KEGG   Cavia porcellus (domestic guinea pig): 100715734
Entry
100715734         CDS       T07777                                 
Symbol
Tyk2
Name
(RefSeq) non-receptor tyrosine-protein kinase TYK2 isoform X1
  KO
K11219  non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
Organism
cpoc  Cavia porcellus (domestic guinea pig)
Pathway
cpoc04217  Necroptosis
cpoc04380  Osteoclast differentiation
cpoc04620  Toll-like receptor signaling pathway
cpoc04621  NOD-like receptor signaling pathway
cpoc04630  JAK-STAT signaling pathway
cpoc04658  Th1 and Th2 cell differentiation
cpoc04659  Th17 cell differentiation
cpoc05145  Toxoplasmosis
cpoc05160  Hepatitis C
cpoc05161  Hepatitis B
cpoc05162  Measles
cpoc05164  Influenza A
cpoc05165  Human papillomavirus infection
cpoc05167  Kaposi sarcoma-associated herpesvirus infection
cpoc05168  Herpes simplex virus 1 infection
cpoc05169  Epstein-Barr virus infection
cpoc05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:cpoc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    100715734 (Tyk2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    100715734 (Tyk2)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100715734 (Tyk2)
   04621 NOD-like receptor signaling pathway
    100715734 (Tyk2)
   04658 Th1 and Th2 cell differentiation
    100715734 (Tyk2)
   04659 Th17 cell differentiation
    100715734 (Tyk2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100715734 (Tyk2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    100715734 (Tyk2)
   05160 Hepatitis C
    100715734 (Tyk2)
   05171 Coronavirus disease - COVID-19
    100715734 (Tyk2)
   05164 Influenza A
    100715734 (Tyk2)
   05162 Measles
    100715734 (Tyk2)
   05168 Herpes simplex virus 1 infection
    100715734 (Tyk2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100715734 (Tyk2)
   05169 Epstein-Barr virus infection
    100715734 (Tyk2)
   05165 Human papillomavirus infection
    100715734 (Tyk2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100715734 (Tyk2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cpoc01001]
    100715734 (Tyk2)
Enzymes [BR:cpoc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     100715734 (Tyk2)
Protein kinases [BR:cpoc01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   100715734 (Tyk2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 SH2_1 Kinase-like Kdo ABC1
Other DBs
NCBI-GeneID: 100715734
NCBI-ProteinID: XP_013000843
Ensembl: ENSCPOG00000004366
LinkDB
Position
Unknown
AA seq 1199 aa
MPLCQWGGSARRGQPDGDELQPLAAAGGLRVLLHWAGPGGGQPWVTFSEASITAEEVCLR
VAQQVGITPACFSLFALFDADAQVWLPPNHILEVSGDTSQTLYFRMRFYFRNWHGMNPHE
PPVYRCRLPGPEVSSEQAEQGIQVLDPASFEYLFEQGKYEFVNDVISLWELSSEEEIHHF
KNESLGMAFLHLCHLAFCRNVPLEEVAKEISFTRCIPSSFRQQIRQHSVLTRLRLRSVFR
RFVRTFRTAQLSRRAVMVKYLATLEHLAPRFGAERIPVRHLELLCQADREPPAAPDPASS
PGPPTHEVLVTGTGGIQWRPVQPEGAGGSGVGSWNPKAGVPGRKARAHREAGGQPADRPQ
QPPWTYFCDFRDVTHVVLKESRVSVHRQDNKCLVRMGLGEPGRPGPVRPLTSPCLQEMSL
PSRAAALSFAALVDGYFRLTADSSHYLCHEVAPPRLVLSIQDGIHGPLLEPFLRAKLQLE
DGLYLFHWSASHLDRLLLAVAQRDLSPGDGGVRSVSLHRFPVERQAGGFVLEGWDRSFPS
VRALRGALRGCCLRAGDHCFSLRRCCLPRPGEISNLIIKRGPQARTRQLNLSQLSFHRVQ
QDDITQLSHLGQGTRTNVYEGLLRVGTPEEDKEDGVDSGEPSGGRGQELRVVLKVLDPGH
HDIMLAFYETASLMSQVSHVHLAFVHGVCVRGSENIMVTEFVEHGPLDVWLRRERGRVPL
AWKLVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALS
REERVERIPWTAPESLPTGAGSLSTAVDKWGFGATLLEICFDGEVPLQGRAPSEKERFYQ
KQHQLPEPACPELAAVTSQCLSYERAQRPSFRTILRDLTRLQPHSLADISTVNPESPASD
PTVFHKRYLKKIRDLGEGHFGKVSLYCYDPNNDGTGEMVAVKSLKADCGPQLHSGWRREI
DILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHSVGLAQLLLFAQQIC
EGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYHVREDGDSPVFWY
APECLKECKFYYASDVWSFGVTLYELLTYCDSRQSPPSKFMELIGVTQGQMTVLRLTELL
EQGERLPRPDRCPPEIYLLMKNCWEAQASFRPTFQNLVPILKSEQEKHQGQAASVFTVC
NT seq 3600 nt   +upstreamnt  +downstreamnt
atgcctctgtgccagtggggaggctcggcgaggcgcggccagcccgacggggatgaattg
cagcccttggccgctgcgggaggcctgcgggtccttctgcactgggctggccctggtggt
gggcagccctgggtcaccttcagcgaggcctcaataacagctgaggaggtctgcctccga
gtggcgcagcaagtcggcatcacaccagcctgcttcagtctcttcgctctctttgatgct
gatgcccaagtgtggctgcccccaaaccacatcctggaagtttctggagacacaagccag
acactgtatttccgcatgaggttttacttccggaactggcatggcatgaacccgcacgag
ccacctgtgtaccgctgcagactcccagggcccgaggtgtcctcagagcaggcggagcag
gggatacaagtcttggatccagcctcctttgagtacctctttgagcagggcaagtatgag
tttgtgaatgatgtgatatccctgtgggagctgtccagtgaggaggaaatccaccacttt
aagaatgagagcctgggcatggcatttctacacctctgccaccttgctttctgccgcaat
gtccctctggaggaggtggccaaagagatcagcttcacgcgctgcatcccgagctccttt
cggcagcagatccgccagcacagcgtgctgacccgcctgcgcctgcgcagcgtcttccgg
cgcttcgtgcgcaccttccggacggcgcagctgtcccggcgggccgtcatggtcaagtac
ctggccacgctggagcacctggcgccccgcttcggcgccgagcgcatcccggtgcgtcac
ctggagctgctgtgccaggccgacagggagccccccgcagcccccgaccccgcctcgtcc
ccgggaccccccacccacgaggtgctggtcacgggcaccgggggcatccagtggcgcccg
gtacagccggagggcgccggtggcagtggtgttggtagctggaatccgaaagccggggtg
cccgggagaaaggccagggcccacagggaggcaggggggcagccggcagaccggccgcag
cagccaccctggacctatttctgcgacttccgggacgtcacccacgtggtcctgaaggag
agtcgcgtcagcgtccaccggcaggacaacaagtgcttggtgcggatggggctgggggag
ccggggcgccctgggcctgtgcgtcccctgacgtccccctgcctgcaggaaatgagcctg
ccctcccgggctgccgccctgtccttcgcagcactggtggacggctacttccgcctgacg
gccgactccagccactacctgtgccatgaggtggctcccccaaggctggtcctgagcatt
caggatggcatccacgggcctctgctggagccgttcctgcgggccaagctgcagctggag
gacggactctacctcttccactggagcgccagccacctggaccgcctcctcctcgccgtg
gcccagcgggacctgagcccgggcgacggtggtgtgcggagcgtgtccctccacaggttt
ccagtcgagcggcaggccgggggcttcgtgctggagggctgggaccgctccttccccagc
gtgcgcgcccttcggggcgccctgcggggctgctgcctccgggctggggaccactgcttc
tccttgcgcaggtgttgcctgccccggccaggagagatctccaacctcatcatcaagcgg
gggcctcaggcccgcacccggcagctcaacctcagccagctgagcttccacagagtccag
caggatgacatcacccagctgtcacacttgggccagggcacgaggaccaacgtgtatgag
ggtctcctgagagtggggacgcccgaggaggacaaagaggatggcgtggactctggggag
cccagtgggggccgtgggcaggagctgcgtgtggtgctgaaggtgctggacccaggtcac
catgacatcatgctggccttctatgagacagccagcctcatgagccaggtgtctcacgtc
cacctggccttcgtgcacggtgtctgcgtgcgtggctctgagaacatcatggtgactgag
ttcgtggagcacgggcccctggacgtgtggctgcggcgggagcggggccgtgtgcccctg
gcttggaagctggtggttgcccagcagctggccagcgccctcagctacctggaggacaag
aacctggtgcacgggaatgtgtgtggccggaacatcctcctggcccggctggggctggca
gaaggcaccagcccgttcatcaagctcagtgaccctggcgtggggctgggtgccctctcc
agggaggagcgggtggagcgcatcccctggacggcgcccgagagcctgcccaccggggcc
ggcagcctgagcacagccgtggacaagtggggcttcggagccaccctgctggagatctgc
tttgacggcgaggtgcccctgcagggccgcgccccctccgagaaagagcgcttctaccag
aagcagcaccagctgcccgagcccgcgtgccctgagctggccgcagtcaccagccagtgc
ctgagctatgagcgggcccagcggccgtccttccgcaccatcttgcgtgacctcactcgg
ctgcagccccacagtcttgcggacatctcgactgtgaaccccgagtcaccagcgtcagac
cccacggtgttccataagcgctatttgaaaaagatccgcgatctgggggagggtcacttt
ggcaaggtcagcctgtactgctatgacccaaacaacgatggcactggcgagatggtggcc
gtgaaatccctcaaggcggactgtgggcctcagctccactcgggctggaggcgggagatc
gacatcctgcgcacgctctaccatgagcacatcgtcaagtacaagggctgctgtgaggac
caaggcgagaagtcggtgcagcttgtcatggagtacgtgccgctgggcagcctccgagat
tacctgccccggcacagcgtcggccttgcccagctgctgctgtttgcccagcagatctgc
gagggcatggcctatctgcacgcccagcactacatccaccgcgacctggccgcgcgcaat
gtgctgctggacaacgacaggctcgtcaagatcggggacttcggcctggccaaggctgtg
cctgaaggccacgagtactaccacgtgcgcgaggacggggacagccccgtgttctggtac
gcccctgagtgcctcaaagagtgtaagttctactatgcgtccgacgtctggtccttcggt
gtcacgctgtatgagctgctgacgtactgtgactccaggcagagcccgccctcgaaattc
atggagctcataggcgtcacccagggccagatgactgtgctgaggctcacggagttgctg
gaacaaggagagaggttgccccggccagacagatgtcccccggagatctatctcctcatg
aagaactgctgggaagcccaggcctccttccggcccaccttccagaacctggttcccatc
ctcaagtcggagcaggagaaacaccagggccaggccgcctccgtgttcactgtgtgctga

DBGET integrated database retrieval system