Cucurbita maxima (winter squash): 111487125 Help Entry 111487125         CDS       T05246                                  Name (RefSeq) auxin transport protein BIG   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism cmax  Cucurbita maxima (winter squash) Brite KEGG Orthology (KO) [BR:cmax00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:cmax04121]     111487125 Enzymes [BR:cmax01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      111487125 Ubiquitin system [BR:cmax04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     111487125 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UbLigase_R4 UBR4 ZZ zf-UBR Motif Other DBs NCBI-GeneID:  111487125 NCBI-ProteinID:  XP_022990147 UniProt:  A0A6J1JHU8 LinkDB All DBs Position Unknown AA seq 5114 aa AA seqDB search MAEQSLVKLVDTLFLDDSSSSANTKDPSSSSDILQLLIRSDDSSIKLDLRQFYSILNAGL RDLGDGKLAFQSWTDPQIQAVCSIAHAITSASRSLTVNQAEAIVVGVIKKSLELVFCYLE KSEFKGDDFSIQNNMLLFMETILADGMDKVSDYAQLCAKNELIDLLKSTGGDCDATIEFH NDVECGFTGGVCCSREEKQASRLLMTIAAECVQVAQLTSESGFSEPTSLEDMNKLVFRCQ HWAVAHLACIQRLILICKDLVILTDALDEKAGSTSFRKRLSCSLRILKLLTELSKKFPYI EYDAKLMEAVAFFANSLPCLFGLCFEFANSHAMVEGSFEGTILLLLEEFLELLQVVFRNS YVCVNIQTCIVSSILDNLSSSVWRYDTSIANLKPPLVYFPRSVMVIIKLIQDLKGHKYHA LSLKDLEMHHTCSTADLSVDMPKCYARLEIVPLHKNYTVEEILGMIFPQSKQWMDDLMHL LFFLYSEGVRLRPKIERSLSSCMKSSSTVEQETAICHEDEALFGDLFSESGRSVGSVDGY DSQNLSVNSASSFCNLPLQAAKELLSFMKLCIFSSEWNASVFADGCNKLNQNHIDILLSL LNCEGCCSDDKASASCLPEHAEKKFGHIHEICYRLLHGLLTCHALPDSLEEYIVKKILNA ENGNFVYNDQTLSLLAHTLFRRTGVAGSQLRTQIYRQFVEFISEKSKTISFKYSSLQEFI GTLPSVFHIEILLVAFHLSSEGEKMEISSLAFSSIRAIDAPSTFSSCTELSMWGLLVSRL IVVLRHIVFHPHTCSSSLLFDFRSKLRDAPAFASSLPYTLNDHLSSWGANVAKNIIGSSV DSKPHFNSLINQLIDISSFPDSLHKHDLTIECPWFNPSEIFSTFSWILGFWNGKQAVTVE DLIIERYIFVLCWDFPSVNALTHVCPLWSDPETLDISNTTCFFYFTNLLLDHSDVIVKSM TFPQVVIGLLRHLHSGSMLEDFKALGWNFLRNGAWLSLILSFLNVGIWRYCNKNMVSTVG SFSTDTTVTDNEHAKFAESIFSSVITDNQISILIRELSAVLCMYLQVHQKAFVATLSSRH DHDAEFSPLLLFKHSEFDKSVQNKILENYGTTSSLLESVFNLMSRLDEIVDKRALGFLSR ASWESMFHGFPSHLETSSGILLSCVLSIGRIISVLAGLLRMVDVKRNIVLETEVIHGILD ALMTIKFDKTFESVHGLCEDMYQSLNAELVGSAYGDLFLLKQLEGYLRHINTIGASDSTI HEWVIVKAIDVLDSIRKDVSKSSLFQFYLGVEDVSEQVRELYALQRGNLLVLLDSLDNCC SELVNLKVLGFFVELLSGDPCSKLKQKIQNKFLSMDLLCLSKWLEKRIFGLYEEDSSGVN VKGSSISLRESSMSFVFCLISSPSEPLALQLQSHIFEAALVSLDMAFLRFDINVAKAYFH FVVQLLKGEKSMKLLLERILILMEKLVGEERLLPGLRCLFSFLEMILIESGSGKNVIEKL SGKPLSRYAPEVGPLSSKSFGSRKNSETLVLSSNQEEGPGSFECDATSAEEDEDDGTSDG EVASLDKDEEEDTNSERALASKVCTFTSSGSNFMEQHWYFCYTCDLTVSKGCCSVCAKVC HHGHRVVYSRSSRFFCDCGAGGVRGSSCQCLKPRKFTGHGSAPAHGASHFQCFLPFSEEG EQLPESESDMEDDVVTDTDKCLRASVPRELLDGVPVLLEKLDVEGRMLKLCSCLLPCITN QRDPDLSKDKKIILGKDKVLSYGLDLLQLKKTYKGGSLDLKIKAEYANAKELKSHLASGS LVKSLLSVSVRGRLAVGEGDKVSIFDVRQLIEQTTAALMTADKTNVKPLSKNVVRFEIVH LTFNPTVENYLAVTGYEDCQVLTLNHRGEVIDRLAIELALQGAHIKRMEWVPGSQVQLMV VTNRFVKIYDLSLDNISPMHYFTLPDDMVVDATLFTASQGRVFLIVLSENGRIFRLELSA LGNVGVTPLKEIIHVQGREMTAKGLSLYFSSCYKLLFLAYADGTTLVGQLSPDATKLTEI SVIYEEEQDGKVRPAGLHRWKELFADSGLFFCFSSGKSNSALAVSMGAHEIYAQNLRHAG GSSSQLVGIDVYKPLSKDKTHCLVLHDDGSLQIYTHTAVGVDASANATAEKIKKLGSGIL NNKAYASTNPEFPLDFFEKTVSISADVRLGGDAIRNGDSDGAKQSLASEDGFLESPSSSG FKITVSNSNPDIVMVGCRINVGNTSANHIPSEITIFQRVIKLDEGMRSWYDIPFTVAESL LADEEFTITVGPAFNGTALPRIDNLEVYGRAKDEFGWKEKLDVVLDMEARALGSNSLLAR TGKKRRSMQCAPIQQQVLADGMKVLSSYYLLRRSQGCPKLDVIDQELSKLKCKQLLETIY ESDREPLLQSAACRVLQAIFPRKEIYYQVKDTMRLTGVVKSTSALSSRLGVGGAASGWII EEFTSQMHAVSKISLHRRSNLACFLEMNGSQVVDELMQILWGILDLEQPNAQTLNNIVIS SVELIYCYAECLALHGPDTGRRSVAPAVVLLKKLLFSSSEAVQTASSLAISSRLLQVPFP KQTMLATDDCADIPLSAPTSTETTGANPQVMIEEDSIASTIQYCCDGCSTVPILRQRWHC TICPDFDLCESCYEVLLDADRLPSPHSRDHPMTAIPIEVESLGDGNEYHFSTEDINDSSL TSARSDISVKNPVSSIHVLEPADSGDFSASVTDPVSISASKQTVNSLLLSELLEQLKGWM ETTSGVQAVPVMQLFYRLSSTMGGPFMNSLKSENLDLERLIKWFLDEINLNKPFEAKSRT SFGEVAILVFMFFTLMLRNWHQPGSDGPVAKPNTTADTHDKNSTQVAPSTSVTAQPSVDD QEKSDFTSQLLRACSSIRQQSFVNYLLDVLKQLVHVFKSSTIESDCGHSFNNGSGCGALL TVRKDLPAGNFSPFFSDSYAKAHRTDLFVDYHRLLLENAFRLVYTLVRPEKYDKTLEKEK EKVYKIYSNKDLKLDIYRDVLCSYINNPNTSFVRRYARRLFLHICGSKSHYYSIRDSWQF STEVKKLFNYINKAGGFQNPMSYERSVKIVKCLTTMAEVAAARPRNWQKYCLQHGDVLPF LLNGVFYFGEESVIQTLKLLNLVFYTGKDIGHSVQKSEAGDTGTSINKSCTQTVDSRKKR KGEDGNDSALEKSCLDMESMVNIFVDKGNNVLSNFIDCFLLEWNSSSVRAEAKGVVCGIW HHGKQTFKETLLMSLLQKVKSLPMYGLNIAEYSELVTWLLGKVPDVGSKQQSSELLDRCL TSDVIRSIYETLHSQNELLANHPNSRIYNTLSGLVEFDGYYLESEPCAACSSPEMPYSRM KLESLKSETKFTDNRIIVKCTGSYTIQTVIMNVHDARKSKSVKVLNLYYNNRPVADLSEL KNNWSLWKRAKSCHLAFNQTELKVEFPIPITACNFMIELDSFYENLQALSLEPLQCPRCS RPVTDRYGLCNNCHENAYQCRQCRNINYENLDSFLCNECGYSKYGRFEFNFMAKPSFTFD NMESDDDMKRGLAAIESESENAHRRYQQLLGFKKPLLKIVSSIGENEMDSQQKDSVQQMM VSLPGPSCKINRKIALLGVLYGEKCKTAFDSVSKSVQTLQGLRRVLMTYLHQKHTDDGFP ASRFVISRSPNNCYGCATTFVTQCLEILQVLSKHHCSKKQLISLGILSELFENNIHHGPK TARIQARSVLCSFSEGDVDAVSGLNNLIQKKVMYCLEHHRSMDIALATREELSLLSEVCS LADEFWEARLRLVFQLLFSSIKSGAKHPAISEHIILPCLRIISQACTPPKSETVDKEQRM GKSTSVSQNKDETTTNISGSFSGPVSGSKSAPESLEHNWDSSHRAQDIQLLSYAEWEKGA SYLDFVRRQYKVSQVFKGTVQRSRTQKSDYLSLKYALKWKRVVCRNAKSDLSAFELGSWV TELVLCACSQSIRSEMCMLISLLCAQSSSRQFRLLDLLVSLLPATLAAGESAAEYFELLF KMVESEDARLFLTVRGCLRTICQLISQEVGNVESLERSLRIDISQGFILHKLIELLGKFL EIPNIRSRFMWDNLLSEVLEALIVIRGLVVQKTKLISDCNRLLKDLLDSLLLESNDNKRQ FIRACISGLQIHGEERKGRTCLFIQEQLCNLISPKKPEPVYLMVLNKAHTQEEFMRGSMT KNPYSSAEIGPLMRDVKNKICHQLELLSFLEDDYGMELLVAGNIISLDLSIALVYEQVWK KSNQSSSSISNSALISTISARDPPPMTVTYRLQGLDGEATEPMIKELEEDREESQDPELE FAIAGAVREYGGLEIVLRMIQRIWDNFKSNQEQLVAVLNLLMLCCKIRENRRALLRLGAL GLLLETARRAFAVDAMESAEGILLIVESLTIEANESESISIGQSALTVSSEQTGTGEQAK KIVLMFLERLSHPFGSKKSNKQQRNTEMVARILPYLTYGEPAAMAALIQHFTPYLNDWEK FDRLQKQHEDNPQDKSISEQAAKQRFTVENFVRVSESLKTSSCGERLKDIILEQGITGLA VKHLRDSFAVAGQAGFRSSMEWAFALKRPSIPLILSMLRGLSMGHLATQRCIDEGRILPV LHALERVPGENEIGARAENLLDTLSNKEGNGDGFLEDKVRMLRHARRDEMRRLALKNRED ILEKLGMRQVASDGVERIIVSQSALEGLEDVKEEEDGLACMVCREGYSLRPSDLLGVYSF SKRVNLGVGTSGSNRGECVYTTVSYFNIIHYQCHQEAKRTDAGLKIPKKEWEGATLRNNE SLCNSLFPVRGPSVPLAQYIRYVDQHWDNLNALGRADGNRLRLLTYDIVLMLARFATGAS FSAESRGGGRESNSRFLPFMIQMARHLLDQGSPSQRSTMAKSVSTYLSSSTVDSRPLSPG PQPSAATEETVQFMMVNSLLSESYESWLLHRRAFLQRGIFHAYMQHTHSKSTSRSSVSSS NPNTEAEEANDLLTTIRPMLVYTGLIQQLQHFFKVKKSASIASSAKEGTSATTTEEESET RNLEGWEVVMKERLDNVREMMGFSKELLTWLDEMNLASDLQEAFDVIGVLADVLSGGISR CEDFVHASINTGKG NT seq 15345 nt NT seq  +upstreamnt  +downstreamnt atggcggagcagagtctcgtcaaactcgtagacactctcttccttgatgattccagcagc agcgccaatactaaggacccttcatcttcctccgatattctccagcttcttattcgctcc gatgattcttcgatcaaacttgaccttcgtcaattctattcaattctcaacgccggtctt cgggacctaggcgacgggaagcttgcttttcagtcgtggaccgatcctcagatccaagct gtttgctcaattgctcatgcaattacttctgcttctcgatccctcaccgtgaatcaagct gaagctattgttgttggggttattaaaaaatcactcgagttggttttctgttacttggag aaatcagagtttaagggcgatgactttagtattcagaataatatgttactgtttatggaa acaattttggctgatgggatggataaagtatcagactatgctcagctttgtgccaagaac gaacttatcgacttgttaaaatctactggtggagactgtgatgctactattgagttccac aatgacgttgaatgtggttttacaggaggagtctgttgttccagagaagaaaaacaggca agtaggcttttaatgacaatagctgctgaatgcgtgcaagttgctcagctgacctctgaa tctggattcagtgaacccacatcccttgaagacatgaacaagttggttttccgttgccaa cattgggcagttgcacatttggcatgcattcaacgtttgattttgatctgtaaagatttg gtaatactcacagatgcacttgatgagaaggcaggaagtacaagttttcgaaagagactg tcatgtagtttgaggatattaaagcttctcactgaactctcaaagaaatttccatatatt gaatatgatgctaaactgatggaagcagttgcattctttgccaactcgttgccttgcttg tttggactatgttttgagtttgcaaatagtcatgcaatggttgaaggtagttttgagggc accattttgttactcctagaagaatttttggagctacttcaggttgtatttcgcaacagc tatgtttgtgtgaacatccaaacatgtatagtgtcttccatattggataatttgagttct tcagtttggcggtatgatacatctatcgcaaacctgaagcctcccctggtttattttcct cgaagtgttatggttataataaaactgattcaagatctcaaggggcataaatatcatgcc ttaagtcttaaagatcttgaaatgcatcacacgtgctctactgctgatttatcagtggac atgcctaaatgctatgctcgtttggagattgttcctttgcataagaattatacagttgaa gaaattttgggaatgatattccctcaatcaaaacaatggatggatgatttgatgcatctc ctcttctttctttattctgaaggagtgagattaagaccaaaaatagagagatcattatcc agttgcatgaagagcagtagcacggttgaacaggaaactgctatttgtcatgaagacgaa gctctatttggggacctcttctctgagagtggccgctctgttggttctgtagatggatat gactcgcagaatctttctgtcaattctgcctccagcttttgcaatcttcctctccaagct gctaaagaactattgagctttatgaagttatgcatcttctcttctgaatggaatgcatct gtttttgctgatggttgcaacaaacttaatcagaaccatattgatatattactttccttg ctaaactgtgaggggtgctgttctgatgacaaggcttctgctagttgtctacctgaacat gctgagaagaaattcggccacatccatgaaatttgttacaggttgttgcatggtcttctc acatgccatgcgttgcctgattcccttgaggagtacattgtgaagaaaattttgaatgct gaaaatggtaactttgtttacaatgatcagaccctaagcttactggcccacacacttttc cgtagaactggtgttgctgggtcacagttgaggacccaaatatacaggcaatttgtggaa tttatcagtgagaagtccaaaactatttccttcaaatattccagcctccaggaatttatt gggactctgccctctgtctttcatattgaaattcttcttgtggcatttcacttatcttct gaaggagaaaagatggaaatttcaagcttagctttttcttccattagggcaattgatgct ccgtccacattttctagctgtacagaattgtcaatgtggggtctactggtttcaaggttg attgtagtacttcgccacattgtttttcaccctcatacatgttcctcttcgttgcttttt gattttcgatctaagttgagggatgctcctgcatttgcctccagtttgccttacacgttg aatgatcatttatcatcttggggagcaaatgttgctaagaatataattggttcatccgtg gattccaagccccactttaatagcttgatcaaccagttgattgacatttcttcatttcct gattcactacacaagcatgatttgacaatagaatgtccgtggttcaatcccagtgagatc ttttctacattctcatggattttggggttctggaatggtaaacaagctgttacggtagaa gaccttataattgaaagatatatttttgttctttgctgggattttccttccgtgaatgct ttgacacatgtatgcccattatggagcgacccagagacgctggacatttctaatacaacg tgcttcttttacttcactaatttacttctagatcatagtgatgttattgtcaagagcatg acgtttcctcaagttgtgattggtttgcttcggcatttgcatagtgggagtatgctggag gactttaaagcactgggctggaattttttaagaaacggagcttggctatctctaattctt tccttcctcaatgtaggaatatggagatactgcaataagaatatggtttctacagtgggc tctttctcgacagataccacagtgacagataatgagcatgccaagtttgctgaaagcata ttttcctcggtgattacagataaccaaatttcaattttaatcagggagctgtcagctgta ttgtgcatgtatttacaagttcatcagaaagcttttgttgctactcttagtagtagacat gatcatgatgctgagttttcccctctcttgctctttaaacattctgaatttgataaatct gtgcagaacaagatccttgagaactatggcacaacttcttccttgctggagtctgttttt aacctcatgtctaggttggacgaaatagtggacaaaagagcccttgggttcttatcaagg gcctcttgggaatcaatgtttcatggttttccctctcatttggaaacttccagtggaatt ctgctttcttgtgtccttagcatagggaggattatttctgttttagctgggctcctgagg atggtagatgttaaacgtaatattgttttggagactgaggtaattcatgggattctggat gcactaatgactataaaatttgacaagacctttgaaagtgttcatgggttgtgtgaagat atgtatcagagtttgaatgcggaattggtaggatctgcttacggggatctgtttctgttg aaacaacttgaggggtacttaagacacataaatacaattggggcgagtgatagcactatt catgagtgggtaattgtcaaggctatagatgtcttggacagcatccggaaagatgtttcg aagtcttctttattccaattttatcttggtgttgaagatgtatctgagcaggttagggag ctttatgcattacaacgtggtaatttattggttcttctggactccttagacaattgctgc tccgaattagttaatttgaaggttcttggtttctttgttgaactcttgtctggagatcca tgctccaagcttaaacagaaaatacaaaataaattccttagtatggatttgctttgcctg tcaaaatggttggagaagaggatttttggcttatacgaggaagattcaagtggagtcaat gtgaaaggatcttctatttctcttagagagtcatccatgagttttgtattttgtctcata tcatcaccctcagaacctttggcacttcaactgcagagtcacatctttgaggctgcacta gtatcccttgatatggcatttttacgatttgatatcaatgttgccaaggcctatttccat tttgttgttcagctattgaaaggggagaaatcaatgaaattacttttggagagaattctc atattgatggagaaattggttggtgaagagcgccttcttccagggctgaggtgcctcttt agtttccttgaaatgatcttgattgagagtggatctggtaagaatgttattgagaaactc tctggaaaacccctatcgaggtatgcacctgaagttggacctctttcttctaagtcattt gggtctaggaagaactcggagacattggttctttcttccaatcaagaagagggacctgga tcttttgaatgcgatgcaacttctgccgaggaagatgaggatgatggaacttccgatggt gaggtagctagtctagacaaggacgaggaggaggacacaaacagcgaaagggcacttgct tcaaaagtctgcacatttacatccagtggcagcaatttcatggaacaacactggtacttt tgttatacatgtgatctgactgtctcaaagggatgttgttctgtgtgtgcaaaagtctgt catcatggtcatcgtgttgtttattcccgctccagtcgcttcttttgtgactgtggtgct gggggtgttaggggcagcagttgccaatgtttaaaacctcgcaagtttactggacatggt agtgcccctgcacatggtgccagtcacttccagtgcttcttgcccttctctgaggaggga gagcaacttcctgaaagtgaatctgatatggaagatgatgtggttacagacactgataaa tgcctcagagcttctgttcctagagagcttctggacggagttcctgttttacttgagaaa ctagatgttgaaggaaggatgctcaagctttgctcttgtttattgccttgtataactaac caaagggacccagacctttcaaaagacaaaaaaattattctgggtaaagataaggtgcta tcgtatgggcttgatctcttgcaattgaaaaagacatataaaggtgggtcattggacctt aagattaaggcagaatatgcaaatgccaaggagcttaaatcacatctagctagtggatct cttgtgaaatctttgctcagtgtcagcgttagaggtcgtcttgctgttggtgaaggtgat aaagtgtctatttttgatgttaggcagttaatagaacagaccacagctgcactcatgacg gcagacaagactaatgttaagccactctccaaaaatgtcgttcgttttgaaattgtacat cttacttttaatcccacagtagagaactatcttgctgtgaccggctacgaagattgccaa gttttgactttgaaccatcgtggcgaagtcattgaccgtcttgctattgaacttgctctg caaggtgctcatattaaacgcatggaatgggttccagggtctcaagtccaactaatggtg gttacaaacaggtttgtcaaaatatacgatctatccctggataatatcagtccaatgcac tacttcacgttgccagatgacatggtagttgatgctacactgttcacagcttcacaggga agggtctttcttattgttctttcagaaaatggtaggatattcagacttgagttgtcagcg ctgggaaatgttggagttacacccttgaaggagatcattcacgttcagggaagagaaatg actgcaaagggattgtcattgtacttttcttcatgttacaaattattatttcttgcatat gcagatggcaccacattggttggtcagttaagccctgatgcaacaaaattgactgagata tcagttatatatgaagaggaacaagacggaaaagttcggcctgctggattacaccgttgg aaggagttgtttgctgacagtggcttatttttttgcttttcaagtggaaaatctaattct gctttggctgtatctatgggggctcatgagatttatgctcaaaacttgagacatgcgggt ggttcatcctcgcaattagttggcatagatgtatataagcctttatccaaagataaaaca cactgtcttgttttgcatgatgatggcagccttcaaatatacacacataccgcagttgga gtggatgctagtgcaaatgcaactgcagaaaaaatcaaaaagttgggttctggcattctc aataacaaggcttatgccagtacaaatccagaattcccgcttgatttttttgagaaaact gttagcatctccgcagatgtgagattgggaggtgacgccattcgaaatggtgattctgat ggagctaaacaaagtttggcatctgaggatggttttcttgagagtcctagttcttcaggt ttcaagatcactgtctctaactccaatcctgatattgttatggttggatgccgcattaat gttggtaatacgtccgcaaaccatataccttcagagataactattttccaaagagtcata aaattagacgagggaatgcgatcttggtacgatataccatttactgttgctgagtctctc cttgctgatgaagaattcactataactgttggaccagcattcaatggtactgcacttcca aggatagacaatcttgaagtgtatggtcgagcaaaagatgaatttggttggaaagaaaaa ctggatgttgtcctggacatggaagcacgtgcacttggttccaattccttgcttgccaga actggaaaaaagaggcgatccatgcaatgtgctcctattcaacagcaggtgttagcagat ggtatgaaggtcttgtctagttattatttgcttcgtagatcacaaggatgcccaaaactt gatgttatagatcaggagctgagtaaactgaagtgcaagcaattactagaaacgatatat gaaagtgatcgggagcccttgttgcaatctgctgcttgtcgtgtcctgcaagccatcttc cctagaaaagagatatactatcaagtgaaggacaccatgcgtcttactggtgtggtgaaa tcaacatctgcgctctcctctaggcttggcgttggtggtgctgcaagtggatggattatt gaagaatttacatctcaaatgcacgcagtttctaagatttccctgcatcgtagatctaat ttggcttgtttcctggaaatgaatggttctcaagtggtggatgaactcatgcaaattctg tggggaattttggatttggagcagcctaacgctcagacattgaacaacattgttatttct tctgttgaacttatttattgttatgctgagtgcctggcattgcatggtcctgacactggc agacgctctgttgcacctgctgttgtgctacttaagaaacttctgttttcctccagtgag gctgttcagactgcaagcagcttggctatatcttcaaggttgcttcaggtcccatttcca aagcaaacaatgttagctactgatgattgtgctgatattccattatctgcacctacatcc actgaaacaactggtgccaatccccaggtcatgattgaagaagattctattgcttctact attcaatattgttgtgatggttgctccacagttcctatactgaggcaacggtggcattgt acaatctgtcccgattttgatttatgcgagtcatgctatgaggtactacttgatgcagac aggcttccttcaccacattctagagatcatcctatgactgccatcccaattgaagtggaa tcactgggagatggaaatgaatatcacttttcaacagaagatatcaatgattcaagctta acatcagcaagatcagatattagcgtgaagaatccagtgtcatcaattcatgtcttggag ccagctgattctggggatttttctgcctcagtgactgatccagtttcaatatcagcttct aaacaaactgttaattccttgcttctctctgagctccttgaacagttaaaaggatggatg gagacaacatcaggtgttcaggctgttcctgttatgcagcttttctacagattatcgtcc actatgggtggaccttttatgaacagcttgaaatctgaaaacttggacttggaaagatta attaaatggtttttggatgagattaatctcaacaaaccctttgaagcaaaaagccgtact tcttttggggaagttgcaattcttgttttcatgttcttcaccttgatgctaagaaactgg caccaacctggtagtgatggtccagttgccaagcccaatactactgctgatacacacgac aagaattcaacccaggttgcaccatctacttcagttactgcacaaccatctgtggatgat caagaaaaaagtgactttacctcacaactactccgtgcttgcagttccattagacaacaa tcttttgtaaattatcttttggatgtgttgaagcagctggtgcatgtctttaagtcatcc acaatagaatctgactgtggacatagttttaataatggttctggatgtggagctctgcta acagttcgtaaggatctgccggctggaaatttctctccatttttttcagattcttatgcg aaagcacaccgtacggatctttttgttgactatcacaggctcttattagaaaatgctttt cgtcttgtatatacattggttcgaccagaaaaatatgacaagacattggagaaggagaag gagaaggtttataagatttatagcaacaaggatttgaagttggatatctatcgggatgtt ctttgcagttatattaacaaccccaatactagctttgttagaaggtatgctagaaggctt ttcctccacatttgcggcagcaaaagtcactattacagtattcgggactcttggcagttt tcaactgaagtaaagaaacttttcaattacataaataaggctggtggtttccaaaatcca atgtcatatgagagaagcgtaaagatagtgaaatgtctaacaactatggctgaagtagct gctgcaaggcctcgaaattggcagaaatactgtttacaacacggagatgtgctaccattt ttgctgaatggagttttctactttggggaggagtctgtcattcagactctcaaactgttg aatctcgtcttctatacaggaaaagatattggccattctgtacaaaaatctgaagctgga gatactgggacaagtattaataaatcttgtacacaaactgtggattctagaaagaaaaga aaaggtgaagatggaaatgattctgccttggaaaagtcctgtttggatatggagtccatg gtgaatatctttgttgataagggtaacaatgttttgagcaattttattgattgctttctt cttgaatggaattcaagttctgtccgggcagaggccaagggtgttgtttgtggtatttgg catcatggaaagcagacatttaaagaaactctattgatgtctctcttgcaaaaagttaaa agtcttcctatgtatggtctgaacattgcggaatattcagaactggtcacatggttgctg ggaaaagttcctgatgttggttctaagcagcagagttctgaacttctggaccgatgcttg acctctgatgtaattcgatcaatttatgagacacttcactcacaaaatgagctgttagct aatcatccaaattcacgtatttacaatactttaagtggtttagttgagtttgatggttac tatctagagagtgaaccttgtgccgcttgcagttctcctgagatgccttacagcaggatg aaacttgagagtcttaaatctgaaacaaaattcactgacaaccgcatcattgtcaaatgt acagggagttacacaattcaaactgttataatgaatgttcatgatgctcggaagtccaaa tctgtgaaagttttgaatctatactacaataatcgacctgtggctgacttgtcagagttg aaaaataattggtctttgtggaagcgtgcaaaaagttgccatcttgcattcaatcagact gagctaaaagtagagtttcccattccaattactgcatgtaatttcatgattgagctggat tcattctatgaaaatcttcaggctttgtcccttgaacctttgcaatgccctcgatgcagt cgtccagtcactgataggtatggactatgcaacaattgccatgaaaatgcatatcaatgt cggcaatgccggaacataaattatgagaaccttgactctttcttatgcaatgagtgtgga tacagcaaatatggaagatttgaatttaattttatggcaaagccaagttttacatttgat aatatggagagtgatgatgatatgaagagaggtttagctgcaatagaatctgaatcagaa aacgctcacaggagatatcagcaactcttaggcttcaagaaacccctactaaaaattgtt tcaagcattggtgagaatgaaatggactcgcaacagaaagattctgttcagcaaatgatg gtctcacttccaggaccgtcgtgcaaaattaatcgtaaaattgcgctccttggggtttta tatggtgaaaaatgcaaaacagcctttgattctgtcagtaaaagtgtccagacgcttcaa ggtcttcgtcgggttttaatgacatatttgcaccagaaacatactgatgatgggtttcca gcttcaagatttgtgatttctagatctcctaataactgctatggttgtgcgactactttt gtcactcagtgtcttgagatattgcaagtgttatcaaagcatcattgttccaagaagcaa ctcattagtctgggtatattatctgagctttttgagaataatattcatcatgggcccaaa actgctcgaatacaagctaggtcagttctttgttctttttctgagggggatgtagatgca gtgagtgggctgaataatctcatccaaaagaaagtcatgtactgccttgaacaccatcgt tctatggacattgcattggcaactcgagaggagttatcactgctctccgaagtctgttct ttggctgatgagttctgggaagctagattgcgacttgtcttccagctattgttttcatcc attaagtcgggtgccaaacatccagcaatttctgagcacattattcttccatgtctgagg atcatatctcaagcctgtactccgcctaaatctgaaacggtagacaaggagcagaggatg ggaaaatcaacatctgtttcacaaaataaggatgaaaccactacgaatatatctggatct ttcagtggtcctgttagtgggagtaagtctgcacctgaatcacttgaacataattgggac tcttctcatagggctcaggatattcaattgctgagttatgcagaatgggaaaagggagca tcatatcttgactttgttagaaggcaatacaaagtgtctcaggtgttcaaaggtacagtt caaagatctcggacacaaaaaagtgactatttatccctgaagtatgcacttaagtggaag cgggttgtatgtagaaatgctaagagtgacttgtcagcttttgagctagggtcatgggta acagaacttgtgctatgtgcctgttcccaatctataagatcagaaatgtgtatgctgata agtttgctttgtgctcaaagttcatcaagacaatttcgactattggatttactggtgtct ctgttgccggcaactcttgctgctggcgagagtgctgctgaatattttgaattacttttc aagatggtagaatcagaagatgcacgcttgtttttgactgtacgagggtgtttacgtaca atttgccaattaatttcccaagaagtgggcaatgtggagtctctggagagaagccttcgt atcgatatttcccagggatttattcttcacaagctcatagagctccttgggaaatttcta gagatccctaatattagatcaagattcatgtgggataatctactctctgaagttcttgag gctctcattgtgattcgtggcttggtagtacagaagacaaaattgattagtgattgtaac cggcttctgaaagatctcttggacagccttctgctggaaagcaatgataacaagaggcaa tttattcgagcctgcatttctggtttgcaaatccatggggaggaaagaaaagggcggact tgtttgtttattcaagagcagctctgcaatctgatctcccccaaaaaaccggagccagtg tatctcatggttctaaacaaggcacacacgcaagaagaattcatgaggggatccatgaca aagaatccttattccagcgctgagattggtccattaatgcgtgatgtaaaaaataaaatt tgtcatcaattggagctacttagttttcttgaagatgattacggcatggagttgctagtt gctggaaatataatttctcttgatttgagcattgcactagtctatgagcaagtgtggaag aagtctaaccaatcttcaagttccatatctaatagtgcattaatatctaccatctctgca agagaccctcctcctatgacagtgacttaccggcttcaggggctagatggtgaagcaacg gaacctatgattaaggaattggaggaggacagagaggaatcgcaagatccagagttggaa tttgctatagcaggggcagtgcgtgagtatggaggactggaaatagtgttgcgcatgatc cagcgtatatgggataatttcaagtcaaaccaagagcaattggtggcagttcttaatctt cttatgctttgttgcaaaataagagagaacaggcgtgctttattgaggcttggagctctt ggattacttctagaaacagcaaggcgtgctttcgctgtggatgccatggagtcagctgaa ggcattcttttgattgtggagagtctaacaattgaagcaaatgaaagtgaaagtattagc attggacagagtgctcttaccgtctccagcgaacaaaccggaactggtgaacaggccaaa aaaattgttctcatgttcctggagagattatctcatccttttggttccaagaaatcaaac aaacaacagaggaacactgaaatggttgctagaatcttgccttacttgacctatggtgaa cctgctgctatggctgcactcatccaacattttactccatacctgaatgattgggaaaaa tttgatcgattacagaaacagcatgaagacaatcctcaggataaaagcatctctgagcaa gctgccaagcagagatttactgtggaaaatttcgttagagtctcggagtcgctgaaaaca agttcctgtggggagagactgaaggatattattttggaacagggcatcactggccttgca gttaagcatctgagagatagttttgctgttgcagggcaggctggcttcaggtctagtatg gaatgggccttcgccttgaaacgcccatccattccgctaatactgtctatgctaaggggt ttgtcaatggggcatttggctacacagaggtgtattgatgaaggaaggatcttacctgtg cttcatgcactggaaagagttccgggtgagaatgagattggggcaagggctgaaaacttg ttagataccctctctaacaaggagggaaatggagatggattcttggaggataaagtgcgg atgttaaggcatgccagaagggatgaaatgaggcggcttgctttgaagaacagagaagat atactagagaaacttgggatgcgacaagttgcttcagatggtgttgaacggatcattgtt tctcagtcagctcttgaaggtttggaagatgtaaaggaagaggaagatgggttggcttgc atggtgtgcagagagggctatagtttgaggccttctgacttgctgggggtttattctttc agcaagagggttaaccttggtgttgggacatctggaagtaatcgtggggagtgcgtttat acgactgtgagttatttcaatataattcattatcagtgccatcaagaggccaaaagaaca gacgctggtttgaaaatcccaaagaaagaatgggaaggagcaacactcaggaacaacgaa tccctctgcaattccttgttccccgtgagaggtccgtctgtcccattggcacagtatatc cgatatgttgatcagcattgggacaacctaaatgctcttggtcgtgctgatggaaaccga cttcggctcttgacatatgatattgttctgatgttggctcgatttgctaccggggcatca tttagtgctgaaagcaggggtgggggaagagaaagcaattcccggttccttccttttatg attcaaatggctcgtcacctactggatcaagggagcccatctcaacgttctacgatggct aaatctgtttcaacctatttatcctcgtccactgtagattcgcgaccgttatctccagga ccacaaccttcagcagcaactgaagaaactgttcagtttatgatggtgaactcacttctt tctgagtcttatgaatcctggttgctgcatcgacgtgcattcctacagcgtggaatattc catgcatacatgcagcatactcatagcaaatccaccagtcgctcatcggtgagtagtagt aacccaaacacggaagcagaagaagccaacgatttgttaactactattaggccaatgctc gtctacactggcctgattcagcaactgcaacatttcttcaaggtcaaaaaatcggcaagc attgcatcttctgcaaaagaaggaacatctgccaccacaacggaagaggaaagcgaaacc cgaaaccttgagggttgggaggtggtgatgaaagagcgacttgataacgtaagggaaatg atggggttctccaaggagttactaacatggctcgatgaaatgaacttggccagcgatctg caggaggcatttgatgtaatcggagttttggctgatgtcttgtccggcggaataagccgc tgtgaagactttgtacatgcttcaatcaataccggaaaaggctag

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