KEGG   Cavia porcellus (domestic guinea pig): 100712888
Entry
100712888         CDS       T07777                                 
Symbol
Map2k1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X2
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
cpoc  Cavia porcellus (domestic guinea pig)
Pathway
cpoc01521  EGFR tyrosine kinase inhibitor resistance
cpoc01522  Endocrine resistance
cpoc04010  MAPK signaling pathway
cpoc04012  ErbB signaling pathway
cpoc04014  Ras signaling pathway
cpoc04015  Rap1 signaling pathway
cpoc04022  cGMP-PKG signaling pathway
cpoc04024  cAMP signaling pathway
cpoc04062  Chemokine signaling pathway
cpoc04066  HIF-1 signaling pathway
cpoc04068  FoxO signaling pathway
cpoc04071  Sphingolipid signaling pathway
cpoc04072  Phospholipase D signaling pathway
cpoc04114  Oocyte meiosis
cpoc04140  Autophagy - animal
cpoc04148  Efferocytosis
cpoc04150  mTOR signaling pathway
cpoc04151  PI3K-Akt signaling pathway
cpoc04210  Apoptosis
cpoc04218  Cellular senescence
cpoc04270  Vascular smooth muscle contraction
cpoc04370  VEGF signaling pathway
cpoc04371  Apelin signaling pathway
cpoc04380  Osteoclast differentiation
cpoc04510  Focal adhesion
cpoc04517  IgSF CAM signaling
cpoc04540  Gap junction
cpoc04550  Signaling pathways regulating pluripotency of stem cells
cpoc04613  Neutrophil extracellular trap formation
cpoc04620  Toll-like receptor signaling pathway
cpoc04650  Natural killer cell mediated cytotoxicity
cpoc04660  T cell receptor signaling pathway
cpoc04662  B cell receptor signaling pathway
cpoc04664  Fc epsilon RI signaling pathway
cpoc04666  Fc gamma R-mediated phagocytosis
cpoc04668  TNF signaling pathway
cpoc04720  Long-term potentiation
cpoc04722  Neurotrophin signaling pathway
cpoc04725  Cholinergic synapse
cpoc04726  Serotonergic synapse
cpoc04730  Long-term depression
cpoc04810  Regulation of actin cytoskeleton
cpoc04910  Insulin signaling pathway
cpoc04912  GnRH signaling pathway
cpoc04914  Progesterone-mediated oocyte maturation
cpoc04915  Estrogen signaling pathway
cpoc04916  Melanogenesis
cpoc04917  Prolactin signaling pathway
cpoc04919  Thyroid hormone signaling pathway
cpoc04921  Oxytocin signaling pathway
cpoc04926  Relaxin signaling pathway
cpoc04928  Parathyroid hormone synthesis, secretion and action
cpoc04929  GnRH secretion
cpoc04934  Cushing syndrome
cpoc04935  Growth hormone synthesis, secretion and action
cpoc05010  Alzheimer disease
cpoc05022  Pathways of neurodegeneration - multiple diseases
cpoc05034  Alcoholism
cpoc05132  Salmonella infection
cpoc05135  Yersinia infection
cpoc05160  Hepatitis C
cpoc05161  Hepatitis B
cpoc05163  Human cytomegalovirus infection
cpoc05164  Influenza A
cpoc05165  Human papillomavirus infection
cpoc05166  Human T-cell leukemia virus 1 infection
cpoc05167  Kaposi sarcoma-associated herpesvirus infection
cpoc05170  Human immunodeficiency virus 1 infection
cpoc05200  Pathways in cancer
cpoc05205  Proteoglycans in cancer
cpoc05206  MicroRNAs in cancer
cpoc05207  Chemical carcinogenesis - receptor activation
cpoc05208  Chemical carcinogenesis - reactive oxygen species
cpoc05210  Colorectal cancer
cpoc05211  Renal cell carcinoma
cpoc05212  Pancreatic cancer
cpoc05213  Endometrial cancer
cpoc05214  Glioma
cpoc05215  Prostate cancer
cpoc05216  Thyroid cancer
cpoc05218  Melanoma
cpoc05219  Bladder cancer
cpoc05220  Chronic myeloid leukemia
cpoc05221  Acute myeloid leukemia
cpoc05223  Non-small cell lung cancer
cpoc05224  Breast cancer
cpoc05225  Hepatocellular carcinoma
cpoc05226  Gastric cancer
cpoc05230  Central carbon metabolism in cancer
cpoc05231  Choline metabolism in cancer
cpoc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:cpoc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100712888 (Map2k1)
   04012 ErbB signaling pathway
    100712888 (Map2k1)
   04014 Ras signaling pathway
    100712888 (Map2k1)
   04015 Rap1 signaling pathway
    100712888 (Map2k1)
   04370 VEGF signaling pathway
    100712888 (Map2k1)
   04371 Apelin signaling pathway
    100712888 (Map2k1)
   04668 TNF signaling pathway
    100712888 (Map2k1)
   04066 HIF-1 signaling pathway
    100712888 (Map2k1)
   04068 FoxO signaling pathway
    100712888 (Map2k1)
   04072 Phospholipase D signaling pathway
    100712888 (Map2k1)
   04071 Sphingolipid signaling pathway
    100712888 (Map2k1)
   04024 cAMP signaling pathway
    100712888 (Map2k1)
   04022 cGMP-PKG signaling pathway
    100712888 (Map2k1)
   04151 PI3K-Akt signaling pathway
    100712888 (Map2k1)
   04150 mTOR signaling pathway
    100712888 (Map2k1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    100712888 (Map2k1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100712888 (Map2k1)
   04148 Efferocytosis
    100712888 (Map2k1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    100712888 (Map2k1)
   04210 Apoptosis
    100712888 (Map2k1)
   04218 Cellular senescence
    100712888 (Map2k1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100712888 (Map2k1)
   04540 Gap junction
    100712888 (Map2k1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100712888 (Map2k1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100712888 (Map2k1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100712888 (Map2k1)
   04620 Toll-like receptor signaling pathway
    100712888 (Map2k1)
   04650 Natural killer cell mediated cytotoxicity
    100712888 (Map2k1)
   04660 T cell receptor signaling pathway
    100712888 (Map2k1)
   04662 B cell receptor signaling pathway
    100712888 (Map2k1)
   04664 Fc epsilon RI signaling pathway
    100712888 (Map2k1)
   04666 Fc gamma R-mediated phagocytosis
    100712888 (Map2k1)
   04062 Chemokine signaling pathway
    100712888 (Map2k1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100712888 (Map2k1)
   04929 GnRH secretion
    100712888 (Map2k1)
   04912 GnRH signaling pathway
    100712888 (Map2k1)
   04915 Estrogen signaling pathway
    100712888 (Map2k1)
   04914 Progesterone-mediated oocyte maturation
    100712888 (Map2k1)
   04917 Prolactin signaling pathway
    100712888 (Map2k1)
   04921 Oxytocin signaling pathway
    100712888 (Map2k1)
   04926 Relaxin signaling pathway
    100712888 (Map2k1)
   04935 Growth hormone synthesis, secretion and action
    100712888 (Map2k1)
   04919 Thyroid hormone signaling pathway
    100712888 (Map2k1)
   04928 Parathyroid hormone synthesis, secretion and action
    100712888 (Map2k1)
   04916 Melanogenesis
    100712888 (Map2k1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100712888 (Map2k1)
  09156 Nervous system
   04725 Cholinergic synapse
    100712888 (Map2k1)
   04726 Serotonergic synapse
    100712888 (Map2k1)
   04720 Long-term potentiation
    100712888 (Map2k1)
   04730 Long-term depression
    100712888 (Map2k1)
   04722 Neurotrophin signaling pathway
    100712888 (Map2k1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100712888 (Map2k1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100712888 (Map2k1)
   05206 MicroRNAs in cancer
    100712888 (Map2k1)
   05205 Proteoglycans in cancer
    100712888 (Map2k1)
   05207 Chemical carcinogenesis - receptor activation
    100712888 (Map2k1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100712888 (Map2k1)
   05230 Central carbon metabolism in cancer
    100712888 (Map2k1)
   05231 Choline metabolism in cancer
    100712888 (Map2k1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100712888 (Map2k1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100712888 (Map2k1)
   05212 Pancreatic cancer
    100712888 (Map2k1)
   05225 Hepatocellular carcinoma
    100712888 (Map2k1)
   05226 Gastric cancer
    100712888 (Map2k1)
   05214 Glioma
    100712888 (Map2k1)
   05216 Thyroid cancer
    100712888 (Map2k1)
   05221 Acute myeloid leukemia
    100712888 (Map2k1)
   05220 Chronic myeloid leukemia
    100712888 (Map2k1)
   05218 Melanoma
    100712888 (Map2k1)
   05211 Renal cell carcinoma
    100712888 (Map2k1)
   05219 Bladder cancer
    100712888 (Map2k1)
   05215 Prostate cancer
    100712888 (Map2k1)
   05213 Endometrial cancer
    100712888 (Map2k1)
   05224 Breast cancer
    100712888 (Map2k1)
   05223 Non-small cell lung cancer
    100712888 (Map2k1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100712888 (Map2k1)
   05170 Human immunodeficiency virus 1 infection
    100712888 (Map2k1)
   05161 Hepatitis B
    100712888 (Map2k1)
   05160 Hepatitis C
    100712888 (Map2k1)
   05164 Influenza A
    100712888 (Map2k1)
   05163 Human cytomegalovirus infection
    100712888 (Map2k1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100712888 (Map2k1)
   05165 Human papillomavirus infection
    100712888 (Map2k1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100712888 (Map2k1)
   05135 Yersinia infection
    100712888 (Map2k1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100712888 (Map2k1)
   05022 Pathways of neurodegeneration - multiple diseases
    100712888 (Map2k1)
  09165 Substance dependence
   05034 Alcoholism
    100712888 (Map2k1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100712888 (Map2k1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100712888 (Map2k1)
   01522 Endocrine resistance
    100712888 (Map2k1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cpoc01001]
    100712888 (Map2k1)
Enzymes [BR:cpoc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100712888 (Map2k1)
Protein kinases [BR:cpoc01001]
 Serine/threonine kinases: STE group
  STE7 family
   100712888 (Map2k1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 100712888
NCBI-ProteinID: XP_003463524
Ensembl: ENSCPOG00000003053
UniProt: H0UZY7
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELVFGCQVEGDAAEMPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCATIGLNQPSTPTHVASI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctcggcggtg
aacgggaccagctcggccgagaccaacctagaggctttgcagaagaagctggaggagctg
gagctggatgagcagcagcggaagcgcctcgaagctttcctgacacagaagcagaaggtg
ggcgagctgaaggacgatgactttgagaagatcagtgagctgggtgccggcaatggcggt
gtggtgttcaaggtctcccacaagccatctggcctggtcatggcccgaaagcttatccac
ctggagatcaagccagccatccgcaatcagatcatccgtgagctgcaggttctgcacgag
tgcaactcgccctacattgtgggcttctatggggccttctacagtgatggcgagatcagc
atctgcatggagcacatggatggaggttccttggatcaagtcctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtgatcaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccctccaacatcctggtcaactcc
cgcggggagatcaagctctgtgactttggggtcagcgggcagctcatcgattccatggcc
aactccttcgtgggcacccggtcctacatgtcgccagagagactgcagggcacacactac
tcagtgcagtcggacatctggagcatgggactgtcactggtggagatggcggttgggagg
taccccatcccccctccagatgccaaggagctggagctggtgttcgggtgccaggtggaa
ggagatgcagctgagatgccgcccaggcccaggacccccggaagacccctgagctcatat
ggaatggacagccggcctcccatggcgattttcgagctgttggattacatagtcaacgag
ccacctcccaaactgcccagtggagtcttcagtctggaattccaggactttgtaaataaa
tgcttaataaagaaccctgcggagagagcagacttgaagcagctcatggttcatgccttc
atcaagcgctctgatgctgaggaggtggacttcgcaggttggctctgtgccaccatcggc
cttaaccagcccagtaccccgacccacgtggccagcatctga

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