Cobetia sp. 4B: H2O77_08725
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Entry
H2O77_08725 CDS
T09692
Name
(GenBank) thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha
KO
K00166
2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:
1.2.4.4
]
Organism
cobb
Cobetia sp. 4B
Pathway
cobb00280
Valine, leucine and isoleucine degradation
cobb00640
Propanoate metabolism
cobb00785
Lipoic acid metabolism
cobb01100
Metabolic pathways
cobb01110
Biosynthesis of secondary metabolites
cobb01210
2-Oxocarboxylic acid metabolism
Module
cobb_M00036
Leucine degradation, leucine => acetoacetate + acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
cobb00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00640 Propanoate metabolism
H2O77_08725
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
H2O77_08725
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
H2O77_08725
Enzymes [BR:
cobb01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
H2O77_08725
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Paralog
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Motif
Pfam:
E1_dh
DUF4440
DXP_synthase_N
Motif
Other DBs
NCBI-ProteinID:
QWN38728
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Position
2070286..2071596
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AA seq
436 aa
AA seq
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MTGDELCIPIFKRLRQDGTLYPVDVPQGQSDDTRGGQSQDSSPIDRDTALKIYRTMLFTR
VLDERMLAAQRQGRLSFYMQCTGEEATVIGSAAALQDDDMIMAQYREQGALAWRGFSCDE
FMNQMFGNERDYGKGRQMPIHYGSRDLHYMTISSPLATQIPQATGYAYGQKLAGKGQCTI
TIFGEGAASEGDFHAALNMASVHRVPCIFLCRNNGYAISTPSCEQFAADGIAPRAFGYHM
QSIRVDGNDVIAVYEATLAARKIAVETNQPVLIEAMTYRLAAHSSSDDPSGYRSKKEEAI
WRDKDPILRMRNWLEAQGWWSEEEEKATGDQLRREVLESMKRAEKLAPPALDTLISDVYD
TPTPLLTQQLEDVKQHIRKYPHAYPKGAASMGFTAQELEDSRKAYQARQQRMQSHQPVEN
HQPVESHQPVDGGQTS
NT seq
1311 nt
NT seq
+upstream
nt +downstream
nt
atgaccggcgatgaactctgcatcccgatcttcaagcgcctgcgtcaggacggcaccctt
tatcccgtcgatgtgccacaggggcagagtgacgatacccggggaggccagtcgcaggac
agttcacctatcgaccgcgacacggcgctcaagatctaccggacgatgctgttcacccgg
gtgctggatgagcgcatgctggccgcccagcgccaggggcgcttgagcttctacatgcaa
tgcaccggcgaggaagccacggtgatcggcagtgcggcggcgcttcaagacgatgacatg
atcatggcgcaataccgtgagcagggggcgctggcctggcgcggcttcagctgcgacgaa
ttcatgaaccagatgttcggcaacgagcgcgactacggcaagggccgtcagatgccgatc
cactatgggtcgcgtgacctgcactacatgaccatctcctcgccgctggcgacccagatt
ccccaggcgaccggctatgcctacggccagaagctggcgggcaaggggcagtgcaccatc
accatcttcggtgaaggggccgcctccgagggcgatttccatgccgccctcaacatggcc
tccgtgcatcgggtgccgtgcatcttcctgtgtcgcaacaatggctatgccatttccacc
ccgtcatgcgagcaattcgctgccgatggcatcgcgccacgcgccttcggctatcacatg
cagagcatccgggtggatggcaatgacgtgatcgccgtctacgaagccaccctggcggcg
cgcaagatcgcggtcgagacgaatcagccggtattgatcgaggcgatgacctatcgtctg
gcagcgcactcctcctcggatgacccctccgggtatcgcagcaagaaggaggaggccatc
tggcgtgacaaggaccccatcctgcgcatgcgcaactggctggaagcgcaaggctggtgg
agcgaggaggaggaaaaggccactggcgatcaactgcgtcgcgaagtgcttgagtccatg
aagcgtgccgagaaactggcgccaccggcgctggacacgctgatcagcgatgtctacgac
acgccgacgccgttgctcacgcagcagctcgaagacgtgaaacagcatattcgcaagtat
ccgcatgcctatcccaagggcgccgccagcatggggttcactgcgcaggagctggaagac
agtcgcaaggcgtatcaggcacgtcagcagcgcatgcagagccatcagcctgttgagaac
catcagccggtagagagccatcagcctgtggatggaggccagacatcatga
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