KEGG   Cavia porcellus (domestic guinea pig): 100722333
Entry
100722333         CDS       T07777                                 
Symbol
Mapk8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X2
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
cpoc  Cavia porcellus (domestic guinea pig)
Pathway
cpoc01522  Endocrine resistance
cpoc04010  MAPK signaling pathway
cpoc04012  ErbB signaling pathway
cpoc04014  Ras signaling pathway
cpoc04024  cAMP signaling pathway
cpoc04068  FoxO signaling pathway
cpoc04071  Sphingolipid signaling pathway
cpoc04137  Mitophagy - animal
cpoc04140  Autophagy - animal
cpoc04141  Protein processing in endoplasmic reticulum
cpoc04210  Apoptosis
cpoc04215  Apoptosis - multiple species
cpoc04217  Necroptosis
cpoc04310  Wnt signaling pathway
cpoc04380  Osteoclast differentiation
cpoc04510  Focal adhesion
cpoc04530  Tight junction
cpoc04620  Toll-like receptor signaling pathway
cpoc04621  NOD-like receptor signaling pathway
cpoc04622  RIG-I-like receptor signaling pathway
cpoc04625  C-type lectin receptor signaling pathway
cpoc04657  IL-17 signaling pathway
cpoc04658  Th1 and Th2 cell differentiation
cpoc04659  Th17 cell differentiation
cpoc04660  T cell receptor signaling pathway
cpoc04664  Fc epsilon RI signaling pathway
cpoc04668  TNF signaling pathway
cpoc04722  Neurotrophin signaling pathway
cpoc04723  Retrograde endocannabinoid signaling
cpoc04728  Dopaminergic synapse
cpoc04750  Inflammatory mediator regulation of TRP channels
cpoc04910  Insulin signaling pathway
cpoc04912  GnRH signaling pathway
cpoc04914  Progesterone-mediated oocyte maturation
cpoc04917  Prolactin signaling pathway
cpoc04920  Adipocytokine signaling pathway
cpoc04926  Relaxin signaling pathway
cpoc04930  Type II diabetes mellitus
cpoc04931  Insulin resistance
cpoc04932  Non-alcoholic fatty liver disease
cpoc04933  AGE-RAGE signaling pathway in diabetic complications
cpoc04935  Growth hormone synthesis, secretion and action
cpoc04936  Alcoholic liver disease
cpoc05010  Alzheimer disease
cpoc05012  Parkinson disease
cpoc05016  Huntington disease
cpoc05017  Spinocerebellar ataxia
cpoc05020  Prion disease
cpoc05022  Pathways of neurodegeneration - multiple diseases
cpoc05132  Salmonella infection
cpoc05133  Pertussis
cpoc05135  Yersinia infection
cpoc05142  Chagas disease
cpoc05145  Toxoplasmosis
cpoc05152  Tuberculosis
cpoc05161  Hepatitis B
cpoc05162  Measles
cpoc05166  Human T-cell leukemia virus 1 infection
cpoc05167  Kaposi sarcoma-associated herpesvirus infection
cpoc05169  Epstein-Barr virus infection
cpoc05170  Human immunodeficiency virus 1 infection
cpoc05171  Coronavirus disease - COVID-19
cpoc05200  Pathways in cancer
cpoc05208  Chemical carcinogenesis - reactive oxygen species
cpoc05210  Colorectal cancer
cpoc05212  Pancreatic cancer
cpoc05231  Choline metabolism in cancer
cpoc05415  Diabetic cardiomyopathy
cpoc05417  Lipid and atherosclerosis
cpoc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cpoc00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    100722333 (Mapk8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100722333 (Mapk8)
   04012 ErbB signaling pathway
    100722333 (Mapk8)
   04014 Ras signaling pathway
    100722333 (Mapk8)
   04310 Wnt signaling pathway
    100722333 (Mapk8)
   04668 TNF signaling pathway
    100722333 (Mapk8)
   04068 FoxO signaling pathway
    100722333 (Mapk8)
   04071 Sphingolipid signaling pathway
    100722333 (Mapk8)
   04024 cAMP signaling pathway
    100722333 (Mapk8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100722333 (Mapk8)
   04137 Mitophagy - animal
    100722333 (Mapk8)
  09143 Cell growth and death
   04210 Apoptosis
    100722333 (Mapk8)
   04215 Apoptosis - multiple species
    100722333 (Mapk8)
   04217 Necroptosis
    100722333 (Mapk8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100722333 (Mapk8)
   04530 Tight junction
    100722333 (Mapk8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100722333 (Mapk8)
   04621 NOD-like receptor signaling pathway
    100722333 (Mapk8)
   04622 RIG-I-like receptor signaling pathway
    100722333 (Mapk8)
   04625 C-type lectin receptor signaling pathway
    100722333 (Mapk8)
   04660 T cell receptor signaling pathway
    100722333 (Mapk8)
   04658 Th1 and Th2 cell differentiation
    100722333 (Mapk8)
   04659 Th17 cell differentiation
    100722333 (Mapk8)
   04657 IL-17 signaling pathway
    100722333 (Mapk8)
   04664 Fc epsilon RI signaling pathway
    100722333 (Mapk8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100722333 (Mapk8)
   04920 Adipocytokine signaling pathway
    100722333 (Mapk8)
   04912 GnRH signaling pathway
    100722333 (Mapk8)
   04914 Progesterone-mediated oocyte maturation
    100722333 (Mapk8)
   04917 Prolactin signaling pathway
    100722333 (Mapk8)
   04926 Relaxin signaling pathway
    100722333 (Mapk8)
   04935 Growth hormone synthesis, secretion and action
    100722333 (Mapk8)
  09156 Nervous system
   04728 Dopaminergic synapse
    100722333 (Mapk8)
   04723 Retrograde endocannabinoid signaling
    100722333 (Mapk8)
   04722 Neurotrophin signaling pathway
    100722333 (Mapk8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100722333 (Mapk8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100722333 (Mapk8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100722333 (Mapk8)
   05208 Chemical carcinogenesis - reactive oxygen species
    100722333 (Mapk8)
   05231 Choline metabolism in cancer
    100722333 (Mapk8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100722333 (Mapk8)
   05212 Pancreatic cancer
    100722333 (Mapk8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100722333 (Mapk8)
   05170 Human immunodeficiency virus 1 infection
    100722333 (Mapk8)
   05161 Hepatitis B
    100722333 (Mapk8)
   05171 Coronavirus disease - COVID-19
    100722333 (Mapk8)
   05162 Measles
    100722333 (Mapk8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100722333 (Mapk8)
   05169 Epstein-Barr virus infection
    100722333 (Mapk8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100722333 (Mapk8)
   05135 Yersinia infection
    100722333 (Mapk8)
   05133 Pertussis
    100722333 (Mapk8)
   05152 Tuberculosis
    100722333 (Mapk8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100722333 (Mapk8)
   05142 Chagas disease
    100722333 (Mapk8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100722333 (Mapk8)
   05012 Parkinson disease
    100722333 (Mapk8)
   05016 Huntington disease
    100722333 (Mapk8)
   05017 Spinocerebellar ataxia
    100722333 (Mapk8)
   05020 Prion disease
    100722333 (Mapk8)
   05022 Pathways of neurodegeneration - multiple diseases
    100722333 (Mapk8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100722333 (Mapk8)
   05418 Fluid shear stress and atherosclerosis
    100722333 (Mapk8)
   05415 Diabetic cardiomyopathy
    100722333 (Mapk8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100722333 (Mapk8)
   04936 Alcoholic liver disease
    100722333 (Mapk8)
   04932 Non-alcoholic fatty liver disease
    100722333 (Mapk8)
   04931 Insulin resistance
    100722333 (Mapk8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100722333 (Mapk8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100722333 (Mapk8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cpoc01001]
    100722333 (Mapk8)
Enzymes [BR:cpoc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     100722333 (Mapk8)
Protein kinases [BR:cpoc01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   100722333 (Mapk8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH
Other DBs
NCBI-GeneID: 100722333
NCBI-ProteinID: XP_003466114
Ensembl: ENSCPOG00000038234
UniProt: A0A286XG70
LinkDB
Position
Unknown
AA seq 427 aa
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVTSGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacaacaatttttatagtgtagaaattggagattctacgttc
acagtcctgaaacgataccagaatttaaaacctataggctcaggagctcaaggcatagta
tgtgcagcttatgatgccattctggaaagaaatgttgcaatcaagaagctaagccggcct
tttcagaatcagactcatgccaagcgggcctatcgagagctggttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatcccttgaagaa
tttcaagatgtttacatagtcatggagctcatggatgccaacctctgccaagtgattcag
atggaactagaccacgaaagaatgtcctaccttctctaccagatgctgtgtgggatcaag
caccttcactctgccgggattattcaccgggacttaaagcccagtaatatagtggtaaaa
tcggactgcactttgaagatcctcgacttcgggctggctcggactgcaggcacgagcttc
atgatgacgccctacgtagtgacgcgctactaccgagcgcccgaggtcatcctgggcatg
ggctacaaggagaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgaccagtggaataaagtcatcgaacag
cttggaacaccgtgtcctgagttcatgaagaaactacagccaacagtaaggacttacgtg
gaaaacaggcctaaatatgctggctacagctttgagaagcttttccccgatgtgcttttc
ccggctgactcagagcacaacaaactgaaagccagtcaggcaagggatttgttgtccaag
atgctggtgatcgatgcgtctaaaaggatctccgtggatgaggccctccagcacccctac
atcaacgtgtggtacgacccctccgaggcggaagccccaccaccaaagatccctgacaag
cagctagatgaaagggaacacacgatagaagagtggaaagagttgatatacaaggaagtg
atggacttggaggagagaaccaagaacggagttatccgggggcagccctctcctctaggt
gcagcagtgaccagtggctctcagcatccatcgtcatcgtcgtctgtcaatgatgtgtct
tcgatgtccacagatccgactttggcctcggacaccgacagcagtctcgaggcgtcggcc
ggccctctgggctgctgcagatga

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