTSEPS VETSSRDRIQGEQLDLIENRTEEKDDTKETALRQRVQDKKPTVHNEKHAEPKIAPCSIEP PLEKLPKHVEKKATNRNIIDQRDRKPEKMSDKQVVTTEPSVDTSSRDRLWGEQLGLVEKT SEMKENATDNKPVVLNEEHQEPKIAPTSIEPEEKLLKHVEEKATSGNITDQRSKKQDTII EKVSEIKQTPEPNLPQVIDVSVTEQKNRNQVFKMKKVPELSMTQPQERIPVEVKTEGASV DIKDQKATKQVNQADAATESAKCTTPPQATLAEQPAQDTSGIEISAEDESEMLEAAIKIQ AAFKGFKARKDMRPVFKEVFKNQNVEPRDTVRLECIVEGKASTVRWLKDGVDLKSGKWTK ISHSEDGRCMLVVTNVVPEDAGIYTCEVGNKFGTVSYNGNVTVGHTKKPVNQTPHRPAKE PMLAKEAVQTSKTKEESLRDAYDLPADDANSKFQEKRQSLISVSSVSCPSDYDTAPDVET GYVSRENEVEKIKVQTQFSQSSEEQRTISPEPQKATVQLKVKGSESVSRTPSPKYPHTHK SSANAESLSESDGDEDRAETFDIYVAKADCHPTGGNKETFILKEGQFVEVLDSVHPVKWL VRTKPTKTTPSRQGWLSPAYLEKKTKELFLLAQDQETKDICNKGRRTPPKEEYRVTLRQL IKGLLDGENEFVREMNFFVENHLQYIETNTQVPLTILSQKEGIFRNIRDIASFHECCILP KLGQCTTDDDVAQCFVHYAPDFEMHLQYILGQSQAEACISDKNTQHFFKQFANTAFAHSD TQTFSVSTYLQRPLERIQTYKTLLKELIRNKAKSGQSCCLLEDAFSMVSSLPWRAENLQH VSLIENYPAPLKGLGEPIRQGSFIVWEEAPGTKISLRGHHRHVFLFKDCVIFCKLKRDLN THSEVYVFKNKMKLNDIDLKDTVEGDDRCWGLWHEHRGTVRKITLQARTMLTRLSWLKDL RDLQQRSRIPLWSSPCFELILNESTAKIGQTVKLACKVTGTPKPAVTWYKDGVVVKDDQH HIISEGHSGACYLVLASVTGEDTGQYMCYAASPMGNASTLAKITVVVPPSFTTKLQNTLL VKGRDVQFQCSTGCIPVPTVRWFKDNKQLGNTKKYEIHTDMQTGVLKIIIKKAKEADLGQ YECELLNEVGSAKCKAQLYSAPPPAAESPKDKPLVASAPDTESEGWSSALVKNLFHMFFQ SGSSKQSAGGPSETQAEDKQEIQERREDVPEEETSVESNKTFFISETEEDEYADPPEVQV AMEDLCVRPGQPATFSAVITGQPIPEITWLKDGIKLVSGEHTELVQSGARCSLNLLGVNV ADCGTYTCTATNRSGHASCHAQLTVDTGPEEFEEEQEREVEVEVEVGRRRKLHSVYDVHE EIGRGTFGVVKRVTHRASEEVFAAKFIPLRSSTRTRAFQERDLLSRLAHCRLVCLLDFFC TRRTLVLITEICSSQGLLDHLLLKGTVTEREVRMYIQQLLEGIGYIHSMNILHLDIKTDN ILMVSPEREELKICDFGFCQEIDISRHQYSVYGTPEFVAPEIVHQEPVTTATDIWSVGVV SYLCLTGHCPFFGENDRATLMKVAEGVLYWDIPEISSRSDQAQDFLHRVLQPDPEMRPSA SESLSHEWFQVQCEDVQADSIDTRSLKSFISRRKWQRSLTCLGSVLTLRPIPELLEAPLS EVSVTTPRDTHEPSSTSLSSTSSSEYDEADAWGFFQQTSQEEEEGREDEDEEEYNPYACL PKITPSLKINEEDRIMEQAQRGMVVIPLNKPSRESPTLSPEPASTTKQNQSQLYITSSVE PSNRLLAHSEGGYEEEQDIGPSLCHREQDEGLDLGTPIPRGNVIKSTFYSSSQQLSPMST RHMMLRDKLHGRKQERGRKSLRSSLSGRLNEPLIEYVEDSPDAEAGRGQRRGSVHSATMK SSSFDCGASPAHSDVRVQRRSRSLDESTRRPAVSVEQRKLGDDEEGIDLGHEDEFTDEEE DETPEMLARETSQRTTVTSQGSGQQRMLGDDEEGIQLGHEDEFTDEEEDETSEILARKML RRSSLAPLTLTSGVVAKVTAQRSSMDEQPISTLSHVDGIQSQPGEENVVGSQLSLAESSV LEHGSEASSRLGFFEGLAPTHLPISQRRHKEYDESDERLGALSSGKASECSLLQDSEDED VERVLRSLRQEHLQTLPKQCTHNSGTSDTNKNITLRRSSSAVPIRPILTSPESREVLQRH ASAPALQAKPPSGKSAKAGLLKIFRRQSWTGHSSSQTEGSGKRVDEGPHPQQKTPLLTLR KKMRASASSITKLFTKQSSKEGKEEKRAGPIVKNPVPPEKASITSDFLPSVPFSGSPQKK SKFFSLKVPSFKKSKEMPVKPSRPDVIQLAGGGALVFWKPVPSSGPVTYCIQHSVNGGEW RMLCESVTDSCYVANALPRGPGYMFRVACITKTGSGPFSDPSPPAFMTAPYEDSHIPLIL MESTGSKITVPGGLGSERSYSFQSEINRGRFSVVMQCEDSRSSRPLAAKLTPYEPEQRQL VLREYQLLRRLSHQHLVQLHSAILTPSCLVLIEELCSGREILYSLADRDVYAELHVSELL RQVLNGVDYLHGRHIVHLDLRSDNVLVTDRSVVKIVDLGSAQPFTPGQTLNIEHIKETTE SKVYIVLPKAPEILEGQGVGPATDIWALGVLAFIMLSADSPFHAELNWERDRNIKKGKIQ FGRCYPGLSEGAINFLKTTLNNKAWGRPSAAECLQDSWIRGDCSHAKRADSVVCFSTDKL QAFLRQREVKRDHARTKAAPPLS NT seq 18252 nt NT seq  +upstreamnt  +downstreamnt atggcattgaagaaggtcgaggtggtgaaaggtcttgaggatgcgtcgctgtgtgagaag gagtcctgctcgttcgaggtgactctgagtcactcttatgtccgcggcgtttggaccagg aacggcgttccattcaaatcgaagcccacgtgccgcatctcagctcagggaaagacgcac tgcctgactctgacacgcgtgtctctgtcagacgcaggtctgatcagctttcaggcagaa ggagctgaaacctctgctactctcactgtcacagccagagatatacagattgtgaagcac cttcaggacgtcagtgtgactgagagggagagcgtgacgctggtgtgtgaagtaaacctg gaggatgtggatggaaaatggttcaagaacgacagcagaataaaggccggggacaacgtc aaaatcagacatgaatgtaaaactcactcactgaccttcaaagccatcaagccagaagat gctggtgagatcaaattcacggcagagagagtttcctcagccgcagtgctcagagtgaaa gagcttccagttcatattgtgaagcccctccgggtgaagattggcatgtataaacatcga gcgctgttggagtgccaggtttctcgttccaacgccgaggtcacgtggtacaagaggaac cgagagattgtacctaatgggaaataccaagtgatcagcgaaggtgtttacagacaactc accattgatgaagtgggctcttcagacgaggacatcttcatctgtgatgctggtgatgac aagacctcctgccagctgttcgtggaggagcaggccatcagcattgtgcgtggactgggc tcagttgaagtaacagagcctaaagaggctcgtttcagagtggagaccagcatcaaggcg gagcgagcacccaaatggactttgaacggggagctgctagcttccagcccggaggttaag atcgagagagaaggaacgtcgcaccggctcattttcaccagcaccgacagcagcatgtgt ggcactgtccagttcagctcagggaagagcaagtcaaccgcagagctcactgttacagag cgtcccctggtggtcacccagcccatctcagatgtggaggtcaaagagaatgggtcagtg actctcacctgcgagttctgtccttctcccagagtcgtgcgctggttcaaagggagaatc cctttgctggacaccagcaagtacagaatgaggcgggaaaagaaccgtgcccagatgacc ataatgggcgtgaaggctgcagattcaggggagtatcggtgcctggctggtggagccgag agcaggggtcgggtcaacgtagaagtaaaaagactgaagatcatacggcatctagagcaa gtggagatggaggaagatggaactgcagtgttttcctgtgagctaaaccacgagtcgccc agtgttcagtggcttctcgacgacaaagtgattcaccccagttacttaaacaagatccag aactcaggaaaagtgtacagcctcattctcaaaaggctcactccgcaggacagcagagtg actttcaaaaccatcggcctcagtgagtccacaacgctcagagtgaaagagaggccagca gtgttcctcaggtctctggaagatgtagtggctgaggaacatggcaaagcatgtttacag tgtgaagtctccaagcaagcagtaactgccatttggaggaaagatggtacagtcctaacc gccagcgagaagcaggaaattctacacttgggcaggtcattagctcttatcattcacagt ctcagaaaggacgacgcaggggaatactcttgcgatgtgggaacgagccaaaccaaagcc aaggttattgttcgtgatctccacatcactatcatcaagcgcttgaagacagttgcagct ctcgagggggagagctgccattttgagtgtgttttgtcacatgacatcattgatgaggct tcctggaccctgaacggtgagttgattgtcagcaacggaagaatccaggtggataacaag gggcgcaagtacacaatggacatccatgaggtagtgatttctgatgctggggacgtggtc ttcaccatcaaggatctcagctgcaggaccatgctgttcgtcaaagagaagcctgtgagg gtctttagagacatgctgaatgttaaagcgacacctggagaagacgccgagcttagctgt gagatcactaagcctcaggccaccatcaagtggttgaagaacggcaggttgatcagagcc agtcctaaatatgagattagccaaaaaggccatctggttaggctaatcatccttaacaca actgtaaaggactcgggagagtactgctgtgaggccgacggcattgctactagggcaagg ttagaggtcagagacctccagcacacgtttgctaaagagctgaaagacttacgagcagaa gagaagagcatggccatcctggagtgtgagactaagaggcctgccagtaaagtgacctgg ttaaagggcatggtggtgctcacttcaggccagaagtacctgatgaggaggaaaggagtc atcctgtctcttaccatcttcaaccttgagaagagtgacagtgatctgtacacctgtgat gttggcacgatgcagagcagagcgttgctcacagtacttggtcagaaagtgctcattttg gatgaactggaggatatcgagtgtctagaagggaacactgtgacgttcaggtgtcgcatc tgtccgagcgacttcactgaggttaagtggtatctcgatgagactctgctctacacaaac gacttaaatgagattaacatgctccctggtggctaccatacccttaccatcaaacagctg gagcgcaaagatacaggaaccatctcttttgaagctggagacaagagatcctacgcctca ctgctagtaagagaaaggcgccccacaattatcaaagcgttagaggacactgaagccatt gagggaggaagtttgatgctgctgtgcaggacttccaaaccttgtcatattgtgtggtat aaggacggctgcttagtgtggaattcgtccaactatctgatgagtcgagccggaaacgag gcccggttgaccattcgtgaggtcaaagacacggatgcaggagtgtatgaatgcgatgca gggtctgtaagcaccaaggctgttgtgactgttaaagcggtgccagctgagtttacaaag cagcttcagagtcaagacgctgaagagggaggcagtgtgacactgtcctgtgagttctcc gtgcccggcgttcagtacttgtggcgtaaaggaccagagacactcagatctggagagaag tacctgacgaagcaaagaaaacatcacatttccctcaccatccacaacgtgaagcctgag gactcggggacttacacctgcgtctgcagaaaccaaagaactatggccaccgttacagtc catgcggtccccatcacattcgttaaggagctaaaaaatcaggaatcagaagagggctgg cctgtgacgttacgctgcgaactctccaaggcaggagtgccggtggagtggatgagggag gaggaagtgctaagccatgggatgaagtatctgatgcgacaaatagcatcaatacaggag ctagtaatcaggaatccagcgccagaggacagcggaacctacagctgtgtctgcacaggc caaaggaccaaagcctcaattaagattaatgctcaacccatcacgttcaaacagaagctg aaaactcagacagttgaagaaggaaacagtgttattttgcactgtgagctgtcaaaacct ggacttcctgttgaatggaggaagggcaacgagttgctcaggtctggagaaaagtaccaa atgcgacaaagaggttcagcaatagagctgaagattttctctttgagatgtgacgacagc gccgtctacagctgctcctatggtggcgtccagacgtcagctaaagtcactgttagcagg caacatatcagctttaaagagacgcttaagaaccaagtagttgaggagggcaaagcagtg accatgtgctgcgaactgtccaaagctggtgtcccagtggaatggtggaatggagaggag cttctccagcctgggcaaaagtatcagatgagagaaagagatacaacatatgagctgatc atcaatgacaccgtgcctgaggacagcggagtctacaaatgtgtgtgtggagaccaaaag accaaagctaccatcaaaattattgggctgcctcccactttcaaacaaaacttgaagaac caagaagcttcagaggaaggcagtgtggtactaagatgtgagctttctaaagctggagta cctgtggaatggtggaaaggtgaggaacagctaatgcctggtgggaggtatcagatgaga caggagggcaaagttgctgagatggagatcacaaatgttcatctgaacgatgctgggaag tacagctgtgttattgggaaacaaacgagcacagcagaggtgaaaatcaaagctcttccc atcactttcaaacgggagctccaggaccaggtttctaaagaaggggacagtgctgtgttc acctgtgaactgtctaaacctggcgctccagtagagtggagaaaaggaagagttattctg aaacctggagagaagtacaagatgaagctagagggaagattaaccaaactggtgataaat aaccttgaagagggtgattctgggaaatatatctgtaaaaccaaagatgcacaatcagcg gcggaacttaccgtgcaagcactgcctctaaccttcaaaaccattctgaagaacctggaa gctcaagagggaaacagcctcagtttgtattgtgagctctccagagctggagcacatgta gagtggtggaaaggtgaagaaaggttatgtactggggaaaggtatcagctgaggcaaagg gatgtaaccacagagctgctaatcagaaaagcacaaccagaagacagtggagtgtaccgc tgtgtgtgtggagagcagagtactgaggccaccatcaaagtcaatgcccatcccatcact ttcaaacaagaactgaagagccaagaggttgaagagggaaacactgtcactttacgttgc gaactctctaaggctggtgctcaggtagaatggtggaaaggagaagaactgctcaattct ggggaaaagttccagatgaggcaaatggccacaaaagtggagcttgtcatcaaaaaagca gtgcctgaggatagtggtgtctatgtttgtgtatgtgctgaccagaagtccaaagctacc atcaaaatcaatgcattaccagtgatattcaaacaaaacctcagaaaccaagagacagtg gaaggcaatagtgtcactttacattgtgagctttccaaacctggagcatcggtgaagtgg tggaagggtcaggagatactgactttgggtgaaaagtaccacatgaagactgagggaagg attgctgagttgatcatcaggaatgcagtacttgaggacgttggttcgtacagctgcaca gttggtgaccagaagactacctcggaaatcaaagttcaggctctgcctgtaaccttcaaa cgagaactccaaaatgaagtttccaaagaaggagaaactgccttgtttagttgtgagctc tcaaaanctggagcccaagtggactggagaaaaggacgagttattctgaaggcgggagat aaatatgacatgaaacaagaaggaagattcgccaaacttctcatacacaacattgaggaa agtgacgctgggaactattcatgtaaaaccaaggattctgagtcaactgctaaacttact gttcaggttccacccatcgtttttaaagtgaagctgaagaaccaggaagttgaggaagaa agcaccataaccctgcattgtgagctgtcaaaagctggcatttctgctcggtggaaaaaa ggggaggaagtgctaaagtctggattgaagtatcaaatcaggcaacaagatgctgtaatg gagctgattatcaggaaagcagtgcctgaggacagtggagtctatagctgcctatgtggt gatcagaaaaccaaagccaccgtcaaggtttttgcaactccggttacattcagacaaagc ctgaagaaccaggaggctccagagggaggcgtagtagtcctgcattgtgagctgtcaaaa gctggggtacctgtgcagtggtggaaaggtgaagaggagctaaataatggaggcaaatac aagatgaaacaggaggggtcagttgctgagttgcacattaagaatgtccttcctatggat gttggggaatatagctgtgttatcggagaccaaaagaccacagctgaagtgaatgtgagg gctgcagcttctgcgttctttgagaaggagttacagaatcgagaggcaatggagggaaac tctgtcgtgttcagctgtttgctgtccagttcaaatgctccagtgacttggaaaaaagac tcaaagcaaatcacacaaggtggacggttcaccttacaccagaagggctcgactcatgag cttgagatcagacagctaaagcctgaggatgctggtgtttacacgtgtaacaccaggggc aagaagtcatctgcgaccctgagagtgatagagcgtgtgaggattgtgagagagcttcgg gacatcacagttactgcgggagaaaatgcccgttttgtatgtgagctctcacatgaggac gtcactgacggcgtgtggtggcttggttccagcattctgcaggaaaatgaaatgaatcag atgagctgttatggccgtgagcatcacctggtcctcaccatgacaacgcctgaggagtca ggtaccgtgacctttgtggtaggagaagagaagacctccgctcgtctgacagtgaacagt aaacccaaagttttgatagaagagaagctgaaggacctggttgtctttgagggtgatacc gccatcttatcctgtgttacctccgatgactgcacacccgtcacctggaagcgaaacaac gtcaccctgctggcaggggaaaagtacgaaccccgtaaagaagggaaacggaaccagctt ctaatacacagagtaggaaaggaggatgctggagtttatatgtgtgatacaggagatgtg caaagcgctgctgctctcatcattaaagagcgtccattaatctttcgtgaggaactccac aatcagcaggctgaggagggtgaaactgccttcttgtgctgccagctctccaaacctgga gttgcagtgcagtggaagaagggagctctgctgcttacaccaggatacaagtataaaatg aagcaggatggctgtgatctacagcttcagatctataacctgaccgttgaggacagcggt tcctacagatgctgtgccgacagcattgagactacagccaggcttgatgtgaaagaacaa ccactgttcttccgtgaggaactccacagtgtggaagcagacgagggtgaaactgccctc ttgtgctgtgaactgtctaaacctggggttacagtgcagtggaagaaaggaacagtgctc ctgagacctggaagcaaatatacgatgaagcaagatggttgtgaattagagcttcagata catgacctgcaacgccaggacagtggagtctacaagtgctgtgctggtagcctcgaggcg aaagctaatattgcagtcaaagagcaacccctgttcttccgtgaggatcttcagaatcag caggctgaggagggtgaaactgccttcctgtgctgtgaactctctaaacctggagttgtg gtgaagtggaagaaaggagcggtgctgttgtcaccaggagacaagtatgaaatgaaacag gacggttgtaaagtgcagcttaagatccatgacctgaagggaagggacagtggtacttac aaatgctgtgctggtagcttggtcactacagcatccgttgtggtaaaagaacaaccactt ttcttccgtgaagaacttcaaacggtggaagtggaggagggcgggaatgccttgatgtgc tgcgaactctctaaacctgcagctacagtgcagtggagaaagggcacagtgctgctgagg cctggaaacaaatacgaaatgaaacagaatggctgtcagttacagcttaaaattctagat ttgacaactcaagatagtggttcctacaaatgctgtgcaagtggcattgtgactacagcc tgccttgaagtgaaagaacaaccgttactattttgtaaggaactccaaagtctggaggtg gaggagggtaaaagtgccctactgtactgcgaactctctaaacctggagttgcagtacag tggaagaagggcaccaagctacttagaccaggagataagtatgagacgaaagagaatgga tgcgatatacaacttcgaatatatgacgtttcaagtcaggacagtggcacttatagatgt tgtgctggcagtctggagacaacagcaacactttatgtgagagagcaacctctgttcttc tacaaggagctcagaaatcaagaagtagtggagggtgaaactgccttgctgctctgtgag atctctaaacctggagttccagttcagtggaagaaaggatcgatgctcctgaaggtcgga gacaaatatgaaatgaaacaggatggctgtaagctgcagcttaaaatttatgacctgaat ggtcaagacagtggctcttataagtgctgtgcgggtagcgcagtcaccacagcgtccatt gtagtcaaagaacaccctttgtttttctgcaaggagcttgaaagtcaagagggggtagaa ggtgagactgtcttgctgtgctgtgagctttctaaacctgcagttacagtacagtggaaa aagggagcggtgctgctaaagcatggaaataagtatgagattaagcagaatggctgtgag ctacaacttaaaatccatgatttgaagagccaggatagtggtgtctacaagtgcagtgct gggaacgtagagacaacagcttctgttgttgtaaaagagatttcaactgaacctaagagc aaccctcaggtaccaccacgctcaaagggtaggactttccaagaaggttctattctggat ggacaacacagtgttcttgaacaaaagcagcaatctgtggatgttgtctcagggcaaacg gaggatgaccatgtgaattttggtgtgaaaaccagaggagcaagacatccagaagaaaac ttcagcaagacgaaagataaaggaggatggaaaacccaaaagcagagtgacaaggaacag gagatttttgttgtaaatgctgcagagatttctgccaaacaaatccaagagaagacagag caagtacaaatgaaagctccatgcaaagatacaacagaacgaaaacatgagatgcagggc aaaagcacacctcaggcccctcctcgcagcaaaggaaggtttacccaaccaagtgttgac ccacaagggcaacacagtattctggagccaaagaaacaggttgtggtcaagaagccatct gtggaaacaactttcagagatacatcagagaatgaacaccttgatctcagagaggagaaa agagaagagatacttaatgtgaaggaagcattactaagccaaaacctgaaagatgagaaa tcagttgtccctaatgaaacacatccagaacctaaaaaggttccattctctggtgaacct gagaagaaactgccaaaacatgttcaggagaaagtggatcagagaagtaaaaagcaacat gtcattgttgagaacgtatcagaaatgtcattaaaaaaggttttgacctcagagccatct gtggaaacgtcctccagagacaggatacagggtgaacagctggatcttattgaaaacaga acagaggagaaagatgacacaaaggaaacagcactaaggcaaagggtacaagacaagaaa ccgactgtacataatgaaaagcatgcagaacccaaaattgctccatgctccattgaacct ccattggagaaactgccaaagcatgttgagaagaaagcaacaaacaggaatattatagac cagagagatagaaagccagagaaaatgtcagataaacaggttgtgaccacagagccatct gtggatacgtcttccagagacagattatggggcgaacaactgggtctcgttgaaaaaacg tcagaaatgaaagaaaatgcaaccgataataaaccagttgtccttaatgaagagcatcaa gaacccaaaattgctccaacttccattgaacctgaggaaaaactgctaaagcatgttgag gagaaagcaacaagtgggaatattacagaccagagaagtaaaaagcaagatacaattatt gagaaagtgtcagaaatcaaacaaacccctgaaccgaacctaccacaggtgatagatgtt agtgtcacagagcagaaaaacaggaatcaagtctttaaaatgaaaaaggtcccagagcta tcaatgactcaacctcaggagaggataccagtggaggtcaaaactgagggtgcaagtgtg gacattaaagaccagaaagctacgaaacaggtcaatcaggcagatgcagctacagaatca gcgaagtgcaccacccctcctcaggcaaccctagcagaacagcctgctcaggatacttct ggtatagaaataagtgctgaggacgagtcagagatgttagaggctgccattaagatccaa gccgccttcaagggtttcaaagctcgaaaggacatgcgacctgtctttaaggaggtgttc aagaaccagaacgtggagcccagagacacagttcgtctggagtgtattgttgagggaaag gccagcacagtgcgctggctgaaggacggtgtagacttgaagtcagggaaatggacaaag atcagccacagtgaggatggtaggtgcatgctggtcgtaactaatgtagttcccgaagac gcagggatctatacttgtgaagttggcaacaagtttgggacagttagttacaatgggaat gtgactgtgggtcataccaagaagcctgtaaaccaaactccacatagaccagcaaaagaa cctatgttggcaaaggaagctgtgcagacctctaaaactaaggaggagtcactgagagac gcctatgacctgcctgcagatgatgccaacagcaagtttcaggagaaaaggcaaagtctg atttcagtcagttctgtgtcctgtccatcagattacgacactgctcctgatgtggagaca ggctacgtctccagggaaaatgaagtggaaaagataaaagtccaaactcagttttcccaa agttcagaagagcaaaggaccatcagtcctgagccacaaaaagccactgtacagttgaaa gttaaaggcagtgagtcagtaagcagaacaccatctcccaaatacccacatacccacaag tcctcagccaatgcagaatcactatcagagtcagacggggatgaagacagagcagagacg tttgatatctatgtagccaaagcagactgccaccccactggaggtaataaggaaacattt attctcaaggagggtcagtttgtggaggtgcttgattctgtacatccagttaagtggctg gttcgtactaaaccaaccaaaaccacaccatcccgccaaggatggctgtccccagcatac ctcgagaagaagacaaaggagctgtttttgctggcccaagaccaagagacaaaagatatt tgcaataaaggtagaagaacaccacctaaggaggaatatagagtgactttacgtcagctg atcaagggtctgcttgatggtgagaatgaatttgtgagagaaatgaacttctttgtggag aaccatttacagtacatagagaccaacactcaggtgccactcaccattctcagccagaaa gagggcatattccgcaacataagggacattgcaagcttccatgaatgctgtattttacca aagctaggccagtgcaccacagacgatgatgtggcccagtgctttgtgcattacgcgcca gactttgagatgcatcttcagtacattttaggccagtcccaagccgaggcctgcatatca gacaaaaacacgcagcatttctttaagcaattcgccaacactgcattcgcacattcggat actcaaaccttcagtgtcagcacctacttacagagaccgctggagaggattcagacatac aagactctcctcaaggagttgataaggaataaagcaaagagtgggcagagctgttgttta ctagaggatgccttttccatggtgtccagcttgccttggcgtgcagagaacctgcagcat gtgtccctgattgagaactacccagcacctcttaaaggacttggagagccaattcgacag ggttcttttatcgtatgggaagaagcacctgggaccaaaatctcactgagaggtcaccat cgtcacgtcttcctctttaaggactgtgtcatattctgcaagctgaagagagacttgaac actcattccgaagtttacgtattcaagaacaagatgaagctaaatgacattgatctgaag gacacagtggaaggggacgacagatgctggggtctgtggcatgaacatcgcggtacagtc agaaagatcactcttcaggcgcgcactatgctcacccgtctgtcctggctcaaagacctc cgggacctccagcagcgcagcagaattccactatggagttcgccgtgttttgagctgatt ctaaatgaatccacagctaaaattggacaaactgtaaaactggcctgcaaagtcactgga accccaaaaccagcagtaacttggtacaaagatggtgttgttgtgaaagatgaccagcat catatcatctcagagggacactcaggtgcctgctatttggttctggcttccgtgacgggg gaagacactggtcagtacatgtgttatgcagctagccctatgggtaacgctagcactctg gccaagatcactgttgttgtgcctccaagttttactaccaaacttcagaacactctgctg gtgaaaggcagagatgtgcagttccaatgttcaactggatgcattcctgtgcccactgtg aggtggtttaaggacaacaaacagctggggaataccaagaaatatgaaattcacactgat atgcagacaggggtcctcaaaataattataaagaaggcgaaggaggcagacctggggcaa tatgagtgtgagttgctgaatgaggtgggcagtgccaagtgcaaagcgcagctgtattct gcaccacctcctgcagcagaaagccctaaagacaaaccactggtcgcctcagctccagat acagaatcagaaggctggtccagtgctttggtgaagaacctgttccacatgttctttcag tctggatcctccaaacaatctgcaggtggtccaagtgagactcaagctgaagacaaacag gaaattcaggagagacgagaggacgttccagaagaagagacctcagtggagtccaacaag acattttttatctccgagacagaggaggatgagtacgcagatcctcctgaggtgcaggtg gccatggaggacctgtgtgtaagacctggccaacctgcaactttctctgctgttattact gggcagcccatcccagagatcacctggttaaaggacggtattaagctcgtctccggtgag cacactgagctggtccagagtggagctcgctgctctctcaatctgctgggtgtgaatgtt gctgactgtggcacgtacacctgcacagccacaaacagatcaggacatgcctcctgccac gcccagctcacagtggacacaggtcctgaggagtttgaagaagagcaggagagggaggtg gaggtggaggtggaggtggggagaaggaggaagcttcactctgtttatgatgtccatgaa gagattggaaggggcacttttggggtggtgaagcgagtcacacaccgggcgagtgaggag gtttttgctgctaagttcatccctctgaggagcagcacgaggaccagggccttccaggag agagacctgctgtcccggctggctcactgcaggctggtctgcctactggacttcttctgt acacgccggacccttgtcctcattacagagatctgctcctctcaaggattactggatcat ttgctactaaaaggaaccgtcacagagcgagaggtccggatgtacattcagcagcttctg gaggggattggatatattcacagcatgaacatcctgcatctcgatatcaaaacagacaat atcctaatggtgtcccctgagagagaggagcttaaaatctgtgactttgggttctgccag gagattgacatttccagacaccagtacagtgtttatgggacccctgaatttgtggcccct gaaattgtgcaccaggaaccagtgaccacagcaacggatatctggtctgttggtgttgtt tcttacttatgtctgacaggccattgcccgttctttggagagaatgaccgtgcaaccctg atgaaggtagcagagggcgttctgtactgggatattccagaaatcagcagcaggagtgat caagcacaagatttcctacacagagttttgcagccagacccagagatgagaccgtcagca tcagagagtctgagtcatgagtggtttcaggtccaatgtgaagatgtgcaagctgacagt attgatacaaggagcctaaaatcttttatctctagacggaagtggcagcgctctctgaca tgtcttggatcggtcctgactctgcggccaatccctgagctgctggaggctccactgtct gaagtttctgtcacaacccctcgagatactcatgagcccagcagcacctccctcagcagc acctcctcctctgagtatgacgaggctgacgcatggggcttcttccagcaaaccagccag gaagaagaggagggcagggaggatgaggatgaagaagaatacaacccatacgcttgtcta cctaaaataacaccaagtctaaagataaatgaagaggatagaattatggagcaagcccag agaggcatggtggtgattcctttaaacaagccatccagagagtcacccacgctgtcccca gagccggccagcactacgaaacagaatcagagtcagctttatatcacatcaagtgttgag ccgagtaatagacttctggcccatagtgaaggtggttacgaggaggaacaggatatcggc ccatccctgtgccaccgtgaacaggacgagggcttggaccttggaacccccatcccacgt gggaatgtgatcaagagtaccttctacagcagctcccagcagctttcccccatgtccact cgtcatatgatgctccgggacaagcttcacggcaggaaacaggaaagagggcggaagtcg ttgcgctcaagcctttctgggaggctgaatgaaccactcatagagtatgtggaggactct ccagatgcggaggctggacgtggccagaggagagggtcagtacattcagctactatgaaa tccagctcattcgactgcggagcgagtcctgctcattcagatgtccgtgtccagagaagg agcaggtcgctggatgaatccacgagacgaccggcagtttccgtggagcagaggaagttg ggagatgatgaggaaggcattgatttaggccatgaggatgagttcactgatgaagaggaa gacgaaaccccagagatgttggcgagagagacatcacaacgtacaactgtgacttcacaa ggttcaggacagcagaggatgctgggagatgatgaggaaggcattcagttaggccatgag gatgagtttactgatgaagaggaagacgaaacctcagagatcctggcaagaaagatgtta cgacgttcttcacttgctcctctgacactgacctctggggttgtggcaaaagtgacagca cagaggtctagcatggacgagcagccaatcagcaccctgtctcatgtagatggcatccaa tctcagcctggggaggagaatgttgttggttcacagctgagtctcgctgagtcgtctgtc cttgaacatggctcagaggcttctagcagattgggcttctttgaaggactcgctcccact caccttccgatctcacaaagacggcataaagagtatgacgaatcagacgagcgactgggt gcactgtcatctggaaaagcctcagagtgttctcttttacaggactctgaagatgaagac gtggagagggttctgaggtccctccgccaagagcacctccaaactctaccaaaacagtgc acacataactctggaacaagcgacacaaacaagaacattacattgaggcgaagctcctct gcagttcccatacgcccgattttaacatccccagaaagcagagaagtgcttcagaggcat gcatctgccccggcgctgcaagccaaaccccctagtgggaaatcggccaaagctggactt ctgaagatcttccgcaggcagtcctggacgggacactccagctcccagacagagggctca ggcaagagggttgatgaaggtccacacccacaacagaagactcctctactcactctgagg aagaagatgagggcttcggcctccagcatcaccaagcttttcaccaagcagtccagtaaa gagggcaaggaggagaaaagagcaggaccaattgtgaagaatcctgttcctcctgagaaa gccagcatcacctctgactttctgccatcagttcccttctcaggaagccctcagaaaaaa tcgaagttcttctctctcaaagtgccaagcttcaaaaagagcaaagagatgccagtcaag ccctccagaccggatgtgatccagctggccggtggtggagctctggtgttctggaagcca gtgccatccagtggtcctgtcacttactgcatacagcacagcgtaaatggtggcgagtgg agaatgctgtgtgagagtgtgacagatagctgctacgtagctaacgcgctacctagagga ccaggctacatgttccgagtggcctgcatcaccaaaacagggtcaggacctttcagtgac ccttcaccacctgcttttatgacagccccatatgaagactctcatattcctctgatcctg atggaatccactggatctaagatcactgtgcctggaggcctgggctctgagagatcttac agcttccagtctgagatcaacaggggtcgtttcagtgtggtgatgcagtgtgaggacagc aggagttctcggccgctggcagcgaagctgaccccgtacgagccagagcagaggcagctg gtgctgagggagtatcagctgctgcggaggctgagccaccagcaccttgtccagctccac tctgccatcctcaccccatcatgcctcgtgcttatcgaggagctctgctccggccgagaa atcctctacagcctggctgacagggatgtgtatgcggagctgcatgtgagtgagctgctg cggcaggtcctgaatggggtggactacctgcacggccgccacatcgtccacctggacctg cggtctgacaacgtgctggtgaccgaccgcagcgtggtgaagattgtggacctgggctcc gcacagcctttcactccaggacagacgctcaacattgagcacatcaaagagacgacagag agtaaagtctacattgtccttcctaaagctcctgagattttggaggggcaaggtgttgga cctgccacagatatttgggctcttggtgttctggcttttatcatgctgagtgcggacagc ccgttccatgcggagctgaactgggagagggatcggaatatcaagaaaggaaagatccag ttcggacgctgctatccaggactttctgaaggagccattaacttcctgaagaccactctg aacaataaggcctggggaaggccgtctgctgctgagtgtctgcaggacagctggatacga ggagactgcagccatgccaagcgcgcagactcggtggtgtgcttctccacagacaaactg caggcttttctgaggcagcgtgaggtcaaacgagaccacgctcgcaccaaagccgctccc ccgctgtcctaa

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