Cavia porcellus (domestic guinea pig): 100725363 Help Entry 100725363         CDS       T07777                                  Symbol Egfr Name (RefSeq) epidermal growth factor receptor   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism cpoc  Cavia porcellus (domestic guinea pig) Pathway cpoc01521   EGFR tyrosine kinase inhibitor resistance cpoc01522   Endocrine resistance cpoc03272   Virion - Hepatitis viruses cpoc04010   MAPK signaling pathway cpoc04012   ErbB signaling pathway cpoc04014   Ras signaling pathway cpoc04015   Rap1 signaling pathway cpoc04020   Calcium signaling pathway cpoc04066   HIF-1 signaling pathway cpoc04068   FoxO signaling pathway cpoc04072   Phospholipase D signaling pathway cpoc04144   Endocytosis cpoc04151   PI3K-Akt signaling pathway cpoc04510   Focal adhesion cpoc04520   Adherens junction cpoc04540   Gap junction cpoc04630   JAK-STAT signaling pathway cpoc04810   Regulation of actin cytoskeleton cpoc04912   GnRH signaling pathway cpoc04915   Estrogen signaling pathway cpoc04921   Oxytocin signaling pathway cpoc04926   Relaxin signaling pathway cpoc04928   Parathyroid hormone synthesis, secretion and action cpoc04934   Cushing syndrome cpoc05160   Hepatitis C cpoc05163   Human cytomegalovirus infection cpoc05165   Human papillomavirus infection cpoc05171   Coronavirus disease - COVID-19 cpoc05200   Pathways in cancer cpoc05205   Proteoglycans in cancer cpoc05206   MicroRNAs in cancer cpoc05207   Chemical carcinogenesis - receptor activation cpoc05208   Chemical carcinogenesis - reactive oxygen species cpoc05210   Colorectal cancer cpoc05212   Pancreatic cancer cpoc05213   Endometrial cancer cpoc05214   Glioma cpoc05215   Prostate cancer cpoc05218   Melanoma cpoc05219   Bladder cancer cpoc05223   Non-small cell lung cancer cpoc05224   Breast cancer cpoc05225   Hepatocellular carcinoma cpoc05226   Gastric cancer cpoc05230   Central carbon metabolism in cancer cpoc05231   Choline metabolism in cancer cpoc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:cpoc00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03272 Virion - Hepatitis viruses     100725363 (Egfr)  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100725363 (Egfr)    04012 ErbB signaling pathway     100725363 (Egfr)    04014 Ras signaling pathway     100725363 (Egfr)    04015 Rap1 signaling pathway     100725363 (Egfr)    04630 JAK-STAT signaling pathway     100725363 (Egfr)    04066 HIF-1 signaling pathway     100725363 (Egfr)    04068 FoxO signaling pathway     100725363 (Egfr)    04020 Calcium signaling pathway     100725363 (Egfr)    04072 Phospholipase D signaling pathway     100725363 (Egfr)    04151 PI3K-Akt signaling pathway     100725363 (Egfr)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     100725363 (Egfr)   09144 Cellular community - eukaryotes    04510 Focal adhesion     100725363 (Egfr)    04520 Adherens junction     100725363 (Egfr)    04540 Gap junction     100725363 (Egfr)   09142 Cell motility    04810 Regulation of actin cytoskeleton     100725363 (Egfr)  09150 Organismal Systems   09152 Endocrine system    04912 GnRH signaling pathway     100725363 (Egfr)    04915 Estrogen signaling pathway     100725363 (Egfr)    04921 Oxytocin signaling pathway     100725363 (Egfr)    04926 Relaxin signaling pathway     100725363 (Egfr)    04928 Parathyroid hormone synthesis, secretion and action     100725363 (Egfr)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100725363 (Egfr)    05206 MicroRNAs in cancer     100725363 (Egfr)    05205 Proteoglycans in cancer     100725363 (Egfr)    05207 Chemical carcinogenesis - receptor activation     100725363 (Egfr)    05208 Chemical carcinogenesis - reactive oxygen species     100725363 (Egfr)    05230 Central carbon metabolism in cancer     100725363 (Egfr)    05231 Choline metabolism in cancer     100725363 (Egfr)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100725363 (Egfr)   09162 Cancer: specific types    05210 Colorectal cancer     100725363 (Egfr)    05212 Pancreatic cancer     100725363 (Egfr)    05225 Hepatocellular carcinoma     100725363 (Egfr)    05226 Gastric cancer     100725363 (Egfr)    05214 Glioma     100725363 (Egfr)    05218 Melanoma     100725363 (Egfr)    05219 Bladder cancer     100725363 (Egfr)    05215 Prostate cancer     100725363 (Egfr)    05213 Endometrial cancer     100725363 (Egfr)    05224 Breast cancer     100725363 (Egfr)    05223 Non-small cell lung cancer     100725363 (Egfr)   09172 Infectious disease: viral    05160 Hepatitis C     100725363 (Egfr)    05171 Coronavirus disease - COVID-19     100725363 (Egfr)    05163 Human cytomegalovirus infection     100725363 (Egfr)    05165 Human papillomavirus infection     100725363 (Egfr)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100725363 (Egfr)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100725363 (Egfr)    01522 Endocrine resistance     100725363 (Egfr)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:cpoc01001]     100725363 (Egfr)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:cpoc04147]     100725363 (Egfr) Enzymes [BR:cpoc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100725363 (Egfr) Protein kinases [BR:cpoc01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    100725363 (Egfr) Exosome [BR:cpoc04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    100725363 (Egfr)   Exosomal proteins of pancreatic cancer cells    100725363 (Egfr)   Exosomal proteins of bladder cancer cells    100725363 (Egfr) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Kinase-like ABC1 Haspin_kinase Motif Other DBs NCBI-GeneID:  100725363 NCBI-ProteinID:  XP_003465863 Ensembl:  ENSCPOG00000000040 UniProt:  H0UT18 LinkDB All DBs Position Unknown AA seq 1214 aa AA seqDB search MRPYAAAGPAMCALLALLALLGAHAAPEEKRVCQGTSNKLTQLGTFEDHFLSLQRMFNNC EVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLVALNTVERIPLENLQIVRGNVLYENTYA LAVLSNYGSANSANRTGLRELPLRSLQEILHGAVRFSNNPVLCSVDTIQWRDIVNNLFLS NMSLDWQSPQSGCQKCDPSCPNGSCWGPGAENCQKLTKIICAQQCSGRCRGKSPSDCCHN QCAAGCTGPRESDCLVCRRFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKK CPRNYVVTDHGSCVRACSSDSYEIEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINAT NIKHFRNCTTISGDLHILPVAFRGDSFTRTQPLDPKELDILKTVKEITGFLLIQAWPENR TNLHAFENLEIIRGRTKQHGQFSLAVVGLNLTSLGLRSLKEISDGDVIVSGNRHLCYANT IHWRKLFGTAGQKTKIVNNRNERDCKADGHVCHPLCSSEGCWGPEAQDCVSCQNVSRGRE CVARCNIFEGEPREFVENSECIQCHPECLPQAMNVTCTGRGPDNCVQCAHHIDGPHCVKT CPAGVMGENNTLVWKYADAGRVCRLCHPNCTYGCTGPGLQGCAIEGTKVPSIATGIVGGL FLLVLLGLGIGLLMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKK IKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHV CRLLGICLTSTVQLVTQLMPFGCLLDYVREHKDNIGSQHLLNWCVQIAKGMNYLEDRRLV HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQ SDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMID ADSRPKFRELIVEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDIVDAD EYLIPQQSFFSSPSTSRTPLLSSLSANSNNSTGACVPRNGNCPVRSDGFLQRYSSDPTGT LTEDNLDDAFLPVPEYINQSFPKRPAGSVQNPIYHNQPLHPAPGRDPHYQNPHSHAVGNP EYLNTTQSTGVSGSFDSPGPWTQQGNHQLSLDNPDYQQDFFPKEAKPNGIFKGPTAENTE YLRVAPPSSEFIGA NT seq 3645 nt NT seq  +upstreamnt  +downstreamnt atgcggccgtacgcggcggcagggcccgcgatgtgcgccctactggcgctgctggcgctg ctgggggcgcacgcggcacccgaagagaagcgcgtttgccaaggaacaagcaacaagctc acccagttgggcacttttgaagaccacttcctgagcctccagcggatgttcaacaactgc gaggtggtgctggggaatctagagatcacctatgtgcagaggaactatgacctttccttc ctgaagaccatccaggaggtggccggctacgtgcttgttgccctcaacacggtggagagg atcccactggagaacctgcagatcgtgcgtggaaacgtgctctatgagaacacctatgct ctggccgtgctgtccaactacggcagtgccaacagtgccaacaggaccgggctgcgggag ctgcccctgaggagcctgcaggagatcctgcatggtgccgtgcgcttcagcaacaacccc gtgctctgcagtgtggacaccatccagtggcgggacatcgtgaacaacctcttcctgagc aacatgtcgctggactggcagagccctcagagcggctgccaaaagtgtgatccgagctgt cccaatgggagctgctggggcccgggcgcggagaactgccagaaactgaccaagatcatc tgtgcccagcagtgctcagggcgctgtcgtggcaagtctcccagcgactgctgccacaac cagtgtgcggctggctgcactgggccgcgggagagcgactgtctggtctgccgcaggttc cgtgatgaggccacatgcaaggacacctgcccgccgctcatgctgtacaaccccaccacc taccagatggatgtcaaccccgaagggaagtacagcttcggcgccacctgcgtgaagaag tgtccccggaactacgtggtgactgaccatggctcctgtgtccgggcctgcagctccgac agctacgagatagaggaagacggtgtgcgcaagtgcaaaaaatgtgaagggccctgtcgc aaagtttgcaatggaataggaattggggagtttaaagacacactttccataaacgccacg aacatcaagcacttcaggaactgcacaaccatcagtggggacctgcatatcctcccagtg gcatttcggggggattccttcacgcgcacgcagcccctggatcccaaggagctggacatc ctgaagaccgtgaaggaaatcacagggttcctgctgattcaggcctggcctgagaacagg accaacctccacgcatttgagaacctggaaatcatccgtggccggacaaagcaacatggc cagttttctctggctgtggttggcctgaacctgacgtccctgggtctgcgctccctgaag gagatcagcgacggagacgtgatcgtctccgggaaccggcatctgtgctacgccaacacc atccactggagaaaactgtttggaactgccggacagaaaaccaaaattgtaaacaacagg aatgaaagggactgcaaggctgatggtcacgtctgccacccgctgtgctcctccgagggc tgctggggccccgaggcccaggactgcgtctcctgccagaatgtgagccggggcagggag tgtgtggccaggtgcaacatctttgagggggagcccagagagttcgtggagaattctgag tgcatccagtgccacccggagtgcctgccccaggccatgaacgtgacctgcaccggcagg ggccctgacaactgtgtccagtgcgcccaccacatcgatggcccccactgtgtcaagacc tgcccggccggggtcatgggagagaacaacacgctggtgtggaagtacgcggatgctggc cgggtgtgccgcctgtgccaccccaactgcacctatggatgtaccgggccaggtctgcaa ggctgtgcaatagaagggaccaaggtcccatccattgctactgggatcgtgggtggcctc ttcctgctggtgctgctgggcctgggcatcggcctcctcatgaggcgacgccacattgtc cgcaagcgcacgctgcgccggctgctgcaggaacgcgagctggtggagccccttacaccc agcggagaagcccctaaccaggccctcctgaggatcctgaaggaaacagaattcaagaag atcaaggtgctgggctctggagcattcggcacagtctacaagggactctggatcccggaa ggtgagaaagtgaagattcctgtggccatcaaggagttgcgagaagccacatctccgaaa gccaacaaggaaatcctggatgaagcctatgtgatggccagcgtggacaacccccatgtg tgccgccttctgggcatctgcctgacgtccactgtgcagctggtcacacaactcatgccc tttggctgcctgctggactatgtgcgtgagcacaaggacaacatcgggtcccagcacctg ctcaactggtgtgtgcagatcgccaagggcatgaactacctggaggaccggcgcttggtg caccgagacctggcggccaggaatgtcctggtgaagacaccacagcacgtcaagatcaca gactttgggctggccaagctcctgggcgcggaggagaaggagtaccatgctgagggtggc aaggtgcccatcaaatggatggctttggagtcaattttacaccggatttatacccaccag agtgatgtctggagctacggagtcaccgtgtgggagctgatgaccttcgggtccaagccc tatgacgggatccctgccagtgagatctcatccatcctagagaaaggagagcgcttgcca cagccgcccatctgcaccatcgacgtctacatgatcatggtcaaatgctggatgatagat gcagatagccgcccaaagttccgcgagctgatcgtcgagttctccaaaatggcccgagac ccccagcgctaccttgtcattcagggggatgagaggatgcatttgccgagccctacagac tccaatttctaccgtgccctgatggacgaggaggacatggaggatatcgtggatgcggac gagtatctcattccacagcagagcttcttcagcagcccctccacctctcggacgcccctc ctgagctcgctgagtgcaaacagcaacaattctaccggagcttgtgttcctaggaatggg aactgccctgtcagaagtgatggtttcctgcagcgctacagctcagaccccactggcacc ctgactgaggacaacctggatgatgccttcctccctgtgcccgaatacataaaccagtcc ttccctaaaaggcctgcaggctccgtgcagaaccccatctatcacaatcagcccctgcac cccgctccaggcagagacccacactaccagaacccccacagccatgccgtgggcaacccc gaatatctcaacaccacgcagtccactggtgtcagtggcagctttgacagccctggcccc tggacccagcagggcaaccaccaacttagcctggacaaccccgactaccagcaggacttc tttcccaaggaagccaagcccaacggcatctttaaggggcccacagctgaaaacacagaa taccttcgggtggccccgccaagcagtgagtttattggagcataa

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