Chelonia mydas (green sea turtle): 102931487 Help Entry 102931487         CDS       T02989                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism cmy  Chelonia mydas (green sea turtle) Pathway cmy04020   Calcium signaling pathway cmy04260   Cardiac muscle contraction cmy04261   Adrenergic signaling in cardiomyocytes cmy04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cmy00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102931487 (RYR2)    04020 Calcium signaling pathway     102931487 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     102931487 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     102931487 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cmy04040]     102931487 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:cmy04990]     102931487 (RYR2) Ion channels [BR:cmy04040]  Voltage-gated cation channels   Ryanodine receptor    102931487 (RYR2) Domain-containing proteins not elsewhere classified [BR:cmy04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    102931487 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  102931487 NCBI-ProteinID:  XP_043400278 LinkDB All DBs Position 3:131233139..131932594 Genome browser AA seq 5008 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSISSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQLFRLRHI TTGKYLSLMDDKSLLLTDKEKADVKSTAFCFRSSKEKLDIGMRKEVDGMGASEIKYGDSV CYIQHADTGLWLTYQSVDAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQHEESHTARVIR STVFLFNRFIRGLDALSKKVKSSTVDFPIESVSLSLQDLIGYFHLPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGETWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDYVEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLYSYGFDGLHLWSGCIARTVNSPNPHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFAAGIKVRFLLGGRHGEFKFLPPLGYAPCFEAVLPKEKLKVEHSREY KQDHQCTRDLLGPTISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEYAEEK VKKLKLPKNYQLSSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQSQPASQQREHKLNNKSCSQNCADINADTDHKQDVKNRRNPRLVPYALLDDRTKKSNKD SLREAVRTLLGYGYNLEAPDQDHATRSDMCTGIMERFRIFRTEKTYAVKAGKWYFEFEAV TAGDMRVGWTRPGCQPDQELGSDEQAFVFDGFKAQRWHQGNEHFGRSWLAGDVVGCMVDM NEHTMMFTLNGEILLDDSGSELAFKDFEVGDGLIPVCSLGLSQVGRMNFGKDVSSLKYFT ICGLQEGYEPFAVNTNRDITMWLSKRLPQFFPVPPNHEHIEVMRIDGTVDSSPCLKVTQK SFGSQNSKIGIMFFRLSMPIECAEVFSKTSAGGLPGTGLFGPKSDLEDYDADSDFEVLMK TAHGHLVPDRTEKEKEATKQEFNNHKDYAQEKPSRLKQRFMLRRTKPDYSTSHSARLTED VLADDRDDYDYLMHTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDMTFDLDRVRTVTVT LGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELS TYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHV QFLTHVLWSRMPNHFLKVDISRVSERQGWMVQCLDPLQFMSLHIPEENRSIDILELTEQE ELLKFHYHTLRLYSAVCALGNNRVAHAMCSHVDESQLLYGIENKYMPGLLRTGYYDLLID IHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKKHGLPGIGLSTSLRPRIQFSSPSF VSISSECYQFSPEFPLDILKAKTIEMLTEAVQEGNLHVRDPVGGTTEFLFVPLIKLFYTL LIMGVFHNGDLKHILQLIEPSVFKEGMSQEDESEVPEKELSTEELKPERGEEEVKGGRVL TEGLLQMKLPEPVKLQMCYLLQYLCDCQIRHRIEAIVAFSDDFVFKLQENQRFRYNEVMQ ALNMSAALTARKTREFRSPPQEQINMLLNFKDDKSDCPCSEEIRDQLLEFHEDLMTHCGI ELDEDGALDGNSDLTIRGRLMYLVEKVTYLKKKQNEKPADNDAKKPSTLQQLISETMVRW AQESIIEDPELVRAMFVLLHRQYDGIGGLVRSLPKTYTINGVSVEDTINLLASLGQIRSL LSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITF PKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMD NNELALALREPDLEKVVRYLAGCGLQSCPLLVFKGYPDIGWNPVEGERYLDFLRFAVFCN GESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKISEDSTRDGPSPSNGSS KTLEMEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLE DLVGVISIPFHMPTIAKDGTVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQDFLLHLLEV GFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLH TVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQHLLRRLVFDVPLLNEQTKMPLKLL TNHYERCWKYYCLPSGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLS AVAGALPPDYMESNYVSMMEKQASMDSDGNFNPQPVDTSNITIPEKLEYFINKYAEHSHD KWSMEKFANGWIYGETYSESSKVQPLMKQYKLLSEKEKEIYRWPIKESLKTMLAWGWRIE RTREGDSMALYNRTRRISQTSQVSVDAAHGYTPRAIDMSNVTLSRDLHAMAEMMAENYHN IWAKKKKMELEAKVGGGNHPLLVPYDTLTAKEKAKDREKAQDIFKFLQINGYVVSRGLKD LELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRGKGEQFPYEQEIKFFAKVVLP LIDQYFKNHRLYFLSAASRPLSSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSI VNCLHILGQTLDARTVMKTGLESVKMALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKG VTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILEDVQVSCYRILASLYSLGTSKSIYVE RQRSALGECLAAFAGAFPVAFLETHLNKHNTYSIYNTKSARDRAALNLPISVEEVCPKIP SLEKLMEEIVELAESGIRYTQMPHIMEVILPMLCSYMSHWWEHGPENNPDKAEMCCTALT SEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKVKPQLLKTHFLPLMDKLKKK AAMVVSDEDHLRAEGRGDMSEAELLILDEFTILARDLYAFYPLLIRFVDYNRAKWLKEPN SEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQER KKMKRKGDRYSVQTSLIVAALKRLLPIGLNICAPRDQELIALAKNRFSMKDTEDEVRDII HSNLHLQGKLEDPAIRWQMALYKDLPNRTEDTSDPEKTVERVLHIANVLFHLEQRSSKMR QRFFCLVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWI ETEEHYFEDKLIEDLAKPGAEPPEEDEGIKRVDPLHQLILLFSRTALTEKCKLDEDYLYM AYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVL QTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCS VLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHSSDFQNYLRTQ TGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLT EYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVM LLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKG IISKRDFQKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVL LTNLSEHMRHDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWE KPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSTNKEEN EKDKPEEQDPRMGFFSLVTVKSALIALKYNIMTLTKMLSMKSLKKQMKKMKKMTMKDMFM ALFSSYWSILMGLLHFTCSVFRGFFRIMYSLLLGGSLVEGAKKIKVAELLANMPDPTQDE VRGEGEEGERKPTEAALPAEDLTDLTALSDDGDLLSDIFGLDLKREGGQYKLIPHNPNAG LSDLLSTPSLLPLPEVQEKIQEQKVNEDEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGK QKLRQLHAHRYGEPEVQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLF YKVSTSAVIEEKEVLVVNAEEDSKLNSLESGSHRIIAVHYVLEESSGYMEPTLRILAILH TVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQS FPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLN SIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSS VTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYV GVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQ VKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESY VWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 15027 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggcgagggcgaggacgagatacagttcctgcgaactgatgatgaagtg gttctgcaatgcactgcaaccgttcacaaggaacaacagaaactgtgccttgcggcagaa ggatttggcaacaggctctgttttttggaatccacttcaaattctaagaatgttccaccg gatctctccatttgtacttttgtgctggaacaatccttgtcagtgcgagctcttcaagaa atgctggctaacactgaggagaaagcagaagggctagttgatgtggaaaaatggaaattt atgatgaagactgcacaaggtggtggtcatcgaacgcttctctatggacatgcaatattg ctgcgccattcctacagtggcatgtatctctgctgcctctccacctcacggtcttcgatg gataaattggcatttgatgtgggattgcaagaagacacaacaggtgaagcctgctggtgg accatacatcctgcctccaaacagcgatcagagggagaaaaagtgcgtgttggagatgac ctcatcttagttagtatatcttccgaaagatacttacatctgtcttatggcaatggtagc ttacatgttgatgcagccttccagcaaacactctggagtgtagccccaatcagttcagga agtgaagtagcccaaggatatctgataggaggtgatgtgctgaggctattgcatggtcac atggatgaatgcctaactgttccttcaggggaacatggagaagaacagcgaagaactgtc cattatgaaggtggtgctgtgtcgattcatgctcgttccctttggcgactagagactcta agagttgcgtggagtggaagccacattagatggggacagctattcagactaagacatata acaacagggaaatatttaagcctcatggatgacaagagtcttcttcttacggacaaagag aaagctgacgtgaaatctacagcgttttgttttcggtcttccaaggaaaaattggatata gggatgagaaaagaggttgatggaatgggagcatctgaaataaagtatggtgactcagta tgctacatacaacatgcagacacaggcctgtggctcacgtaccagtctgtggatgcaaag tctgtaagaatgggatctgtgcaacgcaaggctataatgcaccatgaaggccacatggat gatggtttgaccttgtccagatctcagcatgaagaatcccatacagcacgagtcatccgt agtacagtcttccttttcaaccggtttataaggggccttgatgctctcagcaagaaagtg aagtcttccacagttgactttcccattgagtcagtcagtctgagccttcaggacttgatc ggctacttccacctgccagatgaacatttagaacatgaagacaaacagaacaggctaaga gcactgaagaatcgacaaaatctcttccaggaagagggtatgatcaaccttgtccttgaa tgcattgatcgcttgcacgtgtacagcagtgcagcccattttgctgacgtagctgggaag gaagcaggagagacttggaaatctattctaaattctttgtatgaattactagcggcactt attagggggaatcgtaaaaactgtgctcaattttctggatctcttgactggttgatcagc agattggaaagattggaagcctcctctggaattctggaggttttgcactgtgtgttggtg gaaagtccagaagctctaaacattattaaggaaggacatattaaatcgattatctgtctt ttggacaaacatggaagaaaccataaggttttagatgtcttgtgctctctctgtgtatgc catggagtcgctgtgcggtctaatcaacatctaatctgtgacaatctcctaccaggaaga gatctcctcctacagacacgccttgtgaaccatgtgagcagcatgagacccaatatcttc cttgggatcagcgaaggctccgcccaatacagaaaatggtactatgagcttatggtggac tatgtggagccctttgtgacagcagaagctactcatcttcgagtgggctgggcttcaaca gagggctattcaccctaccctgggggaggtgaagaatggggtggaaatggtgttggcgat gacctgtactcttatggatttgatggtcttcatctgtggtcaggctgtattgcacggaca gtgaattctcccaatcctcatctgttaagaacggatgatgtcatcagctgctgtttggat ctgagtgccccaagcatctcattccggataaatggtcagccagttcaagggatgtttgag aatttcaacatagatggcctcttctttccagttgtcagctttgctgcaggaataaaggtg cgttttctgcttggaggccgccatggagaattcaaattcctgcctccacttgggtatgca ccttgctttgaagctgttctaccaaaagagaagctaaaagtagaacatagccgagaatac aaacaggatcaccaatgtacaagagacctattgggtccaaccatctctttatcccaagca gccttcacaccagttcccgtggatactagccagattgtattgcctcctcacctggaaaga attagagaaaaattagcggagaacatccatgaactctgggttatgaataaaattgaactt ggctggcagtatggcccagttagagatgacaacaaaagacaacacccatgcttggtagag ttttcaaagttgccagagcaggaacgaaattataatttacaaatgtcacttgagacgctg aaaaccctgttggcattaggttgtcatgtaggaattgctgatgaatatgctgaagaaaaa gtgaaaaaactgaaacttcctaagaattaccagttatcaagtggatacaagcctgctccc atggatctgagttttatcaagttgaccccctctcaagaagccatggtggataaactagca gagaatgctcataatgtgtgggcaagggaccgtatcaggcagggttggacatatggtatc cagcagagccaaccagccagccagcagagggagcacaagttaaataataaatcctgttcc cagaactgtgctgacatcaatgctgacactgatcacaaacaagatgtgaagaatcgaaga aacccccgccttgtcccatatgcccttctggatgatcgtaccaagaagtcaaacaaagat agcctccgggaggccgtccgcacccttcttggctatggttacaacctggaggctcctgat caagaccacgctacaaggtcagacatgtgcactgggataatggaaaggttccggatattc cgcactgagaagacttacgcagtaaaggctggaaaatggtactttgagtttgaggctgtc actgcaggagacatgagagttggctggaccaggccaggctgccagccagaccaggaactt ggctcagatgagcaagcttttgtctttgatggcttcaaggcccagcggtggcaccagggt aatgagcattttggccgctcttggctggcaggggatgttgtgggatgtatggttgacatg aatgagcacaccatgatgttcaccctgaatggtgaaatcctgctcgatgactcaggttca gagcttgcatttaaggacttcgaggttggtgatggattgatacctgtgtgcagcctgggc ttgtctcaagtgggaagaatgaactttggcaaagatgtcagctccctgaaatattttact atctgtggcttacaagaaggctatgaaccctttgctgttaatacaaacagagacattacc atgtggctgagcaagagactccctcagtttttcccagtgccaccaaaccatgaacacatt gaggtgatgagaatagatggcaccgtagacagctccccctgtttgaaggtcacacagaag tcctttggctcacagaacagcaaaataggcatcatgttttttcgcttgagcatgccaatt gagtgtgcagaagtattctccaaaacatcagcaggagggttgccaggcactggtcttttt ggcccaaaaagcgacttggaggattatgatgctgattctgattttgaggttctgatgaag acagctcatggtcacctagtgcctgatcggacagaaaaagaaaaagaagctacaaaacaa gagttcaataaccacaaggattacgctcaagagaaaccttcacgtcttaaacaaaggttt atgctcagaaggacaaagccagattacagcacaagccactctgcacggctcacagaggat gttctggcagatgacagagacgactatgattacttgatgcatacttctacgtactattac tcagtgagaatatttcctgggcaagaacctgctaatgtctgggtgggctggattacatct gacttccatcaatatgacatgacctttgacttggacagagtacgcaccgttacagtgaca ctaggggatgaaaaaggaaaggttcatgagagtatcaaacgcagcaactgctatatggtg tgcgctggagagagcatgagccctggacaaggacgcaacaacaatggactagagattggt tgcgtggtcgatgctgccagtggtctgctaaccttcactgctaatggcaaggaactgagc acctattatcaggttgaaccaagtactaagttatttcctgcagtatttgcacaagctaca agccccaatgttttccagtttgagttgggaaggataaagaatgtaatgccattgtctgct ggcttgttcaaaagcgagcataaaaacccagtccctcaatgccctccccgtctccatgtc cagtttttgacccatgtgctgtggagcagaatgccaaaccactttctgaaggttgatatc tcacgggtcagtgaacgtcaaggctggatggtacagtgcttggatcctttgcagttcatg tctctccatatcccagaagaaaacaggtctatagatattttagaactgacagaacaggaa gaattgctgaaatttcactatcataccctccgattgtattcagccgtttgtgctctaggg aacaaccgggtggcacatgctatgtgcagccatgtggatgaatctcagcttctgtatggc attgagaataagtatatgccaggcttgcttcgcacaggctattacgacttactcattgac atccacctcaacacctatgccacggccaggttaatgatgaataatgaatttattgttccg atgacagatgagaccaagagcattactctgttccctgatgagaacaaaaaacatggcctc cctggtataggactcagcacctcactacgacctagaatccagttctcctctcccagtttt gtaagcattagcagcgagtgctatcaatttagccctgaatttcctctggatatcttaaag gccaaaactatagagatgctgactgaggctgttcaagagggcaacctccatgtcagagat ccagtagggggtacgacagagtttctctttgtccctctcatcaagcttttttacactctg ctaatcatgggagtcttccataatggggatctgaaacacatcttgcagctgattgagccc agcgttttcaaggaaggcatgagccaggaggatgagagtgaagtgccagagaaggagttg agtacagaggagctaaagccagaaagaggagaggaagaagtcaaaggggggcgggtgctg acggaaggccttcttcaaatgaaacttcctgaaccagtaaaattacagatgtgttaccta ctccagtacctctgtgactgccagatacgtcaccggatagaagccattgtagcattttct gatgattttgtgtttaagcttcaagagaatcaacgattccgatataatgaagttatgcag gccttaaacatgtctgccgcactgacagccagaaaaacaagagagtttcggtctccacct caagagcagattaacatgcttctgaattttaaggatgataaaagtgattgtccttgctct gaagaaattagagatcaactcttggagttccatgaggacttaatgacacattgtggaatt gaattagatgaagatggagccctggatggaaacagtgatttaaccattagaggtcgcctg atgtacctagtagaaaaagtcacatatttaaagaagaaacaaaatgagaaaccagctgat aatgatgctaagaagccctccactcttcagcaattgatttcagagaccatggtacgctgg gctcaggagtcaataatagaggatccggagttagtgagggccatgtttgtattgctgcat cgccagtatgatggtatcggtggtctggttcgaagcttaccgaagacctacaccataaat ggtgtatcagtggaagatacaatcaacctcttggcatccctgggccagatccgttccttg cttagcgtcagaatgggcaaggaggaagagaagcttatgattcgtggattaggagacatc atgaataataaagtgttttaccaacatcctaatcttatgagggctctaggaatgcatgag actgtcatggaagtgatggtaaatgtacttggaggaggagaatccaaggaaatcacgttt cctaagatggtggcaaattgctgtcgttttctatgttatttctgccgcatcagcaggcag aatcaaaaggctatgtttgatcatctcagttacttattggaaaacagcagtgttggactt gcttccccttctatgcgaggatcaacccctctagatgttgcagcagcatctgtgatggat aacaatgaacttgcactagctttaagggagcctgacctggagaaggtagttcgctatttg gctggatgtggtttgcaaagctgccctttgctggtttttaagggatatccagacattgga tggaatccagttgaaggagagcggtatctggattttcttcgctttgcagttttttgcaat ggagagagtgttgaagagaatgctaatgttgtggtcaggctacttattcgtcgtcctgag tgctttggtccagcattgagaggggaaggaggtaacgggttacttgctgccatggaggaa gcaataaaaatatcagaagattctactagagatggaccttccccaagtaatggatccagt aaaactcttgagatggaagaagaagatgacactatccacatgggaaatgccatcatgacc ttctacgctgctttgattgacctcttaggacgttgtgcccctgaaatgcatctaatccat gctggcaaaggggaagccattaggatcaggtcaattctgcggtctttgattcccctggaa gatttggtgggtgtaattagcattcctttccacatgccaacaatagctaaagatggtact gtggtggaacctgacatgtcagcggggttttgcccagatcacaaggcagccatggttttg ttccttgacagagtctatggaattgaggaccaggatttccttctacatctccttgaagtt ggctttctgccagatctccgtgccgctgcttccttagacacggctgctctgagtgctaca gacatggccttggctctgaatcgatacctttgtactgcagtcttgcctttgttgaccaga tgtgctcctctttttgctggcacagagcaccatgcctccctcatagattccttattacat actgtgtacagactctccaagggctgctctcttaccaaagctcagcgggattccattgaa gaatgtttactctctatttgtggccaattgaggccttccatgatgcaacacttgctgagg agattagtgtttgatgttcctctattaaacgagcaaacaaagatgcctctgaagttgctg acaaatcattatgaaagatgctggaagtattattgcctgccaagtgggtggggcaacttt ggtgctgcatcagaagaagaacttcatttatccagaaagttgttctggggtatctttgat gccctgtctcaaaagaagtatgaacaggaactgttcaaactggctttgccctgcctgagt gcagttgcaggagctttacccccagactacatggaatccaattatgtcagtatgatggaa aaacaggcttcaatggattcagatgggaactttaacccacaacctgttgatacctcaaat attacaattcctgaaaagctagaatatttcattaacaaatatgcagaacattctcatgat aaatggtcaatggaaaagtttgcaaatggatggatatatggtgaaacatattctgagtct tccaaggtgcagccattaatgaaacaatataaattattatcagaaaaggaaaaagaaatt tatcggtggccaatcaaagaatctttgaaaaccatgctagcttggggatggcggattgaa aggacaagggaaggagatagtatggccctttataatcggacacgtcgcatatctcagaca agtcaggtgtctgtagatgctgcccatggttacacccctcgagctatcgacatgagcaat gttaccctctccagagatctgcatgcaatggctgagatgatggctgaaaactaccataac atatgggcaaagaaaaagaaaatggaactggaagcaaaagtaggaggaggcaaccatcct 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agagacagagcagctcttaatttgccaatcagtgtagaagaggtttgtccaaaaattcct tccctggagaagttaatggaagaaattgtggaattggcagagtctggtattcgttacaca caaatgccacatataatggaagtgatattgcctatgctgtgtagctacatgtcacactgg tgggaacatggaccagaaaacaatcccgacaaggctgaaatgtgctgcacagccttgacc tcagagcacatgaacactctgttgggtaacatactgaaaatcatctataacaacctgggt attgatgagggagcctggatgaagagattagcagtgttttcccagcctatcataagcaaa gtgaagccccagctcttaaagacccacttcctgccactgatggataagttgaagaaaaaa gcagcaatggttgtatcagatgaagaccatctaagagcagaaggcagaggtgacatgtct gaggctgaactgcttatcctagatgagttcaccattttggcacgggacctctatgccttc taccctttgttgattagatttgtggactataacagggcaaaatggctgaaagaacccaac tcagaagcagaggaattgttccgcatggtggctgaagtattcatttactggtcaaaatcc cacaatttcaaaagggaagagcagaattttgtggtacagaatgaaatcaacaacatgtct ttccttattactgacaccaaatccaagatgtctaaggcagctgtttctgatcaggagaga aagaaaatgaagcgaaaaggggacaggtattctgtgcagacatctctcattgtagcagca ctgaagagattactacctattggtctaaatatttgtgcacccagagaccaagagttaatt gcactggccaaaaacagattcagcatgaaagacactgaagatgaagttagggatattatc cacagtaatcttcatctgcaaggcaagctcgaggatcctgccattaggtggcagatggcc ctttacaaagatttaccaaacaggaccgaagatacttcagatccagagaagaccgtggaa agagttctgcatatagctaatgtacttttccacctggaacagcgatcttctaaaatgcgc cagagatttttctgtttggttgagcatcctcagaggtccaaaaaggcagtgtggcacaaa ctgctatccaaacagagaaaaagagcagtagtggcctgctttagaatggctccattatat aatctgccaaggcatcgagctgtcaatctctttcttcaaggttatgaaaagtcttggatt gaaacagaagagcattactttgaagataaactgatagaagatctagcaaaacctggagcg gagccaccagaggaggatgaaggcattaaaagagttgatccgctgcatcagcttattctg cttttcagtcgaacagccttaactgaaaaatgcaaactggatgaagattacttgtatatg gcatatgctgacattatggcaaagagctgtcatgatgaagaggatgatgatggtgaagaa gaagtgaagagttttgaagtcacaggatcacaacgcagcaaggaaaaagaaatggaaaaa cagaagcttctgtaccagcaagcaagactgcatgatcggggtgctgcagagatggtgctt caaacaatcagcgccagcaaaggtgagatgggtcccatggttgcagccaccttaaagctt gggattgccatcttaaatggaggaaattctacagttcaacagaaaatgctcgactacctc aaggacaaaaaggatgtgggcttctttcagagccttgctggtcttatgcagtcatgtagc gttcttgacctaaatgcatttgaacgccaaaacaaagcagagggccttggcatggtgaca gaagagggatcaggagaaaaggtaatgcaggatgacgaattcacctgtgacctcttccga ttcctccagttgctttgtgaaggacacagttcagattttcagaattatttgagaactcaa actggtaacaacacaactgtcaatattatcatctccactgtggattacttattgagagtt caggaatcaattagtgatttctactggtattattctgggaaggatgttattgatgagcaa ggacaacgtaatttctccaaagcaattcaagttgcaaaacaggtcttcaatactctcaca gagtatattcagggtccatgtacagggaaccagcagagtctggcacacagcaggctgtgg gacgcagtggttggttttctccatgtgtttgcccacatgcagatgaaactatctcaggat tccagtcaaattgaattactgaaagagttaatggatcttcagaaggatatggtggtcatg ttgttgtctatgctggaaggtaatgttgtgaatggaactattggcaagcagatggttgac atgctagtggagtcttccaacaacgtggagatgattctgaagttttttgatatgttctta aagttgaaggatttaacttcatctgatgcattcaaggaatatgatcctgatggtaagggt ataatttcaaagagggactttcagaaggccatggaaagccataagcactacacccagtct gaaactgagtttctactatcttgcgctgagacagatgagaatgagactctggattatgag gaatttgtgaaacggttccatgaacctgccaaagacattggtttcaatgttgctgttctc ctgaccaatctttcagagcacatgcgccatgatacccggttgcagacttttcttgagcta gcagagagtgttctgaattattttcagccctttcttggacgcatagaaatcatgggtagt gcaaagcgcattgagcgagtttactttgaaataagtgagtcaagtcgaactcagtgggag aaacctcaggttaaagagtcaaagaggcagtttatctttgatgtagtaaatgaaggagga gagaaggaaaagatggaactttttgttaatttctgtgaggataccatctttgaaatgcag ctagctgcccagatctctgagtcagatttgaatgagaggtccacaaataaagaagagaat gaaaaagataagcctgaggaacaggaccctagaatgggcttcttctcccttgtgactgtc aagtcagccttgatagccctcaagtataatataatgactcttacaaaaatgctcagcatg aagagtctaaagaagcagatgaagaaaatgaagaaaatgaccatgaaggacatgttcatg gctttattttcttcctattggagcatcttgatgggcttactgcatttcacctgtagtgtt ttccgaggcttctttcgcatcatgtacagtttgctactcggaggaagcttggtagaaggg gctaagaagatcaaggtagctgaacttttagccaatatgccagatcccactcaggatgag gtacgtggtgaaggggaagagggagagaggaaacccacagaagctgcattgccagcagaa gatctgaccgatctgacagctttatcagatgatggtgacctactctcagacatatttggc ttggatttgaaaagagaaggaggccagtataagctgattcctcataatccaaatgctggt ctgagtgatttgctgagcacaccttccttacttccattacctgaggtgcaggaaaaaatt caggagcagaaagtgaatgaagatgaaaaggaggagaaagaagaaactaaatcggaacct gaaaaagcagaaggagaagatggagaaaaggaagaaaaagccaaagaagacaaagggaaa cagaagctgagacagcttcatgcacacagatatggagaaccagaagtccaggaatcagcc ttctggaagaaaatcatagcataccagcagaaacttcttaactattttgctcgcaatttt tataacatgaggatgttggctttgtttgttgcttttgccatcaacttcatcctgctcttc tataaggtctccacctctgctgtgatagaagaaaaggaagttcttgtggtaaatgctgag gaagactccaagttaaacagcctggaaagtggctcccataggatcatcgctgtgcactat gtccttgaagaaagcagtggctatatggaacccacactgcggattttggctatcctacac acagtcatctcctttttctgcatcattggatattactgcttgaaagttcccctggttatt tttaagcgtgaaaaggaagttgcaaggaaattggaatttgatgggctgtacattacagaa cagccttcagaagatgatattaaagggcagtgggacagactcgtcatcaacacacaatct tttcctaacaactactgggacaagtttgttaaaagaaaggttatggataaatatggggag ttctatggccgggacagaatcagtgagttactaggaatggacaaggctgctctggatttt agcgatgcccgagaaaaaaagaaaccaaagaaagatagctccttatctgctgtgctaaat tccattgacgtaaagtatcagatgtggaaattaggagttgttttcactgataattctttc ctttacctagcctggtatatgactatgtcaatccttggccattacaacaactttttcttt gctgctcatctccttgacattgcaatgggattcaagacactacgaactattctgtcatca gtaacccacaatggcaaacagcttgtgttaacagtgggattactggcagtggtagtctac ttgtacacagtagtggcattcaattttttccgtaaattctacaacaagagtgaagatgga gatatgccagatatgaagtgtgatgatatgctaacatgctacatgtttcatatgtatgtt ggagtgcgtgcgggcggaggcattggtgatgaaattgaggatccagcaggagatgaatat gagatctatcggatcatctttgacattactttcttcttctttgtaattgtcattctgcta gccatcatacaaggtttaattattgatgcttttggagaattaagagaccaacaagaacaa gttaaagaagacatggagaccaaatgctttatctgtgggataggcaatgactactttgac acagtgccccatggctttgaaacacacaccctgcaggagcacaacttggccaattatcta ttttttctgatgtatctcattaacaaagatgaaacagagcatacagggcaggaatcctat gtatggaaaatgtatcaagaacggtgctgggagtttttccctgctggtgactgcttccga aaacagtatgaagaccagctcaactaa

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