Callorhinchus milii (elephant shark): 103175198 Help Entry 103175198         CDS       T03088                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism cmk  Callorhinchus milii (elephant shark) Pathway cmk04020   Calcium signaling pathway cmk04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cmk00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103175198 (ryr3)    04020 Calcium signaling pathway     103175198 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cmk04040]     103175198 (ryr3) Ion channels [BR:cmk04040]  Voltage-gated cation channels   Ryanodine receptor    103175198 (ryr3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Motif Other DBs NCBI-GeneID:  103175198 NCBI-ProteinID:  XP_007886252 LinkDB All DBs Position Unknown AA seq 4886 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQSIANIQKEQRKFCLSAEGFGTRLCFLESTSEAKYVPP DLCICNFVLEQSLSVRALQEMLTSTSEKNNEGPIDFTKWKFMIKAAQGGGHRTLLYGHAI LLRHSFSGMYLSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPTSKQRSEGEKVRIGD DLILVSVSSERYLHLSISNGNIQVDASFMQTLWNLHPICSGSNRAEGFLTGGHVLRLFHG HDECLTFPLPAQRKDGQRTVNYESGEAGACARSLWRLELLRISWSGSHIRWGRAFRLRHI TTGLYLGLDEEQGLVLLDREKADTKVSSFCFRTSKEKLDLGAQKETDGMGNPEIKYGDSL CIIQHLASGLWLTYCAPDAKSSRLGTLKRKVILHQEGHMDDGVILQRCQNEESRAARIIR NTTSLFNQFIRGLDYISANGKTAPVTLPMKEIGEVLNDLITYFHPPEEELEHEDKQIKLR SLRNRQNLFKEEAMLRLVLNCIDRLNIYHSAAHFGEFAGEESGAAWKDILNLLYVLLAAL IRGNRSNCAQFSKNLDWLVSKLDRLESSSGILEVLHCILIESPEALNIIKEGHIRSIISL LEKHGRNHKILDVLCSLCVCNGVAVRTNQNLICDNLLPRHDLLLQTRLVNDVTSLRPNIF LGISEGSAQYQKWYYELAIDQVNHFLTADPIHLRVGWASTKGYAPYPGGGEGWGGNGVGD DLYSYGFDGLHLWSGRVARAVASVNQHILNSDDVVSCCLDLGIPSMSFRINGQPVQGMFE KFNTDGLFFPVVSFSAGVKMRFLMGGHHGDFKFLPPPGYAPCYEALLPKEKLRLEPIKEY KRDNNGVRDLLGTTSFLSQASFIPKPVDTSQIVLPPHLEKVRDKLAENIHELWAMNKIEL GWVHGKLRDDNKRQHPCLVSFQKLPEQERNYNLQMSFETLKTLLALGCHVVVAKPKAEEN LQRMKLPKNYMMQNGYKPAPLDLSDVKLLSTQDVLVDKLAENAHNVWAKDRIRQGWTYGI QQDIKNRRNPRLVPYSLLDERTKKSNRDSLREAIRTLIGYGYNIEPSDQETAADKVEKLS LDKIRFFRVETFYAVKTGKWYFEFEAVTAGEMRVGWARPECSPNVELGADRHAFVFDGHK AQCWHQGSVYFGRTWQPGDVVGCMIDMDDKSMVFTLNGELLITNSGSELAFTDFETEDGF TPICCLGLSQIGRMNFGKDANTFKYYTMCGLQEGFEPYAVNMNRDVAMWFSKRLPQFHSL EKYHKHIEITRIDGTIDSPPCVKITHKTIGTQNCIIELAYFRLSMPIEFQSVFKRNAIPH VAHEEEILDKDSISGKTKLRGARLDGGLPGGRDDPKITTYYYSVKIFAGQDPSYAWVGWV TPDYHYYSKTFDLTKHRTVTITLGDEKGRVHESIKRSNCYMIWAGDLVSGSQRSGRSSVD LEVGCLIDVSTGLLTFTANGRNVNTSYQVEPSTKLFPAVFMQATSSNMFQFELGKLKNTM PLSAAMFKSEERNPIPQCPPRLVVQMITPVLWSRMPNEFLNVETARISDRHGWVVQSLDP LQMMAVHIPEENRCLDILELSEHKELIKFHYHTLKLYCALCALGNNRVAHALCSHVNQAQ LLYTIENKYLPGLLRSGFYDLLISIHLQSAKQARLIMNNEFIIPVTAETRSIKLYPEKNR AYGLPGVGTSTCLRPRMNFSTPYFVSNSEDTHLYSPEIPLNVLKFKAIEMLTEAVTGGGH YIRDPVGGSVEFHFVPILKLVKTLLIIGALDNNDVQRILLLIDSDVFGEPKEEVIEEEKT AKELVTKNEEKAVEAGEEATQAAQTPLKGLLEKTLPESVKYQMCELLHYFCDCELRHRVE AIVSFADTFVAKLQKNQKFRYDELMLAFDMSAALTAKKTREFRSPPQEQINMLLNFRNDD DSTCPDEMREELYDLHDDLLTHCGIPSEEEEEEEKDESVMGKLLYLVHKIKGKPKKMDEQ PTEEEEKAPTNLMELISQTMVHWAQESVLHDPELIKSMFSLLRRQYDAMGELLSAMRKAY TISAASVKDTINLLVSLGQIRSLLSVRMGKEEEMLMIRGLGDIMNNKVFYQHPNLMRVLG MHETVMDVMVNVLGGNKSQEIAFPEMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSS VGLASPSMRGSTPLDVAAASVMDNNELALDLREPDLEKVVTYLAGCGLQNCPILVAKGYP DIGWNPIEGERYLLFLRFAVFVNGESVEENANVVVKLLIRHPECFGPALRGEGGNGLLAV MEEAIQISEDPCRDLPPEEAQKDSDEEDIIHMGNAIMSFYSALIDLLGRCAPEMHLIQTG KGEAIRVRAILRSLVPTQDLVGIISIPLKLPTINKDGSINQPDMSASFCPEHKAPMVLFL DRVYGIEDQTFLLHLLEVGFLPDLKASASLDTVPLSTTETALALNRYICSAVLPLLTRCA PLFAGTEHYAARIDAVLHTIYRMSKGPSLTKAQRESIEECLLCICRYLRPAMLQPLLRRF VFDVPILNEYCKMPLKLLTNHYERTWRYYCLASGWGSYGSASDEELHLTKKLFWGIFDSL TQKKYSSELFKMALPCLSAIAGALSPDYVDSSFSDVLEKMTSVDEEGNFDPKPIITSNTS IPENLEYIINKYAEYLHDKWALDKLQNGWTYSDVVNENTKTHPLLRPYKTLSEREKELYR WPAKESIRSMLALSWIIERTKESEAMIQQRESEKQRKASQSSGGYTPILDDLSNVLLSKD VQAMAEVIAENYHNIWAKKRKAELESRGGGSQTMLIPYDTLTAKEKARDREKAHDLFKFL QVNGYAISRGLKDMELDASSFEKRFAYKFLQKVVNCIDSGQEFIVHLEAIVSSGKAEKSP HEQEIKFFAKVLLPLIDDYFKNHCLYFLSSPTKTLTSSGYASNKEKEIIASIFYKLAALV RHRISLFGTDSGTIVNCLHILARTLDTRNVMKFGSELVKAGLRLFFENAAEDLEKTLESL KLGKVSQSRTQLKGVTQNINYTTVALLPVLTSLFEHIGQLQHGVHVLLDDVQASCYRIVC CLYTLGTGKNVYVERQRPVLGECLATLAAAMPVAFLEPSLNQHNPKSVFNTKTPREQAIL GLPDTVEEVCPEIPHLERLMKDIKELAESGARYTEMPHVIEVILPMLCNYLSYWWERGPE STCEEPHCTTVTSEHLSLLLGNILKILNNNLGIDEASWMKRLAVFAQPIISKARPELLKP QFLPTLEKLKKKVVKVVLEEEQLRADSKGDTQEAELLILDEFALLCRDLYAFYPILIRYV DYNRARWLKLPDADSDELFRMVAEVFIMWCKSHNFRREEQNFVVQNEINNMAFLTADNKS KMSKQFKQVGQKAGGQSQERKKIIRRGDYYSIQTSLIVSALKKMLPIGLNMCTAGDQELI SLGKLRYSMKDTDEEVKEFLANNLHLQEKSEDPAVRWQLNLYKNITKPEEFISPEKIVDR VQKISAAVFHLEQVEQPLRSKKIGWQKLLSKQRKRAVVACFRMAPLYNLPRHRGVNLFLQ SYQKSWIETEEYTFEEKLIEDLAKSVTKSEEEEENEKKPDPLHQLILHFSCSALTERSAI EEDDLYMAYVEMMSKSCQAAEEEDEEKEKTFEEKEMEKQMTLYQQARLHQRGAAEMVLQM ISASKGVLGPMVTTTLKLGIAILNGGNTDVQQIMLDYLKEKKDSGFFRSLSSLMQFCSVL DLNAFERQNKAEGLGMVTEDGTLIVREHGEKVLPNDEFTRDLFRFLQLLCEGHNNDFQNY LRTQIGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIMDEQGQRNFSKALAVAKQIF NSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLQKD MVVMMLSLLEGNVVNGTIGKQMVDTLIESSSNVEMILKFFDMFLKLKDLTTSDTFKEYDP DGKGVMSKREFQKALETQKKYTQSEIEFLLSCVEADENDTFNYTEFIDRFHEPAKDIGFN VAVLLTNLSEHMPNDLRLQTFLEPAESVLTYFQPYLGRIEIMGQAKRIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGESEKMEMFVNFCEDTIFEMQLASQISESDMVEVPEE EDEELMHVEEEEEETVQSSNVFVSACHAFKTSFFKAFSLVTVKNIRRHYKKIKRMTNMEM VKAFFSFFWIIFIGLASYFFSIAQGFIHILWNALFGGGLVEGAKNITVTDILASMPDPTQ LGIHGDATEPESAESSATSITAELDNVVKGEKVESDIMPDVFGASIKKGGGKASEEHGGL GDVSEILGVDNTLTLEKAIQQKRFAEVALKNKSETKTEFEKADTEDGEKKDIAKEEQQVE TEVEEKKKKKRRGQKKEEPEAFLENFWKGVDVYQTKLLNYLARNFYNLRFLALFVAFAIN FILLFYKVTESPSDDNNDEEESNIWSNIDDEGDEEDEEYFVLQESTGYMAPTLCFLAIIH TIISFVCIIGYYILKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVINTQS FPNNYWDKFVKRKVINKYGDLYGALRIAELLGLDKNALDFSPIEKAPEQEATLVSWLSSI DLKYHIWKLGVVFTDNSFLYLTWYATMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVT HNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGV RAGGGIGDEIEDPAGDPYEMYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVR EDMETKCFICGIGNDYFDTTPHGFEIHTLQEHNLANYLFFLMYLVNKDETEHTGQESFVW KMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14661 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggtgaaggggaagatgaaatccagttcctcaggactgatgatgaagtt gtgctccaatccattgccaacatccaaaaagaacaaaggaagttttgcctgtcagctgag ggatttggtactcgattgtgcttcctggagtctacctcagaagctaagtatgttccacct gacctttgcatctgtaattttgtgctggagcaatcactctctgttcgagccttgcaggag atgctgactagtaccagtgaaaagaacaatgaagggccaattgacttcaccaaatggaag tttatgataaaggcggctcagggaggcggccacagaacacttctttacggccacgctatt ctgctgcgacactcgttcagtggaatgtatctgagttgtttgacaacatcaaggtcttta acggacaagctagcttttgatgttgggctgcaagaagattcaacaggggaagcatgctgg tggaccattcaccccacttcgaaacagaggtctgaaggggagaaagtacggattggtgac gacctcattctagttagtgtttcatcagaacggtatctgcatctatccatctccaatggc aatatacaagtggatgcgtccttcatgcagacattatggaacctacaccccatatgttca ggcagcaatagagcagaagggtttctgactggtggacatgtcttgcggctttttcatggc catgatgagtgcttgacattccctcttccagcccagaggaaggatgggcagagaacggtt aactatgaaagtggggaagcaggtgcctgtgccagatcactttggcgtctggaactctta cggataagctggagtggaagtcatataagatggggtcgggctttccgtttgcggcacatc acaacaggtctatatctgggcttggatgaagagcaaggtcttgtgctgctagatcgagaa aaggcagacaccaaagtatcatcattctgcttccgaacatcaaaggaaaaactggacttg ggtgcacagaaagagacagatggcatgggaaaccctgagataaagtatggcgattcactt tgcataatccagcacctagctagtggcctatggttgacatactgcgctccagatgccaaa tcatcacgtctaggaactctgaaacggaaagtcatattgcatcaagaaggtcacatggat gatggtgtaatcctgcaacgatgtcagaatgaagaatctcgggcagctcgtattatacgg aacacaacaagcctcttcaatcagtttatcaggggcctcgattatatcagtgcaaatggt aaaactgcaccagtcacattgcccatgaaagaaattggggaagttttgaatgacctgatc acttatttccatccaccggaggaagaattggaacatgaagataaacagatcaaactgcgc tccctcagaaacagacagaatctatttaaagaggaggcaatgctgagattggtgctgaat tgcattgaccggttgaatatctaccacagtgctgcacattttggagaatttgctggtgaa gaatctggggcagcatggaaagacatcttgaatttgctttatgtattgctagctgccctc atacgtggtaatcggagcaactgtgctcagttttccaaaaacttagactggctggtcagc aagttagaccgactggaatcatcttcaggtattctagaagtgctgcactgcatcttgatt gaaagtccagaggctctcaatataattaaagagggacatatcagatctatcatctcatta ctggagaaacatggacggaatcacaagatcctggatgtgttgtgttcactttgtgtatgc aatggtgttgcagttcgaaccaatcaaaatcttatttgtgacaatttgctgcctcgtcat gatttactcctgcaaactcgcttagtcaatgatgtgaccagtttaagaccgaacatcttt ttgggaatcagtgaaggatcagcccagtaccagaagtggtattatgaactggccattgac caagtgaatcactttttgactgcagaccctattcacttgcgtgttggttgggcttccaca aaaggctatgctccctatccaggaggtggggaagggtggggtggcaacggagtgggtgac gatctgtattcctatggatttgatggacttcacttgtggtcaggtcgagtggctcgagca gtggcttcagttaatcaacatatactgaattctgatgatgtagttagctgttgcctggat ttgggcatccctagtatgtctttccgcattaatggtcaaccagttcaaggcatgtttgag aagttcaacactgatggcctcttcttccctgtggttagcttctctgcgggtgtcaaaatg cgctttttgatgggtggtcaccatggagattttaagtttttacctccgcctggttatgcg ccctgctatgaagcacttctaccaaaggagaaactgagattggagccaattaaagagtac aagcgagataacaacggcgttcgagatctactaggcacaacttcctttttatctcaagcc tccttcatccccaaacctgtagataccagccagattgttttacctccacacctggaaaaa gtccgggataaacttgcagaaaacatccatgagctttgggcaatgaataagattgaactt ggctgggtacatgggaagttgcgagatgacaacaagaggcagcatccttgtctggtgagt tttcaaaaactaccagaacaagagaggaactacaatttgcaaatgtcttttgaaactttg aagacattgttggctcttggatgtcacgttgttgttgctaaaccaaaagctgaagaaaat ctacaaagaatgaaacttcccaaaaattatatgatgcaaaatggttataagcctgctccg ctggacctttcggacgtcaagcttctctctacccaagacgttctggttgataaactggct gaaaatgcacataatgtatgggctaaagataggatcagacaaggttggacttatggcatc cagcaggatattaaaaacagaaggaatccacgactggtgccatacagccttctcgatgaa cgaactaaaaagtcaaacagagacagtttgcgtgaagcgattcgcactttaattggctac ggttacaacattgaaccatcagaccaggagacagctgctgataaggtggaaaaactcagc ctcgataagatccgcttcttccgagtggaaacattctacgcggtcaagacagggaagtgg tactttgagtttgaggcagtgacggcaggagaaatgcgtgtcggctgggcaagaccagag tgcagtcctaatgtagaattaggtgctgacaggcacgcctttgtctttgatggccacaag gctcaatgctggcatcagggtagcgtttactttggtcgtacctggcaacctggtgatgtg gttggctgcatgattgatatggatgataaatcaatggtttttactctgaatggagaacta ctcatcactaacagtggctcagaactcgcttttacagattttgagacagaagacggtttt accccaatttgctgtctgggcctatctcagataggtcgaatgaattttggaaaggatgcg aatactttcaaatactacacaatgtgtggtttacaagagggtttcgagccttatgcagta aatatgaaccgtgatgtagctatgtggttcagcaagcgtctgcctcaatttcattctctg gaaaaataccataaacacattgagataaccaggattgatggtaccatcgatagtccaccc tgtgtaaagatcacccacaaaaccatcggcacccagaactgcattattgaattggcatac ttccgcttgagtatgcctattgagtttcagtcagtgtttaagcgtaatgccattccacat gtggctcatgaggaggaaattctcgataaggattcaatatcaggaaaaacgaaactaagg ggtgcccggctggatggtggcctgcctggaggcagagatgaccccaaaataacaacgtat tattactcagtgaagatatttgctggtcaagatccatcttatgcatgggttggttgggta acgccagactaccattactacagtaaaacgtttgacttaactaaacatcggacagtcacc attacactgggtgatgagaaaggacgagtccatgaaagcatcaagcgcagtaattgttac atgatttgggcaggagatttggtcagcggctcacaacgatcaggccgcagtagtgttgac cttgaagttggttgtctcattgatgtctcgaccggcttgttaacattcacagcaaatgga cgcaatgttaatacttcctatcaggttgagccaagcacaaagttatttccagcagtcttt atgcaagctacgagttcaaatatgttccagtttgaacttggaaaattgaagaatactatg cctctgtctgcagcgatgtttaaaagtgaagaaaggaatcctatcccacagtgccctcct cggcttgttgtgcaaatgatcacaccggttctctggagtagaatgcccaatgaatttctc aatgtggagacagcacggattagtgatcgacacggctgggtagtgcaaagtctagaccca ttgcaaatgatggcagtacatatccctgaagagaataggtgcttggatatcttggagcta tctgaacataaagaactcatcaagttccactaccatacattgaagctctactgtgctctc tgtgctttgggaaataatcgtgtagcccatgcactgtgcagccacgttaaccaagctcaa ctgctttacacaattgaaaataaatatctaccagggcttttacgcagtggattctatgac ctacttatcagtattcacttacaatcagcaaaacaagccagattgattatgaacaatgag ttcatcattccagtaaccgccgaaaccaggagcataaagttatatccagaaaagaaccgg gcctatggacttcctggggttggcaccagcacttgtttaagacctcgaatgaacttctca acaccttatttcgtaagcaacagtgaagacacccatttgtacagcccagagatcccactc aatgttcttaagttcaaagccattgagatgctgacagaagcagtgactggcggtgggcat tacatccgagaccctgttggtggaagcgtagaatttcattttgttcctattctcaagctg gttaagactctgctcatcattggtgcacttgacaacaatgatgtccaacggatcttgctt ttgattgattccgatgtgtttggtgagcccaaagaggaggtgatagaggaggagaaaacg gcaaaggagctggtcaccaagaacgaagaaaaggctgtggaggctggtgaggaagcaacg caagcagctcagacgcccttaaaaggattattggaaaagacgttaccagagtcagtcaag tatcagatgtgtgaactcctgcactacttctgtgactgtgaactacgacatcgggttgaa gccattgtttctttcgcagacacgtttgttgcaaagttgcagaaaaaccagaaattccgt tacgatgaacttatgctggcgttcgacatgtcagcagccctcactgccaagaagactaga gagtttcgctcacctcctcaagaacagattaatatgctgctgaactttaggaacgatgat gattccacctgccccgatgagatgcgtgaagagttgtacgacctccatgatgaccttcta acgcactgtgggattccaagtgaagaagaggaggaagaagaaaaagatgaatcagtgatg gggaaactcctttatctagtgcataaaatcaaagggaagccaaagaaaatggacgagcaa ccaactgaagaggaagaaaaagcccccaccaacctgatggaactcatctcacagacaatg gtgcactgggcacaggaatcagtactacacgatccagaattaattaagtcaatgttcagc ctattgcgacgacagtatgatgcaatgggtgagctgctgagtgctatgcgaaaagcatat accattagtgctgcctccgtgaaggataccatcaacctgctagtttcccttggacagatt cgatctcttctcagtgtgcggatggggaaggaagaagaaatgctaatgattcgtggatta ggggatattatgaacaacaaagtattctatcaacatccaaatttgatgagagtgctgggc atgcatgagaccgtcatggatgtcatggtgaatgtacttggaggaaataaatcacaggag attgctttccctgaaatggtggcaagctgttgtcgattcctttgctacttctgccgcatc agtcgacaaaaccagaaggccatgtttgatcatctcagttacttgctggaaaatagcagt gttggactggcatcacccagcatgcgaggttctacccctctcgatgtggcagccgcttct gtaatggacaacaatgagcttgctctagatttgcgggaacctgatttggaaaaggtggta acctatttggctggctgcggactgcagaactgccccattctggtggcgaagggttatcct gatattggttggaatccaattgaaggagaacgttatctacttttcctgcgatttgcagtc tttgttaatggtgaaagtgtagaagaaaatgcaaatgttgttgtgaagttgttaattcgg catccagagtgcttcggccctgctttgaggggtgaggggggaaacggtttgctggcagtg atggaggaagctattcaaatctcagaagatccctgccgtgaccttcctcctgaggaagct cagaaagatagtgatgaagaagacattatacacatgggtaatgctattatgtccttctac tctgctctgatagaccttctgggtcgctgtgctccagagatgcacctaattcaaactgga aaaggcgaggctattcgagttcgagcaatacttcgttcactggtgccaactcaggatctg gtgggcattatcagcataccactaaaattgcccactattaataaagatggatccatcaat caacctgatatgtctgcaagtttctgtcctgaacacaaggcacccatggtactatttctg gaccgtgtgtatggtatcgaggaccaaactttcctgcttcatttactggaagttggattt ttacctgatttaaaagcatctgcctctctagatacagttcctttgagtactacagagaca gctcttgcccttaacagatacatctgttctgcggtactgccccttctcacaagatgtgca ccccttttcgctgggactgaacactatgctgctcggatagatgccgtactccacacaatc tatcgaatgtccaagggtcctagtcttaccaaagctcagcgagaatcgattgaagaatgt ttgctgtgcatatgccgttacctccgaccagctatgttgcaaccccttctgcgacgtttt gtttttgatgtccccatcctcaatgagtactgtaaaatgccactaaagcttttaaccaat cactatgagcggacctggagatactattgcttagcatcaggatggggaagttatggaagt gcctctgatgaagaattacatctgaccaaaaagttgttctggggaatttttgattcactc actcaaaagaaatacagctccgaactctttaaaatggctttaccatgcctgagtgctata gcaggggctctgtcacctgactatgtggattccagcttttcagatgttttggagaaaatg acttcagtggatgaagagggcaattttgacccaaaacccatcatcacgtctaatacttca attccagaaaatttggagtatattatcaacaaatatgctgaatatttacatgacaaatgg gctcttgacaagcttcaaaatgggtggacatatagtgatgttgtaaatgaaaacacaaag actcatccattattgagaccgtacaaaacattatcagaaagggaaaaagagttgtaccgc tggcctgccaaagagtctattcgaagcatgctggctctttcttggatcattgaaaggaca aaggaaagtgaagctatgattcagcaacgggaaagtgaaaaacagcgcaaggcttcccag agttcaggaggatatacccctattcttgatgacttgtccaatgttttgctctccaaagac gtgcaggccatggcagaagtcattgcagagaattatcacaacatttgggctaaaaaacga aaagctgaattagaaagcagaggtggtggcagtcaaacaatgcttattccatatgataca ctgactgccaaagagaaggcccgagatcgtgagaaggctcatgatctcttcaagtttctc caagtgaatggctatgcgatatccagaggccttaaggacatggagttggatgcttcgtct tttgaaaagcgatttgcttataaattcctacaaaaggtggtaaattgcattgactcaggc caggaattcatcgtacatttagaggccattgtcagcagtggcaaagcagagaaatctcct catgagcaggagataaaattttttgcaaaggttctgcttcctctgattgatgactacttt aagaaccactgcctatacttcttatcctctccaaccaagactctcaccagcagtggatac gcatccaacaaggaaaaggaaataatagcaagtattttctacaaacttgcagcccttgtc agacataggatctcactctttgggactgattctggtacaatagtgaactgtttgcacatc ttggcacggacgctggacaccagaaatgtcatgaagtttggttcggagctggtgaaggct ggattgcgtttgttctttgaaaatgcagccgaagaccttgaaaagacattagaaagtttg aagcttggaaaagtctcacagtcacgaactcagttaaagggagttactcagaatatcaat tatacaactgtggctttgctgcctgtactgacttcactatttgaacacattggtcaactt cagcatggggttcacgttctcttggatgatgtacaagcttcatgctataggatcgtgtgt tgtctctacactttaggaactggaaagaatgtctatgttgaaaggcagcggccagtgctg ggggagtgtttggcaacgctggcagcagccatgccggtagctttccttgaaccgtctctc aaccagcacaacccaaagtcagttttcaacacaaaaactcctcgggaacaagccattcta ggtttgccagacactgttgaggaggtgtgcccagagattcctcacctggaacggttgatg aaggatatcaaagagctggccgagtctggagctcgatacactgagatgccccacgtcatt gaagtgattttacccatgctgtgtaattacctctcctattggtgggagcgaggccctgag agcacgtgtgaagaacctcactgtaccacagtcacttctgagcaccttagtttactgctg ggcaacatcctgaaaatcctcaacaataatctgggcattgatgaagcatcctggatgaag agacttgctgtgtttgctcagccaatcatcagcaaagcgaggcctgaactgctcaagcca cagtttctgccaaccctggagaaactcaagaagaaagtggtaaaggttgttctggaggag gagcagctgagggcagatagcaaaggtgatacccaggaagctgagttgcttattctggat gagtttgctctcctttgccgagacctctatgctttctatccaattctgatccgctacgtg gattacaacagggcaaggtggttgaagctgccagatgcagattcagatgaattgttccgt atggtggctgaggttttcattatgtggtgcaaatcacataatttcagacgagaggaacag aattttgtggtccagaatgaaatcaacaacatggcttttctgactgcagataataagagc aagatgtctaaacagtttaaacaagttggccaaaaggctggaggacaaagccaagaaagg aagaaaataatacgcagaggtgattattactccatacagacctcattgatcgtatctgcc cttaaaaagatgcttcctatcggtttaaatatgtgcacggctggagaccaagaactcatc tcattgggaaaactgagatacagcatgaaagatacagatgaggaggttaaagagttcctt gcaaataatctgcacctacaggaaaagtctgaagacccagctgttagatggcagctaaat ctgtacaagaatattaccaagcctgaagagtttattagtcctgaaaagattgtagaccga gtgcaaaagatttcagccgccgtcttccacttggaacaggtcgagcaacctttgagatca aagaagattgggtggcagaaactcctgtccaagcaacgcaaaagagctgtggttgcctgc ttccggatggcaccattatataacttaccaaggcatcggggtgttaacctcttccttcag agttatcagaaatcatggatagagacagaggagtacacatttgaggagaaactaattgag gatttagctaaatctgttacaaagtcagaagaagaagaagagaatgaaaagaaacctgac ccgcttcatcagctcattctacacttcagttgtagtgccctcactgaaaggagtgcaatt gaagaagatgacttatacatggcgtatgttgagatgatgtcgaagagctgccaagctgca gaggaggaagatgaagaaaaagagaagacatttgaagaaaaagaaatggagaaacagatg acactgtaccagcaagcaaggcttcatcagcgtggagcagccgagatggttttacaaatg atcagtgcgagcaaaggtgtgctgggccccatggtgactacaaccttaaagcttggtatt gctattctgaatggtggtaacactgatgtccagcagataatgttggactatctgaaggag aagaaagacagtggtttcttccggagtctgtctagtttaatgcagttctgcagtgtcctt gacttgaatgcatttgaaagacagaacaaagcagaaggtctgggaatggtcactgaggat gggacactcattgttcgtgaacatggtgaaaaggtattgccgaatgacgaattcactcga gatttgttcaggtttttgcaactgctctgtgaagggcacaataatgatttccagaattat ctaagaactcaaataggtaacacaactacagtgaatatcattatcagcactgttgactac ctgctacgccttcaggaatcaatcagcgatttctattggtattactcaggaaaagatatc atggatgaacaaggacaacgtaacttctccaaagctttggctgtagccaaacaaatcttt aactcgcttacagagtacatccagggcccttgcattggtaaccagcagagccttgcgcac agtagattgtgggatgctgtggttggtttccttcatgtctttgctaatatgcaaatgaag ctttctcaggattccagccagattgagttgttgaaggaattgctggatcttcagaaagat atggtggtgatgatgttgtcattgctggaaggtaatgttgtcaatggaactataggcaaa cagatggtagatacattgattgaatcttctagcaacgtggaaatgatattgaagttcttt gatatgtttctaaaattaaaggatctaaccacttctgataccttcaaagagtatgaccca gatggcaaaggagtgatgtcaaaaagagaattccaaaaagctctggagactcaaaagaaa tacacacaatcagaaatcgagttcctgttaagctgtgttgaagcagatgaaaatgatacg tttaactatacagagtttattgaccgattccatgagccagccaaggatattggctttaat gtagctgttttgctaactaacttgtctgaacacatgcccaatgatctccgcctgcagacc tttttggagccagcagaaagtgttttgacatactttcaaccttatttaggtcgcattgag attatgggacaagcaaagcgcatagaacgggtttattttgaaatcagtgaatcaagtagg acacagtgggagaagcctcaagttaaggagtccaagaggcaatttatctttgacgtagtg aatgaaggaggagaatcagaaaaaatggaaatgtttgtgaacttttgtgaggacactata tttgaaatgcaactagcatctcaaatctctgaatctgacatggtcgaggtaccagaagag gaggatgaagaacttatgcatgttgaggaagaggaagaggagacagtccagtcctcgaat gtctttgtgtcagcttgtcatgctttcaaaactagtttttttaaagcttttagtctggtg acagttaaaaacatcagaaggcattataagaagattaagaggatgacaaacatggagatg gtaaaagcatttttctccttcttctggattatcttcataggccttgcctcttactttttc agtatagctcaagggttcatccatattctatggaatgccttgtttggaggcggcttagtt gaaggcgccaaaaacattactgtcacagacattttagctagcatgcctgatccaacgcaa cttggaatccatggagatgcgactgaaccagaaagtgcagaaagttctgcaacaagtata acagctgagcttgacaatgtcgtaaagggtgaaaaagttgaatcagacattatgcctgat gtctttggtgcaagtataaaaaaaggtgggggtaaagcatctgaagagcatggtggcctt ggtgatgtctcagaaatcttgggtgtagacaatactttgactcttgaaaaagcaatacaa cagaaaagatttgcagaggttgcactaaagaacaaatctgagaccaaaactgagtttgag aaagctgacacagaggatggtgagaaaaaggatatagctaaggaggaacagcaagttgaa actgaggtcgaagagaaaaagaaaaagaagagacgggggcagaaaaaagaagagcctgag gcatttttggaaaacttttggaaaggtgtggacgtctatcaaactaaattgctgaattac ctggcaaggaatttctacaacctgagatttctagctctgtttgtggcatttgctatcaat tttattctcctcttttacaaggtgactgaatccccttctgacgataacaatgatgaggag gaatccaatatatggagcaatatcgatgatgagggtgatgaagaagatgaagagtatttt gtgttacaggagagcactggctacatggctccaacactgtgctttcttgctattattcac actatcatttcatttgtttgtatcattgggtactatattttgaaggtcccccttgtggtc tttaagcgtgaaaaggagattgccagaaagctggagtttgatggtctgtacattacagag caaccgtctgatgatgacattaaaggacaatgggatcgtcttgtgatcaacacacaatct ttccccaacaactattgggataaatttgtcaaaagaaaggtcattaataagtatggagat ctctatggagctctgcgaattgccgagcttttgggcttggacaaaaatgctctcgacttt agtcccatagaaaaagcaccagaacaagaggcaacattggtatcatggttgagttctatt gatttgaaataccatatctggaaacttggagttgtgttcactgacaattccttcttatac ctaacatggtacgccactatgtccatcctgggtcactacaataacttcttctttgctgcc cacttattggatattgctatgggattcaagacattgcgtactatcctgtcctccgtcact cacaatggcaaacagcttgttttgacggttggtctcctggccgttgtcgtgtatctttac acagttgttgctttcaactttttccgcaagttctacaacaagagtgaggatgaagatgaa cccgacatgaaatgtgatgatatgatgacgtgctacttgttccatatgtatgtgggtgtc agagctggaggtggcattggtgatgaaattgaagatcctgctggtgatccttatgaaatg taccggattatctttgacatcacattcttcttctttgtcattgtcatcttgctggctatt attcagggtttaatcattgatgcttttggtgagctgagagaccaacaggaacaagtgaga gaagatatggagaccaaatgcttcatttgtggaattgggaatgactactttgacactacg ccgcatggttttgagatacacacattacaagaacacaatcttgcaaactacctgttcttc ctgatgtaccttgtaaacaaagatgaaactgaacacactggtcaggagtcgtttgtgtgg aaaatgtaccaggagcgttgttgggacttcttccctgctggagactgtttccgtaaacag tatgaggatcaacttggttaa

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