Cavia porcellus (domestic guinea pig): 100714821 Help Entry 100714821         CDS       T07777                                  Symbol Top2b Name (RefSeq) DNA topoisomerase 2-beta   KO K03164   DNA topoisomerase II [EC:5.6.2.2] Organism cpoc  Cavia porcellus (domestic guinea pig) Pathway cpoc01524   Platinum drug resistance Brite KEGG Orthology (KO) [BR:cpoc00001]  09160 Human Diseases   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     100714821 (Top2b)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:cpoc03032]     100714821 (Top2b)    03036 Chromosome and associated proteins [BR:cpoc03036]     100714821 (Top2b) Enzymes [BR:cpoc01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.2  DNA topoisomerase (ATP-hydrolysing)      100714821 (Top2b) DNA replication proteins [BR:cpoc03032]  Eukaryotic type   DNA Topoisomerases    100714821 (Top2b) Chromosome and associated proteins [BR:cpoc03036]  Eukaryotic type   Chromosome condensation proteins    Other regulators of chromosome condensation     100714821 (Top2b)   Centrosome formation proteins    Centriole proteins     100714821 (Top2b) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT Toprim HATPase_c DUF7180 Microp_apicomplexa_20 Motif Other DBs NCBI-GeneID:  100714821 NCBI-ProteinID:  XP_023417556 Ensembl:  ENSCPOG00000015416 LinkDB All DBs Position Unknown AA seq 1633 aa AA seqDB search MSCRGDLSAQSWSYGFGAQFLLRSNSSNCGELTLFDQNNAAKKEESETANKNDSSKKLSV ERVYQKKTQLEHILLRPDTYIGSVEPLTQMMWVYDDDVGMNCREVTFVPGLYKIFDEILV NAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSN YDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFD GEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSY VDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVV DQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGS KCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGK HSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNI IKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFL EEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFAD MERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTAT KHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGS VAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTML SSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAR EIVNNVRRMLEGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRT WTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFK LQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESAKLNN QARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEETQNQHDDS SSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAA FVEELDKVEAQEREDILAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKA DASKKLLKKKKGDLDTTVVKVEFDEEFSGTPVEGTGEEALAPSAPISKGPKPKREKKEPG TRVRKTPTASGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYT FDFSEEDDDDADDDDDNNDLEELKVKASPITNDGEDEFIPSDGLDKDEYTFSASKSKTTP EKSSHEKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDTASVFSPSFGLKQTDKVPSKTV AAKKGKPPLDIASKPKRAPKQKKVVETVNSDSDSEFGIPKKTAAPKGKGRGAKKRKASGS ENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFTSDPPSLPRTGRARKEVKYFAE SDEEEDVDFAMFN NT seq 4902 nt NT seq  +upstreamnt  +downstreamnt atgtcctgcagaggtgacttaagtgcccaatcctggagttacggatttggcgcgcagttc ttgctgagaagtaatagtagcaattgcggagaattgactctttttgatcagaacaatgct gcaaaaaaagaagagtcagaaactgcaaacaaaaatgattcttcaaagaagctgtctgtt gagagagtatatcagaagaagacacaacttgaacacattctccttcgtcctgatacgtat attggatcagtagaaccattgacacagatgatgtgggtgtatgatgacgatgtaggaatg aactgcagagaggttacctttgttccaggtttatataagatctttgatgaaattttggtt aatgctgctgacaataagcagagggataagaatatgacctgtattaaggtttctattgat ccggaatctaatatcataagcatttggaataatggaaaaggcattcccgtagtagaacac aaagtagagaaagtttatgttcctgctttaatatttggacagcttttaacatccagtaac tatgatgatgatgagaaaaaagttacaggtggccgcaatggttatggtgcaaaactttgt aatattttcagtacaaagtttacagtagaaacagcttgcaaagaatacaaacatagtttt aaacagacatggatgaataatatgatgaagacttctgaagccaaaattaaacatttcgat ggtgaagattacacatgcataacattccaaccagatctatctaaatttaagatggaaaaa cttgacaaggatattgtggctctcatgacaagacgagcatatgatttggctggttcatgt aaaggagtcaaggtcatgtttaatggaaagaaattgccagtaaatggatttcgtagttat gtagatctttatgtgaaagacaaattggatgaaactggagtagccctgaaagttattcat gaacttgcaaatgaaagatgggatgtttgtcttacgttgagtgaaaaaggattccagcaa atcagctttgtaaatagtattgcaactacaaaaggtggacggcatgtggattatgtagtg gatcaagttgttggcaaactgattgaagtagttaagaaaaagaacaaagctggtgtatca gtaaaaccatttcaagtaaaaaaccatatatgggtttttattaattgtcttattgaaaat ccaacttttgattctcagactaaggaaaacatgactctgcaacccaaaagttttgggtcc aaatgccaactatcagaaaaattttttaaagcagcctctaattgtggaattgtagaaagt attctgaactgggtgaaatttaaagcacagactcaactgaataaaaaatgctcatcagta aaatacagtaaaatcaaaggtatccccaaactggatgatgctaatgatgctggtggcaaa cattccctggagtgtacactgatattaacagaaggagactctgccaaatcactggcagtg tctggattaggtgtaattggacgagatagatatggagtctttccactaaggggtaaaatt cttaatgtaagagaagcttctcataaacagattatggaaaatgctgaaataaacaatatt attaagatagttggtctacaatacaagaaaagttatgatgatgcagaatctctaaaaaca ttacgttatgggaagattatgattatgactgatcaggatcaagatggttctcacataaaa ggtctgcttattaatttcatccatcataattggccatcacttctgaaacatggttttctt gaagaatttattacaccaattgtaaaggcaagcaaaaataagcaggaactttccttctac agcattcccgaatttgatgagtggaaaaaacatatagaaaaccaaaaagcctggaaaata aaatactacaaaggtttgggtaccagtacagctaaagaagcaaaggaatattttgctgat atggaaaggcatcgcattttgtttagatatgctggtcctgaagatgatgctgccattact ttggcattcagtaagaagaaaattgatgacagaaaagaatggttaacaaatttcatggaa gatcggagacagcgtaggttacatggtttaccagagcaatttttatatggtacagcaaca aagcatttgacttacaatgatttcatcaacaaggaattgatcctattctcaaactcagat aatgaaagatctataccatctcttgttgatggctttaaaccaggacaacgtaaagtttta tttacctgtttcaagaggaatgataaacgagaagttaaagttgctcagttggctggatct gttgctgaaatgtctgcatatcatcatggagaacaagcattgatgatgactattgtgaat ttggctcagaactttgtgggaagtaataatattaacttgcttcagcccattggtcagttt ggaactcggcttcatggtggcaaagatgctgcaagccctcgttatattttcacaatgtta agctctttagcaagactactttttcctgctgtggatgacaacctgcttaagttcctttat gatgataatcagcgtgttgagcctgagtggtatattcctataattcccatggttttaata aatggtgctgagggcattggtactggatgggcttgcaaactacccaactatgatgctagg gaaattgtcaacaatgtcagacgaatgctagaaggattggatcctcatcccatgcttcca aattacaaaaattttaaaggcacaatccaggagcttggtcaaaaccagtatgcggtcagt ggtgaaatatttgtggtggatagaaacacagtggaaattacagagcttccagttagaacc tggacacaggtatataaggaacaggttttagaacctatgctaaatggaacagataaaaca ccagcactaatttctgattataaagaatatcatactgatacaactgtgaaatttgtggtg aaaatgacagaagagaaactagcacaagcagaagctgccggattacataaagtttttaaa cttcaaactactcttacttgtaactccatggtacttttcgatcatatggggtgtctgaag aagtatgaaactgtgcaagacattctgaaagaattctttgatttacgattaagttattat ggtttacgtaaggagtggcttgtaggaatgctgggagcagaatctgcaaagcttaacaat caagcccgtttcattttagagaagatacaagggaaaattactatagagaataggtcaaag aaagatttgattcaaatgttagtccagagaggttatgaatctgacccagtgaaagcctgg aaagaagcacaagaaaaggcagcagaagaagaagaaacacaaaaccaacatgatgatagt tcctctgattcaggaaccccttcaggccctgattttaattatattttaaatatgtctctg tggtctcttactaaagaaaaagttgaagaactgattaaacagagagatgcaaaaggccga gaggtcaatgatcttaaaagaaaatcaccttcagatctttggaaagaagatttagcagca tttgttgaagaactggataaagtggaagcacaagaaagagaagatattctggcaggaatg tctgggaaagcaataaaaggtaaagttggcaaacctaaggtgaagaaacttcaattggaa gaaacaatgccttcaccttatgggagaagaataattcctgaaattactgctatgaaggca gatgccagcaaaaagttgttgaagaagaagaagggtgaccttgatactacagtagtgaaa gtggaatttgatgaagaattcagtggaacaccagtagaaggtacaggagaagaggcgttg gccccatcagctcctataagtaaaggtcctaagcccaaaagggaaaaaaaggagcctggt accagggttagaaaaacacctacagcatctggaaaacctagtgcaaaaaaagtgaagaaa cggaatccttggtcagatgatgaatccaagtcagaaagtgacttggaagaaacagaacct gtggttattccaagagattctttgcttaggagagcagctgctgaaagacctaaatacaca tttgatttctcggaagaagatgatgatgatgctgatgatgatgatgacaacaatgattta gaagaattgaaagttaaagcatctcccataacaaatgatggagaagatgagtttattcct tcagatggcttagataaggatgaatatacattttctgccagcaaatctaaaactactcca gaaaaatcttcacatgaaaaaaaaagtcaggattttgggaatctcttttcatttccttca tactctcagaagtcagaagatgattcagctaaatttgacagtaatgaagaagatactgct tctgttttttcaccatcatttggtctgaagcaaacagacaaagttccaagtaaaacagta gctgctaaaaaaggaaaaccacctttggatatagcttctaaacccaagagagcccccaag cagaagaaagtagtggagactgtaaactctgattcagattcagaatttggcattccaaag aagactgcagcaccaaaaggtaaaggccgaggggcaaagaaaaggaaagcatctggctct gaaaatgaaggtgattataaccccggcaggaaaacatccaaaacaacaagcaagaaaccg aagaaaacatcttttgatcaggactcagacgtggacatcttcccctcagatttcacttct gacccaccttctctgccacggaccgggcgggctaggaaagaagtaaaatattttgcagag tctgatgaagaagaagatgttgattttgcaatgtttaattaa

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