Colossoma macropomum (tambaqui): 118823245 Help Entry 118823245         CDS       T09004                                  Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism cmao  Colossoma macropomum (tambaqui) Pathway cmao04020   Calcium signaling pathway cmao04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cmao00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118823245    04020 Calcium signaling pathway     118823245  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cmao04040]     118823245 Ion channels [BR:cmao04040]  Voltage-gated cation channels   Ryanodine receptor    118823245 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_5 EF-hand_6 Ago_Mid Motif Other DBs NCBI-GeneID:  118823245 NCBI-ProteinID:  XP_036448593 LinkDB All DBs Position Unknown AA seq 4886 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCVACIQKENRKFCLSAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLAKTGQNNDRLIRKATHGGGHRTLLYGHAILLRHSFSGM YLTCLKTSRSLTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSS ERYLHLSICNGNIQVDASFMQTLWNVHPTCSGSNVEEGYLLGGHVMRLFHGHDEVLTIPG SDQSEEQQRIVNYETGKVGAKARSLWRLEPLRISWCGSHIRWGQPFRLRHLTTGHYLALT EDRGLVLQDREKSDTASTAFCFRASKEKLESSPKRDIEGMGVAEIKYGDSLCFVTHMAAG LWLSYQAPDVKSTRLGPLKRRACLHAEGHMDDGFTLQRCQHEESRAARIIRNTTRLFSRF IRDLDNLAGKNRVIMLLPIEEVLQTLNDLITYFQLPDAELEHEEKQIKLRSLKNRQNLFK QEGMLTLVSNCIDRLSVYNSAAHFGECAGEEAGAAWKDILNLLYELLAALIRGNRNNCTQ FSQNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHKI LDVLCSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIFLGVREGSAQY KKWYFELMIDQVEHFMTSEPTHLRVGWASTKGYAPYPGGGEGWGGNGVGDDLYSYGFDGL YLWSGRIPRTVASVNQHILTSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFP VVSFSAGVKARFLLGGRHGDFKFLPPSGYAPCYEALLPKEKMRVEPVKEYKRDMDGVRDL LGTTQFLSQASFIPTPVDTSQIVMPPHLEKVRDRLAENIHELWAMNKIELGWSYGKIRDD NKRQHPCLVDFSKLPETERNYNLQMSTETLKTLLALGCHVVQVNINAEEDLKKVKLPKNY MMSNGYKPTPLDLSDVKLTPSQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSKRNP RLVPYALLDERTKKSNRDSLREAIRTLIGYGYNIEPPDQEGGHVVERLSIDKIRFFRLER TYAVTTGKWYFEFEAVTGGDMRVGWARPGLRPDVELGTDDQAYVFDGYRGHRLHQGSRLF GRCWHAGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETDDGFIPVCSLGLSQV GRMNLGKDASSFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPKDHSHIAVTR IDGTIDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFDSTFKSGPTIDMNGVHEEEPLK LKHRHPVKSMKHIDDGRRTDYSSITTYYHSVRVFAGQDPSCVWVGWVTPDYHYYSNFFNL SKNRTVTVTLGDERGRVHESVKRSNCYMVWGGDISSATHSSSRSNVDLEIGCLIDLATGL VTFTVNGKELATSYQVEPNTKLFPAVFVRPTSQNLFQFELAKIKNAMPLSSAIFKSEHKN PVPQCPPRLDVQTIKSVLWSRMPNTFLKVETARVSERHGWQVQCLEPLQMLAVHIPEENR CVDIMELSEQEELRKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYAIDNQYLSGM LREGFYNVLICIHLETAKASRLMMNNEFIIPVTPETRSIRLFPDVSKHHQPPGVGLSTSL KPRLSFAPPCFISTKRDQHLYSPEIPLEILREKAISMLTEAVQGGGDHIRDPVGGSVEYQ FVPILRLISTLLTMGVLASQDIHMILLLIEPGVFGDKKDDGVGEPTEKEGVTGAEEKAVE AGEEDAKDTKPPIRGLLEKRLPESVKRQMCELLHYFCDCELRHRIEAIVSFSDTYVSKLQ FNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFSMGEDCPCPEDVQEELYD FHNELRLHCGIPMEEEEEEQDTSIKGRLLALVYKIKGQPHRAEEKPMEKEQAAPSNLKEL VSQTMVSWAQESHIQDPQLVRMMFSLLRRQYDSIGELLRAMRKSYSISAASVHDTINLLA SLGQIRSLLSVRMGKEEEQLMIDGLSDIMNNKVFYQHPNLMRILGMHETVMEVMVNVLGG GKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLD VAASSVMDNYGLALALEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSF LRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISETPALDL PSTAQGLLSDASTEDDEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIR AILRSLVPTEDLVGIISIPLKMPVANKDGSVTEPDMSACFCPDHKSPMVLFLDRVYGIED QSFLLHLLEVGFLPDLRAAASMDTDALRTTETALAMNRYIGSAMLPLLTRCATHFANTEH HAALIDSTLHTIYRLSKGSSLTKAQRDAIEECLLAVCKYLRPSMLQQLLRRLVFDVPLLS EYCKMPLKLLTNHYEQNWKYYCLPSGWGSYGMASEEELLLTKKIFWGIFDSLSQKKYEQE LFKMAMPCLSAIAGALPPDYVDSSLSTTLEKPVSVDAQGNFDPRPISTTNISLPEKLEYI ANKYAEHSHDKWSAEKVVLGWKYGDTTDEKAKTHPMLRSYKSLTEKEKEVYRFPVKESLK SMLAMGWNIDRTKEGETMFQQRENEKMRKISQVSQGSGFNPSPIDMSNVLLSRELQAMVE VLAENYHNIWAKKKKSDLGAKGGGTHPLLVPYDTLTAKEKAKDREKAQDLFRFLQINGYA ITRGLKDMEQDSSSMEKRFAYKFLKKLLKYVDSAQEFIAHLEAMAVSGKNDRSPHEQEIK FFAKVLLPLIDQYFKNHSLYFLSSPSKNLSSSGYATNKEKEMVTSLFCKLAALVRHRISL FGSDSATMVSCLHILAHTLDTRTVMKSGSELVKAGLRTFFENAAEDLEKTLENLKLGKFT HSRSQMKGVSQNINYTTVALLPILTALFEHITEHQFGVDLLLDDVQVSCYRILTSLYSLG TGKNIYVERQLPALGECLATLAGAMPVAFLEPHLNTHNPCSVFNSKTARERAILGMPDTV EEMCPEVPRLDCLMKDINDMSESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENQPKSA ATVCSTTVTSEHLSVILGNILKILNSNLGIDEASWMKRIAVYAQPIISKARADLLKAHFL PTLEKLKKKAVKVVAEEELLKADSKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNS RSRWLKEPDADSDELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDSKTKMA KSFLPKAGGQDQERKHKKRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKAR YSLKDTDEEVKDHLKQNMHLQEKSEDPAVRWQLNLYKDVIVKNEGPPDPERTVDRLQTIS AAVFHLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRCINLFLTGYQRI WIETETYSFEEKLVQDLARTQRKVEEEEEEVAEAQPDPLHQLILHFSHNALTERSSLEED PLYIAYADMMAKSCAEDEDEDEEGKEKTFEEKEMEKQKTLYQQARLHDRGAAEMVLQTIS ASKGRLGPMVTFTLKLGISILNGGNILVQQKMLDYLKEKRDAGFFKSLSGLMQSCSVLDL NAFERQNKAEGLGMVTEEGSIAVNVRERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNF LRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVMDEAGQRNFSKALAVAKQIF NSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKD MIVMLLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDSFKEHDA DGKGVISKREFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYVEFVKRFHEPAKDIGFN VAVLLTNLSEHMPHDSRLAAFLNLAESVLNYFEPFLGRIEIMGGAKRIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASLISEPDAVERSEE DEDDLRSVVEELEEEEEERTLESFSAFTMACVSMRKNLCSLRKLLTLKSMKKQYKKFRKM SVREMIRGFFSFFWRIFIGLFRFLYNLVWGFFHILWSTLFGGGLVEGAKNMKVTDILGNM PDPTQFGVHGDVLETEKLEANEACLVAEIGQMAEGDQVEVDLMSELLSIQPKKEGGKHGA EPGLGDVSEVVGMDSPSLAAAVRQKKAQEAASKKAVESESKTESEKDAEDGEKKDQDKGK EDSLIEPPSDEEKKPTKRRPGQKKEEPEVFMASVFAGLDIYQTKILNYLARNFYNLRFLA LFVAFAINFILLFYKVTGEESEEVDPWTGRGDEEDGVEYFVLQESTGYMAPTLRFLAVLH TVISFLCVVGYYYLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVINTPS FPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFNPTEEAIAKEASLVAWLSSV DTKYHIWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVT HNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGV RAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVK EDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVW KMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14661 nt NT seq  +upstreamnt  +downstreamnt atggctgacggcggagaaggagaagacgagatacagtttctacggacggatgatgaggtg gtgctgcagtgtgtggcctgcatccagaaggagaatcgcaagttctgcctttctgctgaa ggactcggcaatcggctgtgctacctggagcccacctcagaggccaagtatgttcctcca gacctctgcatctgtaacttcgtgctggaacagtcgctttcagtccgggcactgcaggag atgcttgccaaaactgggcaaaataacgatagactcattagaaaggcaactcatggaggc ggacacagaacactgttatatggacacgccattctcctccgacactccttcagtggaatg tacctgacctgcttgaagacgtccagatctctgacagataagttgtcttttgatgtggga cttcaggaggactcaacaggtgaggcttgttggtggaccatccaccccgcctcaaagcag agatctgagggggagaaagttcggattggtgacgacctcatactcgtcagtgtatcatct gaacgctatcttcacctgtccatttgcaatggcaacatccaggtggatgcttccttcatg caaaccctgtggaatgtccaccctacctgttcaggcagtaatgtggaggaaggatatctc cttggcggtcatgtgatgcgcttgttccacggccatgacgaggttctgaccattccaggc tcagatcagagtgaggagcagcagaggatagtgaactatgagacgggtaaggtaggagcc aaggccaggtctctatggaggttggagcctctacggatcagttggtgcggcagtcacatc cgctggggccagccattccgcctgcgtcacctcaccactggtcactacctggcactgaca gaggacagagggctggtgctgcaggaccgggagaaatcggacaccgcctccacagccttc tgcttccgagcctccaaggagaagctggaatcaagcccgaagcgtgatattgaggggatg ggggtggctgagattaagtatggggactcgctttgcttcgtcacgcacatggccgcaggc ttgtggctctcttaccaggcaccggacgtcaagtcaacccgtttggggcctctcaagaga cgggcctgcctccatgcagaaggacatatggacgatggttttaccctccagcgctgtcag catgaagagtcacgtgctgcccgcatcatccgcaacactaccagactcttcagccgtttt atcagagacctggacaatctggctgggaaaaaccgtgtgatcatgcttctgcccatcgag gaagtcctccagaccctcaatgacctcatcacttatttccagctacctgatgctgagctg gagcacgaggagaaacagataaagctgcgctccctcaagaaccgccagaacctcttcaag caggaggggatgctgactctggtgtctaactgcattgatcgcttgagtgtgtacaacagt gcggcacactttggagagtgtgcaggagaagaggcaggagcagcctggaaagacatcctc aacctgctctatgaactgctggctgcccttatccggggaaataggaataattgcacacag ttctcccaaaaccttgactggctggtcagtaaattggagagactggagtcatcctcaggg attctggaggtcctccactgcatcctaatcgagagcccggaggcactcaacatcattcag agaggacatattaagtccatcatctcgctgctatacaaacatggtcgcaaccacaagatt ctagatgttctctgctctctatgtgtttgtaatggagtggctgtgcgagccaatcagaac ctcatctgtgatcatctgctcccaaagagagacctgctacttcagacacgattggtcaat gatgtacaaagcatgagaccgaacatctttctgggcgtgagagaaggttcagctcagtat aagaagtggtactttgagctgatgattgaccaggtggagcacttcatgactagcgagcct actcacctgcgggtcgggtgggcctccaccaaaggctacgcgccctacccagggggtgga gagggctggggcgggaatggagtcggcgatgacctctactcttacggcttcgatggacta tacttgtggtctgggcgaattccacgaacggtggcttcagtaaaccagcacattctcaca tcagatgatgtagtcagctgctgcttggacttgggtgttcccagcatctccttcaggatc aatggtcagcccgtgcaaggcatgttcgaaaacttcaacactgacggcctcttcttccct gtggtcagcttctctgctggggtcaaggcgcgcttccttttaggcggtcgccatggagac ttcaagttcctgcctccatcaggctacgcaccatgctatgaggcattgctgcccaaagag aagatgagggttgagccagtaaaggagtacaagagagacatggacggagtgagagacctg ctgggtaccacacagtttctgtcccaggcctctttcatacccacaccagtggacacctct cagattgttatgcctcctcacctggagaaagtgcgcgacagactggccgagaacatccat gagctttgggccatgaacaagatcgaacttggctggtcttatggcaagataagagatgat aataaaaggcagcacccctgcctggtggatttctccaagcttcctgaaacggagaggaat tacaacctgcagatgtcaacagagaccttgaagactctgttggctcttggctgccatgtg gttcaagtcaatatcaacgctgaggaggacctgaaaaaagtcaaactcccaaagaactac atgatgtctaatggttacaaacccaccccgctggacctgtctgatgtgaagctgacccct agtcaagagctcctggttgacaaactggcagaaaacgcccacaatgtttgggccaaggat cggatcaaacagggctggacttacggcatacagcaggatctgaagagcaagcgcaatcct cgcctggtgccatatgctttgcttgatgagcgcaccaagaagtcaaacagggacagcctc cgtgaagccatccgcacgctaatcggatacggctacaacatcgagcctccagaccaggaa gggggtcacgtggtggagagactgagcattgataagatccggttcttccgcttggagagg acgtatgcagtgacgacggggaagtggtattttgagtttgaggcagtgaccggaggagat atgagggtaggctgggctcggcccggtctgcggcctgatgtggaactgggaaccgatgac caggcatacgtctttgatggctataggggtcatcgtctccatcagggcagccgtttgttt ggccgttgctggcatgctggggatgtggtgggctgcatgataaacatggaggacaagtcc atgatcttcaccctcaatggagaaattcttatcacaaacaagggctctgagctctgcttc gccgacttcgagactgacgatggctttattccggtctgcagcctggggctttctcaagtt ggtcgcatgaacctgggcaaggacgccagctccttcaagtactacaccatgtgtggcctt caggaagggtttgaaccttttgctgtcaacatgaaccgggaagtcaccatgtggttcagc aaacgccttcctacctttgtcaacgtgcccaaagatcacagtcatatcgcagtcacgagg atcgacggcactatcgatagccctccgtgtctgaaagtgacccacaagacctttgggact cagaacagtaatgctgacatggtgttctgccgtctgagcatgcccgtggagttcgactcg accttcaagagcggccctactattgacatgaatggagtacatgaagaggagccactcaaa ctcaaacacaggcatcctgtgaaatctatgaaacatatagacgatggaagaagaactgac tacagtagtattacaacttactaccactcagttcgggtgtttgctggccaagatccctcc tgtgtttgggttggctgggtcacccctgactaccattactatagcaacttcttcaacctc agtaagaaccgcactgtaacagtcacactgggggatgaacgaggccgagttcatgagagt gtgaagaggagcaactgctacatggtgtggggaggagatatcagtagtgctacccattcg tccagcaggagtaatgtggatttagagattggttgcctgattgatttggctactgggttg gtaaccttcacagtcaatggcaaagagctagcaacctcataccaggttgagcccaacaca aagcttttccctgctgtatttgtaaggcccaccagccagaatctgttccagttcgaactc gccaagatcaagaacgctatgccgctctcatcagcgatctttaaaagcgagcacaagaac ccagttccccagtgtccacctcggctggatgtccagaccattaagtcagtgctgtggagc cggatgccaaacaccttcctgaaagtggagacagcccgggtcagcgaaagacacggctgg caggtgcagtgcctggagcccttgcaaatgctggcagtgcacataccagaggagaaccgc tgtgtagacatcatggagctctctgagcaggaagagctacgcaagttccattaccacaca ctaaagctttactgtgctctctgcgccctcggcaacacccgcgtagcccacgccctctgc agccacctcgaccagtcgcagctcctctacgccatcgacaaccagtacctgtccggcatg ctgcgtgaaggcttctacaatgttcttatatgcatccacctggagacagctaaagcttcc cgtcttatgatgaacaatgagtttattatccctgttacaccagagacccgcagcatcagg ctctttccggatgtttccaagcaccaccagcctccaggtgttggacttagcacatcgcta aagcccaggcttagctttgccccaccctgtttcatcagcaccaagcgcgaccaacatctt tacagtcctgaaatccctctagagattctgagggagaaagcgattagcatgctaacagag gctgttcaaggtggaggagaccatatacgagatcctgtagggggcagcgtggagtatcag tttgtgcccattctgcgattaattagtacattgctaactatgggcgtgcttgccagccag gacattcatatgatcttgctcctcattgagcccggtgtgtttggggacaagaaggacgat ggtgttggggagcctacagagaaagaaggagtgacaggagcagaagagaaggcagtggag gccggagaggaagatgccaaagacaccaagccgccaatcagaggactgctagagaagaga ttgcccgagtcagtgaaacggcagatgtgtgaacttcttcactacttctgtgactgtgaa ctaaggcaccgcattgaggccatcgtgtccttctctgatacctacgtgtcaaagctgcag ttcaaccaaaagttccgatacaacgagttaatgctggctcttaacatgtctgctgcagtc accgccaagaagaccaaagagtttcgctcaccaccacaggaacagatcaacatgctgttg aacttcagtatgggggaggactgtccatgccctgaggacgtacaggaggagctctatgac tttcacaacgagctccgtctacactgtggtattcctatggaggaggaggaagaggagcag gacacgtcaattaaaggccgcctgctggctctggtgtacaagatcaagggacagccacac agagcagaagagaagccgatggagaaagaacaagctgctccctctaatctgaaggagctg gtctctcagacgatggtgagctgggctcaggagagtcatattcaggacccgcagctggtg cggatgatgttcagcctgctgcggcggcagtatgacagcatcggcgagctgctgcgtgcc atgcgcaagagctacagcatcagcgctgcttctgtccatgacaccatcaacctgctggcc tcattgggccagatccgctcactgctcagtgtccgcatgggcaaggaggaggagcagctc atgatcgatggcctgagtgacatcatgaacaacaaggtgttttaccaacaccccaacctg atgagaatactgggcatgcatgagaccgtcatggaggttatggtgaacgtactaggggga ggcaagtctcaggaaattgcattccctaaaatggttgctagctgctgtcgctttctgtgc tacttctgtcgaatcagccgtcagaaccagaaggccatgtttgaccacctgagctacctg ctggagaacagcagcgtggggctggcatctccatccatgagaggttccactcctctggat gttgctgcgtcctctgtgatggacaactatggccttgcactcgcactcgaggagcctgac ctggaaaaggtggtaacatatctggctggctgtggactacagagctgccccatgctgctt gctaaaggctatccagatatagggtggaaccccattgagggagagcgctatctctccttt cttcgctttgctgtcttcgtcaatggtgagagtgtggaggagaactccagtgtggtagtg aagttgctgattcgtcggcccgagtgttttggccccgccctgcgtggagagggaggaaac ggactgctggcagcaatgaaggaggccattaaaatatcagagacaccagcacttgacctg cccagcaccgcacagggcctcctatctgatgcatctactgaggatgatgaagaggaagag gtggttcacatgggcaacgccatcatgtccttctactcagccctcattgatcttctggga cgatgcgcacctgaaatgcatcttatcaataagggtaaaggggaggctctgagaatccga gctatcctgcgctctctagtgcccactgaagacttggttggcataatcagtattccactc aagatgcctgttgccaataaagatggtagtgtgactgagcctgacatgtctgcctgtttc tgccctgatcacaagtcacccatggtgctgtttctggaccgagtttatggcatagaggac cagagcttcctcctgcatctgctggaggtgggcttcctgcctgacctgcgggctgccgcc tccatggacacggatgcactgaggaccactgagacagctctggctatgaatcggtacatc ggttcagccatgttgccacttttgacccgctgcgccactcactttgccaatacagagcac cacgcagcgctcatcgactctaccctccacactatctaccggctgtccaaggggtcctca ctcaccaaggcccagagagatgccatcgaggagtgcctgctggctgtctgcaagtacttg aggccctcaatgcttcagcagttgttgcgtcggctggtgtttgatgtgcctttgctgtct gagtattgtaagatgcctctcaagcttttgactaaccactatgagcagaactggaagtat tactgcctgccctctggttggggcagttatgggatggcctctgaggaagagctgctgctc actaagaagattttctgggggatctttgattcactctcgcaaaagaagtatgagcaggag ctgtttaagatggccatgccgtgtctgagtgctatagctggagctttgccgccagactat gtggactcgtctctcagcaccacactggagaagcctgtctcggtggatgctcagggcaac ttcgacccccgacccatcagcaccaccaacatttctcttccggagaagctggagtacatc gctaacaagtatgctgagcactctcatgacaaatggtccgctgagaaggtagttctgggc tggaagtatggagataccactgacgagaaagccaagactcaccccatgctgagatcttac aaatcactcacagagaaggaaaaggaggtttaccgttttccagtgaaagagtctttaaag agcatgctagccatgggctggaacattgacaggaccaaagaaggagagaccatgtttcag caacgtgagaatgaaaagatgcgcaaaatctcccaggtgtctcagggtagtggcttcaac ccaagtccaatagatatgagtaatgtgcttctgtctcgagagctgcaggcaatggtagaa gtactagcagaaaactaccacaatatttgggcaaagaagaaaaagagtgacctaggagca aaaggtggaggaacacatcctttgttggtgccatatgacaccctcacagccaaagagaaa gctaaagaccgagagaaagcgcaggatttgttccgcttcctccaaatcaatggctatgcg attaccaggggtttgaaggatatggagcaggactcttcctcgatggagaaaaggtttgcc tataaattcctgaagaagctgctgaaatatgtggactctgcacaagagttcattgcacac ctggaggctatggctgttagtgggaagaatgacaggtctcctcatgagcaagaaatcaag ttctttgccaaggtgcttctgccgctcatagaccaatacttcaagaaccactctctctac ttcctctcctcacccagcaagaacctaagcagcagcggctatgccaccaacaaggagaag gagatggtcaccagtcttttctgtaagctggcagctcttgtcagacacaggatttctctc tttggaagtgactctgccacaatggttagctgccttcacatcctggcccacacacttgat accagaacagtgatgaagtctggctctgagctggtgaaggcaggattgaggactttcttt gagaatgcagcagaggatctagagaagactctggagaatctgaagctggggaagttcaca cactcccgcagtcagatgaagggcgtgtctcagaatatcaactacaccacagtggccctg ctgcccatcctaactgccctgttcgagcacatcactgagcatcagtttggagtggacctg ctgttggatgatgtccaggtgtcttgctatcgaatcctgaccagcctttattcactggga actgggaagaacatctatgtggaaagacagcttccagctctaggggaatgtttggcaact ctggcaggagccatgcctgtggcctttttggagcctcacctcaatacacacaacccctgc tctgtctttaactccaaaacagcacgagaacgggccatcttaggcatgccagacactgta gaagagatgtgtccggaagtgcctcgtctggactgtctaatgaaggacattaatgacatg tctgagtctggagcccgctacactgaaatgcctcacgtcattgaggtggtgttgcccatg ctgtgtaactatttgtcctactggtgggagagaggcccagagaaccagccaaagagtgca gcaactgtctgcagcaccactgtcacctctgagcacctcagcgtcatcctggggaacatc ctcaagatcctgaacagcaatctgggcatcgatgaggcctcctggatgaagaggatagca gtgtatgctcagccaatcatcagcaaggccagggcagaccttttgaaggcacatttcctg cccacactggaaaagctgaagaagaaggctgttaaggtagtggcagaggaggaacttctg aaggcggatagcaagggtgacacccaggaggcagagctgctgatcctggatgagtttgca gtgctgtgcagagatctatatgccttctaccccatgcttatccgttatgtggacaacagc aggtcgaggtggctgaaagaacctgatgctgactccgatgagctcttcaggatggtggca gagatcttcatcctttggtgcaagtcacacaactttaagcgagaggagcagaactttgtg gttcagaacgagataaacaacctctcctttctgacaggagacagcaagaccaagatggcg aagtcgtttctgccgaaggcaggaggacaggatcaggagaggaagcataagaagcgacgt ggtgagttttactccatccagacttcgctcatagtggctgctctgaagaagatgctgccc atcggcctcaacatgtgcactcccggtgaccaggagctcatctcattggccaaggcgcgc tacagcctgaaagacacagatgaagaagtcaaggatcatttgaagcagaatatgcacctg caggagaagtcagaggaccctgcagtgaggtggcagctgaacctgtataaggatgtaata gtgaagaatgaagggcctcctgatcctgagcgaacagtggaccgtctgcagaccatctct gctgcagtgttccaccttgagcaggtggagcaaccactcaggtccaagaagtgtgtgtgg cagaagctactgtccaaacagcgtaagcgtgcagtggtggcctgtttccgtatggcacca ttgtataatctgcccaggcatcgttgtattaacctgttcctcacgggctatcagagaata tggatagagacagagacctactcttttgaggagaagctagtgcaggatctggcaaggacg cagcggaaagtggaggaggaggaagaggaggttgcggaggcacagccggaccctcttcac cagctcatcctgcattttagtcataatgctctgacagagagaagttccctagaagaggat ccgctatacatagcctatgcggacatgatggcaaagagttgtgctgaagatgaggacgag gatgaagaaggaaaagaaaaaactttcgaggaaaaggagatggaaaaacagaagacactg tatcagcaggccaggttacacgacagaggagctgctgagatggtcttacagacaatcagt gccagcaaaggtcgactgggtcccatggtaaccttcactctgaagctgggcatctccatt ctgaatggaggaaacattttagttcagcagaaaatgctggactatctgaaggagaagcgt gatgctggcttcttcaagagtctgtctggactaatgcagtcatgcagcgtattggacctg aatgcgtttgagaggcaaaacaaagctgaaggactgggcatggtgactgaagagggctca atcgcagtcaacgtgagggagcggggttccaaggtgctccaaaatgatgagttcactaaa gacctttttaggttcctgcagctgctctgtgagggtcacaacaacgatttccagaacttt ttaaggacacagactggaaacacaactactgttaacataatcataagcacagtggactac cttcttaggctacaggagtccatcagtgatttttactggtattactcggggaaagatgtc atggacgaagccggtcagcgtaacttctctaaagccttggctgtggccaagcagatcttt aactccctcactgaatatatccagggtccgtgcataggcaaccagcagagtttggctcac agtaggttatgggatgcggtggttggctttttacatgtcttcgccaacatgcagatgaag ctctcgcaggactccagccagattgagctgctgaaggagctgatggatctgcagaaggac atgatagtcatgttgctgtcccttctggaaggtaatgttgtaaatggaaccattggcaag caaatggtggatactttggtggaatcctccagcaacgtggagatgatcctcaaatttttt gacatgttcctcaagctgaaggatctcaccacctctgacagtttcaaagagcatgacgct gatggcaaaggagtcatctccaaaagagagttccagaaatcaatggagaatcagaagcag tactctcaatctgaaattgagttcctgctttcttgtgctgaggcggacgagaacgacatg ttcaactatgtggagtttgtgaaacgcttccatgagcctgccaaggacattggtttcaac gtggccgtgctgctcaccaacctgtcggaacacatgccccatgactcccgtctggcagcc ttcctgaatctggccgagagtgtcctcaactactttgagccgtttctgggccgcatcgag atcatgggcggcgccaaaagaattgaaagagtttactttgagattagtgagtctagcaga acccagtgggaaaagccacaagtcaaggaatccaagcgtcagttcatctttgacgtagtt aatgagggtggagaatcagagaagatggaactctttgtaaacttctgtgaggacactatc tttgaaatgcaactggcctctttgatatcagaaccagatgctgtggaacggtcggaagaa gacgaagacgatttgcggagtgtggttgaagaactagaagaggaagaagaagagagaacg ttggaatccttctcagcttttaccatggcttgtgtatccatgaggaagaacctgtgcagc cttcgcaagctgctaacccttaagagcatgaagaaacaatacaagaagttccgtaaaatg agcgtgagggagatgatccgtggcttcttctctttcttctggaggatcttcatcggcctc ttccgcttcctctacaacctggtttggggcttcttccacatcctgtggtccacgctgttt ggcggaggcctggtggaaggtgccaagaacatgaaggtgacagatatcctgggcaacatg ccggaccccactcagtttggtgtccatggagatgttctagagactgaaaagctggaggca aacgaggcttgtttggtagcggaaattggccagatggcagagggagaccaagtggaagtg gacctcatgtcagagctgttgagtattcagcccaagaaggaggggggcaagcatggggct gagcctggactgggggacgtgtcagaagtggttggcatggattctccttctctagctgct gctgtgcggcagaaaaaagcccaggaagctgcgagtaagaaggcagttgaaagtgaatca aaaacagaatcagagaaagatgcagaggatggagagaagaaggaccaagacaaagggaag gaggattctctcatagaacccccatcggatgaagagaagaagccaaccaagcggagacct gggcagaagaaagaagaaccagaggtcttcatggccagcgtttttgctggattggacatc tatcagactaagattctgaattacctagcacgaaacttctacaacctgcgattcctggct ctgtttgtggcatttgccatcaacttcattctgcttttctacaaggtgactggtgaggag tctgaggaggtggatccatggacagggagaggtgatgaggaggatggtgtagagtatttt gttctgcaggaaagcactggctacatggcacccacacttcgcttcttagcagtgctacat actgtcatttccttcctctgtgtggtgggatattactatctgaaggtgcccttggtggtt tttaagcgggagaaggaaatcgccaggaaacttgagtttgatggtctttatatcactgag cagccttcagatgatgacatcaaagggcaatgggacagacttgtgattaacacaccatcc ttccccaataactactgggataagtttgtcaaacgcaaggtaataaataagtatggagac ctgtacggggcagagcggattgctgagcttctcggtctagacaagagcgctctggacttc aaccccactgaagaggccatcgcaaaagaggcctccttggtggcctggttaagttcagtc gacaccaagtatcatatttggaagatgggcgtggtgttcacagacaattctttcctgtac ctggtgtggtacaccaccatgtccatcctgggacactacaacaacttcttctttgccgct cacctgctggacattgccatgggcttcaagaccttgaggaccatcctctcctcagtcacc cacaatggcaaacagctggtgctgactgtgggtctgctggctgtagtagtgtacctttac accgtggtggcattcaacttcttccggaagttctacaacaagagcgaggacgaggacgag ccagacatgaagtgtgacgatatgatgacttgctatcttttccacatgtatgtgggagtg cgtgctggtggcggaataggtgatgagatcgaggacccagcgggggacccctatgagctt taccgcatcctcttcgacatcaccttcttcttctttgtcatcgtcatccttctggccatt atccagggtttgatcattgatgcttttggagaattgagagaccagcaagagcaagtcaaa gaggacatggagaccaaatgtttcatctgtggtattggaaatgactactttgacaccacc ccacatggctttgagacacacaccttacaagagcacaacttggccaactacctgttcttc ctcatgtatcttataaacaaggatgaaaccgagcacacaggccaggagtcttatgtgtgg aagatgtaccaggagcgatgctgggacttcttcccagctggagactgcttccggaagcag tacgaggaccagctgggctag

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